trimethadione has been researched along with Cleft Palate in 5 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, RC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Wells, PG | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
| Nichols, MM | 1 |
5 other studies available for trimethadione and Cleft Palate
| Article | Year |
|---|---|
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Fetal anomalies following maternal trimethadione ingestion.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Female; Heart Defects, Congen | 1973 |