trimethoprim--sulfamethoxazole-drug-combination and Conjunctivitis

Sudden conjunctivitis, lymphopenia, and rash combined with hemodynamic changes (SCoRCH) is a recently described hypersensitivity reaction to trimethoprim-sulfamethoxazole. To date, only 1 case of histologic findings in SCoRCH has been reported, revealing a superficial perivascular dermatitis. In this article, we present a 53-year-old woman with a four-day history of a widespread, confluent, erythematous, and dusky rash after exposure to trimethoprim-sulfamethoxazole. Histologic examination revealed a vacuolar interface dermatitis with several apoptotic keratinocytes at multiple levels of the epidermis, similar to an erythema multiforme-like presentation. As described in SCoRCH, our patient's clinical findings rapidly improved within 48 hours of presentation without treatment. This case adds to the current literature by identifying a newly described histopathological presentation of SCoRCH.

Topics: Conjunctivitis; Dermatitis; Exanthema; Female; Humans; Lymphopenia; Middle Aged; Thrombocytopenia; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-Infective Agents; Conjunctivitis; Corneal Diseases; Eyelids; Female; Humans; Middle Aged; Stevens-Johnson Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Adult; Anti-Bacterial Agents; Conjunctivitis; Drug Therapy, Combination; Eye Infections, Bacterial; Humans; Male; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Orbital Diseases; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Tobramycin; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin