trimethoprim--sulfamethoxazole-drug-combination and Edema

Topics: Abscess; Aged; Diagnosis, Differential; Edema; Female; Hand; Humans; Lymphangitis; Lymphatic Diseases; Nocardia; Nocardia Infections; Skin; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Abdominal Pain; Administration, Oral; Amylases; Cells, Cultured; Child; Drug-Related Side Effects and Adverse Reactions; Edema; Enzyme-Linked Immunospot Assay; Female; Humans; Immunization; Lipase; Lymphocyte Activation; Pancreatitis; T-Lymphocytes, Cytotoxic; Trimethoprim, Sulfamethoxazole Drug Combination; Vomiting; Withholding Treatment

Topics: Abdominal Cavity; Aged, 80 and over; Anti-Infective Agents; Ascites; Cefotaxime; Diagnosis, Differential; Diet, Sodium-Restricted; Diuretics; Edema; Humans; Inflammation; Liver Cirrhosis; Lower Extremity; Male; Norfloxacin; Paracentesis; Peritonitis; Spironolactone; Tomography, X-Ray Computed; Trimethoprim, Sulfamethoxazole Drug Combination; Ultrasonography

Topics: Anti-Infective Agents; Ceftriaxone; Constriction, Pathologic; Diagnosis, Differential; Edema; Emotions; Heart; Heart Diseases; Humans; Male; Middle Aged; Trimethoprim, Sulfamethoxazole Drug Combination; Whipple Disease; Wit and Humor as Topic

Nocardia is a rare pathogen of mainly immunocomprised patients. Only two cases of nocardiosis have previously been identified in Iceland.. A 92-year-old male on glucocorticoid therapy with metastatic bladder cancer presented with two weeks history of progressive swelling and erythema of the hand and deteriorating cognitive functioning. A brain lesion and pulmonary nodules were identified and Nocardia farcinia was cultured from a hand abscess. The patient was initially treated with trimethoprim/sulfamethoxazole but because of rapid deterioration and old age an end-of-life decision was made.. This case of nocardiosis illustrates the importance of uncommon opportunistic infections in immunocompromised Icelandic patients.

Topics: Aged, 80 and over; Anti-Infective Agents; Cellulitis; Edema; Erythema; Glucocorticoids; Hand; Humans; Immunocompromised Host; Male; Nocardia; Nocardia Infections; Opportunistic Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Bladder Neoplasms

Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-HIV Agents; Bone Marrow Diseases; Diarrhea; Duodenal Diseases; Edema; Enteral Nutrition; Humans; Hypotension; Leg; Male; Middle Aged; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Trimethoprim, Sulfamethoxazole Drug Combination

A 50-year-old woman was admitted to our emergency room because of progressive weakness. She collapsed the night before admission. Skin and mucosa were pale, she denied major infections or bleedings. An alcohol abuse was known for many years. Because of edema she received a therapy with triamteren, an infection of the urinary tract was treated with cotrimoxacol.. In addition to thrombocytopenia (50 Gpt/l) and leukocytopenia (1,51 10 (9)/l) we diagnosed a hyperchromic and macrocytic anemia (Hb 3,6 mmol/l [5,8 g/dl], Hk 0,17, MCH 2.52 fmol, 116,8 fl). Folic acid was decreased to 0.677 ng/ml, whereas levels of cobalamin, ferritin and iron were normal. Examination of bone marrow showed a hypercellular marrow with typical megaloblastic features of erythropoiesis and granulopoiesis. A systemic hematological disorder could be ruled out. The folic acid deficiency in our patient was the result of a long time alcohol abuse and a simultaneous therapy with mild folate antagonists (triamteren and cotrimoxacol).. The patient received folic acid (5 mg/d orally). Within one week the peripheral blood counts increased to normal, the follow up bone marrow examination showed a hyperplastic marrow with normal hematopoietic maturation.. Folic acid deficiency can be aggravated because of simultaneous therapy with mild folate antagonists. In addition to megaloblastic anemia this can lead to thrombocytopenia and/or leukocytopenia. Therefore in patients with pancytopenia a deficiency of folic acid should be ruled out.

Topics: Alcoholism; Anemia, Macrocytic; Anti-Infective Agents, Urinary; Diagnosis, Differential; Diuretics; Edema; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Middle Aged; Pancytopenia; Triamterene; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections

Topics: Adult; Agranulocytosis; Decision Making; Diagnosis, Differential; Dyspnea; Edema; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Infant, Newborn; Leukopenia; Lung Diseases; Lupus Erythematosus, Systemic; Pregnancy; Pregnancy Complications; Puerperal Disorders; Trimethoprim, Sulfamethoxazole Drug Combination

Fifty male children, aged between 3 and 10 years, were treated for a 12-day period with either trimethoprim (80-160 mg) plus sulphamethoxazole (400-800 mg) daily (co-trimoxazole) or 50-125 mg/day flurbiprofen rectally. The patients had been treated surgically for criptorchidism. Flurbiprofen showed good effectivity in controlling post-operative inflammation in urology. It is concluded that antimicrobial agents such as cotrimoxazole, because of their potential risks of damage at the cell's level, should be used only in presence of a bacterial infection.

Topics: Anti-Inflammatory Agents; Child; Child, Preschool; Cryptorchidism; Drug Combinations; Edema; Flurbiprofen; Humans; Male; Postoperative Complications; Propionates; Random Allocation; Scrotum; Sulfamethoxazole; Suppositories; Therapeutic Equivalency; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination