trimethoprim--sulfamethoxazole-drug-combination and Eyelid-Diseases

Topics: Abscess; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; COVID-19; Disinfectants; Eye Protective Devices; Eyelid Diseases; Female; Humans; Intensive Care Units; SARS-CoV-2; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult

Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Eyelid Diseases; Gram-Positive Bacterial Infections; Humans; Immunocompetence; Male; Middle Aged; Rifampin; Skin Diseases, Bacterial; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Child, Preschool; Drug Therapy, Combination; Eye Infections, Viral; Eyelid Diseases; HIV Seropositivity; Humans; Lamivudine; Male; Molluscum Contagiosum; Nevirapine; Trimethoprim, Sulfamethoxazole Drug Combination; Viral Load; Zidovudine

To report a rare case of lymphocutaneous Nocardia brasiliensis originating in the eyelid.. Observational case report.. The clinical presentation, workup, and treatment of a case of lymphocutaneous Nocardia brasiliensis originating in the eyelid are presented.. The patient presented with a preseptal cellulitis from an abrasion of the eyelid that progressed to submandibular lymph node suppuration. Culture was performed, and a diagnosis of lymphocutaneous Nocardia brasiliensis was made.. Nocardia brasiliensis may cause a lymphocutaneous infection of the face and must be considered in the differential diagnosis of preseptal cellulitis.

Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Drug Therapy, Combination; Eye Infections, Bacterial; Eyelid Diseases; Humans; Lymph Nodes; Lymphatic Diseases; Male; Nocardia; Nocardia Infections; Skin Diseases, Bacterial; Trimethoprim, Sulfamethoxazole Drug Combination

To report a new surgical technique to manage severe acute toxic epidermal necrolysis.. Two interventional case reports.. Two patients. Case 1: A 6-year-old boy had severe toxic epidermal necrolysis develop after being treated with trimethoprim and sulfamethoxazole for chronic otitis media. Both eyes and eyelids were affected. He underwent bilateral lysis of symblepharon and all adhesions and bilateral amniotic membrane transplantation to the entire ocular surface except the cornea. Loss of eyelid skin required transplantation of amniotic membrane to all four eyelids and strips of amniotic membrane at the eyelid margins. Case 2: An 8-year-old girl with severe toxic epidermal necrolysis associated with mycoplasma pneumonia had bilateral, diffuse keratoconjunctivitis, diffuse corneal epithelial defects, and bilateral symblepharon. Amniotic membrane transplantation was performed bilaterally, using a symblepharon ring in the left eye.. Amniotic membrane transplantation.. Preservation of normal ocular and eyelid surfaces and prevention of blindness.. Case 1: Thirty-six months after bilateral ocular surgery, there is no symblepharon, good ocular surface wetting, and an uncorrected bilateral vision of 20/20. Case 2: Amniotic membrane transplantation protected both ocular surfaces and prevented conjunctival contracture without adhesion of the eyelids to the ocular surface. The central vision was preserved. There was minimal peripheral corneal vascularization and mild conjunctival scarring of the tarsal conjunctival surface 34 months postoperatively.. These are the first cases of acute toxic epidermal necrolysis treated with amniotic membrane transplantation and the first use of the procedure on external eyelid surfaces with good healing of the eyelids. This new treatment for acute toxic epidermal necrolysis preserves normal ocular and eyelid surfaces and may prevent blindness.

Topics: Acute Disease; Amnion; Child; Eyelid Diseases; Female; Humans; Keratoconjunctivitis; Male; Ophthalmologic Surgical Procedures; Pneumonia, Mycoplasma; Stevens-Johnson Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination; Visual Acuity