trimethoprim--sulfamethoxazole-drug-combination and Genital-Diseases--Male

A pure seminal vesicle abscess is a rare condition. We report case 7 in the literature and to our knowledge the first patient who has been managed successfully by noninvasive, conservative antibiotic treatment alone. All previously reported cases of seminal vesicle abscesses have been managed with invasive therapy. In 5 cases the seminal vesicle abscess was incised and drained surgically, while in 1 the abscess was drained percutaneously. We describe a patient with a seminal vesicle abscess, review the literature and recommend a more conservative method of management.

Topics: Abscess; Anti-Infective Agents; Drug Combinations; Escherichia coli Infections; Genital Diseases, Male; Humans; Male; Middle Aged; Seminal Vesicles; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A total of 105 patients with established fixed drug eruption (FDE) by oral provocation were evaluated with regard to a drug-related site involvement. Cotrimoxazole was the leading causative agent (63.8%), followed by naproxen sodium (23.8%), dipyrone (5.7%), oxicams (4.8%) and other rare causes (1.9%). Cotrimoxazole most frequently induced lesions on genital mucosa; naproxen and oxicams on lips; and dipyrone on trunk and extremities. Isolated FDE on male genitalia (n = 16) was exclusively because of cotrimoxazole. A highly significant association could be established between naproxen and FDE on lips (chi-square = 28.3; corrected P =.000002). As this study represents the largest series of patients with naproxen-induced FDE, we would suggest that naproxen should be considered as an important potential cause of FDE on lips.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dipyrone; Drug Eruptions; Facial Dermatoses; Female; Foot Dermatoses; Genital Diseases, Male; Hand Dermatoses; Humans; Lip Diseases; Male; Middle Aged; Naproxen; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Doxycycline; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Lymphogranuloma Venereum; Male; Pregnancy; Pregnancy Complications, Infectious; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

Absent for several decades, the chancroid reappeared in Algeria in 1988. In the unique department of Dermatology and Venereology of the University Hospital of the country of Tlemcen (more than 700,000 inhabitants), we wanted to know the state of this STD seven years after the report of the first cases. The file of the consulting patients were examined. We looked for the principal characteristics of this STD: age, sex, incubation period, place infection contact, type of relation, clinical presentation, evolution without and with treatment, other associated STD (syphilis, HIV). From August 1988 (1st case) to December 1995, 144 cases of chancroid were collected = 1988: 6, 1989: 5, 1990: 7, 1991: 18, 1992: 11, 1993: 33, 1994: 48, 1995: 16. The presentation is quite stereotyped; it concerns males only, singles in must cases, having had sexual relations with prostitutes. The incubation period is short (less than 10 days), the characteristic ulceration presents, very often, some adenopathies. The treatment by cotrimoxazole is efficient. They are no concomitant syphilis or HIV infection. The chancroid is the first cause of genital ulceration in the world. Since 1991, it is the principal STD in our department. It spreads within a male population, young singles associated with prostitutes. It is well installed in Algeria, and its role, although minor, in the transmission of the HIV infection, should not be neglected.

Topics: Adolescent; Adult; Age Factors; Algeria; Anti-Infective Agents; Chancroid; Genital Diseases, Male; HIV Infections; Humans; Lymph Nodes; Male; Marital Status; Middle Aged; Penile Diseases; Retrospective Studies; Scrotum; Sex Factors; Sex Work; Sexual Partners; Sexually Transmitted Diseases, Bacterial; Skin Ulcer; Syphilis; Trimethoprim, Sulfamethoxazole Drug Combination

In Yaoundé, chancroid occurs frequently among adolescents and young men (95 p. 100 of the cases) who have sexual contacts regularly with prostitutes. Apart of classical clinical forms complicated in 2/3 of cases by inguinal adenopathies, we have observed furuncular chancroid which is quite characteristic of the disease. Giemsa stain represents for us a simple and reliable diagnostic method for this disease because in 1/3 of smears, typical cultural aspects of Haemophilus ducreyi were seen.

Topics: Adolescent; Adult; Cameroon; Chancroid; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Trimethoprim, Sulfamethoxazole Drug Combination