trimethobenzamide has been researched along with Hirschsprung Disease in 1 studies
trimethobenzamide: major descriptor (64-84); on-line search BENZAMIDES (64-84); Index Medicus search TRIMETHOBENZAMIDE (64-84); RN given refers to parent cpd
trimethobenzamide : The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans.
Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethobenzamide (TMB) has a pregnancy category C labeling." | 3.77 | Growth failure, tardive dyskinesia, megacolon development, and hepatic damage in neonatal rats following exposure to trimethobenzamide in utero. ( Gokcimen, A; Goksu Erol, AY; Ozdemir, O, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goksu Erol, AY | 1 |
| Gokcimen, A | 1 |
| Ozdemir, O | 1 |
1 other study available for trimethobenzamide and Hirschsprung Disease
| Article | Year |
|---|---|
Growth failure, tardive dyskinesia, megacolon development, and hepatic damage in neonatal rats following exposure to trimethobenzamide in utero.
Topics: Animals; Animals, Newborn; Antiemetics; Benzamides; Chemical and Drug Induced Liver Injury; Female; | 2011 |