trimethadione has been researched along with Acute Liver Injury, Drug-Induced in 10 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Fatty liver is paralleled by the block in Triton-induced hypertriglyceridaemia." | 1.27 | A model for monitoring changes in liver function. ( Aragno, M; Brando, C; Burdino, E; Danni, O; Ugazio, G, 1986) |
| "6 h and 163 microgram/ml at 8 h and declined with a half-life of 2." | 1.26 | Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury. ( Kinoshita, H; Kuroiwa, Y; Takabatake, E; Tanaka, E; Yamamoto, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Snyman, T | 1 |
| Stewart, MJ | 1 |
| Grove, A | 1 |
| Steenkamp, V | 1 |
| Tanaka, E | 3 |
| Nakamura, T | 1 |
| Misawa, S | 1 |
| Yoshida, T | 2 |
| Kuroiwa, Y | 3 |
| Kinoshita, H | 2 |
| Yamamoto, T | 1 |
| Takabatake, E | 1 |
| Danni, O | 1 |
| Brando, C | 1 |
| Burdino, E | 1 |
| Aragno, M | 1 |
| Ugazio, G | 1 |
1 review available for trimethadione and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
9 other studies available for trimethadione and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
Effects of allyl alcohol and bromobenzene on trimethadione metabolism in the rat.
Topics: 1-Propanol; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Dimethadione; Kinetics; | 1984 |
Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and D-galactosamine intoxicated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Dimethadione; Galactosamine; Kinetics; | 1982 |
Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride Poi | 1981 |
A model for monitoring changes in liver function.
Topics: Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver | 1986 |