trimetazidine has been researched along with Myocardial Ischemia in 137 studies
*Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (19.71) | 18.2507 |
| 2000's | 76 (55.47) | 29.6817 |
| 2010's | 27 (19.71) | 24.3611 |
| 2020's | 7 (5.11) | 2.80 |
| Authors | Studies |
|---|---|
| Arrhenius, T; Barr, R; Brown, S; Chen, M; Cheng, JF; Dyck, JR; Haramura, M; Harmon, C; Liu, B; Lopaschuk, GD; Mak, CC; Nadzan, AM; Reily, S; Thorn, V; Tith, S; Wallace, D | 1 |
| Arrhenius, T; Barbosa, M; Barr, R; Cheng, JF; Dyck, JR; Huang, Y; Liu, L; Lopaschuk, GD; Nadzan, AM; Nishimoto, M; O'leary, E; Penuliar, R; Yang, G | 1 |
| Arduini, A; Ceccarelli, SM; Chomienne, O; Gubler, M | 1 |
| Ajabnoor, A; Mukhtar, A | 1 |
| El-Khodary, NM; El-Tayaar, AA; El-Touny, EM; Ghoneim, AI | 1 |
| Bahrudin, U; Harjoko, RP; Herminingsih, S; Maharani, N; Sobirin, MA; Tsutsui, H; Uddin, I | 1 |
| Chen, R; Ge, J; Guan, L; Li, M; Qin, S; Shi, H; Su, Y; Xiao, Z; Yu, Y; Yu, Z | 1 |
| Thadani, U | 1 |
| Ahangarpour, A; Amini, N; Badavi, M; Dianat, M; Mard, SA; Sarkaki, A | 1 |
| Duan, Y; Lin, Y; Sun, ZQ; Wang, ZL; Yan, M; Zhu, FY | 1 |
| Mahajan, AU; Mahajan, S | 1 |
| Li, C; Li, G; Shangguan, W; Shi, W; Zhang, Y | 1 |
| Gaszner, B; Hild, G; Kónyi, A; Meiszterics, Z; Sárszegi, Z | 1 |
| Bego, T; Čaušević, A; Dujić, T; Malenica, M; Prnjavorac, B; Prnjavorac, I; Šaranović, L; Suljić, U | 1 |
| Lu, X; Ma, X; Wang, J; Wen, J; Yang, Y; Zhang, L; Zhao, Y | 1 |
| Amin, MR; Arzu, J; Banerjee, RS; Ear-E-Mahabub, SM; Hoque, MH; Joarder, AI; Kabir, FI; Singha, CK; Zaman, SM | 1 |
| Cheng, B; Li, Y; Liu, L; Liu, Y; Qi, B; Wang, Q; Wu, Q | 1 |
| Gorbach, TV; Kukes, VG; Romashchenko, OV; Rumbesht, VV; Zhernakova, NI | 1 |
| Altamirano, R; Castro, PF; Chiong, M; Concepción, R; Enriquez, A; García, L; Jalil, JE; Lavandero, S; Mellado, R; Quintana, JC; Rossel, V; Sepúlveda, L; Sepúlveda, P; Verdejo, HE; Winter, JL | 1 |
| Shehata, M | 1 |
| Avcı, B; Çavun, S; Savcı, V; Şentürk, T; Serdar, Z; Yermezler, A | 1 |
| Biziaeva, EA; Karpova, ÉS; Kotel'nikova, EV; Liamina, NP | 1 |
| Fi, Z; Kovács, G; Szentes, V | 1 |
| Rehberger-Likozar, A; Šebeštjen, M | 1 |
| Dong, R; Li, S; Liu, J; Luo, Y; Peng, L; Zhao, Y; Zheng, Z; Zhu, J | 1 |
| Colombo, A; Fragasso, G; Fumero, A; Giannini, F; Godino, C; Maranta, F; Margonato, A; Oppizzi, M; Slavich, M | 1 |
| Glezer M, G; On Behalf Of The Choice-Study Participants, OB | 1 |
| Gorbunova, ML; Vilkova, AV | 1 |
| Belardinelli, R; Cianci, G; Gigli, M; Lacalaprice, F; Mazzanti, M | 1 |
| Arora, R; Jawad, E | 1 |
| Belardinelli, R; Faccenda, E; Lacalaprice, F; Volpe, L | 1 |
| Chen, S; Jin, J; Lu, Q; Song, WZ; Wang, WY; Xie, HJ; Xu, GH; Zhong, P; Zhou, XF | 1 |
| Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY | 1 |
| Dronova, EP; Lopatin, IuM | 1 |
| Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C | 1 |
| Caminiti, G; Fini, M; Gebara, O; Marazzi, G; Ramires, JA; Rosano, G; Vitale, C; Volterrani, M; Wajngarten, M | 1 |
| Cerrahoglu, M; Eserdag, M; Iskesen, I; Kurdal, AT; Sirin, BH | 1 |
| Aispuru, GR; Caminiti, N; Grimolizzi, NS; Páez Gill, NE; Ugartemendia, M | 1 |
| Bunc, M; Vrtovec, B; Zemljic, G | 1 |
| Arioli, F; Cera, M; Facchini, A; Fragasso, G; Gardini, C; Godino, C; Margonato, A; Marinosci, G; Montanaro, C; Salerno, A; Spoladore, R | 1 |
| Beresewicz, A; Skierczynska, A | 1 |
| Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL | 1 |
| Qizhu, T; Wenmeng, W | 1 |
| Inzhutova, AI; Larionov, AA; Petrova, MM; Salmina, AB | 1 |
| Assunção, CR; Bottino, F; Carvalho, KG; Martins, GF; Santos, JB; Siqueira Filho, AG; Valência, A | 1 |
| Tian, Y; Xu, H; Zhu, G | 1 |
| Bochkareva, EV; Butina, EK; Dmitrieva, NA; Kokurina, EV | 1 |
| Dec, I; Poloński, L; Wilczek, K; Wojnar, R | 1 |
| Aronov, DM; Novikova, NK; Pisareva, NA; Smolenskiĭ, VS; Tartakovskiĭ, LB; Zhidko, NI | 1 |
| Kutuzova, AE; Liasnikova, EA; Mikhaĭlova, IE; Nedoshivin, AO; Nesterova, IV; Novikova, NA; Perepech, NB; Rubashkina, EI | 1 |
| Marzilli, M; Stanley, WC | 1 |
| Binding, P; Fairman, DA; Haddock, PS; Karran, EH; MacInnes, A; Phelan, A; Rhodes, Ja; Wyatt, MJ | 1 |
| Barr, R; Dyck, JR; Lopaschuk, GD; Thomas, PD | 1 |
| Churshin, AD; Pimenov, LT | 1 |
| Calori, G; Fragasso, G; Lopaschuk, GD; Margonato, A; Monti, L; Palloshi, A; Piatti Md, PM; Puccetti, P; Setola, E | 1 |
| Dernek, S; Ikizler, M; Kural, T; Sevin, B | 1 |
| Hill, JA; Schofield, RS | 1 |
| Broustet, JP; Sellier, P | 1 |
| Biggi, A; Feola, M; Ferrero, V; Francini, A; Leonardi, G; Ribichini, F; Uslenghi, E | 2 |
| Belardinelli, R | 2 |
| Frenneaux, M; Horowitz, J; Lee, L | 1 |
| Fedorova, TA; Il'ina, IuV; Loshchits, NV; Rybakova, MK; Sotnikova, TI | 1 |
| Akhmedov, ShD; Dzhavadova, GK; Tepliakov, AT; Vecherskiĭ, IuIu; Vesnina, ZhV | 1 |
| Atroshenkov, AV; Chernov, VI; Efimova, EV; Karpov, RS; Koshel'skaia, OA; Ocheredko, NA | 1 |
| Pauly, DF; Pepine, CJ | 1 |
| Fini, M; Gebara, O; Rosano, GM; Rossini, P; Sposato, B; Vitale, C; Volterrani, M; Wajngaten, M | 1 |
| Lupanov, VP; Matveeva, MA; Mironova, IIu; Naumov, VG; Orlova, EM; Samoĭlenko, LE | 1 |
| Duarte, AI; Gonçalves, LM; Monteiro, P; Moreno, A; Providência, LA | 1 |
| Galaris, D; Korantzopoulos, P; Kountouris, E; Siogas, K | 1 |
| Fedorova, TA; Il'ina, IuV; Rybakova, MK; Sotnikova, TI | 1 |
| McMurray, JJ; O'Meara, E | 1 |
| Al-Ghazali, R; Liang, WW; Liu, TW; Tao, XZ; Yin, RX; Zhu, LG | 1 |
| Cerquetani, E; Fini, M; Marazzi, G; Mercuro, G; Patrizi, R; Rosano, GM; Vitale, C; Volterrani, M | 1 |
| Allard, MF; Bescond-Jacquet, A; Grist, M; Lucien, A; Saeedi, R; Wambolt, RB | 1 |
| Arroyo Espliguero, R; Cosín Sales, J; Kaski, JC | 1 |
| Aguilar Llopis, A; Azorín Villena, I; Capdevilla Carbonell, C; Cosín Aguilar, J; Hernándiz Martinez, A; Martinez, VB; Morillas Blasco, PJ; Pallarés Carratala, V; Portolés Sanz, M | 1 |
| Abdel-Hady, S; El-Kady, T; El-Sabban, K; Gabaly, M; Sabry, A | 1 |
| Camisasca, RP; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Origgi, A; Piatti, P; Setola, E | 1 |
| Bakhmatova, IuA; Gapon, LI; Petelina, TI; Zhevagina, IA | 1 |
| Fini, M; Rosano, GM; Vitale, C; Volterrani, M | 1 |
| Affinito, S; Marzilli, M | 1 |
| Arora, R; Parang, P; Singh, B | 1 |
| Bettaieb, A; Filomenko, R; Gambert, S; Moreau, D; Opie, LH; Rochette, L; Vergely, C | 1 |
| Altekin, E; Goldeli, O; Kuralay, F; Onvural, B; Yazlar, AS | 1 |
| Sabbah, HN; Stanley, WC | 1 |
| Bassanelli, G; Calori, G; Fragasso, G; Lattuada, G; Locatelli, M; Lopaschuk, G; Margonato, A; Montano, C; Oggionni, S; Palloshi, A; Perseghin, G | 1 |
| Bertomeu-Gonzalez, V; Bouzas-Mosquera, A; Kaski, JC | 1 |
| Fini, M; Gebara, O; Marazzi, G; Patrizi, R; Pelliccia, F; Pierri, H; Ramires, JA; Rosano, GM; Vitale, C; Volterrani, M; Wajngarten, M | 1 |
| Barkhudarian, AL; Sisakian, AS; Torgomian, AL | 1 |
| Armaganijan, D; Bicudo, L; Brasil, CK; Cesar, LA; Del Monaco, MI; Gimenez, V; Gomes, EP; Jallad, S; Mathias, W; Meneguin, S; Ramires, JF | 1 |
| Barsotti, A; D'Apolito, G; Di Giovanni, P; Di Napoli, P; Gaeta, MA | 1 |
| Barkhudaryan, A; Sisakian, H; Torgomyan, A | 1 |
| Barsotti, A; Di Giovanni, P; Di Napoli, P; Gaeta, MA; Taccardi, AA | 1 |
| Bescond-Jacquet, A; Bricca, G; Bui-Xuan, B; Descotes, J; Tabib, A; Timour, Q; Tsibiribi, P; Vaillant, F | 1 |
| Makolkin, VI; Mikova, NV; Petriĭ, VV | 1 |
| Baksheev, VI; Kolomoets, NM; Uvaĭsova, IU; Zarubina, EG | 1 |
| Chaitman, BR; Sano, J | 1 |
| Kus, M; Tanda, K; Williams, FM; Williams, TJ | 1 |
| Boucher, FR; Hearse, DJ; Opie, LH | 1 |
| Hue, L; Maisin, L; Veitch, K | 1 |
| Boucher, F; Opie, LH | 1 |
| Boucher, F; de Leiris, J | 1 |
| Ribeiro, C | 1 |
| Bezstarosti, K; Koning, MM; Krams, R; Lamers, JM; van Meegen, JR; Verdouw, PD; Xiao, CS | 1 |
| Buck, T; Kober, G; Pennaforte, S; Sievert, H; Vallbracht, C | 1 |
| Guarnieri, C; Muscari, C | 1 |
| Iliceto, S; Marangelli, V; Rizzon, P | 1 |
| Garcia-Dorado, D; González, MA; Inserte, J; Juliá, M; Ruiz-Meana, M; Soler-Soler, J | 1 |
| Arvieux, C; Cannet, E; de Lorgeril, M; Ferrera, R; Forrat, R; Guidollet, J; Hadour, G; Lehot, JJ; Sebbag, L; Vedrinne, C | 1 |
| Eliseev, OM | 1 |
| Jackson, G | 1 |
| Albengres, E; Berland, Y; Crevat, A; d'Athis, P; Hestin, D; Jaber, K; Kessler, M; Olivier, P; Roux, F; Simon, N; Tillement, JP | 1 |
| Lopaschuk, GD | 3 |
| Grynberg, A; Lucien, A; Sentex, E; Sergiel, JP | 1 |
| Buxton, DB; Coyle, KB; Hansen, HW; Mody, FV; Mohiuddin, IH; Schelbert, HR; Singh, BN; Sumida, R | 1 |
| Jones, BE; King, LM; Taegtmeyer, H | 1 |
| Celegon, L; Desideri, A | 1 |
| Bernard, M; Cozzone, PJ; el Banani, H; Feuvray, D | 1 |
| Horowitz, JD; Kennedy, JA | 1 |
| Domzał-Bocheńska, M; Elikowski, W; Gajos, G; Kałuza, G; Kulon, I; Kuźniak, M; Pachocki, R; Paradowski, A; Sadowski, Z; Szwed, H; Szydłowski, Z; Szymczak, K; Wator-Brzezińska, A | 1 |
| Ferrari, R | 1 |
| Akhmetov, KZh; Goncharov, LF; Goncharova, ZF; Kelimberdieva, ES; Komissarova, IA; Teĭblium, MM; Zaslavskaia, RM | 1 |
| Afanas'eva, IV; Goncharova, LL; Miroshnichenko, AG; Petrash, VV; Pokrovskaia, LA | 1 |
| Kantor, PF; Kozak, R; Lopaschuk, GD; Lucien, A | 1 |
| Minners, J; Opie, LH; Sack, MN; Schwalb, H; van den Bos, EJ; Yellon, DM | 1 |
| Cross, HR | 1 |
| Baetz, D; Bernard, M; Cabanes, E; Cozzone, P; El Banani, H; Feuvray, D; Lucien, A | 1 |
| Baj, Z; Kowalski, J; Olejniczak, J; Paśnik, J; Pawlicki, L | 1 |
| Gaĭsin, IR; Karbasnikova, GV; Leshchinskiĭ, LA; Logacheva, IV; Perevalov, AP; Romanova, ZD | 1 |
| Allibardi, S; Chierchia, S; Costa, S; Monti, LD; Piatti, PM; Pozza, G; Samaja, M; Valsecchi, G | 1 |
| Cokkinos, DV | 1 |
| Belardinelli, R; Purcaro, A | 1 |
| Kalinina, EB; Komissarova, IA; Zaslavskaia, RM; Zhdanov, IuA | 1 |
30 review(s) available for trimetazidine and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of trimetazidine on the functional capacity of ischemic heart disease patients not suitable for revascularization: Meta-analysis of randomized controlled trials.
Topics: Cross-Over Studies; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Stroke Volume; Trimetazidine; Vasodilator Agents; Walk Test | 2022 |
Effect of Trimetazidine on Diabetic Patients with Coronary Heart Diseases: A Meta-Analysis of Randomized, Controlled Trials.
Topics: Blood Glucose; Coronary Disease; Diabetes Mellitus; Diastole; Exercise Tolerance; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Ventricular Function, Left | 2020 |
Current Clinical Evidence of Trimetazidine in the Management of Heart Disease in Patients with Diabetes.
Topics: Coronary Artery Disease; Diabetes Mellitus; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2020 |
Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.
Topics: Cardiovascular Agents; Drug Therapy, Combination; Drugs, Chinese Herbal; Heart Failure; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine | 2018 |
[Role of trimetazidine in the treatment of diabetic microangiopathy in ischaemic heart disease].
Topics: Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Heart; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2015 |
Trimetazidine improves exercise tolerance in patients with ischemic heart disease : A meta-analysis.
Topics: Dose-Response Relationship, Drug; Evidence-Based Medicine; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prevalence; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2016 |
Chronic stable angina pectoris.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents | 2008 |
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].
Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents | 2009 |
Modulation of myocardial metabolism: an emerging therapeutic principle.
Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 2010 |
Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine.
Topics: Angina Pectoris; Carbohydrate Metabolism; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2003 |
Role of metabolically active drugs in the management of ischemic heart disease.
Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Acid; Energy Metabolism; Fatty Acids; Glucose; Humans; Insulin; Myocardial Ischemia; Myocardium; Piperazines; Potassium; Ranolazine; Trimetazidine | 2001 |
[Ischemic heart disease and left ventricular dysfunction: the role of trimetazidine].
Topics: Clinical Trials as Topic; Humans; Myocardial Ischemia; Trimetazidine; Ventricular Dysfunction, Left | 2004 |
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Glucose; Humans; Hypoglycemic Agents; Insulin; Myocardial Ischemia; Myocardium; Perhexiline; Piperazines; Potassium; Ranolazine; Trimetazidine | 2004 |
Ischemic heart disease: metabolic approaches to management.
Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine; Ribose; Trimetazidine | 2004 |
Silent myocardial ischaemia: clinical relevance and treatment.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Coronary Artery Disease; Electrocardiography; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Myocardial Revascularization; Nitric Oxide Donors; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic therapy for the diabetic patients with ischaemic heart disease.
Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2005 |
Meeting the challenge of chronic ischaemic heart disease with trimetazidine.
Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic modulators for chronic cardiac ischemia.
Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; Heart; Humans; Lipid Metabolism; Myocardial Ischemia; Myocardium; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents; Vitamin B Complex | 2005 |
Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation.
Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2005 |
Role of trimetazidine in management of ischemic cardiomyopathy.
Topics: Humans; Myocardial Ischemia; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2006 |
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents | 2007 |
Intervention in ischaemia. Reperfusion syndrome. Rationale for trimetazidine.
Topics: Acidosis; Calcium; Energy Metabolism; Free Radicals; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocarditis; Reactive Oxygen Species; Trimetazidine | 1994 |
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease?
Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Superoxide Dismutase; Trimetazidine; Ubiquinone; Vasodilator Agents | 1995 |
[Trimetazidine (Preductal). A new approach in controlling myocardial ischemia].
Topics: Animals; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 1996 |
Potential interest of anti-ischemic agents for limiting cyclosporin A nephrotoxicity.
Topics: Adenosine Triphosphate; Calcium; Creatinine; Cyclosporine; Humans; Kidney; Mitochondria; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 1997 |
Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism.
Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents | 1998 |
Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 1998 |
Metabolic management of ischemic heart disease: clinical data with trimetazidine.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; Energy Metabolism; Exercise Test; Hemodynamics; Humans; Myocardial Ischemia; Myocardium; Treatment Outcome; Trimetazidine; Vasodilator Agents | 1998 |
Trimetazidine and the contractile response of dysfunctional myocardium in ischaemic cardiomyopathy.
Topics: Humans; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2000 |
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?
Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Glycolysis; Humans; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2001 |
44 trial(s) available for trimetazidine and Myocardial Ischemia
| Article | Year |
|---|---|
The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients.
Topics: Angina Pectoris; Cardiomyopathies; Fibrosis; Humans; Inflammation; Myocardial Ischemia; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2023 |
Trimetazidine improves left ventricular global longitudinal strain value in patients with heart failure with reduced ejection fraction due to ischemic heart disease.
Topics: Aged; Heart Failure; Humans; Middle Aged; Myocardial Ischemia; Stroke Volume; Trimetazidine; Ventricular Dysfunction, Left | 2022 |
The role of metabolic therapy with trimetazidine in effort tolerance in patients with ischemic heart disease.
Topics: Echocardiography; Exercise Test; Exercise Tolerance; Female; Heart; Humans; Male; Metabolic Equivalent; Myocardial Ischemia; Myocardium; Patient Discharge; Physical Exertion; Quality of Life; Stroke Volume; Trimetazidine; Ultrasonography; Vasodilator Agents | 2018 |
Comparison between Glyceryl Trinitrate and Trimetazidine in Ischaemic Cardiomyopathy Patients.
Topics: Bangladesh; Cardiomyopathies; Humans; Male; Myocardial Contraction; Myocardial Ischemia; Nitroglycerin; Pilot Projects; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2019 |
Effects of trimetazidine in nonischemic heart failure: a randomized study.
Topics: Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Radionuclide Imaging; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Impact of trimetazidine on incidence of myocardial injury and contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention.
Topics: Contrast Media; Coronary Angiography; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Elective Surgical Procedures; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Renal Insufficiency; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents | 2015 |
Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy.
Topics: Cardiomyopathies; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Systole; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2008 |
Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.
Topics: Aged; Biomarkers; Blood Pressure; Body Mass Index; Brachial Artery; Cardiomyopathies; Combined Modality Therapy; Echocardiography, Doppler, Pulsed; Electrocardiography; Exercise Test; Exercise Therapy; Female; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Ischemia; Oxygen Consumption; Stroke Volume; Time Factors; Treatment Outcome; Trimetazidine; Vasodilation; Vasodilator Agents; Ventricular Dysfunction, Left | 2008 |
[Effects of trimetazidine on myocardial metabolism evaluated by PET-CT in patients with ischemic cardiomyopathy].
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Trimetazidine | 2008 |
[Clinical-pharmacoeconomic aspects of trimetazidine modified release use in patients with ischemic heart disease undergoing coronary artery bypass grafting].
Topics: Adult; Aged; Coronary Artery Bypass; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2009 |
Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy.
Topics: Aged; Cardiomyopathy, Dilated; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Severity of Illness Index; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2009 |
Trimetazidine may protect the myocardium during cardiac surgery.
Topics: Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2009 |
Trimetazidine shortens QTc interval in patients with ischemic heart failure.
Topics: Aged; Angiography; Electrocardiography; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2010 |
Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.
Topics: Aged; Aged, 80 and over; Antisocial Personality Disorder; Arrhythmias, Cardiac; Chronic Disease; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents | 2010 |
Trimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.
Topics: Biomarkers; Coronary Artery Bypass; Creatine Kinase, MB Form; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Placebo Effect; Postoperative Complications; Prospective Studies; Time Factors; Treatment Outcome; Trimetazidine; Troponin T; Vasodilator Agents | 2011 |
[Decrease in the sensitivity to the anti-ischemic effect of propranolol and prospects for correcting it in patients with stable angina pectoris].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Myocardial Ischemia; Placebos; Propranolol; Trimetazidine | 2002 |
Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Chi-Square Distribution; Coronary Stenosis; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2002 |
[Significance of trimetazidine for out of hospital physical rehabilitation after myocardial infarction].
Topics: Adult; Ambulatory Care; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2002 |
[Trimetazidine in correction of chronic heart failure in patients with ischemic heart disease].
Topics: Chronic Disease; Cross-Sectional Studies; Humans; Middle Aged; Myocardial Ischemia; Prospective Studies; Severity of Illness Index; Trimetazidine; Vasodilator Agents | 2002 |
[Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and postmenopausal women with ischemic heart disease].
Topics: Aged; Drug Therapy, Combination; Female; Humans; Middle Aged; Myocardial Ischemia; Postmenopause; Premenopause; Treatment Outcome; Trimetazidine; Vasodilator Agents; Verapamil | 2003 |
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
Topics: Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Echocardiography; Energy Metabolism; Glucose; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Trimetazidine | 2003 |
Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Angina Pectoris; Double-Blind Method; Europe; Exercise Test; Female; Humans; Israel; Latvia; Male; Middle Aged; Myocardial Ischemia; Russia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2003 |
[Clinical and hemodynamic efficacy of selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Bisoprolol; Cardiac Output, Low; Drug Administration Schedule; Drug Therapy, Combination; Echocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Quality of Life; Time Factors; Treatment Outcome; Trimetazidine; Ventricular Function, Left | 2004 |
[Clinical Efficacy of Combination Therapy With Trimetazidine and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension and Ischemic Heart Disease Associated With Type II Diabetes].
Topics: Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type 2; Humans; Hypertension; Myocardial Ischemia; Treatment Outcome; Trimetazidine | 2004 |
Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease.
Topics: Aged; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
[Potentialities of cytoprotection in the treatment of chronic heart failure in patients with coronary heart disease].
Topics: Aged; Aged, 80 and over; Bisoprolol; Chronic Disease; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Sympathomimetics; Trimetazidine; Vasodilator Agents | 2004 |
Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.
Topics: Adult; Aged; Analysis of Variance; Coitus; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Erectile Dysfunction; Humans; Male; Middle Aged; Myocardial Ischemia; Nitrates; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2005 |
Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study.
Topics: Aged; Cardiomyopathies; Coronary Circulation; Echocardiography; Exercise Test; Female; Heart Function Tests; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.
Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Citric Acid; Cross-Over Studies; Cyclic GMP; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Forearm; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Muscle, Skeletal; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine | 2006 |
[Clinical efficacy of combined therapy with enalapril + trimetazidine in patients with hypertension comorbid with ischemic heart disease and metabolic disturbances].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Catalase; Comorbidity; Drug Therapy, Combination; Enalapril; Female; Humans; Hypercholesterolemia; Hypertension; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Trimetazidine; Vasodilator Agents | 2005 |
The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.
Topics: Aged; Dietary Carbohydrates; Dietary Fats; Double-Blind Method; Echocardiography, Stress; Female; Food; Humans; Male; Myocardial Ischemia; Postprandial Period; Trimetazidine; Vasodilator Agents | 2006 |
Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Electrocardiography, Ambulatory; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2007 |
[The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].
Topics: Aged; Cardiomyopathies; Exercise; Exercise Tolerance; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2006 |
Trimetazidine to reverse ischemia in patients with class I or II angina: a randomized, double-blind, placebo-controlled dobutamine-atropine stress echocardiography study.
Topics: Aged; Angina Pectoris; Atropine; Dobutamine; Double-Blind Method; Echocardiography, Stress; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2007 |
Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy.
Topics: Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Natriuretic Peptide, Brain; Trimetazidine; Troponin T; Vasodilator Agents | 2007 |
Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.
Topics: Aged; C-Reactive Protein; Cardiomyopathy, Dilated; Echocardiography; Exercise Test; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Myocardial Ischemia; Stroke Volume; Survival Rate; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left; Walking | 2007 |
[Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus].
Topics: Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2007 |
[Efficacy of long-term therapy with trimetazidine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].
Topics: Aged; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Pulmonary Disease, Chronic Obstructive; Time Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2008 |
Myocardial cytoprotection during percutaneous transluminal coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Reproducibility of Results; Trimetazidine | 1993 |
The antiischemic effects and tolerability of trimetazidine in coronary diabetic patients. A substudy from TRIMPOL-1.
Topics: Diabetes Complications; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents | 1999 |
[Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina].
Topics: Aged; Aged, 80 and over; Angina Pectoris; Cysteine; Drug Therapy, Combination; Echocardiography; Electrocardiography, Ambulatory; Female; Glutamic Acid; Glycine; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 1999 |
[Effect of trimetazidine on biological activity of neutrophils in patients with transient myocardial ischemia induced by exercise testing].
Topics: Adult; Angina Pectoris; Cell Aggregation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Neutrophils; Trimetazidine | 2000 |
Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy.
Topics: Analysis of Variance; Cardiomyopathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2001 |
63 other study(ies) available for trimetazidine and Myocardial Ischemia
| Article | Year |
|---|---|
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Topics: Animals; Carboxy-Lyases; Energy Metabolism; Fatty Acids; Glucose; In Vitro Techniques; Male; Malonyl Coenzyme A; Morpholines; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine | 2006 |
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Topics: Administration, Oral; Animals; Biological Availability; Carboxy-Lyases; Cardiotonic Agents; Crystallography, X-Ray; Isoxazoles; Molecular Conformation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2006 |
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catalytic Domain; Diabetes Mellitus, Type 2; Energy Metabolism; Enzyme Activators; Ethylene Oxide; Heart Failure; Humans; Insulin Resistance; Isoenzymes; Lipid Metabolism; Myocardial Ischemia; Organ Specificity; Protein Conformation; Sequence Homology, Amino Acid; Stereoisomerism | 2011 |
Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition.
Topics: Animals; Calcium; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Trimetazidine | 2023 |
Trimetazidine for stable and unstable ischemic heart diseases and for heart failure: Is its routine use justified from available data?
Topics: Angina Pectoris; Heart Failure; Humans; Myocardial Ischemia; Trimetazidine | 2020 |
Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.
Topics: Acute Kidney Injury; Animals; Flavanones; Glutathione Peroxidase; Male; Malondialdehyde; Myocardial Ischemia; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Trimetazidine | 2019 |
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Topics: Animals; Disease Models, Animal; Male; Mitochondria; Myocardial Ischemia; Rats; Rats, Wistar; Respiratory Physiological Phenomena; Trimetazidine; Vasodilator Agents | 2017 |
Effectiveness and safety of anti-ischemic trimetazidine in patients with stable angina pectoris and Type 2 diabetes.
Topics: Aged; Angina, Stable; Canada; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Administration Schedule; Female; Humans; Male; Myocardial Ischemia; Prospective Studies; Pulse Wave Analysis; Trimetazidine; Vasodilator Agents | 2017 |
Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways.
Topics: Antioxidants; Cardiotonic Agents; Cells, Cultured; Endothelial Cells; Humans; Hydrogen Peroxide; Malondialdehyde; Myocardial Ischemia; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ribonucleosides; Signal Transduction; Stem Cells; Superoxide Dismutase; Trimetazidine | 2013 |
[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
Topics: Adenosine Triphosphate; Age Factors; Animals; Cell Membrane; Citrate (si)-Synthase; Disease Models, Animal; Glycolysis; Ketone Oxidoreductases; Lactic Acid; Male; Mitochondria; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2013 |
Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury.
Topics: Acetylcysteine; Animals; Apoptosis; Blood Pressure; Caspase 3; Cell Death; Coronary Vessels; Disease Models, Animal; Fatty Acids; Glucose; Glutathione; Inflammation; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; Trimetazidine | 2014 |
[Approaches potentiating cardioprotective effect of ambulatory physical training in patients with ischemic heart disease and multivessel coronary artery involvement after coronary stenting].
Topics: Cardiotonic Agents; Coronary Vessels; Echocardiography; Electrocardiography; Exercise Therapy; Exercise Tolerance; Female; Home Care Services, Hospital-Based; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Russia; Severity of Illness Index; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Long-Term Preservation of Left Ventricular Systolic Function in Patients With Refractory Angina Pectoris and Inducible Myocardial Ischemia on Optimal Medical Therapy.
Topics: Aged; Angina Pectoris; Benzazepines; Cardiovascular Agents; Echocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Ivabradine; Male; Myocardial Ischemia; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Stroke Volume; Systole; Time Factors; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2016 |
[Treatment of Patients With Stable Ischemic Heart Disease in Real Clinical Practice in Russia. The CHOICE-2 Program].
Topics: Angina Pectoris; Coronary Artery Disease; Humans; Myocardial Ischemia; Russia; Trimetazidine | 2016 |
[Assessment of Efficacy and Safety of Metabolic Therapy With Trimetazidine MB in Patients With Ischemic Heart Disease and Chronic Heart Failure].
Topics: Chronic Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2016 |
Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Occlusion; Drug Combinations; Electrocardiography; Heart; Malates; Male; Mitochondria, Heart; Myocardial Ischemia; Oxidative Phosphorylation; Rats; Rats, Wistar; Succinic Acid; Tachycardia; Trimetazidine; Vasodilator Agents | 2008 |
[Coronary-ventricular sinusoid communications].
Topics: Cardiac Catheterization; Coronary Angiography; Female; Humans; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2009 |
Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.
Topics: Animals; Coronary Circulation; Dichloroacetic Acid; Disease Models, Animal; Dobutamine; Fatty Acids; Glucose; Glycolysis; Male; Myocardial Ischemia; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Trimetazidine | 2010 |
Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.
Topics: Animals; Diabetes Mellitus; Diabetic Cardiomyopathies; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Models, Theoretical; Myocardial Ischemia; Myocardium; Research Design; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2011 |
[Stabilization of cellular membranes as a target of vascular therapy].
Topics: Adult; Cell Membrane; Cell-Derived Microparticles; Comparative Effectiveness Research; Cytoprotection; Endothelium, Vascular; Female; Humans; Hypertension; Lymphocytes; Male; Microscopy, Phase-Contrast; Middle Aged; Models, Cardiovascular; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2011 |
Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.
Topics: Animals; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Ischemia; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2012 |
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Topics: Acetanilides; Acetyl-CoA C-Acyltransferase; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Recombinant Proteins; Trimetazidine; Vasodilator Agents | 2003 |
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Cardiotonic Agents; Dichloroacetic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Fatty Acids; Glucose; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recovery of Function; Trimetazidine; Vasodilator Agents | 2003 |
Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.
Topics: Administration, Oral; Animals; Coronary Circulation; Creatine Kinase; Disease Models, Animal; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; Trimetazidine; Troponin T; Vasodilator Agents | 2003 |
Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.
Topics: Aged; Coronary Artery Disease; Coronary Vessels; Gated Blood-Pool Imaging; Heart Ventricles; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Single-Blind Method; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
[Effect of trimetazidine on regressione of ischemic dysfunction of myocardium after coronary bypass surgery on beating heart].
Topics: Coronary Artery Bypass; Humans; Myocardial Contraction; Myocardial Ischemia; Myocardium; Trimetazidine | 2004 |
[Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].
Topics: Angina Pectoris; Angina, Stable; Coronary Artery Disease; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2004 |
Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Electrochemistry; Electron Transport; Energy Metabolism; Female; In Vitro Techniques; Membrane Potentials; Mitochondria, Heart; Myocardial Ischemia; Myocytes, Cardiac; Oxidative Phosphorylation; Oxygen Consumption; Perfusion; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2004 |
The acute administration of trimetazidine modified myocardial perfusion and left ventricular function in 31 patients with ischaemic ventricular dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Echocardiography; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Radiopharmaceuticals; Stroke Volume; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Function, Left | 2004 |
The potential benefits of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
Topics: Anti-Arrhythmia Agents; Antioxidants; Diabetes Complications; Diabetes Mellitus; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Oxidative Stress; Trimetazidine; Vasodilator Agents | 2004 |
Myocardial metabolic manipulation: a new therapeutic approach in heart failure?
Topics: Blood Glucose; Fatty Acids, Nonesterified; Heart Failure; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2005 |
Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.
Topics: Animals; Apoptosis; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Rabbits; Random Allocation; Superoxide Dismutase; Trimetazidine | 2004 |
Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Glucose; Glycolysis; Kinetics; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Palmitates; Perfusion; Protons; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents | 2005 |
Mitochondrial changes induced by trimetazidine in the myocardium.
Topics: Animals; Dogs; Double-Blind Method; Female; Heart; Lipofuscin; Male; Mitochondria, Heart; Models, Animal; Myocardial Ischemia; Random Allocation; Trimetazidine; Vasodilator Agents | 2005 |
Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.
Topics: Animals; Ascorbic Acid; Fatty Acids, Nonesterified; Free Radicals; Heart; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2006 |
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Nitrites; Reactive Oxygen Species; Time Factors; Treatment Outcome; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2006 |
The effect of trimetazidine on left ventricular systolic function and physical tolerance in patients with ischaemic cardiomyopathy.
Topics: Aged; Cardiomyopathy, Dilated; Cardiotonic Agents; Exercise Test; Exercise Tolerance; Female; Health Status Indicators; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Prospective Studies; Stroke Volume; Systole; Trimetazidine; Vasodilator Agents | 2007 |
Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Electric Stimulation; Female; Heart Rate; Homeostasis; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Ischemia; Swine; Trimetazidine; Vasodilator Agents; Ventricular Fibrillation | 2008 |
Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits.
Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Heart Rate; Interleukin-8; Leukotriene B4; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Rabbits; Trimetazidine; Zymosan | 1993 |
Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts.
Topics: Animals; Blood Pressure; Coronary Circulation; Glucose; Heart Rate; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine | 1994 |
Trimetazidine effects on the damage to mitochondrial functions caused by ischemia and reperfusion.
Topics: Animals; In Vitro Techniques; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyruvate Dehydrogenase Complex; Rats; Trimetazidine | 1995 |
Trimetazidine and myocardial ischemic contracture in isolated rat heart.
Topics: Animals; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Rats; Trimetazidine | 1995 |
[Therapeutic application of myocardial cytoprotection].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 1994 |
Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia.
Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Animals; Coronary Circulation; Disease Models, Animal; Female; Free Radicals; Heart; Hemodynamics; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Oxygen; Oxygen Consumption; Regional Blood Flow; Swine; Trimetazidine | 1993 |
Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium.
Topics: Animals; Hypertrophy, Right Ventricular; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Trimetazidine | 1993 |
Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes.
Topics: Animals; Cells, Cultured; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Osmotic Pressure; Oxygen; Rats; Rats, Sprague-Dawley; Sarcolemma; Stress, Mechanical; Trimetazidine; Video Recording | 1996 |
Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog.
Topics: Adenine Nucleotides; Anesthetics, Inhalation; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Erythrocyte Count; Female; Halothane; Heart; Hemodynamics; Lipid Peroxidation; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Reactive Oxygen Species; Trimetazidine; Vasodilator Agents | 1996 |
Angina, myocardial hibernation and trimetazidine.
Topics: Angina Pectoris; Humans; Myocardial Ischemia; Myocardial Stunning; Trimetazidine; Vasodilator Agents | 1997 |
Is the cytoprotective effect of trimetazidine associated with lipid metabolism?
Topics: Animals; Cells, Cultured; Choline; Chromatography, Gas; Ethanolamine; Fatty Acids; Inositol; Linoleic Acid; Myocardial Ischemia; Myocardium; Oleic Acid; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Rats; Rats, Wistar; Stearic Acids; Trimetazidine; Vasodilator Agents | 1998 |
Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glucose; Heart; Heart Rate; Lactic Acid; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Tomography, Emission-Computed; Trimetazidine; Vasodilator Agents | 1998 |
Ionic and metabolic imbalance in various conditions of ischemia-reperfusion: a 31P- and 23Na-NMR study.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Diastole; Dichloroacetic Acid; Enzyme Inhibitors; Guanidines; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Phosphorus; Rats; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Trimetazidine; Vasodilator Agents | 1998 |
Effect of trimetazidine on carnitine palmitoyltransferase-1 in the rat heart.
Topics: Amiodarone; Animals; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Perhexiline; Rats; Rats, Sprague-Dawley; Trimetazidine | 1998 |
[Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism].
Topics: Animals; Energy Metabolism; Heart; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents | 1998 |
Metabolic treatment of myocardial ischaemia.
Topics: Cytoprotection; Humans; Mitochondria, Heart; Myocardial Ischemia; Oxygen; Trimetazidine; Vasodilator Agents | 1999 |
[Myocardial cytoprotection with trimetazidine in patients with ischemic heart disease during surgical stress].
Topics: Aged; Cytoprotection; Disulfides; Electrocardiography; Heart; Humans; Middle Aged; Myocardial Ischemia; Stress, Physiological; Sulfhydryl Compounds; Trimetazidine; Urologic Surgical Procedures, Male; Vasodilator Agents | 1999 |
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Topics: Angina Pectoris; Animals; Carboxy-Lyases; Dose-Response Relationship, Drug; Energy Metabolism; Esters; Fatty Acids; Glucose; Glycolysis; Male; Malonyl Coenzyme A; Mitochondria; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Myocardial Ischemia; Myocardium; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents | 2000 |
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
Topics: Animals; Anti-Arrhythmia Agents; Cyclosporine; Decanoic Acids; Dinitrophenols; Enzyme Inhibitors; Homeostasis; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Ischemia; Perfusion; Rats; Rats, Long-Evans; Trimetazidine; Uncoupling Agents | 2000 |
Trimetazidine: a novel protective role via maintenance of Na(+)/K(+)-ATPase activity?
Topics: Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Oxygen Consumption; Premedication; Sodium; Sodium-Potassium-Exchanging ATPase; Trimetazidine; Vasodilator Agents | 2000 |
Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischaemia.
Topics: Analysis of Variance; Animals; Coronary Circulation; Fatty Acids; Hydrogen-Ion Concentration; Intracellular Fluid; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Trimetazidine; Vasodilator Agents | 2000 |
[Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].
Topics: Antioxidants; Coronary Angiography; Coronary Circulation; Humans; Hyperlipidemias; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2001 |
Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine.
Topics: Animals; Dose-Response Relationship, Drug; Endothelin-1; Glucose; Heart Rate; Hyperglycemia; Hyperinsulinism; In Vitro Techniques; Insulin; Male; Myocardial Ischemia; Myocardial Reperfusion; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Triglycerides; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2001 |
Can metabolic manipulation reverse myocardial dysfunction?
Topics: Heart Failure; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2001 |
[Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].
Topics: Adult; Aged; Antioxidants; Drug Therapy, Combination; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Proteins; Radiation-Protective Agents; Trimetazidine; Vasodilator Agents | 2002 |