trimethadione has been researched along with Seizures in 82 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 5.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| "The natural compounds carvacrol and thymol completely prevented seizures in the 6 Hz, 32 mA partial seizure model." | 3.80 | Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model. ( Baker, MT; Mishra, RK, 2014) |
| "The cholinergic agonist pilocarpine triggers sustained limbic seizures in rodents." | 3.68 | Substantia nigra regulates action of antiepileptic drugs. ( Andrews, JS; Bortolotto, ZA; Bressler, K; Calderazzo-Filho, LS; Cavalheiro, EA; Löschmann, PA; Turski, L, 1990) |
| "The effects of AEDS on seizures of the tremor rat showed profiles similar to those observed in human absence seizures and also in absence-like seizures of SER." | 1.29 | Effect of antiepileptic drugs on absence-like seizures in the tremor rat. ( Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T, 1995) |
| "The kindled-convulsion model was used to assess the development of tolerance and cross tolerance to the anticonvulsant effects of antiepileptic drugs." | 1.28 | Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine. ( Hudda, MM; Kim, CK; Pinel, JP; Wong, DJ; Yung, A, 1992) |
| " The dose-response curve for naloxone against seizure activity induced by leucine enkephalin was the same as that in gamma-hydroxybutyrate-induced petit mal." | 1.26 | Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. ( Bearden, LJ; Snead, OC, 1980) |
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 1.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| " In order to test the validity of FEAD as an absence seizure model, the present experiments determined dose-response relationships for the suppression of FEAD by six antiepileptic drugs with established clinical profiles." | 1.26 | Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs. ( Burnham, WM; King, GA; Livingston, KE, 1980) |
| "5." | 1.26 | The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam. ( Anhut, H; Hertting, G; Steinhauer, HB, 1979) |
| "Phenytoin was in effective for most withdrawal signs and some signs were made worse." | 1.26 | Evaluation of anticonvulsants in barbiturate withdrawal. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1977) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| "n-DPA proved to be most active against convulsions induced by picrotoxin (ED50 200 mg/kg orally), which might indicate a role of the elevation of the central levels of gamma-aminobutyric acid in the anticonvulsant effect of the drug." | 1.26 | Di-n-propylacetic acid--profile of anticonvulsant activity in mice. ( Frey, HH; Löscher, W, 1976) |
| "During seizure activity there was a calcium dependent increase in ACh efflux which was related to increase EEG activity and clonic muscle movements." | 1.26 | Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. ( Gardner, CR; Webster, RA, 1977) |
| "Drug-induced systemic lupus erythematosus (SLE)-like syndromes in children are most commonly associated with the administration of ethosuximide, diphenylhydantoin, and trimethadione." | 1.26 | Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants. ( Fishman, L; Hanson, V; Singsen, BH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (90.24) | 18.7374 |
| 1990's | 3 (3.66) | 18.2507 |
| 2000's | 2 (2.44) | 29.6817 |
| 2010's | 3 (3.66) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witiak, DT | 2 |
| Vishnuvajjala, BR | 1 |
| Cook, WL | 2 |
| Minatelli, JA | 1 |
| Gupta, TK | 2 |
| Gerald, MC | 2 |
| Sharma, G | 1 |
| Park, JY | 1 |
| Park, MS | 1 |
| Pastore, V | 2 |
| Sabatier, L | 1 |
| Enrique, A | 1 |
| Marder, M | 2 |
| Bruno-Blanch, LE | 2 |
| Mishra, RK | 1 |
| Baker, MT | 1 |
| Wasowski, C | 1 |
| Higgs, J | 1 |
| Mangialavori, IC | 1 |
| LOEWE, S | 1 |
| LIEBERT, E | 1 |
| SIMONS, DJ | 1 |
| RICHARDS, RK | 2 |
| EVERETT, GM | 1 |
| BELNAP, WD | 1 |
| TOMAN, JE | 2 |
| GOODMAN, LS | 2 |
| DRIVER, RL | 1 |
| ORDWAY, GL | 1 |
| PERLSTEIN, MA | 1 |
| ANDELMAN, MB | 1 |
| SWINYARD, EA | 2 |
| THORNE, FC | 1 |
| LAWRENCE, DE | 1 |
| HIMWICH, HE | 1 |
| ESSIG, CF | 1 |
| HAMPSON, JL | 1 |
| BALES, PD | 1 |
| FREEDMAN, AM | 1 |
| Snyman, T | 1 |
| Stewart, MJ | 1 |
| Grove, A | 1 |
| Steenkamp, V | 1 |
| Paton, WD | 1 |
| Chernov, HI | 1 |
| Wilson, DE | 1 |
| Fowler, WF | 1 |
| Plummer, AJ | 1 |
| Lorenzo, AV | 1 |
| Barlow, CF | 1 |
| Macko, E | 1 |
| Wilfon, G | 1 |
| Greene, L | 1 |
| Bender, AD | 1 |
| Tedeschi, RE | 1 |
| Wilder, BJ | 1 |
| Bruni, J | 1 |
| Sklenovský, A | 1 |
| Chmela, Z | 1 |
| Snead, OC | 1 |
| Bearden, LJ | 1 |
| Sagratella, S | 1 |
| Passarelli, F | 1 |
| Scotti de Carolis, A | 1 |
| Czuczwar, SJ | 1 |
| Turski, L | 2 |
| Turski, W | 1 |
| Kleinrok, Z | 1 |
| Beckman, DL | 1 |
| Crittenden, DJ | 1 |
| Powers, DL | 1 |
| Sowell, JW | 1 |
| Freeman, JJ | 1 |
| Kosh, JW | 1 |
| Oana, Y | 1 |
| Arai, M | 1 |
| Miura, S | 1 |
| King, GA | 1 |
| Burnham, WM | 1 |
| Livingston, KE | 1 |
| Callaghan, DA | 1 |
| Schwark, WS | 1 |
| Hanaya, R | 1 |
| Sasa, M | 1 |
| Ujihara, H | 1 |
| Fujita, Y | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Serikawa, T | 1 |
| Uozumi, T | 1 |
| Mayevsky, A | 1 |
| Ito, T | 1 |
| Hori, M | 1 |
| Yoshida, K | 1 |
| Shimizu, M | 1 |
| Steinhauer, HB | 1 |
| Anhut, H | 1 |
| Hertting, G | 1 |
| Okamoto, M | 1 |
| Rosenberg, HC | 1 |
| Boisse, NR | 1 |
| Banerjee, U | 1 |
| Yeoh, PN | 2 |
| Novack, GD | 1 |
| Stark, LG | 1 |
| Peterson, SL | 1 |
| Frey, HH | 3 |
| Löscher, W | 1 |
| Gardner, CR | 2 |
| Webster, RA | 2 |
| Craig, CR | 1 |
| Chiu, P | 1 |
| Colasanti, BK | 1 |
| Singsen, BH | 1 |
| Fishman, L | 1 |
| Hanson, V | 1 |
| Kim, CK | 1 |
| Pinel, JP | 1 |
| Hudda, MM | 1 |
| Wong, DJ | 1 |
| Yung, A | 1 |
| Andrews, JS | 1 |
| Löschmann, PA | 1 |
| Bressler, K | 1 |
| Bortolotto, ZA | 1 |
| Calderazzo-Filho, LS | 1 |
| Cavalheiro, EA | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
| Killam, KF | 2 |
| Killam, EK | 2 |
| Naquet, R | 2 |
| Brink, JJ | 1 |
| Freeman, EA | 1 |
| Diaz, PM | 1 |
| Millichap, JG | 2 |
| Hooshmand, H | 1 |
| Suter, CG | 2 |
| Stille, G | 1 |
| Sayers, A | 1 |
| Rümke, CL | 1 |
| Wolf, HH | 1 |
| Kutt, H | 1 |
| Louis, S | 1 |
| Johnson, DD | 1 |
| Crichlow, EC | 1 |
| Crawford, RD | 1 |
| Andermann, F | 1 |
| Robb, JP | 1 |
| Tannhauser, M | 1 |
| Izquierdo, I | 2 |
| Arushanian, EB | 1 |
| Bimar, J | 1 |
| Poncet, M | 1 |
| Halpern, LM | 1 |
| Ward, AA | 1 |
| Lipman, IJ | 1 |
| Isaacs, ER | 1 |
| Osuide, G | 1 |
| Borgstedt, AD | 1 |
| Bryson, MF | 1 |
| Young, LW | 1 |
| Forbes, GB | 1 |
| Kretschmer, BH | 1 |
| Kästner, I | 1 |
| Müller, M | 1 |
| Wenzel, J | 1 |
| Weissman, A | 1 |
| Koe, BK | 1 |
| Ahmad, A | 1 |
| Dhawan, BN | 1 |
| Ferngren, H | 3 |
| Paalzow, L | 2 |
| Wallin, RF | 1 |
| Blackburn, WH | 1 |
| Napoli, MD | 1 |
| Downes, H | 1 |
| Perry, RS | 1 |
| Ostlund, RE | 1 |
| Karler, R | 1 |
| Elazar, Z | 1 |
| Blum, B | 1 |
| Southgate, PJ | 1 |
| King, LJ | 1 |
| Carl, J | 1 |
3 reviews available for trimethadione and Seizures
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
[Neurophysiologic mechanisms of action of anticonvulsive agents (review of the literature)].
Topics: Animals; Anticonvulsants; Brain Stem; Cats; Meprobamate; Mesencephalon; Motor Activity; Reticular Fo | 1966 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; El | 1969 |
1 trial available for trimethadione and Seizures
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
79 other studies available for trimethadione and Seizures
| Article | Year |
|---|---|
3,4-Methylenedioxyphenyl-, isopropylidenedioxyphenyl-, and benzyl-substituted chiral 2-aminosuccinimides and 3-aminopyrrolidines. Stereoselective investigations of potential anti-parkinsonian, antipsychotic, and anticonvulsant activities.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Antipsychotic Agents; Humans; Male; Mice; Postural B | 1977 |
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants.
Topics: Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Drug Design; Electroshock; Male; Mice; | 2008 |
Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides.
Topics: Amides; Animals; Anticonvulsants; Behavior, Animal; Male; Mice; Microwaves; Phenytoin; Seizures; Str | 2013 |
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model.
Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Perfor | 2014 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazep | 2014 |
Anticonvulsant actions of trimethadione-phenobarbital and trimethadione-diphenylhydantoin combinations.
Topics: Anticonvulsants; Humans; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1948 |
Treatment of neurological disorders with tridione.
Topics: Epilepsy; Nervous System Diseases; Seizures; Trimethadione | 1947 |
The use of tridione in the treatment of convulsive disorders.
Topics: Epilepsy; Seizures; Trimethadione | 1947 |
Tridione: a new anticonvulsant drug.
Topics: Anticonvulsants; Epilepsy; Seizures; Trimethadione | 1946 |
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia.
Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenyto | 1947 |
Comparative anticonvulsant actions of isopropyl alcohol, diphenylhydantoin, phenobarbital and tridione.
Topics: 1-Propanol; 2-Propanol; Anticonvulsants; Humans; Phenobarbital; Phenytoin; Propanols; Seizures; Trim | 1947 |
Tridione; its use in convulsive and related disorders.
Topics: Seizures; Trimethadione | 1946 |
The anticonvulsant properties of tridione.
Topics: Anticonvulsants; Seizures; Trimethadione | 1946 |
The anticonvulsant action of tridione; preliminary report.
Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Trimethadione | 1945 |
Tridione; a new experimental drug for treatment of convulsive and related disorders; pharmacologic aspects.
Topics: Drugs, Investigational; Epilepsy; Personality Disorders; Seizures; Trimethadione | 1946 |
Near fatal hemolytic anemia during anti-epileptiform convulsion therapy with tridione.
