trimetazidine has been researched along with Cardiovascular Stroke in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (14.49) | 18.2507 |
| 2000's | 40 (57.97) | 29.6817 |
| 2010's | 17 (24.64) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| A, X; Chen, Y; Dong, W; Guo, J; Jiang, X; Jiang, Z; Li, T; Qian, G | 1 |
| Barchukov, VV; Gudasheva, TA; Kryzhanovskii, SA; Likhosherstov, AM; Mokrov, GV; Tsorin, IB; Vititnova, MB | 1 |
| Fedorchenko, MV; Petrovskyi, RV; Seredyuk, NM | 1 |
| Liu, H; Lu, S; Yu, L | 1 |
| Chen, A; Chen, B; Fu, S; He, S; Ling, Y; Luo, T; Tang, L; Tang, Y; Wang, X; Yang, P; Zhang, Y; Zhong, P; Zhong, Y | 1 |
| Han, X; Jing, Q; Li, R; Tang, X; Wang, Q; Yang, M; Yu, X; Zhao, J | 1 |
| Ding, JN; Liu, MY; Rastogi, R; Zhang, LJ | 1 |
| Gong, W; Li, A; Ma, Y; Nie, S; Shi, H | 1 |
| Ahn, EY; Choi, JH; Chun, KJ; Jeong, MH; Kim, CH; Kim, EJ; Kim, J; Kim, JH; Kim, JS; Lee, SH; Park, YH; Yu, DG | 1 |
| Fan, G; Gong, X; Wang, G; Wang, W | 1 |
| Li, L; Liu, T; Liu, YC; Su, Q; Tang, ZL | 1 |
| Fi, Z; Kovács, G; Szentes, V | 1 |
| Chen, JM; Guo, HM; Huang, H; Kuznicki, M; Li, J; Liu, Z; Quan, N; Sun, W; Wang, L; Yang, H; Zheng, S; Zhu, P; Zhuang, J | 1 |
| Bai, J; Liu, D; Luo, H; Ma, N; Qiao, C; Zhang, W; Zhang, X | 1 |
| Liu, MY; Zhang, LJ | 1 |
| Kurashvili, LV; Ushakova, SV | 1 |
| Banach, M; Goch, A; Mikhailidis, DP; Rosano, GM; Rysz, J | 1 |
| Kulikov, KG; Shal'nova, SA; Shkol'nik, EL; Vasiuk, IuA | 2 |
| Chacko, SM; Hideg, K; Khan, M; Kuppusamy, ML; Kuppusamy, P; Mohan, IK; Rivera, BK; Sun, BC; Wisel, S | 1 |
| Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C | 1 |
| Shen, JX; Wang, F; Wang, YM; Yu, P; Zhang, RY | 1 |
| Lei, LC; Liang, Y; Ma, ZM; Peng, JJ; Ren, LH; Ren, WL | 1 |
| Domergue-Dupont, V; Grynberg, A; Liao, R; Mouquet, F; Rousseau, D | 1 |
| Kudriakov, ON; Kulikov, KG; Shkol'nik, EL; Vasiuk, YA | 1 |
| Abdullaev, AA; Gafurova, RM; Islamova, UA; Kadieva, IA; Mutalipov, KhM | 1 |
| Kaliuzhin, VV; Kamaev, DIu; Solovtsov, MA; Tepliakov, AT | 1 |
| Aleksandriia, LG; Moiseev, VS; Tereshchenko, SN | 1 |
| Afanas'ev, SA; Lasukova, TV; Maksimov, IV; Markov, VA; Perchatkin, VA; Rebrova, TY | 1 |
| Drobotia, NV; Eroshenko, OL; Kastanaian, AA; Kazarian, NB; Nelasov, NIu | 1 |
| Eryonucu, B; Güler, N; Günes, A; Güntekin, U; Ozbek, H; Tuncer, M | 1 |
| Biggi, A; Feola, M; Ferrero, V; Francini, A; Leonardi, G; Ribichini, F; Uslenghi, E | 1 |
| Efimova, I; Filippov, EA; Garganeeva, AA; Kaliuzhin, VV; Pushnikova, EIu; Sankevich, qV; Stepacheva, TA; Tepliakov, AT; Zavadovskiĭ, KV | 1 |
| Celik, A; Demiryürek, AT; Demiryürek, S; Kara, AF; Tarakçioğlu, M | 2 |
| Gorbachenkov, AA; Khobot, VV | 1 |
| Barbarash, LS; Kokov, AN; Tarasov, II | 1 |
| Biggi, A; Feola, M; Francini, A; Leonardi, G; Ribichini, F; Uslenghi, E; Vado, A | 1 |
| Ganesan, LP; Hideg, K; Kalai, T; Khan, M; Kuppusamy, P; Kutala, VK; Mandal, R; Tridandapani, S | 1 |
| Dzhaiani, NA; Golubev, AV; Kochetov, AG; Kositsyna, IV; Tereshchenko, SN | 1 |
| Altekin, E; Goldeli, O; Kuralay, F; Onvural, B; Yazlar, AS | 1 |
| Glonti, TG; Gorgoshidze, ML; Svanidze, TD; Tsintsadze, IN | 1 |
| Chandler, MP; Hoit, BD; Kung, TA; McElfresh, TA; Morgan, EE; Stanley, WC; Young, ME | 1 |
| Fragakis, N; Giannoglou, G; Katsaris, G; Labrou, A; Louridas, G; Zioutas, D | 1 |
| Dong, XD; Hu, DY; Jia, SQ; Wang, L; Yan, SB | 1 |
| Dzhindzholiia, NR; Megreladze, II | 1 |
| Kus, M; Tanda, K; Williams, FM; Williams, TJ | 1 |
| Belcher, PR; Drake-Holland, AJ; Noble, MI | 1 |
| Boucher, F; de Leiris, J | 1 |
| Kanonidis, IE; Kotridis, PS; Koukoulekidis, GN; Missopoulou-Kokka, AI; Nikolaidis, NK; Papadopoulos, CL; Papayannis, IL; Sakadamis, GC; Savatis, SC | 1 |
| Antonov, AIa; Bryl', ZhV; Irkin, OI; Parkhomenko, AE; Shkliar, LV | 1 |
| Akimova, OS; Tereshchenko, SN; Tertychnaia, GF | 1 |
| Aladag, M; Güven, A; Korkmaz, ME; Müderrisoglu, H; Ozdemir, R; Pekdemir, H; Sezgin, AT; Tuncer, C | 1 |
| Bucca, V; Cannizzaro, S; Di Pasquale, P; Lo Verso, P; Maringhini, G; Paterna, S; Rizzo, R; Scalzo, S | 1 |
| Doehner, W | 1 |
| Tognoni, G | 1 |
| Akdemir, O; Toprak, N; Ulgen, MS | 1 |
| Arnaud, P; Benamer, H; Bourguignon, C; Gallay, P; Grollier, G; Harpey, C; Karrillon, GJ; Kempf, C; Laperche, T; Morice, M; Sellier, P; Steg, PG | 1 |
| Beygui, F | 1 |
| Mariani, M; Marzilli, M | 1 |
| Grynberg, A | 1 |
| Lopaschuk, GD | 1 |
| Szwed, H | 1 |
| Huikuri, HV | 1 |
| Dimitroula, V; Karanikis, P; Kountouris, E; Pappa, E; Pappas, K; Siogas, K; Tzimas, T | 1 |
| Andrýs, C; Bláha, V; Drahosová, M; Gregor, J; Krejsek, J; Pidrman, V; Pudil, R; Tichý, M | 1 |
| Belooussoff, T; Cirimele, V; Dumestre-Toulet, V; Gromb, S; Kintz, P; Lavault, D; Ludes, B | 1 |
6 review(s) available for trimetazidine and Cardiovascular Stroke
| Article | Year |
|---|---|
[Role of trimetazidine in the treatment of diabetic microangiopathy in ischaemic heart disease].
Topics: Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Heart; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Trimetazidine; Vasodilator Agents | 2015 |
The role of trimetazidine after acute myocardial infarction.
Topics: Acute Coronary Syndrome; Angina Pectoris; Cardiovascular Agents; Energy Metabolism; Humans; Myocardial Infarction; Myocardium; Practice Guidelines as Topic; Treatment Outcome; Trimetazidine | 2008 |
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].
Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents | 2009 |
[Effect of therapy with trimetazidine modified release on quality of life of patients with stable effort angina survivors after acute myocardial infarction. Results of PRIMA study].
Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Humans; Myocardial Infarction; Quality of Life; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2010 |
Rationale for trimetazidine administration in myocardial ischaemia-reperfusion syndrome.
Topics: Animals; Calcium; Energy Metabolism; Free Radicals; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Reactive Oxygen Species; Thrombolytic Therapy; Trimetazidine | 1993 |
Trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Trimetazidine; Vasodilator Agents | 2000 |
27 trial(s) available for trimetazidine and Cardiovascular Stroke
| Article | Year |
|---|---|
Early Trimetazidine Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Segment Elevation Myocardial Infarction Reduces Myocardial Infarction Size.
Topics: Humans; Myocardial Infarction; Myocardium; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction; Treatment Outcome; Trimetazidine | 2023 |
The effect of trimetazidine treatment in patients with type 2 diabetes undergoing percutaneous coronary intervention for AMI.
Topics: Adenosine; Aged; Alanine Transaminase; Aspartate Aminotransferases; Aspirin; Blood Glucose; Cardiac Output; China; Creatine Kinase; Creatine Kinase, MB Form; Creatinine; Diabetes Mellitus, Type 2; Echocardiography; Female; Glycated Hemoglobin; Heart Atria; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stroke Volume; Ticagrelor; Treatment Outcome; Trimetazidine; Troponin I; Urea; Vasodilator Agents | 2017 |
[Oxidative stress in myocardial infarction and the efficiency of its correction with the drug Trimetazidine].
Topics: Aged; Biomarkers; Electrocardiography; Female; Follow-Up Studies; Glutathione Peroxidase; Glutathione Reductase; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Myocardial Infarction; Oxidative Stress; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2008 |
[Clinical outcomes of trimetazidine in patients with acute ST segment elevation myocardial infarction without ST segment resolution after primary percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Electrocardiography; Humans; Middle Aged; Myocardial Infarction; Prospective Studies; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2009 |
[Efficacy of ramipril, carvedilol, and trimetazidine MR in improvement of quality of life of patients after myocardial infarction].
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Carvedilol; Dose-Response Relationship, Drug; Drug Therapy, Combination; Echocardiography; Electrocardiography; Follow-Up Studies; Humans; Myocardial Infarction; Propanolamines; Quality of Life; Ramipril; Retrospective Studies; Time Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2010 |
[The (PRIMA) Study. Comparison of clinical effect of trimetazidine MR in men and women].
Topics: Aged; Angina Pectoris; Cardiotonic Agents; Drug Monitoring; Exercise Test; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Nitro Compounds; Russia; Severity of Illness Index; Sex Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2011 |
[Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].
Topics: Anti-Arrhythmia Agents; Atenolol; Humans; Myocardial Infarction; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2002 |
[Use of trimetazidine in the combined therapy of myocardial infarction with left ventricular dysfunction].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Diuretics; Drug Therapy, Combination; Echocardiography; Echocardiography, Doppler; Female; Fibrinolytic Agents; Follow-Up Studies; Hemodynamics; Heparin; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Time Factors; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Remodeling | 2002 |
Cardioprotective effect of trimetazidine during thrombolytic therapy in patients with acute myocardial infarction.
Topics: Coronary Circulation; Creatine Kinase; Drug Therapy, Combination; Female; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Thrombolytic Therapy; Time Factors; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2002 |
[Effect of acetyl-CoA C-acyltransferase inhibitor trimetazidine on parameters of global and local systolic and diastolic functions of left ventricular myocardium in patients with combined postinfarction ischemic syndrome].
Topics: Acetyl-CoA C-Acyltransferase; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Syndrome; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2003 |
Effects of trimetazidine on submaximal exercise test in patients with acute myocardial infarction.
Topics: Cross-Over Studies; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 2003 |
[Anti-ischemic effects of trimetazidine in patients with post-infarction heart failure].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 2004 |
[Trimetazidine effects on postinfarction remodeling of the left ventricle].
Topics: Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Streptokinase; Trimetazidine; Vasodilator Agents; Ventricular Remodeling | 2005 |
Placebo or trimetazidine (99m)Tc tetrofosmin myocardial SPECT and low-dose dobutamine echocardiography in hibernating myocardium.
