trimethoprim--sulfamethoxazole-drug-combination and Encephalitis--Viral

Human herpesvirus 6 (HHV-6), the causative agent of the common exanthem subitum, is a known cause of central nervous system infection in immunocompromised patients. It has been suggested that HHV-6 participate in the development of drug-induced hypersensitivity syndrome.. We reported a case of HHV-6 encephalitis associated with hypersensitivity syndrome induced by trimethoprim-sulfamethoxazole in a 72-year-old HIV-negative woman.. Our case confirmed that reactivation of HHV-6 infection may contribute to the development of the hypersensitivity syndrome.

Topics: Aged; Anti-Infective Agents; Antiviral Agents; Drug Hypersensitivity; Encephalitis, Viral; Female; Ganciclovir; Herpesvirus 6, Human; Humans; Roseolovirus Infections; Syndrome; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination