trimethadione has been researched along with Epilepsy in 92 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "The dislocation of the hip and the patent ductus arteriosus have been corrected surgically." | 1.25 | Persistent fifth aortic arch in man. ( Lawrence, TY; Stiles, QR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 90 (97.83) | 18.7374 |
| 1990's | 1 (1.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caplan, A | 1 |
| Teagarden, JR | 1 |
| Bacher, HP | 1 |
| Jarvis, MF | 1 |
| KLOEK, J | 1 |
| LEDEBOER, BC | 1 |
| DE LEENER, L | 1 |
| VERJAAL, A | 1 |
| SCHREIBER, G | 1 |
| DAVIDOFF, E | 2 |
| BUTTER, AJ | 2 |
| ROBINSON, LJ | 1 |
| LIEBERT, E | 1 |
| SIMONS, DJ | 1 |
| RICHARDS, RK | 2 |
| EVERETT, GM | 1 |
| MERRITT, HH | 1 |
| LENNOX, WG | 2 |
| RICKLES, NK | 1 |
| POLAN, CG | 1 |
| RAMSAY, HH | 1 |
| BELNAP, WD | 1 |
| TOMAN, JE | 1 |
| GOODMAN, LS | 1 |
| DE JONG, RN | 1 |
| THORNE, FC | 1 |
| DeJONG, RN | 1 |
| DREYER, R | 1 |
| LAWRENCE, DE | 1 |
| REDIN, B | 1 |
| SREEBNY, LM | 1 |
| McGREW, EA | 1 |
| BLUMBERG, ML | 1 |
| HOLOWACH, J | 1 |
| SANDEN, HV | 1 |
| BERGSTRAND, A | 1 |
| BERGSTRAND, CG | 1 |
| ENGSTROM, N | 1 |
| HERRLIN, KM | 1 |
| HANSEN, HA | 1 |
| NORDQVIST, P | 1 |
| SOURANDER, P | 1 |
| MILLICHAP, JG | 3 |
| JONES, JD | 1 |
| KIORBOE, E | 1 |
| CHAMBERLIN, HR | 1 |
| WADDELL, WJ | 1 |
| BUTLER, TC | 1 |
| BRANDT, S | 1 |
| BILLE, S | 1 |
| LIVINGSTON, S | 2 |
| BOKS, LL | 1 |
| JENSEN, BN | 1 |
| HOENIG, J | 1 |
| STONE, TT | 1 |
| NORDLANDER, NB | 1 |
| TEGELAERS, WH | 1 |
| TIDDENS, H | 1 |
| MUSTARD, HS | 1 |
| Weitz, R | 1 |
| Merlob, P | 1 |
| LEFEVRE, AB | 1 |
| WHITTY, CW | 1 |
| DAVIES, GR | 1 |
| SPILLANE, JD | 1 |
| Beuter, W | 1 |
| Kelly, TE | 1 |
| Friis, ML | 1 |
| Clifford, DB | 1 |
| Goldner, JC | 1 |
| Macdonald, RL | 1 |
| Kelly, KM | 1 |
| Bohlen, N | 1 |
| Hertl, M | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Hecht, F | 1 |
| Goldman, AS | 1 |
| Yaffe, SJ | 1 |
| Faugier-Grimaud, S | 1 |
| Thomas, JA | 1 |
| Knotts, GR | 1 |
| Krolner, B | 1 |
| Smith, DW | 1 |
| Anderson, RC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Dam, M | 1 |
| Kiørboe, E | 1 |
| Lawrence, TY | 1 |
| Stiles, QR | 1 |
| Wallace, SJ | 1 |
| Dalessio, DJ | 1 |
| Frey, HH | 1 |
| Löscher, W | 1 |
| Stumpf, DA | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
| Eadie, MJ | 1 |
| Tyrer, JH | 1 |
| Killam, KF | 1 |
| Killam, EK | 1 |
| Naquet, R | 1 |
| German, J | 1 |
| Ehlers, KH | 1 |
| Kowal, A | 1 |
| De George, FV | 1 |
| Engle, MA | 1 |
| Passarge, E | 1 |
| Saper, JR | 1 |
| Lossing, JH | 1 |
| Hooshmand, H | 1 |
| Boshes, LD | 1 |
| Friedlander, WJ | 1 |
| Jannasch, R | 1 |
| Kutt, H | 1 |
| Louis, S | 1 |
| Andermann, F | 2 |
| Robb, JP | 1 |
| Halpern, LM | 2 |
| Julien, RM | 2 |
| DeVivo, DC | 1 |
| Pagliara, AS | 1 |
| Prensky, AL | 1 |
| Cremers, HM | 1 |
| Verheesen, PE | 1 |
| Shimazono, Y | 1 |
| Fukuta, T | 1 |
| Spilker, B | 1 |
| Yeager, CL | 1 |
13 reviews available for trimethadione and Epilepsy
| Article | Year |
|---|---|
[Antiepileptic agents (anticonvulsants)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbonic Acid; Dibenza | 1983 |
Teratogenicity of anticonvulsant drugs. I: Review of the literature.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Pregnancy; Pregnancy Complications; | 1984 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu | 1995 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
Use of ethosuximide and valproate in the treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P | 1986 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Plasma levels of anticonvulsants.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine; | 1973 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Epilepsy.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba | 1967 |
[Antiepileptics. 39].
Topics: Acetazolamide; Adrenocorticotropic Hormone; Aminoglutethimide; Anticonvulsants; Barbiturates; Carbam | 1969 |
[Drug therapy of epilepsy].
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea | 1967 |
1 trial available for trimethadione and Epilepsy
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
79 other studies available for trimethadione and Epilepsy
| Article | Year |
|---|---|
A Patient-Centric Model for Discontinuation of a Single-Sourced Approved Drug.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Compassionate Use Trials; Drug Industry; Drug Substituti | 2019 |
[Tridione therapy of petit mal epilepsy].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1950 |
The treatment of petit Epilepsy With Tridione (Absentol, Petidion) and With Ketogenic Diet.
Topics: Diet, Ketogenic; Epilepsy; Humans; Trimethadione | 1948 |
Tridione treatment of petit mal.
Topics: Epilepsy; Trimethadione | 1948 |
Tridione and absentol as an anti-epileptic.
Topics: Epilepsy; Trimethadione | 1948 |
Tridione treatment for epilepsy.
Topics: Epilepsy; Trimethadione | 1948 |
Clinical and electroencephalographic observations concerning the effect of tridione in epileptic patients.
Topics: Brain; Electroencephalography; Epilepsy; Trimethadione | 1948 |
Tridione in the treatment of petit mal.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1948 |
Treatment of epilepsy with tridione.
Topics: Epilepsy; Humans; Trimethadione | 1947 |
Treatment of neurological disorders with tridione.
Topics: Epilepsy; Nervous System Diseases; Seizures; Trimethadione | 1947 |
The use of tridione in the treatment of convulsive disorders.
Topics: Epilepsy; Seizures; Trimethadione | 1947 |
Tridione therapy in institutionalized epileptic patients.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione: a new anticonvulsant drug.
Topics: Anticonvulsants; Epilepsy; Seizures; Trimethadione | 1946 |
Recent advances in treatment of epilepsy, with particular emphasis on use of tridione.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione in the treatment of epilepsy.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione; its use in treatment of epilepsy and other neurologic disorders.
Topics: Epilepsy; Humans; Nervous System Diseases; Trimethadione | 1947 |
Treatment of epilepsy with tridione.
Topics: Epilepsy; Trimethadione | 1946 |
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia.
Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenyto | 1947 |
Further observations on the use of tridione in the control of psychomotor attacks.
Topics: Animals; Behavior, Animal; Epilepsy; Movement Disorders; Social Behavior; Trimethadione | 1946 |
The petit mal epilepsies; their treatment with tridione.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1945 |
The anticonvulsant action of tridione; preliminary report.
Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Trimethadione | 1945 |
Effect of tridione in the control of psychomotor attacks.
Topics: Animals; Behavior, Animal; Epilepsy; Social Behavior; Trimethadione | 1946 |
Tridione; a new experimental drug for treatment of convulsive and related disorders; pharmacologic aspects.
Topics: Drugs, Investigational; Epilepsy; Personality Disorders; Seizures; Trimethadione | 1946 |
TRIDIONE: new hope in epilepsy.
Topics: Epilepsy; Hope; Trimethadione | 1946 |
[Tridione in therapy of epilepsy].
Topics: Epilepsy; Trimethadione | 1952 |
Near fatal hemolytic anemia during anti-epileptiform convulsion therapy with tridione.
Topics: Anemia, Hemolytic; Animals; Dog Diseases; Dogs; Epilepsy; Oxazoles; Seizures; Trimethadione | 1952 |
[Complications of tridione therapy of epilepsy in children].
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Pregnancy; Trimethadione | 1953 |
Fatal agranulocytosis due to tridione therapy.
Topics: Agranulocytosis; Anticonvulsants; Epilepsy; Trimethadione | 1953 |
Abdominal epilepsy; report of a case controlled with tridione.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Trimethadione | 1954 |
Alopecia as a side effect of treatment of epilepsy with trimethadione. Report of two cases.
Topics: Alopecia; Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Iatrog | 1960 |
Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione).
Topics: Anticonvulsants; Epilepsy; Humans; Kidney; Kidney Function Tests; Kidney Glomerulus; Nephrotic Syndr | 1962 |
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai | 1964 |
ACID-BASE, ELECTROLYTE, AND AMINO-ACID METABOLISM IN CHILDREN WITH PETIT MAL. ETIOLOGIC SIGNIFICANCE AND MODIFICATION BY ANTICONVULSANT DRUGS AND THE KETOGENIC DIET.
Topics: Acetazolamide; Acid-Base Equilibrium; Adrenocorticotropic Hormone; Amino Acids; Anticonvulsants; Bar | 1964 |
[DRUG THERAPY OF EPILEPSY. PREPARATIONS. II].
Topics: Ammonium Chloride; Anticonvulsants; Chloral Hydrate; Drug Therapy; Epilepsy; Ethosuximide; Humans; M | 1965 |
A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY.
Topics: Anticonvulsants; Biomedical Research; Blood Chemical Analysis; Child; Drug Therapy; Epilepsy; Epilep | 1965 |
[Treatment of epileptic lapses of consciousness in children; dimedione as compared with tridione, paradione and milontin in clinical use].
Topics: Anticonvulsants; Consciousness; Epilepsy; Oxazoles; Succinimides; Trimethadione | 1955 |
Use of the dione drugs (propazone, tridione, paradione, dimedione and malidone) in the treatment of epilepsy of children.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Infant; Oxazoles; Trimethadione | 1955 |
Trimethadione in serum of patients with petit mal epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Trimethadione | 1962 |
Fifty cases of epilepsy treated with "tridione".
Topics: Epilepsy; Trimethadione | 1951 |
The treatment of petit mal epilepsy with tridione; report of 21 cases.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1951 |
[Exfoliative dermatitis following tridione therapy in epilepsy].
Topics: Dermatitis; Dermatitis, Exfoliative; Epilepsy; Trimethadione | 1950 |
Tridione compared with malidone in the treatment of petit mal.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazoles; Trimethadione | 1952 |
[Tridione and nephrosis].
Topics: Epilepsy; Nephrosis; Oxazoles; Trimethadione | 1952 |
Tridione therapy in epilepsy; a review of results in 156 patients with petit mal epilepsy with special reference to side reactions.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazolidinones; Trimethadione | 1949 |
[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers].
Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli | 1979 |
[Petit mal epilepsy in children; considerations on the effect of tridione in four cases].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
Tridione in the treatment of epilepsy.
Topics: Epilepsy; Trimethadione | 1949 |
Tridione therapy in minor epilepsy.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Seizures and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Hydantoins; | 1984 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Fetal trimethadione toxicity: an historical footnote.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Epilepsy; Female; Humans; Infant, Newborn; Oxazo | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Eyebrows; Female; Humans; Male; Oxazoles; Pala | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr | 1978 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
[Trimethadione nephropathy].
Topics: Adult; Epilepsy; Humans; Male; Nephrotic Syndrome; Oxazoles; Trimethadione | 1977 |
Teratogenicity of anticonvulsive medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin | 1975 |
Persistent fifth aortic arch in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aorta; Child, Preschool; Ductus Arteriosus, Pa | 1975 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1976 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Evoked potential studies in response to light in the baboon (Papio papio).
Topics: Animals; Cerebral Cortex; Chlorpromazine; Diazepam; Epilepsy; Evoked Potentials; Haplorhini; Light; | 1967 |
Possible teratogenicity of trimethadione and paramethadione.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Heart Defec | 1970 |
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse | 1974 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Days of our years.
Topics: Anticonvulsants; Bromides; Epilepsy; Female; History, 20th Century; Humans; Male; Phenobarbital; Tri | 1967 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Absence status. A reappraisal following review of thirty-eight patients.
Topics: Adolescent; Adult; Barbiturates; Carbon Dioxide; Child; Consciousness; Conversion Disorder; Diagnosi | 1972 |
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin.
Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Pheny | 1972 |
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electr | 1972 |
Ketotic hypoglycemia and the ketogenic diet.
Topics: Acetazolamide; Acetone; Acidosis; Blood Glucose; Child, Preschool; Diet Therapy; Dietary Carbohydrat | 1973 |
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as T | 1973 |
Self-induced television epilepsy.
Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Te | 1971 |
Ten years EEG studies in epileptic children (two cases).
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbit | 1969 |