trimethadione and Delayed Effects, Prenatal Exposure studies

trimethadione and Delayed Effects, Prenatal Exposure

Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.

Research Excerpts

Excerpt	Relevance	Reference
"The broadest dosing regimen yielded the highest incidence and the most severe heart and axioskeletal findings with a decrease in mean fetal body weight."	1.37	Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. ( Brown, NA; Ozolinš, TR; Weston, AD, 2011)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

2 (50.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

1 (25.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Weston, AD	1
Brown, NA	1
Ozolinš, TR	1
Weitz, R	1
Merlob, P	1
Nakane, Y	1
Vorhees, CV	1

Studies

Weston, AD

Brown, NA

Ozolinš, TR

Weitz, R

Merlob, P

Nakane, Y

Vorhees, CV

Reviews

Article	Year
[Fetal trimethadione effects]. Ryoikibetsu shokogun shirizu, 2000, Issue:30 Pt 5 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema	2000

Article

Year

[Fetal trimethadione effects].

Ryoikibetsu shokogun shirizu, 2000, Issue:30 Pt 5

Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema

2000

Other Studies

3 other studies available for trimethadione and Delayed Effects, Prenatal Exposure

Article	Year
Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:3 Topics: Animals; Bone and Bones; Cardiovascular Abnormalities; Cesarean Section; Dimethadione; Female; Heart	2011
[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers]. Harefuah, 1979, Volume: 97, Issue:11-12 Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli	1979
Fetal anticonvulsant exposure: effects on behavioral and physical development. Annals of the New York Academy of Sciences, 1986, Volume: 477 Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital;	1986

Article

Year

Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.

Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:3

Topics: Animals; Bone and Bones; Cardiovascular Abnormalities; Cesarean Section; Dimethadione; Female; Heart

2011

[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers].

Harefuah, 1979, Volume: 97, Issue:11-12

Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli

1979

Fetal anticonvulsant exposure: effects on behavioral and physical development.

Annals of the New York Academy of Sciences, 1986, Volume: 477

Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital;

1986