trimebutine has been researched along with Muscle Contraction in 26 studies
Trimebutine: Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimebutine maleate, which modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome." | 7.76 | Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome. ( Hou, X; Liu, Y; Long, Y; Qian, W; Tong, J, 2010) |
| "Trimebutine maleate, which modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome." | 3.76 | Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome. ( Hou, X; Liu, Y; Long, Y; Qian, W; Tong, J, 2010) |
| "Trimebutine is an opiate modulator of the gastrointestinal motility that interacts with enkephalinergic receptors." | 2.69 | Effects of trimebutine on sphincter of Oddi motility in patients with post-cholecystectomy pain. ( Abou, E; Barthet, M; Berdah, S; Bouvier, M; Grimaud, JC; Mambrini, P; Pecout, C; Salducci, J; Viviand, X, 1998) |
| "Nor-trimebutine has a blocking activity on sodium channels and a potent local anesthetic effect." | 1.33 | Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat. ( Bonaz, B; Mouchet, P; Sinniger, V, 2005) |
| "Trimebutine derivatives were synthesized by utilizing alkylation or acylation of isonitriles and nitrile as a key step." | 1.29 | Synthesis and structure-activity relationship of trimebutine derivatives. ( Hayashi, K; Onoda, Y; Ozaki, Y; Sai, H; Yamada, K, 1996) |
| " In mechanical experiments using the taenia cecum, trimebutine (3-30 microM) caused a parallel rightward shift of the dose-response curve for the contractile response to a higher concentration range of Ca2+ under high-K+ conditions in a noncompetitive manner." | 1.28 | Allosteric interaction of trimebutine maleate with dihydropyridine binding sites. ( Kurosawa, H; Nagasaki, M; Naito, K; Tamaki, H, 1990) |
| " TM-906 noncompetitively antagonized the contractile response to methacholine, and it caused a parallel shift of dose-response curves for the contractile response to CaCl2 to higher concentrations." | 1.27 | Effects of trimebutine maleate (TM-906) on the smooth muscles of isolated guinea pig gallbladder. ( Magaribuchi, T; Takenaga, H; Tamaki, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (50.00) | 18.7374 |
| 1990's | 9 (34.62) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Qian, W | 2 |
| Hou, X | 2 |
| Long, Y | 1 |
| Liu, Y | 1 |
| Tong, J | 1 |
| Tan, W | 1 |
| Zhang, H | 1 |
| Luo, HS | 1 |
| Xia, H | 1 |
| Sinniger, V | 1 |
| Mouchet, P | 1 |
| Bonaz, B | 1 |
| Yamada, K | 4 |
| Iizuka, M | 2 |
| Takaiti, O | 1 |
| Furukawa, K | 1 |
| Kimoto, Y | 1 |
| Takenaga, H | 4 |
| Magaribuchi, T | 4 |
| Tamaki, H | 7 |
| Ishizawa, M | 1 |
| Nagasaki, M | 4 |
| Itagaki, M | 1 |
| Komori, S | 1 |
| Ohashi, H | 1 |
| Uchida, M | 1 |
| Iwata, T | 1 |
| Takagi, S | 1 |
| Sugiyama, Y | 1 |
| Ishitani, K | 1 |
| Honda, H | 1 |
| Sakai, Y | 1 |
| Defilippi, C | 1 |
| Gomez, E | 1 |
| Sai, H | 1 |
| Ozaki, Y | 1 |
| Hayashi, K | 1 |
| Onoda, Y | 1 |
| Barthet, M | 1 |
| Bouvier, M | 1 |
| Pecout, C | 1 |
| Berdah, S | 1 |
| Viviand, X | 1 |
| Mambrini, P | 1 |
| Abou, E | 1 |
| Salducci, J | 1 |
| Grimaud, JC | 1 |
| Taniyama, K | 1 |
| Sano, I | 1 |
| Nakayama, S | 2 |
| Matsuyama, S | 1 |
| Takeda, K | 1 |
| Yoshihara, C | 1 |
| Tanaka, C | 1 |
| Kobayashi, T | 1 |
| Kaneto, H | 1 |
| Takahashi, M | 1 |
| Watanabe, J | 1 |
| Kurosawa, H | 1 |
| Naito, K | 1 |
| Ikezawa, K | 1 |
| Kobayashi, K | 1 |
| Mitani, E | 1 |
| Tatsumi, S | 1 |
| Sasaki, Y | 1 |
| Nakamura, M | 1 |
| Yamada, H | 1 |
| Daniel, EE | 1 |
| Kostolanska, F | 1 |
| Allescher, HD | 1 |
| Ahmad, S | 1 |
| Fox, JE | 1 |
| Yamasato, T | 1 |
| Takaki, M | 1 |
| Schuurkes, JA | 1 |
| Helsen, LF | 1 |
| Van Nueten, JM | 1 |
1 trial available for trimebutine and Muscle Contraction
| Article | Year |
|---|---|
Effects of trimebutine on sphincter of Oddi motility in patients with post-cholecystectomy pain.
Topics: Adult; Aged; Cholecystectomy; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; In | 1998 |
25 other studies available for trimebutine and Muscle Contraction
| Article | Year |
|---|---|
Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit.
Topics: Animals; Carbachol; Domperidone; Gastrointestinal Agents; Gastrointestinal Motility; Indoles; Male; | 2009 |
Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.
Topics: Acetylcholine; Animals; Body Weight; Colon; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Colon; Dose-Response Relationship, Drug; Gastr | 2011 |
Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.
Topics: Abdominal Pain; Acetic Acid; Anesthetics, Local; Animals; Colitis; Immunohistochemistry; Injections, | 2005 |
Effect of trimebutine maleate on bethanechol-induced contractions of gastrointestinal tract in conscious and anaesthetized dogs.
Topics: Animals; Atropine; Benzoates; Bethanechol; Bethanechol Compounds; Digestive System Physiological Phe | 1983 |
Effects of trimebutine maleate (TM-906) on electrical and mechanical activities of smooth muscles of the guinea-pig stomach.
Topics: Animals; Benzoates; Electrophysiology; Female; Guinea Pigs; Male; Membrane Potentials; Muscle Contra | 1984 |
Effects of trimebutine maleate (TM-906) on the smooth muscles of isolated guinea pig gallbladder.
Topics: Acetylcholine; Animals; Atropine; Benzoates; Calcium Chloride; Electric Stimulation; Gallbladder; Gu | 1984 |
[Effects of trimebutine and metoclopramide on colonic motility in the guinea pig].
Topics: Animals; Benzoates; Colon; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Mot | 1984 |
Effects of trimebutine maleate (TM-906) on the spontaneous contraction of isolated guinea pig colon.
Topics: Animals; Atropine; Benzoates; Calcium Chloride; Colon; Diltiazem; Gastrointestinal Motility; Guinea | 1984 |
[Effects of trimebutine maleate (TM-906) on the spontaneous contraction of the isolated guinea pig stomach].
Topics: Animals; Atropine; Benzoates; Calcium; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; In | 1982 |
Effect of trimebutine on contractile responses in skinned ileal smooth muscle.
Topics: Animals; Caffeine; Calcimycin; Calcium; Carbachol; Dose-Response Relationship, Drug; Drug Interactio | 1994 |
Effect of trimebutine maleate on the contractile response of the isolated ileum from diabetic rats.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Gastrointestinal Di | 1994 |
Short report: effect of two prokinetic drugs on the electrical and motor activity of the small bowel in dogs.
Topics: Animals; Dogs; Domperidone; Electrophysiology; Gastrointestinal Motility; Membrane Potentials; Muscl | 1993 |
Synthesis and structure-activity relationship of trimebutine derivatives.
Topics: Animals; Colon; Gastrointestinal Agents; Gastrointestinal Motility; In Vitro Techniques; Magnetic Re | 1996 |
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Pen | 1991 |
Effects of trimebutine on cytosolic Ca2+ and force transitions in intestinal smooth muscle.
Topics: Animals; Caffeine; Calcium; Carbachol; Cytosol; Fura-2; Guinea Pigs; In Vitro Techniques; Intestines | 1991 |
The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
Topics: Animals; Drug Tolerance; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smoot | 1990 |
Allosteric interaction of trimebutine maleate with dihydropyridine binding sites.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Cecum; Dihydropyridines; Guinea Pigs; Ileum; Kine | 1990 |
Contribution of peripheral opioid receptors to the trimebutine-induced contractions of the proximal colon in anesthetized rats.
Topics: Anesthesia; Animals; Benzoates; Colon; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; | 1989 |
Studies on papillary function and effect of prifinium bromide and other antispasmodics on motility of the papillary region (sphincter of Oddi) in humans.
Topics: Adult; Aged; Ampulla of Vater; Biliary Dyskinesia; Endoscopes; Female; Gastritis; Gastrointestinal M | 1985 |
Local actions of trimebutine maleate in canine small intestine.
Topics: Animals; Benzoates; Dogs; Dynorphins; Enkephalin, Methionine; Intestine, Small; Morphine; Muscle Con | 1988 |
Opiate-like inhibitory effect of trimebutine on the twitch response of the isolated guinea pig ileum.
Topics: Animals; Benzoates; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Technique | 1987 |
Effects of trimebutine maleate (TM-906) on the spontaneous contraction of isolated duodenum and ileum in both guinea pigs and rabbits.
Topics: Acetylcholine; Animals; Atropine; Benzoates; Duodenum; Guinea Pigs; Ileum; In Vitro Techniques; Musc | 1986 |
Contractions of the stomach and duodenum induced by trimebutine in conscious fasted dogs.
Topics: Action Potentials; Animals; Benzoates; Dogs; Duodenum; Gastrointestinal Motility; Male; Metocloprami | 1985 |
A comparative study on the effects of domperidone, metoclopramide, clebopride and trimebutine on the gastro-duodenal preparation of the guinea pig.
Topics: Animals; Benzamides; Benzoates; Domperidone; Drug Antagonism; Duodenum; Female; Gastrointestinal Mot | 1985 |