trimethadione has been researched along with Aura in 92 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "The dislocation of the hip and the patent ductus arteriosus have been corrected surgically." | 1.25 | Persistent fifth aortic arch in man. ( Lawrence, TY; Stiles, QR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 90 (97.83) | 18.7374 |
| 1990's | 1 (1.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caplan, A | 1 |
| Teagarden, JR | 1 |
| Bacher, HP | 1 |
| Jarvis, MF | 1 |
| KLOEK, J | 1 |
| LEDEBOER, BC | 1 |
| DE LEENER, L | 1 |
| VERJAAL, A | 1 |
| SCHREIBER, G | 1 |
| DAVIDOFF, E | 2 |
| BUTTER, AJ | 2 |
| ROBINSON, LJ | 1 |
| LIEBERT, E | 1 |
| SIMONS, DJ | 1 |
| RICHARDS, RK | 2 |
| EVERETT, GM | 1 |
| MERRITT, HH | 1 |
| LENNOX, WG | 2 |
| RICKLES, NK | 1 |
| POLAN, CG | 1 |
| RAMSAY, HH | 1 |
| BELNAP, WD | 1 |
| TOMAN, JE | 1 |
| GOODMAN, LS | 1 |
| DE JONG, RN | 1 |
| THORNE, FC | 1 |
| DeJONG, RN | 1 |
| DREYER, R | 1 |
| LAWRENCE, DE | 1 |
| REDIN, B | 1 |
| SREEBNY, LM | 1 |
| McGREW, EA | 1 |
| BLUMBERG, ML | 1 |
| HOLOWACH, J | 1 |
| SANDEN, HV | 1 |
| BERGSTRAND, A | 1 |
| BERGSTRAND, CG | 1 |
| ENGSTROM, N | 1 |
| HERRLIN, KM | 1 |
| HANSEN, HA | 1 |
| NORDQVIST, P | 1 |
| SOURANDER, P | 1 |
| MILLICHAP, JG | 3 |
| JONES, JD | 1 |
| KIORBOE, E | 1 |
| CHAMBERLIN, HR | 1 |
| WADDELL, WJ | 1 |
| BUTLER, TC | 1 |
| BRANDT, S | 1 |
| BILLE, S | 1 |
| LIVINGSTON, S | 2 |
| BOKS, LL | 1 |
| JENSEN, BN | 1 |
| HOENIG, J | 1 |
| STONE, TT | 1 |
| NORDLANDER, NB | 1 |
| TEGELAERS, WH | 1 |
| TIDDENS, H | 1 |
| MUSTARD, HS | 1 |
| Weitz, R | 1 |
| Merlob, P | 1 |
| LEFEVRE, AB | 1 |
| WHITTY, CW | 1 |
| DAVIES, GR | 1 |
| SPILLANE, JD | 1 |
| Beuter, W | 1 |
| Kelly, TE | 1 |
| Friis, ML | 1 |
| Clifford, DB | 1 |
| Goldner, JC | 1 |
| Macdonald, RL | 1 |
| Kelly, KM | 1 |
| Bohlen, N | 1 |
| Hertl, M | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Hecht, F | 1 |
| Goldman, AS | 1 |
| Yaffe, SJ | 1 |
| Faugier-Grimaud, S | 1 |
| Thomas, JA | 1 |
| Knotts, GR | 1 |
| Krolner, B | 1 |
| Smith, DW | 1 |
| Anderson, RC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Dam, M | 1 |
| Kiørboe, E | 1 |
| Lawrence, TY | 1 |
| Stiles, QR | 1 |
| Wallace, SJ | 1 |
| Dalessio, DJ | 1 |
| Frey, HH | 1 |
| Löscher, W | 1 |
| Stumpf, DA | 1 |
| Krip, G | 1 |
| Vazquez, AJ | 1 |
| Eadie, MJ | 1 |
| Tyrer, JH | 1 |
| Killam, KF | 1 |
| Killam, EK | 1 |
| Naquet, R | 1 |
| German, J | 1 |
| Ehlers, KH | 1 |
| Kowal, A | 1 |
| De George, FV | 1 |
| Engle, MA | 1 |
| Passarge, E | 1 |
| Saper, JR | 1 |
| Lossing, JH | 1 |
| Hooshmand, H | 1 |
| Boshes, LD | 1 |
| Friedlander, WJ | 1 |
| Jannasch, R | 1 |
| Kutt, H | 1 |
| Louis, S | 1 |
| Andermann, F | 2 |
| Robb, JP | 1 |
| Halpern, LM | 2 |
| Julien, RM | 2 |
| DeVivo, DC | 1 |
| Pagliara, AS | 1 |
| Prensky, AL | 1 |
| Cremers, HM | 1 |
| Verheesen, PE | 1 |
| Shimazono, Y | 1 |
| Fukuta, T | 1 |
| Spilker, B | 1 |
| Yeager, CL | 1 |
13 reviews available for trimethadione and Aura
| Article | Year |
|---|---|
[Antiepileptic agents (anticonvulsants)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbonic Acid; Dibenza | 1983 |
Teratogenicity of anticonvulsant drugs. I: Review of the literature.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Humans; Hydantoins; Pregnancy; Pregnancy Complications; | 1984 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu | 1995 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
Use of ethosuximide and valproate in the treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P | 1986 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Plasma levels of anticonvulsants.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine; | 1973 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Epilepsy.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amphetamine; Anesthetics, Local; Anticonvulsants; Ba | 1967 |
[Antiepileptics. 39].
Topics: Acetazolamide; Adrenocorticotropic Hormone; Aminoglutethimide; Anticonvulsants; Barbiturates; Carbam | 1969 |
[Drug therapy of epilepsy].
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea | 1967 |
1 trial available for trimethadione and Aura
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
79 other studies available for trimethadione and Aura
| Article | Year |
|---|---|
A Patient-Centric Model for Discontinuation of a Single-Sourced Approved Drug.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Compassionate Use Trials; Drug Industry; Drug Substituti | 2019 |
[Tridione therapy of petit mal epilepsy].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1950 |
The treatment of petit Epilepsy With Tridione (Absentol, Petidion) and With Ketogenic Diet.
Topics: Diet, Ketogenic; Epilepsy; Humans; Trimethadione | 1948 |
Tridione treatment of petit mal.
Topics: Epilepsy; Trimethadione | 1948 |
Tridione and absentol as an anti-epileptic.
Topics: Epilepsy; Trimethadione | 1948 |
Tridione treatment for epilepsy.
Topics: Epilepsy; Trimethadione | 1948 |
Clinical and electroencephalographic observations concerning the effect of tridione in epileptic patients.
Topics: Brain; Electroencephalography; Epilepsy; Trimethadione | 1948 |
Tridione in the treatment of petit mal.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1948 |
Treatment of epilepsy with tridione.
Topics: Epilepsy; Humans; Trimethadione | 1947 |
Treatment of neurological disorders with tridione.
Topics: Epilepsy; Nervous System Diseases; Seizures; Trimethadione | 1947 |
The use of tridione in the treatment of convulsive disorders.
Topics: Epilepsy; Seizures; Trimethadione | 1947 |
Tridione therapy in institutionalized epileptic patients.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione: a new anticonvulsant drug.
Topics: Anticonvulsants; Epilepsy; Seizures; Trimethadione | 1946 |
Recent advances in treatment of epilepsy, with particular emphasis on use of tridione.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione in the treatment of epilepsy.
Topics: Epilepsy; Trimethadione | 1947 |
Tridione; its use in treatment of epilepsy and other neurologic disorders.
Topics: Epilepsy; Humans; Nervous System Diseases; Trimethadione | 1947 |
Treatment of epilepsy with tridione.
Topics: Epilepsy; Trimethadione | 1946 |
Tridione-diphenylhydantoin combination therapy in grand mal with slow-wave EEG dysrhythmia.
Topics: Combined Modality Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenyto | 1947 |
Further observations on the use of tridione in the control of psychomotor attacks.
Topics: Animals; Behavior, Animal; Epilepsy; Movement Disorders; Social Behavior; Trimethadione | 1946 |
The petit mal epilepsies; their treatment with tridione.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1945 |
The anticonvulsant action of tridione; preliminary report.
Topics: Anticonvulsants; Epilepsy; Humans; Seizures; Trimethadione | 1945 |
Effect of tridione in the control of psychomotor attacks.
Topics: Animals; Behavior, Animal; Epilepsy; Social Behavior; Trimethadione | 1946 |
Tridione; a new experimental drug for treatment of convulsive and related disorders; pharmacologic aspects.
Topics: Drugs, Investigational; Epilepsy; Personality Disorders; Seizures; Trimethadione | 1946 |
TRIDIONE: new hope in epilepsy.
Topics: Epilepsy; Hope; Trimethadione | 1946 |
[Tridione in therapy of epilepsy].
Topics: Epilepsy; Trimethadione | 1952 |
Near fatal hemolytic anemia during anti-epileptiform convulsion therapy with tridione.
Topics: Anemia, Hemolytic; Animals; Dog Diseases; Dogs; Epilepsy; Oxazoles; Seizures; Trimethadione | 1952 |
[Complications of tridione therapy of epilepsy in children].
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Pregnancy; Trimethadione | 1953 |
Fatal agranulocytosis due to tridione therapy.
Topics: Agranulocytosis; Anticonvulsants; Epilepsy; Trimethadione | 1953 |
Abdominal epilepsy; report of a case controlled with tridione.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Trimethadione | 1954 |
Alopecia as a side effect of treatment of epilepsy with trimethadione. Report of two cases.
Topics: Alopecia; Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Iatrog | 1960 |
Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione).
Topics: Anticonvulsants; Epilepsy; Humans; Kidney; Kidney Function Tests; Kidney Glomerulus; Nephrotic Syndr | 1962 |
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai | 1964 |
ACID-BASE, ELECTROLYTE, AND AMINO-ACID METABOLISM IN CHILDREN WITH PETIT MAL. ETIOLOGIC SIGNIFICANCE AND MODIFICATION BY ANTICONVULSANT DRUGS AND THE KETOGENIC DIET.
Topics: Acetazolamide; Acid-Base Equilibrium; Adrenocorticotropic Hormone; Amino Acids; Anticonvulsants; Bar | 1964 |
[DRUG THERAPY OF EPILEPSY. PREPARATIONS. II].
Topics: Ammonium Chloride; Anticonvulsants; Chloral Hydrate; Drug Therapy; Epilepsy; Ethosuximide; Humans; M | 1965 |
A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY.
Topics: Anticonvulsants; Biomedical Research; Blood Chemical Analysis; Child; Drug Therapy; Epilepsy; Epilep | 1965 |
[Treatment of epileptic lapses of consciousness in children; dimedione as compared with tridione, paradione and milontin in clinical use].
Topics: Anticonvulsants; Consciousness; Epilepsy; Oxazoles; Succinimides; Trimethadione | 1955 |
Use of the dione drugs (propazone, tridione, paradione, dimedione and malidone) in the treatment of epilepsy of children.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Infant; Oxazoles; Trimethadione | 1955 |
Trimethadione in serum of patients with petit mal epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Trimethadione | 1962 |
Fifty cases of epilepsy treated with "tridione".
Topics: Epilepsy; Trimethadione | 1951 |
The treatment of petit mal epilepsy with tridione; report of 21 cases.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1951 |
[Exfoliative dermatitis following tridione therapy in epilepsy].
Topics: Dermatitis; Dermatitis, Exfoliative; Epilepsy; Trimethadione | 1950 |
Tridione compared with malidone in the treatment of petit mal.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazoles; Trimethadione | 1952 |
[Tridione and nephrosis].
Topics: Epilepsy; Nephrosis; Oxazoles; Trimethadione | 1952 |
Tridione therapy in epilepsy; a review of results in 156 patients with petit mal epilepsy with special reference to side reactions.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Absence; Humans; Oxazolidinones; Trimethadione | 1949 |
[Fetal trimethadione syndrome and behavior disorders in children of epilectic mothers].
Topics: Child; Epilepsy; Female; Fetal Diseases; Humans; Male; Mental Disorders; Pregnancy; Pregnancy Compli | 1979 |
[Petit mal epilepsy in children; considerations on the effect of tridione in four cases].
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
Tridione in the treatment of epilepsy.
Topics: Epilepsy; Trimethadione | 1949 |
Tridione therapy in minor epilepsy.
Topics: Epilepsy; Epilepsy, Absence; Trimethadione | 1949 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Seizures and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Hydantoins; | 1984 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Fetal trimethadione toxicity: an historical footnote.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Epilepsy; Female; Humans; Infant, Newborn; Oxazo | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Eyebrows; Female; Humans; Male; Oxazoles; Pala | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr | 1978 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
[Trimethadione nephropathy].
Topics: Adult; Epilepsy; Humans; Male; Nephrotic Syndrome; Oxazoles; Trimethadione | 1977 |
Teratogenicity of anticonvulsive medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin | 1975 |
Persistent fifth aortic arch in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aorta; Child, Preschool; Ductus Arteriosus, Pa | 1975 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1976 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Effects of diphenylhydantoin and cholinergic agents on the neuronally isolated cerebral cortex.
Topics: Animals; Atropine; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; | 1971 |
Evoked potential studies in response to light in the baboon (Papio papio).
Topics: Animals; Cerebral Cortex; Chlorpromazine; Diazepam; Epilepsy; Evoked Potentials; Haplorhini; Light; | 1967 |
Possible teratogenicity of trimethadione and paramethadione.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Heart Defec | 1970 |
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse | 1974 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Days of our years.
Topics: Anticonvulsants; Bromides; Epilepsy; Female; History, 20th Century; Humans; Male; Phenobarbital; Tri | 1967 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Absence status. A reappraisal following review of thirty-eight patients.
Topics: Adolescent; Adult; Barbiturates; Carbon Dioxide; Child; Consciousness; Conversion Disorder; Diagnosi | 1972 |
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin.
Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Pheny | 1972 |
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electr | 1972 |
Ketotic hypoglycemia and the ketogenic diet.
Topics: Acetazolamide; Acetone; Acidosis; Blood Glucose; Child, Preschool; Diet Therapy; Dietary Carbohydrat | 1973 |
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as T | 1973 |
Self-induced television epilepsy.
Topics: Adolescent; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; Myoclonus; Phenytoin; Te | 1971 |
Ten years EEG studies in epileptic children (two cases).
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbit | 1969 |