trimethoprim--sulfamethoxazole-drug-combination has been researched along with Glioma* in 1 studies
1 other study(ies) available for trimethoprim--sulfamethoxazole-drug-combination and Glioma
| Article | Year |
|---|---|
Evaluation of laboratory disturbance risk when adding low-dose cotrimoxazole for PJP prophylaxis to regimens of high-grade glioma patients taking RAAS inhibitors.
Cotrimoxazole is associated with the development of hyponatremia, hyperkalemia and elevated serum creatinine, especially when combined with inhibitors of the renin-angiotensin-aldosterone system (RAAS).. We evaluated whether high-grade glioma patients taking renin-angiotensin-aldosterone system inhibitors receiving low-dose cotrimoxazole for. We conducted a retrospective chart review of adult neuro-oncology patients treated for WHO Grade III or IV glioma between 2013 and 2016. Patient serum Na, K, creatinine, and eGFR were compared (renin-angiotensin-aldosterone system vs. non-renin-angiotensin-aldosterone system) using the chi-square test. Binary logistic regression analysis was then performed to account for differences between cohorts.. Of 63 patients (35 non-renin-angiotensin-aldosterone system, 28 renin-angiotensin-aldosterone system), patients in the renin-angiotensin-aldosterone system cohort were more likely to experience a laboratory disturbance (odds ratio=3.17,. Adding low-dose cotrimoxazole for Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Antibiotic Prophylaxis; Creatinine; Drug Interactions; Female; Glioma; Glomerular Filtration Rate; Humans; Hyperkalemia; Male; Middle Aged; Neoplasm Grading; Pneumonia, Pneumocystis; Potassium; Renin-Angiotensin System; Retrospective Studies; Sodium; Trimethoprim, Sulfamethoxazole Drug Combination | 2019 |