trimethadione has been researched along with Pregnancy in 48 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 5.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "The broadest dosing regimen yielded the highest incidence and the most severe heart and axioskeletal findings with a decrease in mean fetal body weight." | 1.37 | Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. ( Brown, NA; Ozolinš, TR; Weston, AD, 2011) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 1.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "Interspecies differences in regard to the teratogenicity of drugs can be the result of differing pharmacokinetic processes that determine the crucial concentration-time relationships in the embryo." | 1.27 | Species differences in pharmacokinetics and drug teratogenesis. ( Nau, H, 1986) |
| "The dislocation of the hip and the patent ductus arteriosus have been corrected surgically." | 1.25 | Persistent fifth aortic arch in man. ( Lawrence, TY; Stiles, QR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (85.42) | 18.7374 |
| 1990's | 2 (4.17) | 18.2507 |
| 2000's | 3 (6.25) | 29.6817 |
| 2010's | 2 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozolinš, TR | 2 |
| Weston, AD | 2 |
| Perretta, A | 1 |
| Thomson, JJ | 1 |
| Brown, NA | 3 |
| REDIN, B | 1 |
| Weitz, R | 1 |
| Merlob, P | 1 |
| Vorhees, CV | 2 |
| Chernoff, GF | 1 |
| Jones, KL | 1 |
| Kelly, TE | 1 |
| Cordero, JF | 1 |
| Oakley, GP | 3 |
| Friis, ML | 1 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Harned, HS | 1 |
| Clifford, DB | 1 |
| Goldner, JC | 1 |
| Azarbayjani, F | 2 |
| Danielsson, BR | 2 |
| Nakane, Y | 1 |
| Nagai, T | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Feldman, GL | 1 |
| Weaver, DD | 1 |
| Lovrien, EW | 1 |
| Rosen, RC | 1 |
| Lightner, ES | 1 |
| Hecht, F | 1 |
| Midha, KK | 1 |
| Buttar, HS | 1 |
| Rowe, M | 1 |
| Dupuis, I | 1 |
| Shull, G | 1 |
| Fabro, S | 1 |
| Shepard, TH | 1 |
| Rischbieth, RH | 1 |
| Goldman, AS | 1 |
| Yaffe, SJ | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Smith, DW | 1 |
| Anderson, RC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Lawrence, TY | 1 |
| Stiles, QR | 1 |
| Ohtsubo, K | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Wells, PG | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
| Nau, H | 1 |
| Dalessio, DJ | 1 |
| Stumpf, DA | 1 |
| Khera, KS | 1 |
| German, J | 2 |
| Ehlers, KH | 2 |
| Kowal, A | 2 |
| De George, FV | 1 |
| Engle, MA | 1 |
| Passarge, E | 1 |
| Nichols, MM | 1 |
| Zellweger, H | 1 |
| Pegg, DE | 1 |
| Burns, JE | 1 |
12 reviews available for trimethadione and Pregnancy
| Article | Year |
|---|---|
Fetal preventive medicine: teratogens and the unborn baby.
Topics: Abnormalities, Drug-Induced; Dronabinol; Drug Evaluation; Ethanol; Female; Heroin; Hormones; Hot Tem | 1981 |
Teratogenicity of anticonvulsant drugs. I: Review of the literature.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Pregnancy; Pregnancy Complications; | 1984 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Cardiovascular problems of the newborn and their etiologies.
Topics: Amphetamines; Animals; Cardiovascular Diseases; Estrogens; Ethanol; Female; Fetal Hypoxia; Heart Def | 1983 |
[Fetal trimethadione effects].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
[Fetal trimethadione syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Pregn | 2001 |
Drug influences on malformations.
Topics: Abnormalities, Drug-Induced; Amphetamines; Anesthetics; Animals; Anti-Anxiety Agents; Anticonvulsant | 1979 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
36 other studies available for trimethadione and Pregnancy
| Article | Year |
|---|---|
Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels.
Topics: Animals; Anticonvulsants; Dimethadione; Dose-Response Relationship, Drug; Embryo Culture Techniques; | 2015 |
Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.
Topics: Animals; Bone and Bones; Cardiovascular Abnormalities; Cesarean Section; Dimethadione; Female; Heart | 2011 |
[Complications of tridione therapy of epilepsy in children].
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Pregnancy; Trimethadione | 1953 |
[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers].
Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli | 1979 |
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Re | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Seizures and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Hydantoins; | 1984 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
Causal inference in teratology.
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Diazepam; Epidemiologic Methods; Female; Humans; I | 1980 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Drug Therapy, Combination; Epilepsy, Absence; Fe | 1977 |
Phenotypic malformations in association with maternal trimethadione therapy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1978 |
Fetal trimethadione toxicity: an historical footnote.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Epilepsy; Female; Humans; Infant, Newborn; Oxazo | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Metabolism and disposition of trimethadione in pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethadione; Drug Evaluation, Preclinical; Female; Fetus; Oxa | 1979 |
Assessment of the teratogenic potential of trimethadione in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gestational Age; Growth; Lethal Dos | 1979 |
Teratogenicity of therapeutic agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima | 1979 |
Troxidone (trimethadione) embryopathy: case report with reveiw of the literature.
Topics: Abnormalities, Drug-Induced; Aorta; Child; Ductus Arteriosus, Patent; Ear, External; Female; Heart D | 1979 |
Fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Eyebrows; Female; Humans; Male; Oxazoles; Pala | 1978 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Teratogenicity of anticonvulsive medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Persistent fifth aortic arch in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aorta; Child, Preschool; Ductus Arteriosus, Pa | 1975 |
[Therapeutic drug monitoring of trimethadione].
Topics: Abnormalities, Drug-Induced; Adult; Aged; Biological Availability; Chromatography, Gas; Female; Huma | 1990 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Species differences in pharmacokinetics and drug teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Cricetinae; Female; Half-Life; Haplorhini; Hum | 1986 |
Fetal anticonvulsant exposure: effects on behavioral and physical development.
Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital; | 1986 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Phenytoin and trimethadione: pharmacokinetics, embryotoxicity, and maternal toxicity.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Half-Life; Humans; Infant, Newborn; | 1985 |
Possible teratogenicity of trimethadione and paramethadione.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Heart Defec | 1970 |
Fetal anomalies following maternal trimethadione ingestion.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Female; Heart Defects, Congen | 1973 |
Trimethadione and human teratogenesis.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Adult; Epilepsy, Absenc | 1970 |
A sex-dependent factor in aplastic anaemia?
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Child; Child, Preschool; Chloramph | 1965 |