trimethoprim--sulfamethoxazole-drug-combination and Chorioamnionitis

A secundigravida developed culture-proved Listeria monocytogenes sepsis with signs and symptoms of chorioamnionitis at 13 weeks' gestation. Pregnancy termination was refused, and she was treated with intravenous ampicillin and gentamicin followed by oral trimethoprim/sulfamethoxazol. Fifteen days after initiation of therapy, an amniotic fluid culture was negative, although uterine tenderness persisted for 7 weeks. A healthy, culture-negative infant was delivered at term.

Topics: Adult; Ampicillin; Anti-Infective Agents; Chorioamnionitis; Drug Combinations; Drug Therapy, Combination; Female; Gentamicins; Humans; Listeriosis; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnancy Trimester, First; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination