trimetazidine has been researched along with Heart Disease, Ischemic in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (19.71) | 18.2507 |
| 2000's | 76 (55.47) | 29.6817 |
| 2010's | 27 (19.71) | 24.3611 |
| 2020's | 7 (5.11) | 2.80 |
| Authors | Studies |
|---|---|
| Arrhenius, T; Barr, R; Brown, S; Chen, M; Cheng, JF; Dyck, JR; Haramura, M; Harmon, C; Liu, B; Lopaschuk, GD; Mak, CC; Nadzan, AM; Reily, S; Thorn, V; Tith, S; Wallace, D | 1 |
| Arrhenius, T; Barbosa, M; Barr, R; Cheng, JF; Dyck, JR; Huang, Y; Liu, L; Lopaschuk, GD; Nadzan, AM; Nishimoto, M; O'leary, E; Penuliar, R; Yang, G | 1 |
| Arduini, A; Ceccarelli, SM; Chomienne, O; Gubler, M | 1 |
| Ajabnoor, A; Mukhtar, A | 1 |
| El-Khodary, NM; El-Tayaar, AA; El-Touny, EM; Ghoneim, AI | 1 |
| Bahrudin, U; Harjoko, RP; Herminingsih, S; Maharani, N; Sobirin, MA; Tsutsui, H; Uddin, I | 1 |
| Chen, R; Ge, J; Guan, L; Li, M; Qin, S; Shi, H; Su, Y; Xiao, Z; Yu, Y; Yu, Z | 1 |
| Thadani, U | 1 |
| Ahangarpour, A; Amini, N; Badavi, M; Dianat, M; Mard, SA; Sarkaki, A | 1 |
| Duan, Y; Lin, Y; Sun, ZQ; Wang, ZL; Yan, M; Zhu, FY | 1 |
| Mahajan, AU; Mahajan, S | 1 |
| Li, C; Li, G; Shangguan, W; Shi, W; Zhang, Y | 1 |
| Gaszner, B; Hild, G; Kónyi, A; Meiszterics, Z; Sárszegi, Z | 1 |
| Bego, T; Čaušević, A; Dujić, T; Malenica, M; Prnjavorac, B; Prnjavorac, I; Šaranović, L; Suljić, U | 1 |
| Lu, X; Ma, X; Wang, J; Wen, J; Yang, Y; Zhang, L; Zhao, Y | 1 |
| Amin, MR; Arzu, J; Banerjee, RS; Ear-E-Mahabub, SM; Hoque, MH; Joarder, AI; Kabir, FI; Singha, CK; Zaman, SM | 1 |
| Cheng, B; Li, Y; Liu, L; Liu, Y; Qi, B; Wang, Q; Wu, Q | 1 |
| Gorbach, TV; Kukes, VG; Romashchenko, OV; Rumbesht, VV; Zhernakova, NI | 1 |
| Altamirano, R; Castro, PF; Chiong, M; Concepción, R; Enriquez, A; García, L; Jalil, JE; Lavandero, S; Mellado, R; Quintana, JC; Rossel, V; Sepúlveda, L; Sepúlveda, P; Verdejo, HE; Winter, JL | 1 |
| Shehata, M | 1 |
| Avcı, B; Çavun, S; Savcı, V; Şentürk, T; Serdar, Z; Yermezler, A | 1 |
| Biziaeva, EA; Karpova, ÉS; Kotel'nikova, EV; Liamina, NP | 1 |
| Fi, Z; Kovács, G; Szentes, V | 1 |
| Rehberger-Likozar, A; Šebeštjen, M | 1 |
| Dong, R; Li, S; Liu, J; Luo, Y; Peng, L; Zhao, Y; Zheng, Z; Zhu, J | 1 |
| Colombo, A; Fragasso, G; Fumero, A; Giannini, F; Godino, C; Maranta, F; Margonato, A; Oppizzi, M; Slavich, M | 1 |
| Glezer M, G; On Behalf Of The Choice-Study Participants, OB | 1 |
| Gorbunova, ML; Vilkova, AV | 1 |
| Belardinelli, R; Cianci, G; Gigli, M; Lacalaprice, F; Mazzanti, M | 1 |
| Arora, R; Jawad, E | 1 |
| Belardinelli, R; Faccenda, E; Lacalaprice, F; Volpe, L | 1 |
| Chen, S; Jin, J; Lu, Q; Song, WZ; Wang, WY; Xie, HJ; Xu, GH; Zhong, P; Zhou, XF | 1 |
| Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY | 1 |
| Dronova, EP; Lopatin, IuM | 1 |
| Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C | 1 |
| Caminiti, G; Fini, M; Gebara, O; Marazzi, G; Ramires, JA; Rosano, G; Vitale, C; Volterrani, M; Wajngarten, M | 1 |
| Cerrahoglu, M; Eserdag, M; Iskesen, I; Kurdal, AT; Sirin, BH | 1 |
| Aispuru, GR; Caminiti, N; Grimolizzi, NS; Páez Gill, NE; Ugartemendia, M | 1 |
| Bunc, M; Vrtovec, B; Zemljic, G | 1 |
| Arioli, F; Cera, M; Facchini, A; Fragasso, G; Gardini, C; Godino, C; Margonato, A; Marinosci, G; Montanaro, C; Salerno, A; Spoladore, R | 1 |
| Beresewicz, A; Skierczynska, A | 1 |
| Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL | 1 |
| Qizhu, T; Wenmeng, W | 1 |
| Inzhutova, AI; Larionov, AA; Petrova, MM; Salmina, AB | 1 |
| Assunção, CR; Bottino, F; Carvalho, KG; Martins, GF; Santos, JB; Siqueira Filho, AG; Valência, A | 1 |
| Tian, Y; Xu, H; Zhu, G | 1 |
| Bochkareva, EV; Butina, EK; Dmitrieva, NA; Kokurina, EV | 1 |
| Dec, I; Poloński, L; Wilczek, K; Wojnar, R | 1 |
| Aronov, DM; Novikova, NK; Pisareva, NA; Smolenskiĭ, VS; Tartakovskiĭ, LB; Zhidko, NI | 1 |
| Kutuzova, AE; Liasnikova, EA; Mikhaĭlova, IE; Nedoshivin, AO; Nesterova, IV; Novikova, NA; Perepech, NB; Rubashkina, EI | 1 |
| Marzilli, M; Stanley, WC | 1 |
| Binding, P; Fairman, DA; Haddock, PS; Karran, EH; MacInnes, A; Phelan, A; Rhodes, Ja; Wyatt, MJ | 1 |
| Barr, R; Dyck, JR; Lopaschuk, GD; Thomas, PD | 1 |
| Churshin, AD; Pimenov, LT | 1 |
| Calori, G; Fragasso, G; Lopaschuk, GD; Margonato, A; Monti, L; Palloshi, A; Piatti Md, PM; Puccetti, P; Setola, E | 1 |
| Dernek, S; Ikizler, M; Kural, T; Sevin, B | 1 |
| Hill, JA; Schofield, RS | 1 |
| Broustet, JP; Sellier, P | 1 |
| Biggi, A; Feola, M; Ferrero, V; Francini, A; Leonardi, G; Ribichini, F; Uslenghi, E | 2 |
| Belardinelli, R | 2 |
| Frenneaux, M; Horowitz, J; Lee, L | 1 |
| Fedorova, TA; Il'ina, IuV; Loshchits, NV; Rybakova, MK; Sotnikova, TI | 1 |
| Akhmedov, ShD; Dzhavadova, GK; Tepliakov, AT; Vecherskiĭ, IuIu; Vesnina, ZhV | 1 |
| Atroshenkov, AV; Chernov, VI; Efimova, EV; Karpov, RS; Koshel'skaia, OA; Ocheredko, NA | 1 |
| Pauly, DF; Pepine, CJ | 1 |
| Fini, M; Gebara, O; Rosano, GM; Rossini, P; Sposato, B; Vitale, C; Volterrani, M; Wajngaten, M | 1 |
| Lupanov, VP; Matveeva, MA; Mironova, IIu; Naumov, VG; Orlova, EM; Samoĭlenko, LE | 1 |
| Duarte, AI; Gonçalves, LM; Monteiro, P; Moreno, A; Providência, LA | 1 |
| Galaris, D; Korantzopoulos, P; Kountouris, E; Siogas, K | 1 |
| Fedorova, TA; Il'ina, IuV; Rybakova, MK; Sotnikova, TI | 1 |
| McMurray, JJ; O'Meara, E | 1 |
| Al-Ghazali, R; Liang, WW; Liu, TW; Tao, XZ; Yin, RX; Zhu, LG | 1 |
| Cerquetani, E; Fini, M; Marazzi, G; Mercuro, G; Patrizi, R; Rosano, GM; Vitale, C; Volterrani, M | 1 |
| Allard, MF; Bescond-Jacquet, A; Grist, M; Lucien, A; Saeedi, R; Wambolt, RB | 1 |
| Arroyo Espliguero, R; Cosín Sales, J; Kaski, JC | 1 |
| Aguilar Llopis, A; Azorín Villena, I; Capdevilla Carbonell, C; Cosín Aguilar, J; Hernándiz Martinez, A; Martinez, VB; Morillas Blasco, PJ; Pallarés Carratala, V; Portolés Sanz, M | 1 |
| Abdel-Hady, S; El-Kady, T; El-Sabban, K; Gabaly, M; Sabry, A | 1 |
| Camisasca, RP; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Origgi, A; Piatti, P; Setola, E | 1 |
| Bakhmatova, IuA; Gapon, LI; Petelina, TI; Zhevagina, IA | 1 |
| Fini, M; Rosano, GM; Vitale, C; Volterrani, M | 1 |
| Affinito, S; Marzilli, M | 1 |
| Arora, R; Parang, P; Singh, B | 1 |
| Bettaieb, A; Filomenko, R; Gambert, S; Moreau, D; Opie, LH; Rochette, L; Vergely, C | 1 |
| Altekin, E; Goldeli, O; Kuralay, F; Onvural, B; Yazlar, AS | 1 |
| Sabbah, HN; Stanley, WC | 1 |
| Bassanelli, G; Calori, G; Fragasso, G; Lattuada, G; Locatelli, M; Lopaschuk, G; Margonato, A; Montano, C; Oggionni, S; Palloshi, A; Perseghin, G | 1 |
| Bertomeu-Gonzalez, V; Bouzas-Mosquera, A; Kaski, JC | 1 |
| Fini, M; Gebara, O; Marazzi, G; Patrizi, R; Pelliccia, F; Pierri, H; Ramires, JA; Rosano, GM; Vitale, C; Volterrani, M; Wajngarten, M | 1 |
| Barkhudarian, AL; Sisakian, AS; Torgomian, AL | 1 |
| Armaganijan, D; Bicudo, L; Brasil, CK; Cesar, LA; Del Monaco, MI; Gimenez, V; Gomes, EP; Jallad, S; Mathias, W; Meneguin, S; Ramires, JF | 1 |
| Barsotti, A; D'Apolito, G; Di Giovanni, P; Di Napoli, P; Gaeta, MA | 1 |
| Barkhudaryan, A; Sisakian, H; Torgomyan, A | 1 |
| Barsotti, A; Di Giovanni, P; Di Napoli, P; Gaeta, MA; Taccardi, AA | 1 |
| Bescond-Jacquet, A; Bricca, G; Bui-Xuan, B; Descotes, J; Tabib, A; Timour, Q; Tsibiribi, P; Vaillant, F | 1 |
| Makolkin, VI; Mikova, NV; Petriĭ, VV | 1 |
| Baksheev, VI; Kolomoets, NM; Uvaĭsova, IU; Zarubina, EG | 1 |
| Chaitman, BR; Sano, J | 1 |
| Kus, M; Tanda, K; Williams, FM; Williams, TJ | 1 |
| Boucher, FR; Hearse, DJ; Opie, LH | 1 |
| Hue, L; Maisin, L; Veitch, K | 1 |
| Boucher, F; Opie, LH | 1 |
| Boucher, F; de Leiris, J | 1 |
| Ribeiro, C | 1 |
| Bezstarosti, K; Koning, MM; Krams, R; Lamers, JM; van Meegen, JR; Verdouw, PD; Xiao, CS | 1 |
| Buck, T; Kober, G; Pennaforte, S; Sievert, H; Vallbracht, C | 1 |
| Guarnieri, C; Muscari, C | 1 |
| Iliceto, S; Marangelli, V; Rizzon, P | 1 |
| Garcia-Dorado, D; González, MA; Inserte, J; Juliá, M; Ruiz-Meana, M; Soler-Soler, J | 1 |
| Arvieux, C; Cannet, E; de Lorgeril, M; Ferrera, R; Forrat, R; Guidollet, J; Hadour, G; Lehot, JJ; Sebbag, L; Vedrinne, C | 1 |
| Eliseev, OM | 1 |
| Jackson, G | 1 |
| Albengres, E; Berland, Y; Crevat, A; d'Athis, P; Hestin, D; Jaber, K; Kessler, M; Olivier, P; Roux, F; Simon, N; Tillement, JP | 1 |
| Lopaschuk, GD | 3 |
| Grynberg, A; Lucien, A; Sentex, E; Sergiel, JP | 1 |
| Buxton, DB; Coyle, KB; Hansen, HW; Mody, FV; Mohiuddin, IH; Schelbert, HR; Singh, BN; Sumida, R | 1 |
| Jones, BE; King, LM; Taegtmeyer, H | 1 |
| Celegon, L; Desideri, A | 1 |
| Bernard, M; Cozzone, PJ; el Banani, H; Feuvray, D | 1 |
| Horowitz, JD; Kennedy, JA | 1 |
| Domzał-Bocheńska, M; Elikowski, W; Gajos, G; Kałuza, G; Kulon, I; Kuźniak, M; Pachocki, R; Paradowski, A; Sadowski, Z; Szwed, H; Szydłowski, Z; Szymczak, K; Wator-Brzezińska, A | 1 |
| Ferrari, R | 1 |
| Akhmetov, KZh; Goncharov, LF; Goncharova, ZF; Kelimberdieva, ES; Komissarova, IA; Teĭblium, MM; Zaslavskaia, RM | 1 |
| Afanas'eva, IV; Goncharova, LL; Miroshnichenko, AG; Petrash, VV; Pokrovskaia, LA | 1 |
| Kantor, PF; Kozak, R; Lopaschuk, GD; Lucien, A | 1 |
| Minners, J; Opie, LH; Sack, MN; Schwalb, H; van den Bos, EJ; Yellon, DM | 1 |
| Cross, HR | 1 |
| Baetz, D; Bernard, M; Cabanes, E; Cozzone, P; El Banani, H; Feuvray, D; Lucien, A | 1 |
| Baj, Z; Kowalski, J; Olejniczak, J; Paśnik, J; Pawlicki, L | 1 |
| Gaĭsin, IR; Karbasnikova, GV; Leshchinskiĭ, LA; Logacheva, IV; Perevalov, AP; Romanova, ZD | 1 |
| Allibardi, S; Chierchia, S; Costa, S; Monti, LD; Piatti, PM; Pozza, G; Samaja, M; Valsecchi, G | 1 |
| Cokkinos, DV | 1 |
| Belardinelli, R; Purcaro, A | 1 |
| Kalinina, EB; Komissarova, IA; Zaslavskaia, RM; Zhdanov, IuA | 1 |
30 review(s) available for trimetazidine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Effect of trimetazidine on the functional capacity of ischemic heart disease patients not suitable for revascularization: Meta-analysis of randomized controlled trials.
Topics: Cross-Over Studies; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Stroke Volume; Trimetazidine; Vasodilator Agents; Walk Test | 2022 |
Effect of Trimetazidine on Diabetic Patients with Coronary Heart Diseases: A Meta-Analysis of Randomized, Controlled Trials.
Topics: Blood Glucose; Coronary Disease; Diabetes Mellitus; Diastole; Exercise Tolerance; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Ventricular Function, Left | 2020 |
Current Clinical Evidence of Trimetazidine in the Management of Heart Disease in Patients with Diabetes.
Topics: Coronary Artery Disease; Diabetes Mellitus; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2020 |
Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.
Topics: Cardiovascular Agents; Drug Therapy, Combination; Drugs, Chinese Herbal; Heart Failure; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine | 2018 |
[Role of trimetazidine in the treatment of diabetic microangiopathy in ischaemic heart disease].
Topics: Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Heart; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2015 |
Trimetazidine improves exercise tolerance in patients with ischemic heart disease : A meta-analysis.
Topics: Dose-Response Relationship, Drug; Evidence-Based Medicine; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prevalence; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2016 |
Chronic stable angina pectoris.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents | 2008 |
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].
Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents | 2009 |
Modulation of myocardial metabolism: an emerging therapeutic principle.
Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 2010 |
Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine.
Topics: Angina Pectoris; Carbohydrate Metabolism; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2003 |
Role of metabolically active drugs in the management of ischemic heart disease.
Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Acid; Energy Metabolism; Fatty Acids; Glucose; Humans; Insulin; Myocardial Ischemia; Myocardium; Piperazines; Potassium; Ranolazine; Trimetazidine | 2001 |
[Ischemic heart disease and left ventricular dysfunction: the role of trimetazidine].
Topics: Clinical Trials as Topic; Humans; Myocardial Ischemia; Trimetazidine; Ventricular Dysfunction, Left | 2004 |
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Glucose; Humans; Hypoglycemic Agents; Insulin; Myocardial Ischemia; Myocardium; Perhexiline; Piperazines; Potassium; Ranolazine; Trimetazidine | 2004 |
Ischemic heart disease: metabolic approaches to management.
Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine; Ribose; Trimetazidine | 2004 |
Silent myocardial ischaemia: clinical relevance and treatment.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Coronary Artery Disease; Electrocardiography; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Myocardial Revascularization; Nitric Oxide Donors; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic therapy for the diabetic patients with ischaemic heart disease.
Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2005 |
Meeting the challenge of chronic ischaemic heart disease with trimetazidine.
Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic modulators for chronic cardiac ischemia.
Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; Heart; Humans; Lipid Metabolism; Myocardial Ischemia; Myocardium; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents; Vitamin B Complex | 2005 |
Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation.
Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2005 |
Role of trimetazidine in management of ischemic cardiomyopathy.
Topics: Humans; Myocardial Ischemia; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2006 |
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents | 2007 |
Intervention in ischaemia. Reperfusion syndrome. Rationale for trimetazidine.
Topics: Acidosis; Calcium; Energy Metabolism; Free Radicals; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocarditis; Reactive Oxygen Species; Trimetazidine | 1994 |
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease?
Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Superoxide Dismutase; Trimetazidine; Ubiquinone; Vasodilator Agents | 1995 |
[Trimetazidine (Preductal). A new approach in controlling myocardial ischemia].
Topics: Animals; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 1996 |
Potential interest of anti-ischemic agents for limiting cyclosporin A nephrotoxicity.
Topics: Adenosine Triphosphate; Calcium; Creatinine; Cyclosporine; Humans; Kidney; Mitochondria; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 1997 |
Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism.
Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents | 1998 |
Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 1998 |
Metabolic management of ischemic heart disease: clinical data with trimetazidine.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; Energy Metabolism; Exercise Test; Hemodynamics; Humans; Myocardial Ischemia; Myocardium; Treatment Outcome; Trimetazidine; Vasodilator Agents | 1998 |
Trimetazidine and the contractile response of dysfunctional myocardium in ischaemic cardiomyopathy.
Topics: Humans; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2000 |
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?
Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Glycolysis; Humans; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2001 |
44 trial(s) available for trimetazidine and Heart Disease, Ischemic
| Article | Year |
|---|---|
The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients.
Topics: Angina Pectoris; Cardiomyopathies; Fibrosis; Humans; Inflammation; Myocardial Ischemia; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2023 |
Trimetazidine improves left ventricular global longitudinal strain value in patients with heart failure with reduced ejection fraction due to ischemic heart disease.
Topics: Aged; Heart Failure; Humans; Middle Aged; Myocardial Ischemia; Stroke Volume; Trimetazidine; Ventricular Dysfunction, Left | 2022 |
The role of metabolic therapy with trimetazidine in effort tolerance in patients with ischemic heart disease.
Topics: Echocardiography; Exercise Test; Exercise Tolerance; Female; Heart; Humans; Male; Metabolic Equivalent; Myocardial Ischemia; Myocardium; Patient Discharge; Physical Exertion; Quality of Life; Stroke Volume; Trimetazidine; Ultrasonography; Vasodilator Agents | 2018 |
Comparison between Glyceryl Trinitrate and Trimetazidine in Ischaemic Cardiomyopathy Patients.
Topics: Bangladesh; Cardiomyopathies; Humans; Male; Myocardial Contraction; Myocardial Ischemia; Nitroglycerin; Pilot Projects; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2019 |
Effects of trimetazidine in nonischemic heart failure: a randomized study.
Topics: Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Radionuclide Imaging; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Impact of trimetazidine on incidence of myocardial injury and contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention.
Topics: Contrast Media; Coronary Angiography; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Elective Surgical Procedures; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Renal Insufficiency; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease.
Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents | 2015 |
Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy.
Topics: Cardiomyopathies; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Systole; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2008 |
Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.
Topics: Aged; Biomarkers; Blood Pressure; Body Mass Index; Brachial Artery; Cardiomyopathies; Combined Modality Therapy; Echocardiography, Doppler, Pulsed; Electrocardiography; Exercise Test; Exercise Therapy; Female; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Ischemia; Oxygen Consumption; Stroke Volume; Time Factors; Treatment Outcome; Trimetazidine; Vasodilation; Vasodilator Agents; Ventricular Dysfunction, Left | 2008 |
[Effects of trimetazidine on myocardial metabolism evaluated by PET-CT in patients with ischemic cardiomyopathy].
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Trimetazidine | 2008 |
[Clinical-pharmacoeconomic aspects of trimetazidine modified release use in patients with ischemic heart disease undergoing coronary artery bypass grafting].
Topics: Adult; Aged; Coronary Artery Bypass; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2009 |
Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy.
Topics: Aged; Cardiomyopathy, Dilated; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Severity of Illness Index; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2009 |
Trimetazidine may protect the myocardium during cardiac surgery.
Topics: Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2009 |
Trimetazidine shortens QTc interval in patients with ischemic heart failure.
Topics: Aged; Angiography; Electrocardiography; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2010 |
Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.
Topics: Aged; Aged, 80 and over; Antisocial Personality Disorder; Arrhythmias, Cardiac; Chronic Disease; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents | 2010 |
Trimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.
Topics: Biomarkers; Coronary Artery Bypass; Creatine Kinase, MB Form; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Placebo Effect; Postoperative Complications; Prospective Studies; Time Factors; Treatment Outcome; Trimetazidine; Troponin T; Vasodilator Agents | 2011 |
[Decrease in the sensitivity to the anti-ischemic effect of propranolol and prospects for correcting it in patients with stable angina pectoris].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Myocardial Ischemia; Placebos; Propranolol; Trimetazidine | 2002 |
Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Chi-Square Distribution; Coronary Stenosis; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2002 |
[Significance of trimetazidine for out of hospital physical rehabilitation after myocardial infarction].
Topics: Adult; Ambulatory Care; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2002 |
[Trimetazidine in correction of chronic heart failure in patients with ischemic heart disease].
Topics: Chronic Disease; Cross-Sectional Studies; Humans; Middle Aged; Myocardial Ischemia; Prospective Studies; Severity of Illness Index; Trimetazidine; Vasodilator Agents | 2002 |
[Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and postmenopausal women with ischemic heart disease].
Topics: Aged; Drug Therapy, Combination; Female; Humans; Middle Aged; Myocardial Ischemia; Postmenopause; Premenopause; Treatment Outcome; Trimetazidine; Vasodilator Agents; Verapamil | 2003 |
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
Topics: Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Echocardiography; Energy Metabolism; Glucose; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Trimetazidine | 2003 |
Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Angina Pectoris; Double-Blind Method; Europe; Exercise Test; Female; Humans; Israel; Latvia; Male; Middle Aged; Myocardial Ischemia; Russia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2003 |
[Clinical and hemodynamic efficacy of selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Bisoprolol; Cardiac Output, Low; Drug Administration Schedule; Drug Therapy, Combination; Echocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Quality of Life; Time Factors; Treatment Outcome; Trimetazidine; Ventricular Function, Left | 2004 |
[Clinical Efficacy of Combination Therapy With Trimetazidine and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension and Ischemic Heart Disease Associated With Type II Diabetes].
Topics: Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type 2; Humans; Hypertension; Myocardial Ischemia; Treatment Outcome; Trimetazidine | 2004 |
Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease.
Topics: Aged; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
[Potentialities of cytoprotection in the treatment of chronic heart failure in patients with coronary heart disease].
Topics: Aged; Aged, 80 and over; Bisoprolol; Chronic Disease; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Sympathomimetics; Trimetazidine; Vasodilator Agents | 2004 |
Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.
Topics: Adult; Aged; Analysis of Variance; Coitus; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Erectile Dysfunction; Humans; Male; Middle Aged; Myocardial Ischemia; Nitrates; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2005 |
Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study.
Topics: Aged; Cardiomyopathies; Coronary Circulation; Echocardiography; Exercise Test; Female; Heart Function Tests; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents | 2005 |
Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.
Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Citric Acid; Cross-Over Studies; Cyclic GMP; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Forearm; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Muscle, Skeletal; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine | 2006 |
[Clinical efficacy of combined therapy with enalapril + trimetazidine in patients with hypertension comorbid with ischemic heart disease and metabolic disturbances].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Catalase; Comorbidity; Drug Therapy, Combination; Enalapril; Female; Humans; Hypercholesterolemia; Hypertension; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Trimetazidine; Vasodilator Agents | 2005 |
The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.
Topics: Aged; Dietary Carbohydrates; Dietary Fats; Double-Blind Method; Echocardiography, Stress; Female; Food; Humans; Male; Myocardial Ischemia; Postprandial Period; Trimetazidine; Vasodilator Agents | 2006 |
Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Electrocardiography, Ambulatory; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2007 |
[The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].
Topics: Aged; Cardiomyopathies; Exercise; Exercise Tolerance; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2006 |
Trimetazidine to reverse ischemia in patients with class I or II angina: a randomized, double-blind, placebo-controlled dobutamine-atropine stress echocardiography study.
Topics: Aged; Angina Pectoris; Atropine; Dobutamine; Double-Blind Method; Echocardiography, Stress; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2007 |
Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy.
Topics: Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Natriuretic Peptide, Brain; Trimetazidine; Troponin T; Vasodilator Agents | 2007 |
Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.
Topics: Aged; C-Reactive Protein; Cardiomyopathy, Dilated; Echocardiography; Exercise Test; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Myocardial Ischemia; Stroke Volume; Survival Rate; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left; Walking | 2007 |
[Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus].
Topics: Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2007 |
[Efficacy of long-term therapy with trimetazidine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].
Topics: Aged; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Pulmonary Disease, Chronic Obstructive; Time Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2008 |
Myocardial cytoprotection during percutaneous transluminal coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Reproducibility of Results; Trimetazidine | 1993 |
The antiischemic effects and tolerability of trimetazidine in coronary diabetic patients. A substudy from TRIMPOL-1.
Topics: Diabetes Complications; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents | 1999 |
[Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina].
Topics: Aged; Aged, 80 and over; Angina Pectoris; Cysteine; Drug Therapy, Combination; Echocardiography; Electrocardiography, Ambulatory; Female; Glutamic Acid; Glycine; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 1999 |
[Effect of trimetazidine on biological activity of neutrophils in patients with transient myocardial ischemia induced by exercise testing].
Topics: Adult; Angina Pectoris; Cell Aggregation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Neutrophils; Trimetazidine | 2000 |
Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy.
Topics: Analysis of Variance; Cardiomyopathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2001 |
63 other study(ies) available for trimetazidine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Topics: Animals; Carboxy-Lyases; Energy Metabolism; Fatty Acids; Glucose; In Vitro Techniques; Male; Malonyl Coenzyme A; Morpholines; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine | 2006 |
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Topics: Administration, Oral; Animals; Biological Availability; Carboxy-Lyases; Cardiotonic Agents; Crystallography, X-Ray; Isoxazoles; Molecular Conformation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2006 |
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catalytic Domain; Diabetes Mellitus, Type 2; Energy Metabolism; Enzyme Activators; Ethylene Oxide; Heart Failure; Humans; Insulin Resistance; Isoenzymes; Lipid Metabolism; Myocardial Ischemia; Organ Specificity; Protein Conformation; Sequence Homology, Amino Acid; Stereoisomerism | 2011 |
Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition.
Topics: Animals; Calcium; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Trimetazidine | 2023 |
Trimetazidine for stable and unstable ischemic heart diseases and for heart failure: Is its routine use justified from available data?
Topics: Angina Pectoris; Heart Failure; Humans; Myocardial Ischemia; Trimetazidine | 2020 |
Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.
Topics: Acute Kidney Injury; Animals; Flavanones; Glutathione Peroxidase; Male; Malondialdehyde; Myocardial Ischemia; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Trimetazidine | 2019 |
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Topics: Animals; Disease Models, Animal; Male; Mitochondria; Myocardial Ischemia; Rats; Rats, Wistar; Respiratory Physiological Phenomena; Trimetazidine; Vasodilator Agents | 2017 |
Effectiveness and safety of anti-ischemic trimetazidine in patients with stable angina pectoris and Type 2 diabetes.
Topics: Aged; Angina, Stable; Canada; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Administration Schedule; Female; Humans; Male; Myocardial Ischemia; Prospective Studies; Pulse Wave Analysis; Trimetazidine; Vasodilator Agents | 2017 |
Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways.
Topics: Antioxidants; Cardiotonic Agents; Cells, Cultured; Endothelial Cells; Humans; Hydrogen Peroxide; Malondialdehyde; Myocardial Ischemia; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ribonucleosides; Signal Transduction; Stem Cells; Superoxide Dismutase; Trimetazidine | 2013 |
[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
Topics: Adenosine Triphosphate; Age Factors; Animals; Cell Membrane; Citrate (si)-Synthase; Disease Models, Animal; Glycolysis; Ketone Oxidoreductases; Lactic Acid; Male; Mitochondria; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2013 |
Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury.
Topics: Acetylcysteine; Animals; Apoptosis; Blood Pressure; Caspase 3; Cell Death; Coronary Vessels; Disease Models, Animal; Fatty Acids; Glucose; Glutathione; Inflammation; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; Trimetazidine | 2014 |
[Approaches potentiating cardioprotective effect of ambulatory physical training in patients with ischemic heart disease and multivessel coronary artery involvement after coronary stenting].
Topics: Cardiotonic Agents; Coronary Vessels; Echocardiography; Electrocardiography; Exercise Therapy; Exercise Tolerance; Female; Home Care Services, Hospital-Based; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Russia; Severity of Illness Index; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2014 |
Long-Term Preservation of Left Ventricular Systolic Function in Patients With Refractory Angina Pectoris and Inducible Myocardial Ischemia on Optimal Medical Therapy.
Topics: Aged; Angina Pectoris; Benzazepines; Cardiovascular Agents; Echocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Ivabradine; Male; Myocardial Ischemia; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Stroke Volume; Systole; Time Factors; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2016 |
[Treatment of Patients With Stable Ischemic Heart Disease in Real Clinical Practice in Russia. The CHOICE-2 Program].
Topics: Angina Pectoris; Coronary Artery Disease; Humans; Myocardial Ischemia; Russia; Trimetazidine | 2016 |
[Assessment of Efficacy and Safety of Metabolic Therapy With Trimetazidine MB in Patients With Ischemic Heart Disease and Chronic Heart Failure].
Topics: Chronic Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2016 |
Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Occlusion; Drug Combinations; Electrocardiography; Heart; Malates; Male; Mitochondria, Heart; Myocardial Ischemia; Oxidative Phosphorylation; Rats; Rats, Wistar; Succinic Acid; Tachycardia; Trimetazidine; Vasodilator Agents | 2008 |
[Coronary-ventricular sinusoid communications].
Topics: Cardiac Catheterization; Coronary Angiography; Female; Humans; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2009 |
Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.
Topics: Animals; Coronary Circulation; Dichloroacetic Acid; Disease Models, Animal; Dobutamine; Fatty Acids; Glucose; Glycolysis; Male; Myocardial Ischemia; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Trimetazidine | 2010 |
Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.
Topics: Animals; Diabetes Mellitus; Diabetic Cardiomyopathies; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Models, Theoretical; Myocardial Ischemia; Myocardium; Research Design; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2011 |
[Stabilization of cellular membranes as a target of vascular therapy].
Topics: Adult; Cell Membrane; Cell-Derived Microparticles; Comparative Effectiveness Research; Cytoprotection; Endothelium, Vascular; Female; Humans; Hypertension; Lymphocytes; Male; Microscopy, Phase-Contrast; Middle Aged; Models, Cardiovascular; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2011 |
Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.
Topics: Animals; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Ischemia; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2012 |
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Topics: Acetanilides; Acetyl-CoA C-Acyltransferase; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Recombinant Proteins; Trimetazidine; Vasodilator Agents | 2003 |
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Cardiotonic Agents; Dichloroacetic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Fatty Acids; Glucose; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recovery of Function; Trimetazidine; Vasodilator Agents | 2003 |
Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.
Topics: Administration, Oral; Animals; Coronary Circulation; Creatine Kinase; Disease Models, Animal; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; Trimetazidine; Troponin T; Vasodilator Agents | 2003 |
Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.
Topics: Aged; Coronary Artery Disease; Coronary Vessels; Gated Blood-Pool Imaging; Heart Ventricles; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Single-Blind Method; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
[Effect of trimetazidine on regressione of ischemic dysfunction of myocardium after coronary bypass surgery on beating heart].
Topics: Coronary Artery Bypass; Humans; Myocardial Contraction; Myocardial Ischemia; Myocardium; Trimetazidine | 2004 |
[Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].
Topics: Angina Pectoris; Angina, Stable; Coronary Artery Disease; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2004 |
Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Electrochemistry; Electron Transport; Energy Metabolism; Female; In Vitro Techniques; Membrane Potentials; Mitochondria, Heart; Myocardial Ischemia; Myocytes, Cardiac; Oxidative Phosphorylation; Oxygen Consumption; Perfusion; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2004 |
The acute administration of trimetazidine modified myocardial perfusion and left ventricular function in 31 patients with ischaemic ventricular dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Echocardiography; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Radiopharmaceuticals; Stroke Volume; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Function, Left | 2004 |
The potential benefits of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
Topics: Anti-Arrhythmia Agents; Antioxidants; Diabetes Complications; Diabetes Mellitus; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Oxidative Stress; Trimetazidine; Vasodilator Agents | 2004 |
Myocardial metabolic manipulation: a new therapeutic approach in heart failure?
Topics: Blood Glucose; Fatty Acids, Nonesterified; Heart Failure; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2005 |
Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.
Topics: Animals; Apoptosis; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Rabbits; Random Allocation; Superoxide Dismutase; Trimetazidine | 2004 |
Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Glucose; Glycolysis; Kinetics; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Palmitates; Perfusion; Protons; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents | 2005 |
Mitochondrial changes induced by trimetazidine in the myocardium.
Topics: Animals; Dogs; Double-Blind Method; Female; Heart; Lipofuscin; Male; Mitochondria, Heart; Models, Animal; Myocardial Ischemia; Random Allocation; Trimetazidine; Vasodilator Agents | 2005 |
Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.
Topics: Animals; Ascorbic Acid; Fatty Acids, Nonesterified; Free Radicals; Heart; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents | 2006 |
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Nitrites; Reactive Oxygen Species; Time Factors; Treatment Outcome; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2006 |
The effect of trimetazidine on left ventricular systolic function and physical tolerance in patients with ischaemic cardiomyopathy.
Topics: Aged; Cardiomyopathy, Dilated; Cardiotonic Agents; Exercise Test; Exercise Tolerance; Female; Health Status Indicators; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Prospective Studies; Stroke Volume; Systole; Trimetazidine; Vasodilator Agents | 2007 |
Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Electric Stimulation; Female; Heart Rate; Homeostasis; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Ischemia; Swine; Trimetazidine; Vasodilator Agents; Ventricular Fibrillation | 2008 |
Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits.
Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Heart Rate; Interleukin-8; Leukotriene B4; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Rabbits; Trimetazidine; Zymosan | 1993 |
Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts.