Topics: Adult; Aged; Aged, 80 and over; Cardiotonic Agents; Coronary Angiography; Coronary Artery Disease; Dobutamine; Echocardiography; Female; Follow-Up Studies; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2006 |
[Effects of metabolic triad (25% polarizing solution, mildronat, preductal MR) in acute myocardial infarction].
Topics: Adult; Aged; Cardiovascular Agents; Drug Therapy, Combination; Female; Glucose; Humans; Insulin; Male; Methylhydrazines; Middle Aged; Myocardial Infarction; Potassium; Trimetazidine; Vasodilator Agents | 2006 |
Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention.
Topics: Acute Disease; Administration, Oral; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Creatine Kinase, MB Form; Echocardiography; Female; Heart Ventricles; Humans; Hypokinesia; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardial Revascularization; Premedication; Syndrome; Trimetazidine; Troponin I; Vasodilator Agents; Ventricular Dysfunction, Left | 2007 |
[Clinical study of trimetazidine for myocardial protection in acute myocardial infarction].
Topics: Aged; Endothelin-1; Follow-Up Studies; Humans; Male; Malondialdehyde; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Trimetazidine; Vasodilator Agents | 2007 |
Free radicals, reperfusion and myocardial infarction therapy: European Myocardial Infarction Project--free radicals pilot study. EMIP-FR Pilot Study Group.
Topics: Double-Blind Method; Female; Free Radicals; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Pilot Projects; Reactive Oxygen Species; Thrombolytic Therapy; Trimetazidine | 1993 |
The effect of trimetazidine on reperfusion arrhythmias in acute myocardial infarction.
Topics: Arrhythmias, Cardiac; Chi-Square Distribution; Confidence Intervals; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Odds Ratio; Severity of Illness Index; Thrombolytic Therapy; Trimetazidine | 1996 |
[The use of the antioxidant trimetazidine (Preductal) in the combined therapy of acute myocardial infarct].
Topics: Adult; Aged; Antioxidants; Drug Therapy, Combination; Heart Function Tests; Humans; Male; Middle Aged; Myocardial Infarction; Recurrence; Tablets; Time Factors; Trimetazidine | 1996 |
Effect of trimetazidine on late potentials after acute myocardial infarction.
Topics: Double-Blind Method; Echocardiography; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Time Factors; Trimetazidine; Vasodilator Agents | 1999 |
Effects of trimetazidine administration before thrombolysis in patients with anterior myocardial infarction: short-term and long-term results.
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Creatine Kinase; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Thrombolytic Therapy; Trimetazidine; Vasodilator Agents | 1999 |
Effect of 48-h intravenous trimetazidine on short- and long-term outcomes of patients with acute myocardial infarction, with and without thrombolytic therapy; A double-blind, placebo-controlled, randomized trial. The EMIP-FR Group. European Myocardial Inf
Topics: Adult; Aged; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Prospective Studies; Survival Analysis; Thrombolytic Therapy; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2000 |
The effects of trimetazidine on heart rate variability and signal-averaged electrocardiography in early period of acute myocardial infarction.
Topics: Adult; Aged; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Infarction; Parasympathetic Nervous System; Prospective Studies; Signal Processing, Computer-Assisted; Trimetazidine; Vasodilator Agents | 2001 |
A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Chemotherapy, Adjuvant; Coronary Angiography; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 2001 |
Metabolic management of coronary heart disease: adjunctive treatment with trimetazidine decreases QT dispersion in patients with a first acute myocardial infarction.
Topics: Aged; Arrhythmias, Cardiac; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Trimetazidine; Vasodilator Agents | 2001 |
The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction.
Topics: C-Reactive Protein; Cell Adhesion Molecules; Combined Modality Therapy; Cytokines; Double-Blind Method; E-Selectin; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-6; Interleukin-8; Male; Middle Aged; Myocardial Infarction; Thrombolytic Therapy; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2001 |
36 other study(ies) available for trimetazidine and Cardiovascular Stroke
| Article | Year |
|---|---|
Anti-Ischemic Activity of Triamine ALM-802 under Conditions of Endothelial Dysfunction.
