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triiodothyronine and Substance Withdrawal Syndrome

triiodothyronine has been researched along with Substance Withdrawal Syndrome in 32 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
"Maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal."7.77Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw. ( Christian Manhães, A; Claudio-Neto, S; de Moura, EG; de Oliveira, E; Lisboa, PC; Passos, MC; Pinheiro, CR; Santos-Silva, AP, 2011)
"To evaluate cardiovascular functionality in patients with thyroid cancer, we have performed echocardiography and ambulatory blood pressure monitoring in 19 women with differentiated thyroid carcinoma during thyroxine withdrawal, at three time points: the last day on TSH-suppressive thyroxine doses (subclinical or mild hyperthyroidism), 4-7 days after withdrawal (normal free thyroxine (FT4) and free triiodothyronine (FT3) levels), and before 131I whole body scanning (overt hypothyroidism)."7.72Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma. ( Barrios, V; Botella-Carretero, JI; Caballero, C; Escobar-Morreale, HF; García-Robles, R; Gómez-Bueno, M; Sancho, J, 2004)
"Blood thyroid hormone levels were measured during, and for 6 days after, treatment with propranolol (160 mg/day, 4-8 weeks) in five hyperthyroid patients and six normal volunteers."7.66The effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects. ( John, R; Jones, MK; Ross, PJ, 1980)
"Maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal."3.77Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw. ( Christian Manhães, A; Claudio-Neto, S; de Moura, EG; de Oliveira, E; Lisboa, PC; Passos, MC; Pinheiro, CR; Santos-Silva, AP, 2011)
" Pertinent history revealed that he took drugs containing triiodothyronine (64 mug) and propranolol (40 mg) twice daily for weight reduction in the past month and discontinued these drugs 3 days before admission."3.75An unusual cause of thyrotoxic periodic paralysis: triiodothyronine-containing weight reducing agents. ( Chou, HK; Lin, SH; Tsao, YT, 2009)
"To evaluate cardiovascular functionality in patients with thyroid cancer, we have performed echocardiography and ambulatory blood pressure monitoring in 19 women with differentiated thyroid carcinoma during thyroxine withdrawal, at three time points: the last day on TSH-suppressive thyroxine doses (subclinical or mild hyperthyroidism), 4-7 days after withdrawal (normal free thyroxine (FT4) and free triiodothyronine (FT3) levels), and before 131I whole body scanning (overt hypothyroidism)."3.72Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma. ( Barrios, V; Botella-Carretero, JI; Caballero, C; Escobar-Morreale, HF; García-Robles, R; Gómez-Bueno, M; Sancho, J, 2004)
"Spermatogenic function was studied in 10 patients, previously diagnosed as having primary hypothyroidism, in whom a state of hypothyroidism has been induced by discontinuation or a decrease in treatment with levothyroxine over at least one spermatogenic cycle."3.68Primary hypothyroidism and human spermatogenesis. ( Corrales Hernández, JJ; García Diez, LC; Miralles García, JM, 1990)
"The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring."3.66Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980)
"Blood thyroid hormone levels were measured during, and for 6 days after, treatment with propranolol (160 mg/day, 4-8 weeks) in five hyperthyroid patients and six normal volunteers."3.66The effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects. ( John, R; Jones, MK; Ross, PJ, 1980)
"During cocaine addiction the hypothalamus-pituitary axis is widely affected and a blunted response of thyroid stimulating hormone (TSH) to thyroid releasing hormone (TRH) consistent with a hyperthyroid state has been observed."2.69Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts. ( Pezzarossa, A; Vescovi, PP, 1999)
