trimedoxime-bromide has been researched along with Respiratory-Tract-Diseases* in 1 studies
1 other study(ies) available for trimedoxime-bromide and Respiratory-Tract-Diseases
| Article | Year |
|---|---|
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
Exposure to the chemical warfare nerve agent VX is extremely toxic, causing severe cholinergic symptoms. If not appropriately treated, death ultimately ensues. Based on our previously described whole-body vapor exposure system, we characterized in detail the clinical outcome, including respiratory dynamics, typical of whole-body exposure to lethal doses of VX vapor in freely moving rats. We further evaluated the efficacy of two different antidotal regimens, one comprising a single and the other repeated administration of antidotes, in countering the toxic effects of the exposure. We show that a 15 min exposure to air VX concentrations of 2.34-2.42 mg/m Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime | 2019 |