Topics: Anemia, Hemolytic; Animals; Dog Diseases; Dogs; Epilepsy; Oxazoles; Seizures; Trimethadione | 1952 |
Effect of trimethadione (tridione) and other drugs on convulsions caused by di-isopropyl fluorophosphate (DFP).
Topics: Fluorides; Isoflurophate; Phosphates; Phosphorus; Phosphorus Compounds; Seizures; Trimethadione | 1950 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
Experiments on the convulsant and anaesthetic effects of oxygen.
Topics: Anesthesia, Inhalation; Animals; Anticonvulsants; Brain; Bromides; Chlorpromazine; Cobalt; Dimercapr | 1967 |
Non-specificity of the mouse writhing test.
Topics: Acetates; Aminopyrine; Analgesics; Animals; Biological Assay; Bradykinin; Cyclazocine; Dextropropoxy | 1967 |
Effect of strychnine convulsions upon the entry of S35 sulfate into the cat central nervous system.
Topics: Animals; Brain; Cats; Female; Liver; Male; Methocarbamol; Muscles; Nerve Tissue; Seizures; Strychnin | 1967 |
Pharmacological properties of the isopropyl ester of o-sulfamoyl-benzoic acid.
Topics: Animals; Behavior, Animal; Benzoates; Carbamates; Carisoprodol; Chlordiazepoxide; Chlormezanone; Chl | 1967 |
Mechanisms of action of antiepileptic drugs.
Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbama | 1982 |
The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state.
Topics: Animals; Anticonvulsants; Bemegride; Brain; Diazepam; Drug Evaluation, Preclinical; Fatty Acids, Non | 1984 |
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Endorphins; Enkephalins; Epilepsy, Absence; Ethosu | 1980 |
An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Phencyclidine; Phenobarbital; Rabbits; Ra | 1983 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; | 1981 |
Protection from oxygen-induced seizures by clonazepam and propylene glycol.
Topics: Animals; Benzodiazepinones; Carbamazepine; Cats; Clonazepam; Hyperbaric Oxygenation; Polyethylene Gl | 1981 |
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Py | 1980 |
[A study of effects on antiepileptic drugs upon the hippocampal afterdischarge (author's transl)].
Topics: Animals; Anticonvulsants; Carbamazepine; Cats; Electric Stimulation; Female; Hippocampus; Male; Phen | 1980 |
Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs.
Topics: Acetazolamide; Animals; Dose-Response Relationship, Drug; Ethosuximide; Evoked Potentials; Male; Mep | 1980 |
Pharmacological modification of amygdaloid-kindled seizures.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Electrodes, Implanted; Ketamine; Male; Phenobarbi | 1980 |
Effect of antiepileptic drugs on absence-like seizures in the tremor rat.
Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroenceph | 1995 |
The effect of trimethadione on brain energy metabolism and EEG activity of the conscious rat exposed to HPO.
Topics: Animals; Brain; Electroencephalography; Energy Metabolism; Hyperbaric Oxygenation; Male; NAD; Oxazol | 1975 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps | 1977 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Pic | 1979 |
Evaluation of anticonvulsants in barbiturate withdrawal.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; | 1977 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
Anticonvulsant effects of benzhydryl piperazines on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzhydryl Compounds; Male; Mice; Pentylenetetrazole; Pi | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; | 1976 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; | 1977 |
Effects of diphenylhydantoin and trimethadione on seizure activity during cobalt experimental epilepsy in the rat.
Topics: Animals; Cobalt; Female; Oxazoles; Phenytoin; Rats; Seizures; Time Factors; Trimethadione | 1976 |
Para-substituted N-acetyl-L(S)- and -D(R)-alpha-amino-N-phenylglutarimides. A structure-activity study of substituent effects on steroselective anticonvulsant activity.
Topics: Animals; Anticonvulsants; Ethosuximide; Male; Mice; Phenytoin; Piperidines; Piperidones; Seizures; S | 1976 |
Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Anticonvulsants; Child; Child, Preschool; Ethosuximide; | 1976 |
Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Drug Tolerance; Electrodes, Im | 1992 |
Substantia nigra regulates action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethosuximide; Ma | 1990 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Elec | 1967 |
Effects of 5-phenyloxazolidinedione on sodium-potassium-magnesium-activated adenosine triphosphatase activity in mouse brain.
Topics: Adenosine Triphosphatases; Animals; Anticonvulsants; Brain; Carbon Isotopes; Chemical Phenomena; Che | 1972 |
Interaction of pentylenetetrazol and trimethadione on the metabolism of serotonin in brain and its relation to the anticonvulsant action of trimethadione.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Brain Chemistry; Dose-Response Relationship, D | 1974 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Classification and treatment of seizure disorders in children.
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, | 1970 |
Motor convulsions and EEG during maximal electroshock in the rat.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cornea; Electric Stimulation; Electroencephalography; Ele | 1967 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock | 1967 |
Pharmacological evaluation of seizures induced by electrical stimulation of the hippocampus.
Topics: Amino Alcohols; Anilides; Animals; Electric Stimulation; Ethanolamines; Hippocampus; Male; Methods; | 1970 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Epileptiform seizures in domestic fowl. IV. The effects of anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Chickens; Diazepam; Electroencephalography; Phenobarbital; Phenytoin; Phot | 1974 |
Absence status. A reappraisal following review of thirty-eight patients.
Topics: Adolescent; Adult; Barbiturates; Carbon Dioxide; Child; Consciousness; Conversion Disorder; Diagnosi | 1972 |
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex.
Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relatio | 1973 |
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.
Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Elec | 1974 |
Effect of anticonvulsant drugs on the number of afferent stimuli needed to cause a hippocampal seizure discharge.
Topics: Animals; Anticonvulsants; Cannabis; Dose-Response Relationship, Drug; Electric Stimulation; Electros | 1974 |
[A new animal model in study of the epilepsy: the baboon, Papio papio].
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Electromyography; Evoked Potentials; Eye | 1968 |
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs.
Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electr | 1969 |
Petit mal status. A variety of non-convulsive status epilepticus.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalograph | 1971 |
Pharmacological properties of amino-oxyacetic acid in the chicken.
Topics: Acetates; Age Factors; Animals; Anticonvulsants; Central Nervous System; Chickens; Electroencephalog | 1972 |
Long-term administration of antiepileptic drugs and the development of rickets.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; | 1972 |
Anticonvulsant effect of trimethadione in mice during continued treatment via the drinking water.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Osmolar Concentration; Oxazoles; Pentylenetetrazole; S | 1971 |
[Experimental animal studies on the effect of trimethadione on acute and chronic epileptiform activity].
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography | 1971 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxid | 1967 |
Metrazol test for rapid screening of anticonvulsants.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole; Phenytoi | 1969 |
High frequency electro-shock seizures and their antagonism during postnatal development in the mouse. II. Effects of phenobarbital sodium, mephobarbital, trimethadione, dimethadione, ethosuximide and acetazolamide.
Topics: Acetazolamide; Age Factors; Animals; Animals, Newborn; Anticonvulsants; Electroshock; Ethosuximide; | 1969 |
Determination of the anticonvulsant potency of unmetabolized trimethadione.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Pentylenetetrazole; Seizures; Trimethadione | 1969 |
Pharmacologic interactions of albutoin with other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; | 1970 |
A study of the excitatory effects of barbiturates.
Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Injections, Intravenous; Male | 1970 |
Effect of drugs on interictal spikes and after-discharges in experimental epilepsy.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; Glutethimide; Hippocampus; Hydantoins; Mepro | 1971 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocai | 1971 |
Studies on electrically induced-seizures and their antagonism by anticonvulsants during neonatal development in the mouse.
Topics: Acetazolamide; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Ethosuximide; Mice; | 1967 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotox | 1968 |
Effects of antiepileptic drugs on brain energy reserves during convulsions.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Electroshock; Gl | 1969 |