Topics: Animals; Blood Pressure; Coronary Circulation; Glucose; Heart Rate; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine | 1994 |
Trimetazidine effects on the damage to mitochondrial functions caused by ischemia and reperfusion.
Topics: Animals; In Vitro Techniques; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyruvate Dehydrogenase Complex; Rats; Trimetazidine | 1995 |
Trimetazidine and myocardial ischemic contracture in isolated rat heart.
Topics: Animals; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Rats; Trimetazidine | 1995 |
[Therapeutic application of myocardial cytoprotection].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 1994 |
Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia.
Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Animals; Coronary Circulation; Disease Models, Animal; Female; Free Radicals; Heart; Hemodynamics; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Oxygen; Oxygen Consumption; Regional Blood Flow; Swine; Trimetazidine | 1993 |
Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium.
Topics: Animals; Hypertrophy, Right Ventricular; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Trimetazidine | 1993 |
Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes.
Topics: Animals; Cells, Cultured; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Osmotic Pressure; Oxygen; Rats; Rats, Sprague-Dawley; Sarcolemma; Stress, Mechanical; Trimetazidine; Video Recording | 1996 |
Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog.
Topics: Adenine Nucleotides; Anesthetics, Inhalation; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Erythrocyte Count; Female; Halothane; Heart; Hemodynamics; Lipid Peroxidation; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Reactive Oxygen Species; Trimetazidine; Vasodilator Agents | 1996 |
Angina, myocardial hibernation and trimetazidine.
Topics: Angina Pectoris; Humans; Myocardial Ischemia; Myocardial Stunning; Trimetazidine; Vasodilator Agents | 1997 |
Is the cytoprotective effect of trimetazidine associated with lipid metabolism?
Topics: Animals; Cells, Cultured; Choline; Chromatography, Gas; Ethanolamine; Fatty Acids; Inositol; Linoleic Acid; Myocardial Ischemia; Myocardium; Oleic Acid; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Rats; Rats, Wistar; Stearic Acids; Trimetazidine; Vasodilator Agents | 1998 |
Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glucose; Heart; Heart Rate; Lactic Acid; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Tomography, Emission-Computed; Trimetazidine; Vasodilator Agents | 1998 |
Ionic and metabolic imbalance in various conditions of ischemia-reperfusion: a 31P- and 23Na-NMR study.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Diastole; Dichloroacetic Acid; Enzyme Inhibitors; Guanidines; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Phosphorus; Rats; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Trimetazidine; Vasodilator Agents | 1998 |
Effect of trimetazidine on carnitine palmitoyltransferase-1 in the rat heart.
Topics: Amiodarone; Animals; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Perhexiline; Rats; Rats, Sprague-Dawley; Trimetazidine | 1998 |
[Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism].
Topics: Animals; Energy Metabolism; Heart; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents | 1998 |
Metabolic treatment of myocardial ischaemia.
Topics: Cytoprotection; Humans; Mitochondria, Heart; Myocardial Ischemia; Oxygen; Trimetazidine; Vasodilator Agents | 1999 |
[Myocardial cytoprotection with trimetazidine in patients with ischemic heart disease during surgical stress].
Topics: Aged; Cytoprotection; Disulfides; Electrocardiography; Heart; Humans; Middle Aged; Myocardial Ischemia; Stress, Physiological; Sulfhydryl Compounds; Trimetazidine; Urologic Surgical Procedures, Male; Vasodilator Agents | 1999 |
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Topics: Angina Pectoris; Animals; Carboxy-Lyases; Dose-Response Relationship, Drug; Energy Metabolism; Esters; Fatty Acids; Glucose; Glycolysis; Male; Malonyl Coenzyme A; Mitochondria; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Myocardial Ischemia; Myocardium; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents | 2000 |
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
Topics: Animals; Anti-Arrhythmia Agents; Cyclosporine; Decanoic Acids; Dinitrophenols; Enzyme Inhibitors; Homeostasis; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Ischemia; Perfusion; Rats; Rats, Long-Evans; Trimetazidine; Uncoupling Agents | 2000 |
Trimetazidine: a novel protective role via maintenance of Na(+)/K(+)-ATPase activity?
Topics: Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Oxygen Consumption; Premedication; Sodium; Sodium-Potassium-Exchanging ATPase; Trimetazidine; Vasodilator Agents | 2000 |
Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischaemia.
Topics: Analysis of Variance; Animals; Coronary Circulation; Fatty Acids; Hydrogen-Ion Concentration; Intracellular Fluid; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Trimetazidine; Vasodilator Agents | 2000 |
[Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].
Topics: Antioxidants; Coronary Angiography; Coronary Circulation; Humans; Hyperlipidemias; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2001 |
Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine.
Topics: Animals; Dose-Response Relationship, Drug; Endothelin-1; Glucose; Heart Rate; Hyperglycemia; Hyperinsulinism; In Vitro Techniques; Insulin; Male; Myocardial Ischemia; Myocardial Reperfusion; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Triglycerides; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2001 |
Can metabolic manipulation reverse myocardial dysfunction?
Topics: Heart Failure; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents | 2001 |
[Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].
Topics: Adult; Aged; Antioxidants; Drug Therapy, Combination; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Proteins; Radiation-Protective Agents; Trimetazidine; Vasodilator Agents | 2002 |