trimethaphan-camsylate and Aortic-Aneurysm

Severe hypertension is a common clinical problem in the United States, encountered in various clinical settings. Although various terms have been applied to severe hypertension, such as hypertensive crises, emergencies, or urgencies, they are all characterized by acute elevations in BP that may be associated with end-organ damage (hypertensive crisis). The immediate reduction of BP is only required in patients with acute end-organ damage. Hypertension associated with cerebral infarction or intracerebral hemorrhage only rarely requires treatment. While nitroprusside is commonly used to treat severe hypertension, it is an extremely toxic drug that should only be used in rare circumstances. Furthermore, the short-acting calcium channel blocker nifedipine is associated with significant morbidity and should be avoided. Today, a wide range of pharmacologic alternatives are available to the practitioner to control severe hypertension. This article reviews some of the current concepts and common misconceptions in the management of patients with acutely elevated BP.

Topics: Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Clonidine; Diazoxide; Enalaprilat; Female; Fenoldopam; Humans; Hypertension; Labetalol; Nicardipine; Nifedipine; Nitroprusside; Phentolamine; Pre-Eclampsia; Pregnancy; Propanolamines; Trimethaphan

Topics: Acute Disease; Aortic Aneurysm; Aortic Dissection; Brain Diseases; Cerebral Hemorrhage; Coronary Disease; Diazoxide; Eclampsia; Female; Humans; Hypertension; Hypertension, Malignant; Monoamine Oxidase; Nitroprusside; Pheochromocytoma; Pregnancy; Pregnancy Complications, Cardiovascular; Prognosis; Pulmonary Edema; Smoking; Substance Withdrawal Syndrome; Syndrome; Trimethaphan; Tyramine