trimebutine has been researched along with Colitis in 6 studies
Trimebutine: Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Herein, the goal of this work was to convert trimebutine maleate (TMB) into nanostructured lipid carriers (NLC) in order to improve its protective effects in ulcerative colitis." | 8.12 | The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis. ( Abd El Hady, WE; Ahmed El-Emam, G; Motawea, A, 2022) |
| "The use of local anesthetics, such as lidocaine, has been proposed in the treatment of distal ulcerative colitis." | 7.72 | Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. ( Chevalier, E; Chovet, M; Langlois, A; Pétoux, F, 2004) |
| "Trimebutine is a weak opioid receptor agonist used in the treatment of IBS." | 5.35 | A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. ( Caliendo, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Renga, B; Santagada, V; Severino, B, 2009) |
| "The use of local anesthetics, such as lidocaine, has been proposed in the treatment of distal ulcerative colitis." | 3.72 | Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. ( Chevalier, E; Chovet, M; Langlois, A; Pétoux, F, 2004) |
| "Trimebutine is a weak opioid receptor agonist used in the treatment of IBS." | 1.35 | A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. ( Caliendo, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Renga, B; Santagada, V; Severino, B, 2009) |
| "Nor-trimebutine has a blocking activity on sodium channels and a potent local anesthetic effect." | 1.33 | Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat. ( Bonaz, B; Mouchet, P; Sinniger, V, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Motawea, A | 1 |
| Abd El Hady, WE | 1 |
| Ahmed El-Emam, G | 1 |
| Distrutti, E | 1 |
| Mencarelli, A | 1 |
| Renga, B | 1 |
| Caliendo, G | 1 |
| Santagada, V | 1 |
| Severino, B | 1 |
| Fiorucci, S | 1 |
| Chevalier, E | 1 |
| Pétoux, F | 1 |
| Chovet, M | 1 |
| Langlois, A | 1 |
| Sinniger, V | 1 |
| Mouchet, P | 1 |
| Bonaz, B | 1 |
| Lacheze, C | 1 |
| Coelho, AM | 1 |
| Fioramonti, J | 1 |
| Buéno, L | 1 |
| Battocchio, F | 1 |
| Negri, L | 1 |
| Tacchettti, G | 1 |
1 trial available for trimebutine and Colitis
| Article | Year |
|---|---|
[Controlled evaluation of a new synthetic spasmolytic (DA 3177) in/pathology of the digestive system].
Topics: Adult; Aged; Benzoates; Cholecystitis; Clinical Trials as Topic; Colitis; Duodenitis; Female; Gastri | 1979 |
5 other studies available for trimebutine and Colitis
| Article | Year |
|---|---|
The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis.
Topics: Animals; Colitis; Drug Carriers; Lipids; Nanostructures; Rats; Trimebutine | 2022 |
A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats.
Topics: Animals; Colitis; Colon; Dilatation, Pathologic; Gastrointestinal Agents; Gene Expression Profiling; | 2009 |
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Administration, Rectal; Anesthetics, Local; Animals; Bupivacaine; Colitis; Colon; Disease Models, An | 2004 |
Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.
Topics: Abdominal Pain; Acetic Acid; Anesthetics, Local; Animals; Colitis; Immunohistochemistry; Injections, | 2005 |
Influence of trimebutine on inflammation- and stress-induced hyperalgesia to rectal distension in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Gastrointestinal Agents; Hyperalgesia; Male; Peritoneal | 1998 |