trimethoprim--sulfamethoxazole-drug-combination and Dermatomycoses

Topics: Adult; Antifungal Agents; Clofazimine; Dermatomycoses; Drug Combinations; Ear; Ear Auricle; Fibrosis; Histocytochemistry; Humans; Lacazia; Lobomycosis; Male; Mexico; Pathology, Molecular; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Antibodies, Fungal; Antifungal Agents; Dermatomycoses; Humans; Itraconazole; Laryngoscopy; Male; Middle Aged; Paracoccidioides; Paracoccidioidomycosis; Skin; Trimethoprim, Sulfamethoxazole Drug Combination

This is the first reported case of Nocardia niigatensis infection in an adult kidney transplant recipient. A 57-year-old Asian woman presented with multiple cutaneous abscesses and rapidly growing fungating mass on the left pretibial area for 2 months. She received a cadaveric kidney transplant 4 years previously and was undergoing immunosuppression with prednisolone, cyclosporine and mycophenolate sodium. The microbiological diagnosis was established by isolation of Nocardia from the purulent material expressed from a granule. The strain was identified to the species level by 16S rRNA gene-targeted PCR. The closest match was with N. niigatensis. Antibiotic treatment (trimethotrim-sulfamethoxazole) was continued for 6 months and the skin lesions improved.

Topics: Dermatomycoses; Female; Humans; Kidney Transplantation; Middle Aged; Nocardia Infections; Trimethoprim, Sulfamethoxazole Drug Combination

Infections are the leading cause of morbidity and mortality in transplanted patients. The increasing number of immunocompromised patients has not only augmented infections by specific pathogens, but also by opportunistic microbial agents.. A mixed cutaneous infection caused by Nocardia brasiliensis and Exophiala jeanselmei is reported in a liver transplant patient.. The cutaneous lesions were painful nodules which drained purulent material. They were located on the right lower limb, with lymphadenopathies in the groin.. The patient was treated with itraconazole (600 mg/day) plus trimethoprim (1600 mg/day)-sulfamethoxazole (320 mg/day) for 8 weeks, with complete remission of the lesions.

Topics: Adult; Anti-Infective Agents; Dermatomycoses; Exophiala; Humans; Immunocompromised Host; Itraconazole; Liver Transplantation; Lymphangitis; Male; Nocardia; Nocardia Infections; Opportunistic Infections; Skin Diseases, Bacterial; Trimethoprim, Sulfamethoxazole Drug Combination

The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 microg/ml; MIC(50), 1 microg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.

Topics: Acetamides; Amikacin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dermatomycoses; Drug Therapy, Combination; Humans; Linezolid; Microbial Sensitivity Tests; Nocardia; Nocardia Infections; Oxazolidinones; Trimethoprim, Sulfamethoxazole Drug Combination

A case of subcutaneous phycomycosis involving the right thigh for 1 year duration which mimic elephantiasis was reported in a 21-year-old military man. An initial diagnosis was that of a subcutaneous tissue lesion attributed to parasitic manifestation but turned out to be that of subcutaneous fungal infection both clinically and histologically. The lesion was successfully treated with cotrimoxazole for a period of one month, and followed up for 4 1/2 months with complete cure.

Topics: Adult; Anti-Infective Agents; Dermatomycoses; Diagnosis, Differential; Drug Combinations; Elephantiasis; Fungi; Humans; Lymphedema; Male; Sarcoma; Soft Tissue Neoplasms; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination