trimethadione has been researched along with Epilepsy, Absence in 53 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "The effects of AEDS on seizures of the tremor rat showed profiles similar to those observed in human absence seizures and also in absence-like seizures of SER." | 1.29 | Effect of antiepileptic drugs on absence-like seizures in the tremor rat. ( Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T, 1995) |
| "Carbamazepine and phenytoin were ineffective or aggravated the seizures." | 1.27 | Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. ( Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM, 1985) |
| " The dose-response curve for naloxone against seizure activity induced by leucine enkephalin was the same as that in gamma-hydroxybutyrate-induced petit mal." | 1.26 | Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. ( Bearden, LJ; Snead, OC, 1980) |
| " The interaction of optimal doses of succilep with the cliniel characteristics is less expressed than for Trimetin and on a significant level is detected only for two of them: a larger dosage in longer duration of the disease and in the existence of prenatal noxious factors in the past history." | 1.26 | [Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy]. ( Iovlev, BV; Kharitionov, RA; Kozlov, VP, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (96.23) | 18.7374 |
| 1990's | 1 (1.89) | 18.2507 |
| 2000's | 1 (1.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SIMONSEN, H | 1 |
| BUTTER, AJ | 2 |
| VIDART, L | 1 |
| LENNOX, WG | 1 |
| MILLICHAP, JG | 3 |
| JONES, JD | 1 |
| CHAMBERLIN, HR | 1 |
| WADDELL, WJ | 2 |
| BUTLER, TC | 2 |
| JENSEN, BN | 1 |
| STONE, TT | 1 |
| MUSTARD, HS | 1 |
| LIVINGSTON, S | 2 |
| Evason, K | 1 |
| Huang, C | 1 |
| Yamben, I | 1 |
| Covey, DF | 2 |
| Kornfeld, K | 1 |
| LEFEVRE, AB | 1 |
| DAVIES, GR | 1 |
| SPILLANE, JD | 1 |
| HAWARD, FC | 1 |
| Snead, OC | 1 |
| Bearden, LJ | 1 |
| Fromm, GH | 4 |
| Glass, JD | 1 |
| Chattha, AS | 1 |
| Martinez, AJ | 1 |
| Silverman, M | 1 |
| Klunk, WE | 1 |
| McKeon, A | 1 |
| Ferrendelli, JA | 1 |
| Iovlev, BV | 2 |
| Kharitonov, RA | 1 |
| Chelyshev, MM | 1 |
| Hanaya, R | 1 |
| Sasa, M | 1 |
| Ujihara, H | 1 |
| Fujita, Y | 1 |
| Amano, T | 1 |
| Matsubayashi, H | 1 |
| Serikawa, T | 1 |
| Uozumi, T | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 1 |
| Kozlov, VP | 1 |
| Kharitionov, RA | 1 |
| Feldman, GL | 1 |
| Weaver, DD | 1 |
| Lovrien, EW | 1 |
| Rosen, RC | 1 |
| Lightner, ES | 1 |
| Thomas, JA | 1 |
| Knotts, GR | 1 |
| Shearer, DE | 1 |
| Fleming, DE | 1 |
| Bigler, ED | 1 |
| Wallace, SJ | 1 |
| Micheletti, G | 1 |
| Vergnes, M | 1 |
| Marescaux, C | 1 |
| Reis, J | 1 |
| Depaulis, A | 1 |
| Rumbach, L | 1 |
| Warter, JM | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
| Lippe, BM | 1 |
| Crandall, BF | 1 |
| Saper, JR | 1 |
| Lossing, JH | 1 |
| Andermann, F | 1 |
| Kohli, CM | 1 |
| Hooshmand, H | 1 |
| Suter, CG | 2 |
| Jannasch, R | 1 |
| Amores, CY | 1 |
| Thies, W | 1 |
| Auckland, NL | 1 |
| Torres, I | 1 |
| Pauli, LL | 1 |
| Rider, RV | 1 |
| Niedermeyer, E | 1 |
| Khalifeh, R | 1 |
| Peterson, H | 1 |
| Kuroiwa, Y | 1 |
| Poole, DT | 1 |
| Kiehi, Y | 1 |
| Ando, J | 1 |
| Charlton, MH | 1 |
| Yahr, MD | 1 |
| Heymann, W | 1 |
| Booker, HE | 2 |
| Chun, RW | 2 |
| Sanguino, M | 2 |
| Aymat, F | 1 |
| Gilbert, GJ | 1 |
| Lipman, IJ | 1 |
| Isaacs, ER | 1 |
| Killian, JM | 1 |
| Sanchez, F | 1 |
| Waltregny, A | 1 |
| German, J | 1 |
| Kowal, A | 1 |
| Ehlers, KH | 1 |
3 reviews available for trimethadione and Epilepsy, Absence
| Article | Year |
|---|---|
Use of ethosuximide and valproate in the treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P | 1986 |
[Antiepileptics. 39].
Topics: Acetazolamide; Adrenocorticotropic Hormone; Aminoglutethimide; Anticonvulsants; Barbiturates; Carbam | 1969 |
Treatment and prognosis of petit mal epilepsy.
Topics: Acetazolamide; Anticonvulsants; Child; Child, Preschool; Drug Synergism; Epilepsy, Absence; Ethosuxi | 1967 |
1 trial available for trimethadione and Epilepsy, Absence
| Article | Year |
|---|---|
Observations on the discrepancy between the clinical and the laboratory effects of anti-petit mal drugs.
Topics: Action Potentials; Anticonvulsants; Chloralose; Clinical Trials as Topic; Diazepam; Epilepsy, Absenc | 1967 |
49 other studies available for trimethadione and Epilepsy, Absence
| Article | Year |
|---|---|
[Tridione therapy of petit mal epilepsy].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1950 |
Tridion treatment of petit mal.
Topics: Epilepsy, Absence; Trimethadione | 1948 |
Tridione in the treatment of petit mal.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1948 |
About the treatment of three cases of pyknolepsy with tridione.
Topics: Epilepsy, Absence; Humans; Trimethadione | 1947 |
The petit mal epilepsies; their treatment with tridione.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1945 |
ACID-BASE, ELECTROLYTE, AND AMINO-ACID METABOLISM IN CHILDREN WITH PETIT MAL. ETIOLOGIC SIGNIFICANCE AND MODIFICATION BY ANTICONVULSANT DRUGS AND THE KETOGENIC DIET.
Topics: Acetazolamide; Acid-Base Equilibrium; Adrenocorticotropic Hormone; Amino Acids; Anticonvulsants; Bar | 1964 |
A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY.
Topics: Anticonvulsants; Biomedical Research; Blood Chemical Analysis; Child; Drug Therapy; Epilepsy; Epilep | 1965 |
Trimethadione in serum of patients with petit mal epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Trimethadione | 1962 |
The treatment of petit mal epilepsy with tridione; report of 21 cases.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1951 |
Tridione compared with malidone in the treatment of petit mal.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazoles; Trimethadione | 1952 |
Tridione therapy in epilepsy; a review of results in 156 patients with petit mal epilepsy with special reference to side reactions.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazolidinones; Trimethadione | 1949 |
Anticonvulsant medications extend worm life-span.
Topics: Aging; Aldicarb; Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; | 2005 |
[Petit mal epilepsy in children; considerations on the effect of tridione in four cases].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
Tridione therapy in minor epilepsy.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
The use of tridione in petit mal.
Topics: Epilepsy, Absence; Trimethadione | 1949 |
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Endorphins; Enkephalins; Epilepsy, Absence; Ethosu | 1980 |
Antiabsence drugs and inhibitory pathways.
Topics: Animals; Anticonvulsants; Cats; Cerebral Ventricles; Epilepsy, Absence; Ethosuximide; Imipramine; Ne | 1980 |
Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Convulsants; Drug Evaluati | 1982 |
[Predicting therapeutic success in the treatment of children with petit mal using a pattern recognition method].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diagnosis, Computer-Assisted; Epilepsy, Absenc | 1982 |
Effect of antiepileptic drugs on absence-like seizures in the tremor rat.
Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroenceph | 1995 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
[Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy, Absence; Humans; Succinimides; Trimethadione | 1977 |
The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Drug Therapy, Combination; Epilepsy, Absence; Fe | 1977 |
Phenotypic malformations in association with maternal trimethadione therapy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1978 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pent | 1976 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Turner syndrome with partial deletion of the X chromosome long arm.
Topics: Adolescent; Amenorrhea; Dermatoglyphics; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Follicle | 1973 |
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse | 1974 |
Absence attacks and diffuse neuronal disease.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Electroencephalography; Epilepsy, Absence; Etho | 1967 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
The role of inhibitory pathways in petit mal epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamazepine; Cats; Cerebral Cortex; Electric Stimulat | 1972 |
Classification and treatment of seizure disorders in children.
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, | 1970 |
Imipramine in epilepsy.
Topics: Adolescent; Animals; Anticonvulsants; Cats; Child; Child, Preschool; Diazepam; Electroencephalograph | 1972 |
Drugs for petit mal.
Topics: Acetazolamide; Amphetamine; Anticonvulsants; Barbiturates; Child; Child, Preschool; Chlordiazepoxide | 1965 |
Petit mal epilepsy. Results of a prolonged follow-up study of 117 patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1965 |
Petit mal status ("spike-wave stupor"). An electro-clinical appraisal.
Topics: Adolescent; Adult; Anticonvulsants; Blood; Child; Child, Preschool; Diagnosis, Differential; Electro | 1965 |
Association of trimethadione therapy and myasthenia gravis.
Topics: Anticonvulsants; Autoimmune Diseases; Child; Epilepsy, Absence; Female; Humans; Myasthenia Gravis; T | 1966 |
Effects of 5,5-dimethyl-2,4-oxazolidinedione (DMO) on acid-base and electrolyte equilibria.
Topics: Acid-Base Equilibrium; Adolescent; Animals; Anticonvulsants; Bicarbonates; Blood; Child; Chlorides; | 1966 |
[Ethosuximide in treatment of petit mal epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Absen | 1965 |
Long-term follow-up of patients with petit mal.
Topics: Adolescent; Adult; Aging; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 1967 |
Nephrotic syndrome after use of trimethadione and paramethadione in petit mal.
Topics: Anticonvulsants; Epilepsy, Absence; Humans; Nephrotic Syndrome; Trimethadione | 1967 |
Myasthenic syndrome associated with trimethadione.
Topics: Anticonvulsants; Autoantibodies; Child; Epilepsy, Absence; Female; Humans; Myasthenia Gravis; Oxazol | 1968 |
Myasthenia gravis syndrome associated with trimethadione.
Topics: Anticonvulsants; Autoimmune Diseases; Child; Drug Hypersensitivity; Epilepsy, Absence; Female; Human | 1970 |
Myasthenia gravis and epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Humans; Myasthenia Gravis | 1970 |
Petit mal status. A variety of non-convulsive status epilepticus.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalograph | 1971 |
[Absence petit mal. Current status of the question].
Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy, Absence; Humans; Pyrrolidinones; Succin | 1969 |
Trimethadione and human teratogenesis.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Adult; Epilepsy, Absenc | 1970 |