Page last updated: 2024-08-22

trimetazidine and Heart Disease, Ischemic

trimetazidine has been researched along with Heart Disease, Ischemic in 137 studies

Research

Studies (137)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's27 (19.71)18.2507
2000's76 (55.47)29.6817
2010's27 (19.71)24.3611
2020's7 (5.11)2.80

Authors

AuthorsStudies
Arrhenius, T; Barr, R; Brown, S; Chen, M; Cheng, JF; Dyck, JR; Haramura, M; Harmon, C; Liu, B; Lopaschuk, GD; Mak, CC; Nadzan, AM; Reily, S; Thorn, V; Tith, S; Wallace, D1
Arrhenius, T; Barbosa, M; Barr, R; Cheng, JF; Dyck, JR; Huang, Y; Liu, L; Lopaschuk, GD; Nadzan, AM; Nishimoto, M; O'leary, E; Penuliar, R; Yang, G1
Arduini, A; Ceccarelli, SM; Chomienne, O; Gubler, M1
Ajabnoor, A; Mukhtar, A1
El-Khodary, NM; El-Tayaar, AA; El-Touny, EM; Ghoneim, AI1
Bahrudin, U; Harjoko, RP; Herminingsih, S; Maharani, N; Sobirin, MA; Tsutsui, H; Uddin, I1
Chen, R; Ge, J; Guan, L; Li, M; Qin, S; Shi, H; Su, Y; Xiao, Z; Yu, Y; Yu, Z1
Thadani, U1
Ahangarpour, A; Amini, N; Badavi, M; Dianat, M; Mard, SA; Sarkaki, A1
Duan, Y; Lin, Y; Sun, ZQ; Wang, ZL; Yan, M; Zhu, FY1
Mahajan, AU; Mahajan, S1
Li, C; Li, G; Shangguan, W; Shi, W; Zhang, Y1
Gaszner, B; Hild, G; Kónyi, A; Meiszterics, Z; Sárszegi, Z1
Bego, T; Čaušević, A; Dujić, T; Malenica, M; Prnjavorac, B; Prnjavorac, I; Šaranović, L; Suljić, U1
Lu, X; Ma, X; Wang, J; Wen, J; Yang, Y; Zhang, L; Zhao, Y1
Amin, MR; Arzu, J; Banerjee, RS; Ear-E-Mahabub, SM; Hoque, MH; Joarder, AI; Kabir, FI; Singha, CK; Zaman, SM1
Cheng, B; Li, Y; Liu, L; Liu, Y; Qi, B; Wang, Q; Wu, Q1
Gorbach, TV; Kukes, VG; Romashchenko, OV; Rumbesht, VV; Zhernakova, NI1
Altamirano, R; Castro, PF; Chiong, M; Concepción, R; Enriquez, A; García, L; Jalil, JE; Lavandero, S; Mellado, R; Quintana, JC; Rossel, V; Sepúlveda, L; Sepúlveda, P; Verdejo, HE; Winter, JL1
Shehata, M1
Avcı, B; Çavun, S; Savcı, V; Şentürk, T; Serdar, Z; Yermezler, A1
Biziaeva, EA; Karpova, ÉS; Kotel'nikova, EV; Liamina, NP1
Fi, Z; Kovács, G; Szentes, V1
Rehberger-Likozar, A; Šebeštjen, M1
Dong, R; Li, S; Liu, J; Luo, Y; Peng, L; Zhao, Y; Zheng, Z; Zhu, J1
Colombo, A; Fragasso, G; Fumero, A; Giannini, F; Godino, C; Maranta, F; Margonato, A; Oppizzi, M; Slavich, M1
Glezer M, G; On Behalf Of The Choice-Study Participants, OB1
Gorbunova, ML; Vilkova, AV1
Belardinelli, R; Cianci, G; Gigli, M; Lacalaprice, F; Mazzanti, M1
Arora, R; Jawad, E1
Belardinelli, R; Faccenda, E; Lacalaprice, F; Volpe, L1
Chen, S; Jin, J; Lu, Q; Song, WZ; Wang, WY; Xie, HJ; Xu, GH; Zhong, P; Zhou, XF1
Chernyschova, GA; Khazanov, VA; Kiseliova, AA; Vasiliev, KY1
Dronova, EP; Lopatin, IuM1
Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C1
Caminiti, G; Fini, M; Gebara, O; Marazzi, G; Ramires, JA; Rosano, G; Vitale, C; Volterrani, M; Wajngarten, M1
Cerrahoglu, M; Eserdag, M; Iskesen, I; Kurdal, AT; Sirin, BH1
Aispuru, GR; Caminiti, N; Grimolizzi, NS; Páez Gill, NE; Ugartemendia, M1
Bunc, M; Vrtovec, B; Zemljic, G1
Arioli, F; Cera, M; Facchini, A; Fragasso, G; Gardini, C; Godino, C; Margonato, A; Marinosci, G; Montanaro, C; Salerno, A; Spoladore, R1
Beresewicz, A; Skierczynska, A1
Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL1
Qizhu, T; Wenmeng, W1
Inzhutova, AI; Larionov, AA; Petrova, MM; Salmina, AB1
Assunção, CR; Bottino, F; Carvalho, KG; Martins, GF; Santos, JB; Siqueira Filho, AG; Valência, A1
Tian, Y; Xu, H; Zhu, G1
Bochkareva, EV; Butina, EK; Dmitrieva, NA; Kokurina, EV1
Dec, I; Poloński, L; Wilczek, K; Wojnar, R1
Aronov, DM; Novikova, NK; Pisareva, NA; Smolenskiĭ, VS; Tartakovskiĭ, LB; Zhidko, NI1
Kutuzova, AE; Liasnikova, EA; Mikhaĭlova, IE; Nedoshivin, AO; Nesterova, IV; Novikova, NA; Perepech, NB; Rubashkina, EI1
Marzilli, M; Stanley, WC1
Binding, P; Fairman, DA; Haddock, PS; Karran, EH; MacInnes, A; Phelan, A; Rhodes, Ja; Wyatt, MJ1
Barr, R; Dyck, JR; Lopaschuk, GD; Thomas, PD1
Churshin, AD; Pimenov, LT1
Calori, G; Fragasso, G; Lopaschuk, GD; Margonato, A; Monti, L; Palloshi, A; Piatti Md, PM; Puccetti, P; Setola, E1
Dernek, S; Ikizler, M; Kural, T; Sevin, B1
Hill, JA; Schofield, RS1
Broustet, JP; Sellier, P1
Biggi, A; Feola, M; Ferrero, V; Francini, A; Leonardi, G; Ribichini, F; Uslenghi, E2
Belardinelli, R2
Frenneaux, M; Horowitz, J; Lee, L1
Fedorova, TA; Il'ina, IuV; Loshchits, NV; Rybakova, MK; Sotnikova, TI1
Akhmedov, ShD; Dzhavadova, GK; Tepliakov, AT; Vecherskiĭ, IuIu; Vesnina, ZhV1
Atroshenkov, AV; Chernov, VI; Efimova, EV; Karpov, RS; Koshel'skaia, OA; Ocheredko, NA1
Pauly, DF; Pepine, CJ1
Fini, M; Gebara, O; Rosano, GM; Rossini, P; Sposato, B; Vitale, C; Volterrani, M; Wajngaten, M1
Lupanov, VP; Matveeva, MA; Mironova, IIu; Naumov, VG; Orlova, EM; Samoĭlenko, LE1
Duarte, AI; Gonçalves, LM; Monteiro, P; Moreno, A; Providência, LA1
Galaris, D; Korantzopoulos, P; Kountouris, E; Siogas, K1
Fedorova, TA; Il'ina, IuV; Rybakova, MK; Sotnikova, TI1
McMurray, JJ; O'Meara, E1
Al-Ghazali, R; Liang, WW; Liu, TW; Tao, XZ; Yin, RX; Zhu, LG1
Cerquetani, E; Fini, M; Marazzi, G; Mercuro, G; Patrizi, R; Rosano, GM; Vitale, C; Volterrani, M1
Allard, MF; Bescond-Jacquet, A; Grist, M; Lucien, A; Saeedi, R; Wambolt, RB1
Arroyo Espliguero, R; Cosín Sales, J; Kaski, JC1
Aguilar Llopis, A; Azorín Villena, I; Capdevilla Carbonell, C; Cosín Aguilar, J; Hernándiz Martinez, A; Martinez, VB; Morillas Blasco, PJ; Pallarés Carratala, V; Portolés Sanz, M1
Abdel-Hady, S; El-Kady, T; El-Sabban, K; Gabaly, M; Sabry, A1
Camisasca, RP; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Origgi, A; Piatti, P; Setola, E1
Bakhmatova, IuA; Gapon, LI; Petelina, TI; Zhevagina, IA1
Fini, M; Rosano, GM; Vitale, C; Volterrani, M1
Affinito, S; Marzilli, M1
Arora, R; Parang, P; Singh, B1
Bettaieb, A; Filomenko, R; Gambert, S; Moreau, D; Opie, LH; Rochette, L; Vergely, C1
Altekin, E; Goldeli, O; Kuralay, F; Onvural, B; Yazlar, AS1
Sabbah, HN; Stanley, WC1
Bassanelli, G; Calori, G; Fragasso, G; Lattuada, G; Locatelli, M; Lopaschuk, G; Margonato, A; Montano, C; Oggionni, S; Palloshi, A; Perseghin, G1
Bertomeu-Gonzalez, V; Bouzas-Mosquera, A; Kaski, JC1
Fini, M; Gebara, O; Marazzi, G; Patrizi, R; Pelliccia, F; Pierri, H; Ramires, JA; Rosano, GM; Vitale, C; Volterrani, M; Wajngarten, M1
Barkhudarian, AL; Sisakian, AS; Torgomian, AL1
Armaganijan, D; Bicudo, L; Brasil, CK; Cesar, LA; Del Monaco, MI; Gimenez, V; Gomes, EP; Jallad, S; Mathias, W; Meneguin, S; Ramires, JF1
Barsotti, A; D'Apolito, G; Di Giovanni, P; Di Napoli, P; Gaeta, MA1
Barkhudaryan, A; Sisakian, H; Torgomyan, A1
Barsotti, A; Di Giovanni, P; Di Napoli, P; Gaeta, MA; Taccardi, AA1
Bescond-Jacquet, A; Bricca, G; Bui-Xuan, B; Descotes, J; Tabib, A; Timour, Q; Tsibiribi, P; Vaillant, F1
Makolkin, VI; Mikova, NV; Petriĭ, VV1
Baksheev, VI; Kolomoets, NM; Uvaĭsova, IU; Zarubina, EG1
Chaitman, BR; Sano, J1
Kus, M; Tanda, K; Williams, FM; Williams, TJ1
Boucher, FR; Hearse, DJ; Opie, LH1
Hue, L; Maisin, L; Veitch, K1
Boucher, F; Opie, LH1
Boucher, F; de Leiris, J1
Ribeiro, C1
Bezstarosti, K; Koning, MM; Krams, R; Lamers, JM; van Meegen, JR; Verdouw, PD; Xiao, CS1
Buck, T; Kober, G; Pennaforte, S; Sievert, H; Vallbracht, C1
Guarnieri, C; Muscari, C1
Iliceto, S; Marangelli, V; Rizzon, P1
Garcia-Dorado, D; González, MA; Inserte, J; Juliá, M; Ruiz-Meana, M; Soler-Soler, J1
Arvieux, C; Cannet, E; de Lorgeril, M; Ferrera, R; Forrat, R; Guidollet, J; Hadour, G; Lehot, JJ; Sebbag, L; Vedrinne, C1
Eliseev, OM1
Jackson, G1
Albengres, E; Berland, Y; Crevat, A; d'Athis, P; Hestin, D; Jaber, K; Kessler, M; Olivier, P; Roux, F; Simon, N; Tillement, JP1
Lopaschuk, GD3
Grynberg, A; Lucien, A; Sentex, E; Sergiel, JP1
Buxton, DB; Coyle, KB; Hansen, HW; Mody, FV; Mohiuddin, IH; Schelbert, HR; Singh, BN; Sumida, R1
Jones, BE; King, LM; Taegtmeyer, H1
Celegon, L; Desideri, A1
Bernard, M; Cozzone, PJ; el Banani, H; Feuvray, D1
Horowitz, JD; Kennedy, JA1
Domzał-Bocheńska, M; Elikowski, W; Gajos, G; Kałuza, G; Kulon, I; Kuźniak, M; Pachocki, R; Paradowski, A; Sadowski, Z; Szwed, H; Szydłowski, Z; Szymczak, K; Wator-Brzezińska, A1
Ferrari, R1
Akhmetov, KZh; Goncharov, LF; Goncharova, ZF; Kelimberdieva, ES; Komissarova, IA; Teĭblium, MM; Zaslavskaia, RM1
Afanas'eva, IV; Goncharova, LL; Miroshnichenko, AG; Petrash, VV; Pokrovskaia, LA1
Kantor, PF; Kozak, R; Lopaschuk, GD; Lucien, A1
Minners, J; Opie, LH; Sack, MN; Schwalb, H; van den Bos, EJ; Yellon, DM1
Cross, HR1
Baetz, D; Bernard, M; Cabanes, E; Cozzone, P; El Banani, H; Feuvray, D; Lucien, A1
Baj, Z; Kowalski, J; Olejniczak, J; Paśnik, J; Pawlicki, L1
Gaĭsin, IR; Karbasnikova, GV; Leshchinskiĭ, LA; Logacheva, IV; Perevalov, AP; Romanova, ZD1
Allibardi, S; Chierchia, S; Costa, S; Monti, LD; Piatti, PM; Pozza, G; Samaja, M; Valsecchi, G1
Cokkinos, DV1
Belardinelli, R; Purcaro, A1
Kalinina, EB; Komissarova, IA; Zaslavskaia, RM; Zhdanov, IuA1

Reviews

30 review(s) available for trimetazidine and Heart Disease, Ischemic

ArticleYear
Effect of trimetazidine on the functional capacity of ischemic heart disease patients not suitable for revascularization: Meta-analysis of randomized controlled trials.
    PloS one, 2022, Volume: 17, Issue:2

    Topics: Cross-Over Studies; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Stroke Volume; Trimetazidine; Vasodilator Agents; Walk Test

2022
Effect of Trimetazidine on Diabetic Patients with Coronary Heart Diseases: A Meta-Analysis of Randomized, Controlled Trials.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2020, Sep-30, Volume: 35, Issue:3

    Topics: Blood Glucose; Coronary Disease; Diabetes Mellitus; Diastole; Exercise Tolerance; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Ventricular Function, Left

2020
Current Clinical Evidence of Trimetazidine in the Management of Heart Disease in Patients with Diabetes.
    The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:11

    Topics: Coronary Artery Disease; Diabetes Mellitus; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2020
Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.
    Medicine, 2018, Volume: 97, Issue:51

    Topics: Cardiovascular Agents; Drug Therapy, Combination; Drugs, Chinese Herbal; Heart Failure; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine

2018
[Role of trimetazidine in the treatment of diabetic microangiopathy in ischaemic heart disease].
    Orvosi hetilap, 2015, May-10, Volume: 156, Issue:19

    Topics: Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Heart; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents

2015
Trimetazidine improves exercise tolerance in patients with ischemic heart disease : A meta-analysis.
    Herz, 2016, Volume: 41, Issue:6

    Topics: Dose-Response Relationship, Drug; Evidence-Based Medicine; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prevalence; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents

2016
Chronic stable angina pectoris.
    Disease-a-month : DM, 2008, Volume: 54, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents

2008
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].
    Giornale italiano di cardiologia (2006), 2009, Volume: 10, Issue:1

    Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents

2009
Modulation of myocardial metabolism: an emerging therapeutic principle.
    Current opinion in cardiology, 2010, Volume: 25, Issue:4

    Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents

2010
Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine.
    Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:2

    Topics: Angina Pectoris; Carbohydrate Metabolism; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2003
Role of metabolically active drugs in the management of ischemic heart disease.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2001, Volume: 1, Issue:1

    Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Acid; Energy Metabolism; Fatty Acids; Glucose; Humans; Insulin; Myocardial Ischemia; Myocardium; Piperazines; Potassium; Ranolazine; Trimetazidine

2001
[Ischemic heart disease and left ventricular dysfunction: the role of trimetazidine].
    Italian heart journal : official journal of the Italian Federation of Cardiology, 2004, Volume: 5 Suppl 2

    Topics: Clinical Trials as Topic; Humans; Myocardial Ischemia; Trimetazidine; Ventricular Dysfunction, Left

2004
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.
    European heart journal, 2004, Volume: 25, Issue:8

    Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Glucose; Humans; Hypoglycemic Agents; Insulin; Myocardial Ischemia; Myocardium; Perhexiline; Piperazines; Potassium; Ranolazine; Trimetazidine

2004
Ischemic heart disease: metabolic approaches to management.
    Clinical cardiology, 2004, Volume: 27, Issue:8

    Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine; Ribose; Trimetazidine

2004
Silent myocardial ischaemia: clinical relevance and treatment.
    Expert opinion on investigational drugs, 2005, Volume: 14, Issue:4

    Topics: Acetyl-CoA C-Acyltransferase; Animals; Coronary Artery Disease; Electrocardiography; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Myocardial Revascularization; Nitric Oxide Donors; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents

2005
Metabolic therapy for the diabetic patients with ischaemic heart disease.
    Coronary artery disease, 2005, Volume: 16 Suppl 1

    Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents

2005
Meeting the challenge of chronic ischaemic heart disease with trimetazidine.
    Coronary artery disease, 2005, Volume: 16 Suppl 1

    Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Myocardial Ischemia; Randomized Controlled Trials as Topic; Trimetazidine; Vasodilator Agents

2005
Metabolic modulators for chronic cardiac ischemia.
    Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:4

    Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; Heart; Humans; Lipid Metabolism; Myocardial Ischemia; Myocardium; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents; Vitamin B Complex

2005
Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation.
    Heart failure reviews, 2005, Volume: 10, Issue:4

    Topics: Carbohydrate Metabolism; Clinical Trials as Topic; Energy Metabolism; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents

2005
Role of trimetazidine in management of ischemic cardiomyopathy.
    The American journal of cardiology, 2006, Sep-04, Volume: 98, Issue:5A

    Topics: Humans; Myocardial Ischemia; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left

2006
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.
    Clinical cardiology, 2007, Volume: 30, Issue:2 Suppl 1

    Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents

2007
Intervention in ischaemia. Reperfusion syndrome. Rationale for trimetazidine.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1994, Volume: 13, Issue:9

    Topics: Acidosis; Calcium; Energy Metabolism; Free Radicals; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocarditis; Reactive Oxygen Species; Trimetazidine

1994
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease?
    Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:10

    Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Superoxide Dismutase; Trimetazidine; Ubiquinone; Vasodilator Agents

1995
[Trimetazidine (Preductal). A new approach in controlling myocardial ischemia].
    Terapevticheskii arkhiv, 1996, Volume: 68, Issue:8

    Topics: Animals; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

1996
Potential interest of anti-ischemic agents for limiting cyclosporin A nephrotoxicity.
    International journal of clinical pharmacology research, 1997, Volume: 17, Issue:4

    Topics: Adenosine Triphosphate; Calcium; Creatinine; Cyclosporine; Humans; Kidney; Mitochondria; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

1997
Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism.
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents

1998
Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy.
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Energy Metabolism; Hemodynamics; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents

1998
Metabolic management of ischemic heart disease: clinical data with trimetazidine.
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; Energy Metabolism; Exercise Test; Hemodynamics; Humans; Myocardial Ischemia; Myocardium; Treatment Outcome; Trimetazidine; Vasodilator Agents

1998
Trimetazidine and the contractile response of dysfunctional myocardium in ischaemic cardiomyopathy.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2000, Volume: 19 Suppl 5

    Topics: Humans; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2000
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?
    Coronary artery disease, 2001, Volume: 12 Suppl 1

    Topics: Animals; Energy Metabolism; Fatty Acids; Glucose; Glycolysis; Humans; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Trimetazidine; Vasodilator Agents

2001

Trials

44 trial(s) available for trimetazidine and Heart Disease, Ischemic

ArticleYear
The Impact of Trimetazidine on Cardiac Fibrosis, Inflammation, and Function in Ischemic Cardiomyopathy Patients.
    Cardiovascular drugs and therapy, 2023, Volume: 37, Issue:5

    Topics: Angina Pectoris; Cardiomyopathies; Fibrosis; Humans; Inflammation; Myocardial Ischemia; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents

2023
Trimetazidine improves left ventricular global longitudinal strain value in patients with heart failure with reduced ejection fraction due to ischemic heart disease.
    Drug discoveries & therapeutics, 2022, Sep-17, Volume: 16, Issue:4

    Topics: Aged; Heart Failure; Humans; Middle Aged; Myocardial Ischemia; Stroke Volume; Trimetazidine; Ventricular Dysfunction, Left

2022
The role of metabolic therapy with trimetazidine in effort tolerance in patients with ischemic heart disease.
    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2018, Aug-01, Volume: 15, Issue:2

    Topics: Echocardiography; Exercise Test; Exercise Tolerance; Female; Heart; Humans; Male; Metabolic Equivalent; Myocardial Ischemia; Myocardium; Patient Discharge; Physical Exertion; Quality of Life; Stroke Volume; Trimetazidine; Ultrasonography; Vasodilator Agents

2018
Comparison between Glyceryl Trinitrate and Trimetazidine in Ischaemic Cardiomyopathy Patients.
    Mymensingh medical journal : MMJ, 2019, Volume: 28, Issue:1

    Topics: Bangladesh; Cardiomyopathies; Humans; Male; Myocardial Contraction; Myocardial Ischemia; Nitroglycerin; Pilot Projects; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents

2019
Effects of trimetazidine in nonischemic heart failure: a randomized study.
    Journal of cardiac failure, 2014, Volume: 20, Issue:3

    Topics: Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Radionuclide Imaging; Treatment Outcome; Trimetazidine; Vasodilator Agents

2014
Impact of trimetazidine on incidence of myocardial injury and contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention.
    The American journal of cardiology, 2014, Aug-01, Volume: 114, Issue:3

    Topics: Contrast Media; Coronary Angiography; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Elective Surgical Procedures; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Renal Insufficiency; Treatment Outcome; Trimetazidine; Vasodilator Agents

2014
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease.
    Coronary artery disease, 2015, Volume: 26, Issue:8

    Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents

2015
Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy.
    Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:6

    Topics: Cardiomyopathies; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Systole; Trimetazidine; Vasodilator Agents; Ventricular Function, Left

2008
Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2008, Volume: 15, Issue:5

    Topics: Aged; Biomarkers; Blood Pressure; Body Mass Index; Brachial Artery; Cardiomyopathies; Combined Modality Therapy; Echocardiography, Doppler, Pulsed; Electrocardiography; Exercise Test; Exercise Therapy; Female; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Ischemia; Oxygen Consumption; Stroke Volume; Time Factors; Treatment Outcome; Trimetazidine; Vasodilation; Vasodilator Agents; Ventricular Dysfunction, Left

2008
[Effects of trimetazidine on myocardial metabolism evaluated by PET-CT in patients with ischemic cardiomyopathy].
    Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:1

    Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon; Trimetazidine

2008
[Clinical-pharmacoeconomic aspects of trimetazidine modified release use in patients with ischemic heart disease undergoing coronary artery bypass grafting].
    Kardiologiia, 2009, Volume: 49, Issue:2

    Topics: Adult; Aged; Coronary Artery Bypass; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents

2009
Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy.
    Advances in therapy, 2009, Volume: 26, Issue:4

    Topics: Aged; Cardiomyopathy, Dilated; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Severity of Illness Index; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2009
Trimetazidine may protect the myocardium during cardiac surgery.
    The heart surgery forum, 2009, Volume: 12, Issue:3

    Topics: Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents

2009
Trimetazidine shortens QTc interval in patients with ischemic heart failure.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:1

    Topics: Aged; Angiography; Electrocardiography; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Trimetazidine; Vasodilator Agents; Ventricular Function, Left

2010
Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:1

    Topics: Aged; Aged, 80 and over; Antisocial Personality Disorder; Arrhythmias, Cardiac; Chronic Disease; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents

2010
Trimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.
    Arquivos brasileiros de cardiologia, 2011, Volume: 97, Issue:3

    Topics: Biomarkers; Coronary Artery Bypass; Creatine Kinase, MB Form; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Placebo Effect; Postoperative Complications; Prospective Studies; Time Factors; Treatment Outcome; Trimetazidine; Troponin T; Vasodilator Agents

2011
[Decrease in the sensitivity to the anti-ischemic effect of propranolol and prospects for correcting it in patients with stable angina pectoris].
    Terapevticheskii arkhiv, 2002, Volume: 74, Issue:9

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Myocardial Ischemia; Placebos; Propranolol; Trimetazidine

2002
Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.
    Current medical research and opinion, 2002, Volume: 18, Issue:7

    Topics: Angioplasty, Balloon, Coronary; Chi-Square Distribution; Coronary Stenosis; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents

2002
[Significance of trimetazidine for out of hospital physical rehabilitation after myocardial infarction].
    Kardiologiia, 2002, Volume: 42, Issue:11

    Topics: Adult; Ambulatory Care; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2002
[Trimetazidine in correction of chronic heart failure in patients with ischemic heart disease].
    Kardiologiia, 2002, Volume: 42, Issue:3

    Topics: Chronic Disease; Cross-Sectional Studies; Humans; Middle Aged; Myocardial Ischemia; Prospective Studies; Severity of Illness Index; Trimetazidine; Vasodilator Agents

2002
[Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and postmenopausal women with ischemic heart disease].
    Kardiologiia, 2003, Volume: 43, Issue:8

    Topics: Aged; Drug Therapy, Combination; Female; Humans; Middle Aged; Myocardial Ischemia; Postmenopause; Premenopause; Treatment Outcome; Trimetazidine; Vasodilator Agents; Verapamil

2003
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
    American heart journal, 2003, Volume: 146, Issue:5

    Topics: Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Echocardiography; Energy Metabolism; Glucose; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardium; Trimetazidine

2003
Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2003, Volume: 3, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Angina Pectoris; Double-Blind Method; Europe; Exercise Test; Female; Humans; Israel; Latvia; Male; Middle Aged; Myocardial Ischemia; Russia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents

2003
[Clinical and hemodynamic efficacy of selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease].
    Terapevticheskii arkhiv, 2004, Volume: 76, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Bisoprolol; Cardiac Output, Low; Drug Administration Schedule; Drug Therapy, Combination; Echocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Quality of Life; Time Factors; Treatment Outcome; Trimetazidine; Ventricular Function, Left

2004
[Clinical Efficacy of Combination Therapy With Trimetazidine and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension and Ischemic Heart Disease Associated With Type II Diabetes].
    Kardiologiia, 2004, Volume: 44, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type 2; Humans; Hypertension; Myocardial Ischemia; Treatment Outcome; Trimetazidine

2004
Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease.
    European heart journal, 2004, Volume: 25, Issue:20

    Topics: Aged; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Ischemia; Quality of Life; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2004
[Potentialities of cytoprotection in the treatment of chronic heart failure in patients with coronary heart disease].
    Klinicheskaia meditsina, 2004, Volume: 82, Issue:11

    Topics: Aged; Aged, 80 and over; Bisoprolol; Chronic Disease; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Sympathomimetics; Trimetazidine; Vasodilator Agents

2004
Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.
    The American journal of cardiology, 2005, Feb-01, Volume: 95, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Coitus; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Erectile Dysfunction; Humans; Male; Middle Aged; Myocardial Ischemia; Nitrates; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Treatment Outcome; Trimetazidine; Vasodilator Agents

2005
Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2005, Volume: 5, Issue:4

    Topics: Aged; Cardiomyopathies; Coronary Circulation; Echocardiography; Exercise Test; Female; Heart Function Tests; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents

2005
Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Citric Acid; Cross-Over Studies; Cyclic GMP; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Forearm; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Muscle, Skeletal; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine

2006
[Clinical efficacy of combined therapy with enalapril + trimetazidine in patients with hypertension comorbid with ischemic heart disease and metabolic disturbances].
    Terapevticheskii arkhiv, 2005, Volume: 77, Issue:8

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Catalase; Comorbidity; Drug Therapy, Combination; Enalapril; Female; Humans; Hypercholesterolemia; Hypertension; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Trimetazidine; Vasodilator Agents

2005
The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.
    American heart journal, 2006, Volume: 151, Issue:6

    Topics: Aged; Dietary Carbohydrates; Dietary Fats; Double-Blind Method; Echocardiography, Stress; Female; Food; Humans; Male; Myocardial Ischemia; Postprandial Period; Trimetazidine; Vasodilator Agents

2006
Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.
    International journal of cardiology, 2007, Aug-09, Volume: 120, Issue:1

    Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Electrocardiography, Ambulatory; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Oxidation-Reduction; Trimetazidine; Vasodilator Agents

2007
[The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].
    Klinicheskaia meditsina, 2006, Volume: 84, Issue:10

    Topics: Aged; Cardiomyopathies; Exercise; Exercise Tolerance; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2006
Trimetazidine to reverse ischemia in patients with class I or II angina: a randomized, double-blind, placebo-controlled dobutamine-atropine stress echocardiography study.
    Coronary artery disease, 2007, Volume: 18, Issue:4

    Topics: Aged; Angina Pectoris; Atropine; Dobutamine; Double-Blind Method; Echocardiography, Stress; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents

2007
Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy.
    American heart journal, 2007, Volume: 154, Issue:3

    Topics: Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Natriuretic Peptide, Brain; Trimetazidine; Troponin T; Vasodilator Agents

2007
Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:5

    Topics: Aged; C-Reactive Protein; Cardiomyopathy, Dilated; Echocardiography; Exercise Test; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Myocardial Ischemia; Stroke Volume; Survival Rate; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Function, Left; Walking

2007
[Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus].
    Kardiologiia, 2007, Volume: 47, Issue:7

    Topics: Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Severity of Illness Index; Treatment Outcome; Trimetazidine; Vasodilator Agents

2007
[Efficacy of long-term therapy with trimetazidine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].
    Kardiologiia, 2008, Volume: 48, Issue:2

    Topics: Aged; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Pulmonary Disease, Chronic Obstructive; Time Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents

2008
Myocardial cytoprotection during percutaneous transluminal coronary angioplasty.
    European heart journal, 1993, Volume: 14 Suppl G

    Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Reproducibility of Results; Trimetazidine

1993
The antiischemic effects and tolerability of trimetazidine in coronary diabetic patients. A substudy from TRIMPOL-1.
    Cardiovascular drugs and therapy, 1999, Volume: 13, Issue:3

    Topics: Diabetes Complications; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Risk Factors; Trimetazidine; Vasodilator Agents

1999
[Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina].
    Terapevticheskii arkhiv, 1999, Volume: 71, Issue:11

    Topics: Aged; Aged, 80 and over; Angina Pectoris; Cysteine; Drug Therapy, Combination; Echocardiography; Electrocardiography, Ambulatory; Female; Glutamic Acid; Glycine; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents

1999
[Effect of trimetazidine on biological activity of neutrophils in patients with transient myocardial ischemia induced by exercise testing].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 9, Issue:50

    Topics: Adult; Angina Pectoris; Cell Aggregation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Neutrophils; Trimetazidine

2000
Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy.
    European heart journal, 2001, Volume: 22, Issue:23

    Topics: Analysis of Variance; Cardiomyopathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2001

Other Studies

63 other study(ies) available for trimetazidine and Heart Disease, Ischemic

ArticleYear
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
    Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5

    Topics: Animals; Carboxy-Lyases; Energy Metabolism; Fatty Acids; Glucose; In Vitro Techniques; Male; Malonyl Coenzyme A; Morpholines; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine

2006
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
    Journal of medicinal chemistry, 2006, Jul-13, Volume: 49, Issue:14

    Topics: Administration, Oral; Animals; Biological Availability; Carboxy-Lyases; Cardiotonic Agents; Crystallography, X-Ray; Isoxazoles; Molecular Conformation; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2006
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catalytic Domain; Diabetes Mellitus, Type 2; Energy Metabolism; Enzyme Activators; Ethylene Oxide; Heart Failure; Humans; Insulin Resistance; Isoenzymes; Lipid Metabolism; Myocardial Ischemia; Organ Specificity; Protein Conformation; Sequence Homology, Amino Acid; Stereoisomerism

2011
Trimetazidine Affects Mitochondrial Calcium Uniporter Expression to Restore Ischemic Heart Function via Reactive Oxygen Species/NFκB Pathway Inhibition.
    Journal of cardiovascular pharmacology, 2023, 08-01, Volume: 82, Issue:2

    Topics: Animals; Calcium; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Trimetazidine

2023
Trimetazidine for stable and unstable ischemic heart diseases and for heart failure: Is its routine use justified from available data?
    International journal of cardiology, 2020, 02-01, Volume: 300

    Topics: Angina Pectoris; Heart Failure; Humans; Myocardial Ischemia; Trimetazidine

2020
Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.
    Pharmacological reports : PR, 2019, Volume: 71, Issue:6

    Topics: Acute Kidney Injury; Animals; Flavanones; Glutathione Peroxidase; Male; Malondialdehyde; Myocardial Ischemia; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Trimetazidine

2019
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
    Anatolian journal of cardiology, 2017, Volume: 18, Issue:3

    Topics: Animals; Disease Models, Animal; Male; Mitochondria; Myocardial Ischemia; Rats; Rats, Wistar; Respiratory Physiological Phenomena; Trimetazidine; Vasodilator Agents

2017
Effectiveness and safety of anti-ischemic trimetazidine in patients with stable angina pectoris and Type 2 diabetes.
    Journal of comparative effectiveness research, 2017, Volume: 6, Issue:8

    Topics: Aged; Angina, Stable; Canada; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Administration Schedule; Female; Humans; Male; Myocardial Ischemia; Prospective Studies; Pulse Wave Analysis; Trimetazidine; Vasodilator Agents

2017
Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways.
    European journal of pharmacology, 2013, May-05, Volume: 707, Issue:1-3

    Topics: Antioxidants; Cardiotonic Agents; Cells, Cultured; Endothelial Cells; Humans; Hydrogen Peroxide; Malondialdehyde; Myocardial Ischemia; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ribonucleosides; Signal Transduction; Stem Cells; Superoxide Dismutase; Trimetazidine

2013
[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:2

    Topics: Adenosine Triphosphate; Age Factors; Animals; Cell Membrane; Citrate (si)-Synthase; Disease Models, Animal; Glycolysis; Ketone Oxidoreductases; Lactic Acid; Male; Mitochondria; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents

2013
Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury.
    Atherosclerosis, 2014, Volume: 237, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Blood Pressure; Caspase 3; Cell Death; Coronary Vessels; Disease Models, Animal; Fatty Acids; Glucose; Glutathione; Inflammation; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; Trimetazidine

2014
[Approaches potentiating cardioprotective effect of ambulatory physical training in patients with ischemic heart disease and multivessel coronary artery involvement after coronary stenting].
    Kardiologiia, 2014, Volume: 54, Issue:10

    Topics: Cardiotonic Agents; Coronary Vessels; Echocardiography; Electrocardiography; Exercise Therapy; Exercise Tolerance; Female; Home Care Services, Hospital-Based; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Ischemia; Percutaneous Coronary Intervention; Prospective Studies; Russia; Severity of Illness Index; Stents; Treatment Outcome; Trimetazidine; Vasodilator Agents

2014
Long-Term Preservation of Left Ventricular Systolic Function in Patients With Refractory Angina Pectoris and Inducible Myocardial Ischemia on Optimal Medical Therapy.
    The American journal of cardiology, 2016, 05-15, Volume: 117, Issue:10

    Topics: Aged; Angina Pectoris; Benzazepines; Cardiovascular Agents; Echocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Ivabradine; Male; Myocardial Ischemia; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Stroke Volume; Systole; Time Factors; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Function, Left

2016
[Treatment of Patients With Stable Ischemic Heart Disease in Real Clinical Practice in Russia. The CHOICE-2 Program].
    Kardiologiia, 2016, Volume: 56, Issue:5

    Topics: Angina Pectoris; Coronary Artery Disease; Humans; Myocardial Ischemia; Russia; Trimetazidine

2016
[Assessment of Efficacy and Safety of Metabolic Therapy With Trimetazidine MB in Patients With Ischemic Heart Disease and Chronic Heart Failure].
    Kardiologiia, 2016, Volume: 56, Issue:3

    Topics: Chronic Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2016
Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.
    Bulletin of experimental biology and medicine, 2008, Volume: 146, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Occlusion; Drug Combinations; Electrocardiography; Heart; Malates; Male; Mitochondria, Heart; Myocardial Ischemia; Oxidative Phosphorylation; Rats; Rats, Wistar; Succinic Acid; Tachycardia; Trimetazidine; Vasodilator Agents

2008
[Coronary-ventricular sinusoid communications].
    Medicina, 2009, Volume: 69, Issue:5

    Topics: Cardiac Catheterization; Coronary Angiography; Female; Humans; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2009
Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:2

    Topics: Animals; Coronary Circulation; Dichloroacetic Acid; Disease Models, Animal; Dobutamine; Fatty Acids; Glucose; Glycolysis; Male; Myocardial Ischemia; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Rats; Rats, Wistar; Trimetazidine

2010
Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.
    Medical hypotheses, 2011, Volume: 76, Issue:2

    Topics: Animals; Diabetes Mellitus; Diabetic Cardiomyopathies; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Models, Theoretical; Myocardial Ischemia; Myocardium; Research Design; Risk Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents

2011
[Stabilization of cellular membranes as a target of vascular therapy].
    Kardiologiia, 2011, Volume: 51, Issue:4

    Topics: Adult; Cell Membrane; Cell-Derived Microparticles; Comparative Effectiveness Research; Cytoprotection; Endothelium, Vascular; Female; Humans; Hypertension; Lymphocytes; Male; Microscopy, Phase-Contrast; Middle Aged; Models, Cardiovascular; Myocardial Ischemia; Treatment Outcome; Trimetazidine; Vasodilator Agents

2011
Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2012, Volume: 32, Issue:1

    Topics: Animals; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Ischemia; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents

2012
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
    Circulation research, 2003, Aug-08, Volume: 93, Issue:3

    Topics: Acetanilides; Acetyl-CoA C-Acyltransferase; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Recombinant Proteins; Trimetazidine; Vasodilator Agents

2003
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
    Circulation research, 2003, Aug-08, Volume: 93, Issue:3

    Topics: Acetyl-CoA C-Acyltransferase; Animals; Cardiotonic Agents; Dichloroacetic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Fatty Acids; Glucose; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recovery of Function; Trimetazidine; Vasodilator Agents

2003
Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2003, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Coronary Circulation; Creatine Kinase; Disease Models, Animal; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion; Trimetazidine; Troponin T; Vasodilator Agents

2003
Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.
    Clinical nuclear medicine, 2004, Volume: 29, Issue:2

    Topics: Aged; Coronary Artery Disease; Coronary Vessels; Gated Blood-Pool Imaging; Heart Ventricles; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Single-Blind Method; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left

2004
[Effect of trimetazidine on regressione of ischemic dysfunction of myocardium after coronary bypass surgery on beating heart].
    Kardiologiia, 2004, Volume: 44, Issue:4

    Topics: Coronary Artery Bypass; Humans; Myocardial Contraction; Myocardial Ischemia; Myocardium; Trimetazidine

2004
[Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].
    Kardiologiia, 2004, Volume: 44, Issue:9

    Topics: Angina Pectoris; Angina, Stable; Coronary Artery Disease; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2004
Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia.
    European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3

    Topics: Adenosine Triphosphate; Animals; Electrochemistry; Electron Transport; Energy Metabolism; Female; In Vitro Techniques; Membrane Potentials; Mitochondria, Heart; Myocardial Ischemia; Myocytes, Cardiac; Oxidative Phosphorylation; Oxygen Consumption; Perfusion; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents

2004
The acute administration of trimetazidine modified myocardial perfusion and left ventricular function in 31 patients with ischaemic ventricular dysfunction.
    The international journal of cardiovascular imaging, 2004, Volume: 20, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Echocardiography; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Radiopharmaceuticals; Stroke Volume; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Function, Left

2004
The potential benefits of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
    American heart journal, 2004, Volume: 148, Issue:6

    Topics: Anti-Arrhythmia Agents; Antioxidants; Diabetes Complications; Diabetes Mellitus; Fatty Acids; Humans; Myocardial Ischemia; Oxidation-Reduction; Oxidative Stress; Trimetazidine; Vasodilator Agents

2004
Myocardial metabolic manipulation: a new therapeutic approach in heart failure?
    Heart (British Cardiac Society), 2005, Volume: 91, Issue:2

    Topics: Blood Glucose; Fatty Acids, Nonesterified; Heart Failure; Humans; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents

2005
Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2004, Volume: 19, Issue:4

    Topics: Animals; Apoptosis; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Rabbits; Random Allocation; Superoxide Dismutase; Trimetazidine

2004
Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Glucose; Glycolysis; Kinetics; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Palmitates; Perfusion; Protons; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents

2005
Mitochondrial changes induced by trimetazidine in the myocardium.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:6

    Topics: Animals; Dogs; Double-Blind Method; Female; Heart; Lipofuscin; Male; Mitochondria, Heart; Models, Animal; Myocardial Ischemia; Random Allocation; Trimetazidine; Vasodilator Agents

2005
Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.
    Molecular and cellular biochemistry, 2006, Volume: 283, Issue:1-2

    Topics: Animals; Ascorbic Acid; Fatty Acids, Nonesterified; Free Radicals; Heart; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Trimetazidine; Vasodilator Agents

2006
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
    The Tohoku journal of experimental medicine, 2006, Volume: 208, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Nitrites; Reactive Oxygen Species; Time Factors; Treatment Outcome; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents

2006
The effect of trimetazidine on left ventricular systolic function and physical tolerance in patients with ischaemic cardiomyopathy.
    Acta cardiologica, 2007, Volume: 62, Issue:5

    Topics: Aged; Cardiomyopathy, Dilated; Cardiotonic Agents; Exercise Test; Exercise Tolerance; Female; Health Status Indicators; Heart Failure; Heart Ventricles; Humans; Male; Middle Aged; Motor Activity; Myocardial Ischemia; Prospective Studies; Stroke Volume; Systole; Trimetazidine; Vasodilator Agents

2007
Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.
    Cardiovascular drugs and therapy, 2008, Volume: 22, Issue:1

    Topics: Animals; Coronary Vessels; Disease Models, Animal; Electric Stimulation; Female; Heart Rate; Homeostasis; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Ischemia; Swine; Trimetazidine; Vasodilator Agents; Ventricular Fibrillation

2008
Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6

    Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Heart Rate; Interleukin-8; Leukotriene B4; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Rabbits; Trimetazidine; Zymosan

1993
Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:1

    Topics: Animals; Blood Pressure; Coronary Circulation; Glucose; Heart Rate; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine

1994
Trimetazidine effects on the damage to mitochondrial functions caused by ischemia and reperfusion.
    The American journal of cardiology, 1995, Aug-24, Volume: 76, Issue:6

    Topics: Animals; In Vitro Techniques; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyruvate Dehydrogenase Complex; Rats; Trimetazidine

1995
Trimetazidine and myocardial ischemic contracture in isolated rat heart.
    The American journal of cardiology, 1995, Aug-24, Volume: 76, Issue:6

    Topics: Animals; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Rats; Trimetazidine

1995
[Therapeutic application of myocardial cytoprotection].
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1994, Volume: 13, Issue:9

    Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents

1994
Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia.
    Cardiovascular drugs and therapy, 1993, Volume: 7, Issue:5

    Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Animals; Coronary Circulation; Disease Models, Animal; Female; Free Radicals; Heart; Hemodynamics; Male; Malondialdehyde; Myocardial Ischemia; Myocardium; Oxygen; Oxygen Consumption; Regional Blood Flow; Swine; Trimetazidine

1993
Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hypertrophied rat myocardium.
    Pharmacology, 1993, Volume: 46, Issue:6

    Topics: Animals; Hypertrophy, Right Ventricular; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Trimetazidine

1993
Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes.
    Cardiovascular research, 1996, Volume: 32, Issue:3

    Topics: Animals; Cells, Cultured; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Osmotic Pressure; Oxygen; Rats; Rats, Sprague-Dawley; Sarcolemma; Stress, Mechanical; Trimetazidine; Video Recording

1996
Effect of trimetazidine on postischemic regional myocardial stunning in the halothane-anesthetized dog.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4

    Topics: Adenine Nucleotides; Anesthetics, Inhalation; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Erythrocyte Count; Female; Halothane; Heart; Hemodynamics; Lipid Peroxidation; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Reactive Oxygen Species; Trimetazidine; Vasodilator Agents

1996
Angina, myocardial hibernation and trimetazidine.
    International journal of clinical practice, 1997, Volume: 51, Issue:6

    Topics: Angina Pectoris; Humans; Myocardial Ischemia; Myocardial Stunning; Trimetazidine; Vasodilator Agents

1997
Is the cytoprotective effect of trimetazidine associated with lipid metabolism?
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Animals; Cells, Cultured; Choline; Chromatography, Gas; Ethanolamine; Fatty Acids; Inositol; Linoleic Acid; Myocardial Ischemia; Myocardium; Oleic Acid; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Rats; Rats, Wistar; Stearic Acids; Trimetazidine; Vasodilator Agents

1998
Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography.
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Animals; Blood Flow Velocity; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glucose; Heart; Heart Rate; Lactic Acid; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Tomography, Emission-Computed; Trimetazidine; Vasodilator Agents

1998
Ionic and metabolic imbalance in various conditions of ischemia-reperfusion: a 31P- and 23Na-NMR study.
    Magma (New York, N.Y.), 1998, Volume: 6, Issue:2-3

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Diastole; Dichloroacetic Acid; Enzyme Inhibitors; Guanidines; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Phosphorus; Rats; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Trimetazidine; Vasodilator Agents

1998
Effect of trimetazidine on carnitine palmitoyltransferase-1 in the rat heart.
    Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:4

    Topics: Amiodarone; Animals; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Perhexiline; Rats; Rats, Sprague-Dawley; Trimetazidine

1998
[Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism].
    Presse medicale (Paris, France : 1983), 1998, Dec-12, Volume: 27, Issue:39

    Topics: Animals; Energy Metabolism; Heart; Humans; Myocardial Ischemia; Myocardium; Rats; Trimetazidine; Vasodilator Agents

1998
Metabolic treatment of myocardial ischaemia.
    European heart journal, 1999, Volume: 20, Issue:16

    Topics: Cytoprotection; Humans; Mitochondria, Heart; Myocardial Ischemia; Oxygen; Trimetazidine; Vasodilator Agents

1999
[Myocardial cytoprotection with trimetazidine in patients with ischemic heart disease during surgical stress].
    Vestnik khirurgii imeni I. I. Grekova, 1999, Volume: 158, Issue:5

    Topics: Aged; Cytoprotection; Disulfides; Electrocardiography; Heart; Humans; Middle Aged; Myocardial Ischemia; Stress, Physiological; Sulfhydryl Compounds; Trimetazidine; Urologic Surgical Procedures, Male; Vasodilator Agents

1999
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
    Circulation research, 2000, Mar-17, Volume: 86, Issue:5

    Topics: Angina Pectoris; Animals; Carboxy-Lyases; Dose-Response Relationship, Drug; Energy Metabolism; Esters; Fatty Acids; Glucose; Glycolysis; Male; Malonyl Coenzyme A; Mitochondria; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Myocardial Ischemia; Myocardium; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents

2000
Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.
    Cardiovascular research, 2000, Volume: 47, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Cyclosporine; Decanoic Acids; Dinitrophenols; Enzyme Inhibitors; Homeostasis; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Myocardial Ischemia; Perfusion; Rats; Rats, Long-Evans; Trimetazidine; Uncoupling Agents

2000
Trimetazidine: a novel protective role via maintenance of Na(+)/K(+)-ATPase activity?
    Cardiovascular research, 2000, Volume: 47, Issue:4

    Topics: Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Fatty Acids; Glucose; Humans; Myocardial Ischemia; Myocardium; Oxygen Consumption; Premedication; Sodium; Sodium-Potassium-Exchanging ATPase; Trimetazidine; Vasodilator Agents

2000
Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischaemia.
    Cardiovascular research, 2000, Volume: 47, Issue:4

    Topics: Analysis of Variance; Animals; Coronary Circulation; Fatty Acids; Hydrogen-Ion Concentration; Intracellular Fluid; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Trimetazidine; Vasodilator Agents

2000
[Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].
    Klinicheskaia meditsina, 2001, Volume: 79, Issue:1

    Topics: Antioxidants; Coronary Angiography; Coronary Circulation; Humans; Hyperlipidemias; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2001
Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Endothelin-1; Glucose; Heart Rate; Hyperglycemia; Hyperinsulinism; In Vitro Techniques; Insulin; Male; Myocardial Ischemia; Myocardial Reperfusion; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Triglycerides; Trimetazidine; Vasodilator Agents; Ventricular Function, Left

2001
Can metabolic manipulation reverse myocardial dysfunction?
    European heart journal, 2001, Volume: 22, Issue:23

    Topics: Heart Failure; Humans; Myocardial Ischemia; Trimetazidine; Vasodilator Agents

2001
[Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].
    Klinicheskaia meditsina, 2002, Volume: 80, Issue:5

    Topics: Adult; Aged; Antioxidants; Drug Therapy, Combination; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Myocardial Ischemia; Proteins; Radiation-Protective Agents; Trimetazidine; Vasodilator Agents

2002