trimethadione has been researched along with Embryopathies in 6 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weitz, R | 1 |
| Merlob, P | 1 |
| Clifford, DB | 1 |
| Nakane, Y | 1 |
| Nagai, T | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 1 |
2 reviews available for trimethadione and Embryopathies
| Article | Year |
|---|---|
[Fetal trimethadione effects].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
[Fetal trimethadione syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Pregn | 2001 |
4 other studies available for trimethadione and Embryopathies
| Article | Year |
|---|---|
[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers].
Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli | 1979 |
Seizures and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Hydantoins; | 1984 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |