trimethoprim--sulfamethoxazole-drug-combination and Aggressive-Periodontitis

Generalised prepubertal periodontitis is a rare entity that is usually a consequence of severe systemic diseases. Chronic granulomatous disease is one of the extremely rare inherited immunodeficiency diseases, which predisposes the patient to recurrent severe bacterial and fungal infections.. The purpose of this report is to describe a 5-year old male patient suffering from prepubertal periodontitis associated with chronic granulomatous disease, who was referred to the Department of Periodontology for treatment of severe gingival inflammation.. A detailed past history was obtained and thorough clinical and laboratory examinations were performed.. Medical tests revealed the only immunodeficiency sign as the extremely low burst test result. The patient was diagnosed as having an autosomal recessive (AR) form of chronic granulomatous disease. He was put on prophylactic treatment with trimethoprim-sulfamethoxazole (TMP-SMX) and also a periodontal maintenance regimen with regular 1-month intervals.. This case report emphasises the importance of the differential diagnosis of severe immunodeficiency in the background of prepubertal periodontitis.

Topics: Aggressive Periodontitis; Anti-Infective Agents; Child, Preschool; Diagnosis, Differential; Disease Susceptibility; Follow-Up Studies; Genes, Recessive; Gingivitis; Granulomatous Disease, Chronic; Humans; Male; Recurrence; Trimethoprim, Sulfamethoxazole Drug Combination