trimethoprim--sulfamethoxazole-drug-combination and Endometritis

Single-dose trimethoprim-sulfamethoxazole prophylaxis after clamping of the umbilical cord decreased the rate of endomyometritis in high-risk patients by 50% when compared with placebo. This drug combination may affect the normal flora of the cervix the least so that superinfections should be rare.

Topics: Adolescent; Anti-Infective Agents; Cesarean Section; Drug Combinations; Endometritis; Female; Humans; Pregnancy; Premedication; Random Allocation; Risk; Sulfamethoxazole; Surgical Wound Infection; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A 19-year-old Quarter Horse mare was evaluated because of bloody vaginal discharge that was apparent immediately following breeding. On transrectal ultrasonography, it was evident that the uterus was filled with fluid containing echogenic particles; linear hyperechoic structures were also visible. Endoscopy was performed, which revealed a number of bones adhered to the cranial wall and floor of the right uterine horn as well as purulent fluid in both uterine horns. Bacterial endometritis and fetal maceration were diagnosed. The mare was treated with antibiotics, and the fetal bones were manually removed from the uterus. Fetal maceration with intrauterine retention of bones is rare in mares. Use of hysteroscopy supplements ultrasonography in the diagnosis of uncommon conditions of the uterus. Macerated bones may be adhered to the endometrium, thereby requiring manual removal.

Topics: Abortion, Veterinary; Animals; Bone and Bones; Cattle; Dinoprost; Endometritis; Female; Fetus; Horse Diseases; Horses; Hysteroscopy; Oxytocics; Pregnancy; Progesterone; Streptococcal Infections; Streptococcus equi; Trimethoprim, Sulfamethoxazole Drug Combination; Ultrasonography; Uterus; Vaginal Discharge

Bitches with pyometra were treated with dinoprost, a prostaglandin F-2 alpha-THAM salt or luprostiol, a synthetic PG analogue and oral broad-spectrum antibacterial drugs. PGF-2 alpha treatment lasted 2-26 days and dosage varied from 26.8 to 258 micrograms/kg. Clinical cure from symptoms was achieved in 33/40 bitches. Of 14 bitches from which the owners opted to breed, 9 eventually produced litters. Long-term complications were anoestrus, recurrence of metritis, failure to conceive and abortion. One or more of these complications were recorded in 9 of 20 bitches for which long term information was available.

Topics: Amoxicillin; Ampicillin; Animals; Dinoprost; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Doxycycline; Drug Therapy, Combination; Endometritis; Female; Prostaglandins F, Synthetic; Retrospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Animals; Cattle; Drug Combinations; Endometritis; Female; Lactation Disorders; Mastitis, Bovine; Pregnancy; Puerperal Disorders; Sulfanilamides; Swine; Swine Diseases; Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination