trimethadione has been researched along with Abnormalities, Drug-Induced in 43 studies
Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
trimethadione : An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 5.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 1.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "Interspecies differences in regard to the teratogenicity of drugs can be the result of differing pharmacokinetic processes that determine the crucial concentration-time relationships in the embryo." | 1.27 | Species differences in pharmacokinetics and drug teratogenesis. ( Nau, H, 1986) |
| "The dislocation of the hip and the patent ductus arteriosus have been corrected surgically." | 1.25 | Persistent fifth aortic arch in man. ( Lawrence, TY; Stiles, QR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (88.37) | 18.7374 |
| 1990's | 2 (4.65) | 18.2507 |
| 2000's | 3 (6.98) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vorhees, CV | 1 |
| Chernoff, GF | 1 |
| Jones, KL | 1 |
| Cordero, JF | 1 |
| Oakley, GP | 3 |
| Friis, ML | 1 |
| Clifford, DB | 1 |
| Goldner, JC | 1 |
| Azarbayjani, F | 2 |
| Danielsson, BR | 2 |
| Nakane, Y | 1 |
| Nagai, T | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 1 |
| Majewski, F | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Feldman, GL | 1 |
| Weaver, DD | 1 |
| Lovrien, EW | 1 |
| Rosen, RC | 1 |
| Lightner, ES | 1 |
| Hecht, F | 1 |
| Midha, KK | 1 |
| Buttar, HS | 1 |
| Rowe, M | 1 |
| Dupuis, I | 1 |
| Brown, NA | 1 |
| Shull, G | 1 |
| Fabro, S | 1 |
| Shepard, TH | 1 |
| Rischbieth, RH | 1 |
| Goldman, AS | 1 |
| Yaffe, SJ | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Smith, DW | 1 |
| Anderson, RC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Lawrence, TY | 1 |
| Stiles, QR | 1 |
| Ohtsubo, K | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Wells, PG | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
| Wallace, SJ | 1 |
| Nau, H | 1 |
| Dalessio, DJ | 1 |
| Stumpf, DA | 1 |
| Khera, KS | 1 |
| German, J | 2 |
| Ehlers, KH | 2 |
| Kowal, A | 2 |
| De George, FV | 1 |
| Engle, MA | 1 |
| Passarge, E | 1 |
| Rifkind, AB | 1 |
| Nishimura, H | 1 |
| Tanimura, T | 1 |
| Nichols, MM | 1 |
| Zellweger, H | 1 |
12 reviews available for trimethadione and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Fetal preventive medicine: teratogens and the unborn baby.
Topics: Abnormalities, Drug-Induced; Dronabinol; Drug Evaluation; Ethanol; Female; Heroin; Hormones; Hot Tem | 1981 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
[Fetal trimethadione effects].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
[Fetal trimethadione syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetal Diseases; Humans; Infant, Newborn; Pregn | 2001 |
Drug influences on malformations.
Topics: Abnormalities, Drug-Induced; Amphetamines; Anesthetics; Animals; Anti-Anxiety Agents; Anticonvulsant | 1979 |
[On certain embryopathies induced by teratogenic agents (author's transl].
Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany | 1977 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
Use of ethosuximide and valproate in the treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P | 1986 |
Current concepts. Seizure disorders and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Epilepsy; | 1985 |
[Drugs and congenital anomalies of the central nervous system].
Topics: Abnormalities, Drug-Induced; Animals; Brain; Carbon Monoxide Poisoning; Central Nervous System; Drug | 1972 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
31 other studies available for trimethadione and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Re | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Seizures and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Hydantoins; | 1984 |
Anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1981 |
Causal inference in teratology.
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Diazepam; Epidemiologic Methods; Female; Humans; I | 1980 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Drug Therapy, Combination; Epilepsy, Absence; Fe | 1977 |
Phenotypic malformations in association with maternal trimethadione therapy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1978 |
Fetal trimethadione toxicity: an historical footnote.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Epilepsy; Female; Humans; Infant, Newborn; Oxazo | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Metabolism and disposition of trimethadione in pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethadione; Drug Evaluation, Preclinical; Female; Fetus; Oxa | 1979 |
Assessment of the teratogenic potential of trimethadione in the CD-1 mouse.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gestational Age; Growth; Lethal Dos | 1979 |
Teratogenicity of therapeutic agents.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Anima | 1979 |
Troxidone (trimethadione) embryopathy: case report with reveiw of the literature.
Topics: Abnormalities, Drug-Induced; Aorta; Child; Ductus Arteriosus, Patent; Ear, External; Female; Heart D | 1979 |
Fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Eyebrows; Female; Humans; Male; Oxazoles; Pala | 1978 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
Teratogenicity of anticonvulsive medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Persistent fifth aortic arch in man.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aorta; Child, Preschool; Ductus Arteriosus, Pa | 1975 |
[Therapeutic drug monitoring of trimethadione].
Topics: Abnormalities, Drug-Induced; Adult; Aged; Biological Availability; Chromatography, Gas; Female; Huma | 1990 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |
Species differences in pharmacokinetics and drug teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Cricetinae; Female; Half-Life; Haplorhini; Hum | 1986 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Phenytoin and trimethadione: pharmacokinetics, embryotoxicity, and maternal toxicity.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Half-Life; Humans; Infant, Newborn; | 1985 |
Possible teratogenicity of trimethadione and paramethadione.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Heart Defec | 1970 |
Teratogenic effects of trimethadione and dimethadione in the chich embryo.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Dimethylamines; Oxazoles; Spectrophotometry, Ult | 1974 |
Fetal anomalies following maternal trimethadione ingestion.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Female; Heart Defects, Congen | 1973 |
Trimethadione and human teratogenesis.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Adult; Epilepsy, Absenc | 1970 |