trimethoprim--sulfamethoxazole-drug-combination and Ataxia-Telangiectasia

We report a case of toxoplasmosis with bilateral maculopathy in a 7-year-old boy diagnosed with ataxia telangiectasia (AT) at age 6. AT manifests as ataxia, apraxia, telangiectasia, and dysarthria. Common ophthalmologic findings in AT include fine conjunctival telangiectasia. Patients also suffer from recurrent sinopulmonary infections; however, serious opportunistic infection is rarely diagnosed. At 8 years of age he developed disseminated Toxoplasma gondii (toxoplasmosis) infection and meningoencephalitis. This ophthalmologic finding and the subsequent toxoplasmosis meningoencephalitis have not been previously reported in AT.

Topics: Anti-Infective Agents; Ataxia Telangiectasia; Cerebrospinal Fluid; Child; Conjunctival Diseases; Eye Infections, Parasitic; Humans; Magnetic Resonance Imaging; Male; Polymerase Chain Reaction; Retinal Diseases; Tomography, Optical Coherence; Toxoplasma; Toxoplasmosis, Ocular; Trimethoprim, Sulfamethoxazole Drug Combination