trimethadione has been researched along with Liver Cirrhosis in 4 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The trimethadione (TMO) tolerance test was performed to evaluate its usefulness in the assessment of hepatic functional reserve in patients with biliary atresia." | 9.09 | The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia. ( Amagai, T; Hori, T; Ikebukuro, K; Iwakawa, M; Kaneko, M; Nakamura, H; Ohkawa, H; Tanaka, E, 2001) |
| "Dimethadione (DMO)/trimethadione (TMO) ratios in serum after oral administration of TMO were investigated in 15 normal subjects and in 20 patients with cirrhosis and esophageal varices." | 7.67 | Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices. ( Ishikawa, A; Kobayashi, S; Misawa, S; Okamura, T; Ono, A; Tanaka, E; Yasuhara, H, 1986) |
| "The trimethadione (TMO) tolerance test was performed to evaluate its usefulness in the assessment of hepatic functional reserve in patients with biliary atresia." | 5.09 | The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia. ( Amagai, T; Hori, T; Ikebukuro, K; Iwakawa, M; Kaneko, M; Nakamura, H; Ohkawa, H; Tanaka, E, 2001) |
| "We evaluated the adequacy of the trimethadione (TMO) tolerance test (the method of estimation from the serum dimethadione [DMO]/TMO ratio, DMO is only one metabolite of TMO, at 4 hours after oral administration of TMO) for estimating the severity of liver damage in 40 cirrhotic patients with and without hepatic encephalopathy." | 3.68 | Trimethadione tolerance test for one-point estimation of the severity of liver damage in cirrhotic patients. ( Abei, M; Adachi, S; Fukao, K; Ishikawa, A; Iwasaki, Y; Osada, A; Takase, Y; Tanaka, E; Tsuji, K; Yamamoto, Y, 1991) |
| "Dimethadione (DMO)/trimethadione (TMO) ratios in serum after oral administration of TMO were investigated in 15 normal subjects and in 20 patients with cirrhosis and esophageal varices." | 3.67 | Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices. ( Ishikawa, A; Kobayashi, S; Misawa, S; Okamura, T; Ono, A; Tanaka, E; Yasuhara, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, H | 1 |
| Tanaka, E | 4 |
| Kaneko, M | 1 |
| Iwakawa, M | 1 |
| Hori, T | 1 |
| Ikebukuro, K | 1 |
| Amagai, T | 1 |
| Ohkawa, H | 1 |
| Ishikawa, A | 3 |
| Fukao, K | 1 |
| Tsuji, K | 1 |
| Osada, A | 1 |
| Yamamoto, Y | 1 |
| Adachi, S | 1 |
| Takase, Y | 1 |
| Abei, M | 1 |
| Iwasaki, Y | 1 |
| Ono, A | 2 |
| Okamura, T | 2 |
| Misawa, S | 2 |
| Kobayashi, S | 1 |
| Yasuhara, H | 1 |
1 trial available for trimethadione and Liver Cirrhosis
| Article | Year |
|---|---|
The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Biliary Atresia; Child; Child, Preschool; | 2001 |
3 other studies available for trimethadione and Liver Cirrhosis
| Article | Year |
|---|---|
Trimethadione tolerance test for one-point estimation of the severity of liver damage in cirrhotic patients.
Topics: Dimethadione; Female; Hepatic Encephalopathy; Humans; Indocyanine Green; Liver Cirrhosis; Liver Func | 1991 |
Trimethadione metabolism in patients with normal liver and in patients with chronic liver disease.
Topics: Carcinoma, Hepatocellular; Chronic Disease; Dimethadione; Female; Humans; Liver Cirrhosis; Liver Dis | 1987 |
Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices.
Topics: Adult; Dimethadione; Esophageal and Gastric Varices; Female; Humans; Kinetics; Liver Cirrhosis; Live | 1986 |