Topics: Animals; Electrophysiology; Hyperhomocysteinemia; Isoproterenol; Male; Myocardial Infarction; Ranolazine; Rats; Trimetazidine | 2019 |
Influence of trimetazidine and levocarnitine on clinical course, structural and functional changes and myocardial fibrosis in patients with myocardial infarction.
Topics: Fibrosis; Humans; Myocardial Infarction; Treatment Outcome; Trimetazidine | 2019 |
Trimetazidine alleviates hypoxia/reoxygenation-induced apoptosis in neonatal mice cardiomyocytes via up-regulating HMGB1 expression to promote autophagy.
Topics: Animals; Animals, Newborn; Apoptosis; Autophagy; Beclin-1; Cell Hypoxia; Cell Survival; Gene Expression Regulation; HMGB1 Protein; Humans; Mice; Microtubule-Associated Proteins; Myocardial Infarction; Myocytes, Cardiac; Reperfusion Injury; Signal Transduction; Trimetazidine | 2021 |
Trimetazidine Protects Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Promoting AMP-activated Protein Kinase-dependent Autophagic Flux.
Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Autophagy; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Microtubule-Associated Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphorylation; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases; Transfection; Trimetazidine | 2017 |
Psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study.
Topics: Animals; Brain; Comorbidity; Depressive Disorder; Disease Models, Animal; Female; Male; Myocardial Infarction; Random Allocation; Rats, Sprague-Dawley; Serotonin; Trimetazidine; Vasodilator Agents | 2018 |
Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction.
Topics: Animals; Antioxidants; Cell Line; Disease Models, Animal; Down-Regulation; Heart Rupture, Post-Infarction; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Trimetazidine; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry.
Topics: Aged; Coronary Angiography; Coronary Artery Bypass; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Proportional Hazards Models; Registries; Republic of Korea; Retrospective Studies; Stents; Thrombolytic Therapy; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2013 |
Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt.
Topics: Apoptosis; Cell Hypoxia; Culture Media, Serum-Free; Gene Expression Regulation, Developmental; Genes, bcl-2; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Proto-Oncogene Proteins c-akt; Trimetazidine; Umbilical Cord | 2014 |
Trimetazidine pretreatment inhibits myocardial apoptosis and improves cardiac function in a Swine model of coronary microembolization.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Coronary Vessels; Disease Models, Animal; Echocardiography; Embolism; Female; Heart Function Tests; Male; Myocardial Infarction; Myocardium; Swine; Trimetazidine; Vasodilator Agents | 2015 |
The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Coronary Circulation; Fatty Acids; Glucose; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Trimetazidine; Vasodilator Agents | 2016 |
Trimetazidine protects against cardiac ischemia/reperfusion injury via effects on cardiac miRNA‑21 expression, Akt and the Bcl‑2/Bax pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Gene Expression Regulation; Humans; MicroRNAs; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Trimetazidine | 2016 |
[Impact of trimetazidine pre-treatment on 5-hydroxytryptamine and serotonin transporter in rats with experimental myocardial infarction and depression].
Topics: Animals; Depression; Enzyme-Linked Immunosorbent Assay; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Trimetazidine; Vasodilator Agents | 2017 |
[The PRIMA study: trimetazidin in the treatment of patients with stable angina pectoris after myocardial infarction. Epidemiological and clinical phases].
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Retrospective Studies; Russia; Survival Rate; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2008 |
Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression.
Topics: Animals; Blotting, Western; Cell Hypoxia; Cell Survival; Cyclin D1; Disease Models, Animal; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Trimetazidine; Vasodilator Agents | 2009 |
[Effects of Trimetazidine upon ventricular remodeling and GLUT4 in diabetic rats after myocardial infarction].
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Male; Myocardial Infarction; Rats; Rats, Wistar; RNA, Messenger; Trimetazidine; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Effects of trimetazidine, a partial inhibitor of fatty acid oxidation, on ventricular function and survival after myocardial infarction and reperfusion in the rat.
Topics: Animals; Data Interpretation, Statistical; Disease Models, Animal; Fatty Acids; Male; Myocardial Infarction; Myocardial Reperfusion; Oxidation-Reduction; Rats; Rats, Wistar; Survival Analysis; Trimetazidine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2010 |
Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.
Topics: Aged; Coronary Artery Disease; Coronary Vessels; Gated Blood-Pool Imaging; Heart Ventricles; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Single-Blind Method; Stroke Volume; Treatment Outcome; Trimetazidine; Vasodilator Agents; Ventricular Dysfunction, Left | 2004 |
Effects of trimetazidine on myocardial preconditioning in anesthetized rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbachol; Coronary Vessels; Creatine Kinase; Electrocardiography; Heart Rate; Hemodynamics; Ischemic Preconditioning, Myocardial; Isoenzymes; Lactic Acid; Male; Malondialdehyde; Muscarinic Agonists; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Trimetazidine; Troponin T; Vasodilator Agents | 2004 |
[Favorable effect of trimetazidine on clinical state and left ventricular function postinfarction period.].
Topics: Diastole; Heart Ventricles; Humans; Myocardial Infarction; Trimetazidine; Ventricular Function, Left | 2004 |
Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties.
Topics: Animals; Cardiotonic Agents; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Hemodynamics; In Vitro Techniques; Molecular Structure; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Superoxides; Trimetazidine | 2006 |
[Trimetazidine in complex therapy of acute myocardial infarction at the background of diabetes mellitus type 2.].
Topics: Acute Disease; Echocardiography; Humans; Myocardial Infarction; Natriuretic Peptide, Brain; Trimetazidine | 2006 |
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Nitrites; Reactive Oxygen Species; Time Factors; Treatment Outcome; Trimetazidine; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2006 |
Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats.
Topics: Animals; Blood Pressure; Carbachol; Cardiotonic Agents; Heart Rate; Ischemic Preconditioning, Myocardial; Lactic Acid; Male; Malondialdehyde; Myocardial Infarction; Rats; Rats, Wistar; Tachycardia, Ventricular; Trimetazidine; Vasodilator Agents; Ventricular Fibrillation | 2006 |
Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.
Topics: Acyl-CoA Dehydrogenase; Animals; Atrial Natriuretic Factor; Carnitine O-Palmitoyltransferase; Male; Myocardial Infarction; Palmitoyl-CoA Hydrolase; Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Trimetazidine; Up-Regulation; Vasodilator Agents; Ventricular Function, Left | 2006 |
[Effect of combination therapy with preduktal and prestarium on the left ventricular function in the postinfarction period].
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Infarction; Perindopril; Trimetazidine; Vasodilator Agents; Ventricular Function, Left | 2008 |
Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits.
Topics: Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Heart Rate; Interleukin-8; Leukotriene B4; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Rabbits; Trimetazidine; Zymosan | 1993 |
Limitation of infarct size by trimetazidine in the rabbit.
Topics: Animals; Female; Myocardial Infarction; Rabbits; Trimetazidine | 1995 |
[The use of trimetazidine in the combined therapy of postinfarct stenocardia].
Topics: Acute Disease; Aged; Angina Pectoris; Drug Evaluation; Humans; Male; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 1997 |
Cytoprotection in acute myocardial infarction.
Topics: Cytoprotection; Glucose; Human Growth Hormone; Humans; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 1999 |
The EMIP project. European Myocardial Infarction Project.
Topics: Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Reperfusion Injury; Thrombolytic Therapy; Trimetazidine; Vasodilator Agents | 2000 |
About EMIP-FR and reperfusion damage in AMI: a comment to the comment.
Topics: Animals; Humans; Myocardial Infarction; Reperfusion Injury; Trimetazidine; Vasodilator Agents | 2001 |
The EMIP-FR Study: the evolution of scientific background as a non-controlled parameter.
Topics: Humans; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 2001 |
Trimetazidine in AMI.
Topics: Energy Metabolism; Humans; Myocardial Infarction; Myocardium; Trimetazidine; Vasodilator Agents | 2001 |
Comments on EMIP-FR study's editorial.
Topics: Angina Pectoris; Humans; Myocardial Infarction; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2001 |
QT dispersion--what does it mean?
Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Myocardial Infarction; Trimetazidine; Vasodilator Agents | 2001 |
Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample.
Topics: Adult; Autopsy; Bromazepam; Cause of Death; Chromatography, Liquid; Death, Sudden, Cardiac; Drug Interactions; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Mass Spectrometry; Myocardial Infarction; Piperazines; Purines; Sildenafil Citrate; Sulfones; Trimetazidine; Vasodilator Agents; Verapamil; Yohimbine | 2002 |