trimethoprim--sulfamethoxazole-drug-combination and Glomerulonephritis--Membranous

trimethoprim--sulfamethoxazole-drug-combination has been researched along with Glomerulonephritis--Membranous* in 1 studies

Other Studies

1 other study(ies) available for trimethoprim--sulfamethoxazole-drug-combination and Glomerulonephritis--Membranous

ArticleYear
Remission of nephrotic membranous glomerulonephritis after high-dose trimethoprim-sulfamethoxazole treatment for pneumocystis jiroveci pneumonia.
    Clinical nephrology, 2007, Volume: 68, Issue:2

    We report an unusual case of nephrotic syndrome due to membranous glomerulonephritis that responded to high-dose trimethoprim-sulfamethoxazole (TMP-SMX) treatment. A 52-year-old man presented with nephrotic syndrome and was diagnosed to have idiopathic membranous glomerulonephritis. At the time of diagnosis, his serum creatinine level was 1.2 mg/dl and daily urine protein excretion was 7.45 g. The patient was initially treated with angiotensin-converting enzyme inhibitor and diuretics. After a 6-month period, the patient remained symptomatic. Therefore, immunosuppressive therapy with a 6-month course of alternating corticosteroids with cyclophosphamide was commenced. Unfortunately, as a sequel of the immunocompromised state, the patient acquired severe pneumonia due to Pneumocystis jiroveci infection when he was on the fourth month of immunosuppressive therapy. At this time, he still had nephrotic range proteinuria and hypoalbuminemia. Because of the risk of aggravating infection, immunosuppressive agents were discontinued. A 14-day course of intravenous high-dose TMP-SMX therapy was given for the treatment of Pneumocystis jiroveci pneumonia. With this medication, not only the pneumonia was cured, but also a sustained remission of the nephrotic syndrome occurred. This case suggests a possible therapeutic role of high-dose TMP-SMX in membranous glomerulonephritis. We will discuss the possible mechanism.

    Topics: Anti-Infective Agents; Glomerulonephritis, Membranous; Humans; Male; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Remission Induction; Trimethoprim, Sulfamethoxazole Drug Combination

2007