trimethoprim--sulfamethoxazole-drug-combination and Colitis

Aeromonas species, once thought pathogenic only in immunocompromised hosts, have more recently been found to be associated with many different infections in previously healthy individuals. The most common site of these infections is the gastrointestinal tract. We describe a 67-yr-old woman who presented with abdominal pain and bloody diarrhea and was diagnosed with left-sided, segmental colitis due to Aeromonas sobria, which was proven by stool culture. Extensive work-up for ischemic colitis was unremarkable, and after treatment with antibiotics, the patient's symptoms resolved, and follow-up colonoscopy failed to reveal any evidence of residual colitis or inflammatory bowel disease. Our report supports the view that Aeromonas species need to be considered in the differential diagnosis of colitis, and we believe it to be the first report of left-sided, segmental colitis secondary to Aeromonas sobria infection.

Topics: Acute Disease; Aeromonas; Aged; Anti-Bacterial Agents; Colitis; Diarrhea; Endoscopy, Digestive System; Feces; Female; Gram-Negative Bacterial Infections; Humans; Trimethoprim, Sulfamethoxazole Drug Combination

At the Clinic for infectious and dermatovenerologic diseases in Novi Sad a prospective randomized, simple, blind investigation of differently organized treatments of salmonellal gastroenterocolitis (symptomatic therapies, ampicillin, co-trimoxazole and ciprofloxacine) was carried out. It was established that there is no statistically significant difference in the length of febrile states in any of the compared therapeutic groups. However, ciprofloxacine significantly shortens diarrhea and excretion of germs comparing with other therapeutic treatments.

Topics: Adolescent; Adult; Ampicillin; Anti-Infective Agents; Child; Child, Preschool; Ciprofloxacin; Colitis; Female; Gastroenteritis; Humans; Infant; Male; Middle Aged; Penicillins; Prospective Studies; Salmonella Infections; Single-Blind Method; Trimethoprim, Sulfamethoxazole Drug Combination

A deletion of a telomerase RNA component (Terc(-/-)) in C57BL/6 (B6) mice resulted in hematopoietic lineage skewing with increased neutrophils and CD11b(+) myeloid cells and decreased red blood cells and CD45R(+) B lymphocytes when animals reach ages older than 12 months. There was no decline in bone marrow (BM) c-Kit(+)Sca-1(+)Lin(-) (KSL) cells in old Terc(-/-) mice, and the lineage skewing phenomenon was not transferred when BM cells from old Terc(-/-) donors were transplanted into young B6 recipients. Necropsy and histological examinations found minimal to no change in the lung, spleen and liver but detected severe epithelia degeneration, ulceration and infection in small and large intestines, leading to enteritis, typhlitis and colitis in old Terc(-/-) mice. In a mouse model of dextran-sulfate-sodium-induced typhlitis and colitis, development of intestinal pathology was associated with increases in neutrophils and CD11b(+) myeloid cells and a decrease in CD45R(+) B cells, similar to those observed in old Terc(-/-) mice. Treatment of 11-13 month old Terc(-/-) mice with antibiotic trimethoprim-sulfa water reduced neutrophils and myeloid cells and increased B lymphocytes in the blood, indicating that mitigation of intestinal infection and inflammation could alleviate hematological abnormalities in old Terc(-/-) animals.

Topics: Aging; Animals; B-Lymphocytes; Bone Marrow; Bone Marrow Transplantation; Cell Lineage; Colitis; Disease Models, Animal; Female; Flow Cytometry; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA; Sequence Deletion; Telomerase; Trimethoprim, Sulfamethoxazole Drug Combination

We describe a fatal case of haemolytic uraemic syndrome in a young woman with AIDS, and disseminated adenovirus (ADV) and cytomegalovirus (CMV) co-infection. We hypothesize that ADV/CMV co-infection may have a causative role in this clinical picture.

Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenovirus Infections, Human; Colitis; Cytomegalovirus Infections; Enteritis; Fatal Outcome; Female; Foscarnet; Ganciclovir; Hemolytic-Uremic Syndrome; Humans; Respiratory Distress Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Colitis; Dog Diseases; Dogs; Soft Tissue Infections; Sulfasalazine; Trimethoprim, Sulfamethoxazole Drug Combination