" Tapering propranolol dosage is frequently used in the hope of preventing adverse withdrawal events but the success of such a maneuver has not been shown."2.65Prevention of propranolol withdrawal mechanism by prolonged small dose propranolol schedule. ( Lutterodt, A; Nattel, S; Rangno, RE, 1982)
"In patients with differentiated thyroid cancer (DTC), the stimulated serum thyroglobulin (Tg) level at radioiodine ablation is a known predictive factor of persistent disease."1.40Stimulated thyroglobulin level at ablation in differentiated thyroid cancer: the impact of treatment preparation modalities and tumor burden. ( Bardet, S; Blanchard, D; Ciappuccini, R; de Raucourt, D; Hardouin, J; Heutte, N; Quak, E; Rame, JP; Vaur, D, 2014)
" This case illustrates the potential for hypothyroid-induced renal dysfunction to lead to adverse clinical consequences in patients taking medications cleared by the kidneys."1.35Lithium toxicity precipitated by profound hypothyroidism. ( Gohh, R; Gopalakrishnan, G; Hennessey, JV; Phillips, BD, 2008)
"The severity of opioid abuse and of withdrawal symptoms was assessed."1.35Alterations in pituitary-thyroid axis function among opioid-dependent subjects after acute and protracted abstinence. ( Chi, Y; Du, WJ; Guo, S; Jiang, ZN; Liu, ZQ; Luo, XN; Sheng, LX; Smith, AK; Tang, YL; Xiao, L; Zhang, GF; Zhang, HX, 2009)
"The effect of chronic administration of morphine and subsequent withdrawal on brain and pituitary receptors for thyrotropin releasing hormone (TRH) was investigated in Sprague-Dawley rats."1.28The binding of 3H-(3-MeHis2) thyrotropin releasing hormone to brain and pituitary membranes of morphine tolerant-dependent and abstinent rats. ( Bansinath, M; Bhargava, HN; Das, S; Prasad, R, 1989)
"The group of patients with thyroid adenoma served as control (group I)."1.26TSH and prolactin secretions in Hashimoto's thyroiditis following withdrawal of thyroid hormone therapy. ( Fukuda, H; Kamio, N; Kobayashi, I; Kobayashi, S; Maruta, S; Ohsawa, N; Ohshima, K; Suwa, K, 1981)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199016 (50.00)18.7374
1990's4 (12.50)18.2507
2000's8 (25.00)29.6817
2010's4 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciappuccini, R1
Hardouin, J1
Heutte, N1
Vaur, D1
Quak, E1
Rame, JP1
Blanchard, D1
de Raucourt, D1
Bardet, S1
Papadakis, G1
Kalaitzidou, S1
Triantafillou, E1
Drosou, A1
Kakava, K1
Dogkas, N1
Pappa, T1
Kaltzidou, V1
Tertipi, A1
Villiotou, V1
Pappas, A1
Phillips, BD1
Gopalakrishnan, G1
Gohh, R1
Hennessey, JV1
Chou, HK1
Tsao, YT1
Lin, SH1
Zhang, GF1
Tang, YL1
Smith, AK1
Liu, ZQ1
Sheng, LX1
Chi, Y1
Du, WJ1
Guo, S1
Jiang, ZN1
Xiao, L1
Zhang, HX1
Luo, XN1
Brenta, G1
Celi, FS1
Pisarev, M1
Schnitman, M1
Sinay, I1
Arias, P1
Lee, J1
Yun, MJ1
Nam, KH1
Chung, WY1
Soh, EY1
Park, CS1
de Oliveira, E1
de Moura, EG1
Santos-Silva, AP1
Pinheiro, CR1
Claudio-Neto, S1
Christian Manhães, A1
Passos, MC1
Lisboa, PC1
Hermann, D1
Heinz, A1
Mann, K1
SOYKA, LF1
CRAWFORD, JD1
Rasmussen, DD1
Botella-Carretero, JI1
Gómez-Bueno, M1
Barrios, V1
Caballero, C1
García-Robles, R1
Sancho, J1
Escobar-Morreale, HF1
Regalbuto, C1
Alagona, C1
Maiorana, R1
Di Paola, R1
Cianci, M1
Alagona, G1
Sapienza, S1
Vigneri, R1
Pezzino, V1
Duick, DS1
Wahner, HW1
Edis, AJ1
van Heerden, JA1
Rangno, RE2
Nattel, S1
Lutterodt, A2
Ohsawa, N1
Kobayashi, I1
Suwa, K1
Kamio, N1
Maruta, S1
Ohshima, K1
Fukuda, H1
Kobayashi, S1
Melander, A1
Thorell, J1
Wadstein, J1
Langlois, S1
Jhaveri, RC2
Glass, L2
Evans, HE2
Dube, SK2
Rosenfeld, W2
Khan, F2
Salazar, JD1
Chandavasu, O1
Schaeffer, HA1
Ross, PJ1
Jones, MK1
John, R1
Kaptein, EM1
Vescovi, PP1
Pezzarossa, A1
Kristensen, BO2
Steiness, E1
Weeke, J1
Vagenakis, AG1
Braverman, LE1
Azizi, F1
Portinay, GI1
Ingbar, SH1
Denicoff, KD1
Joffe, RT1
Lakshmanan, MC1
Robbins, J1
Rubinow, DR1
Corrales Hernández, JJ1
Miralles García, JM1
García Diez, LC1
Bhargava, HN1
Das, S1
Bansinath, M1
Prasad, R1
English, TN1
Ruxton, D1
Eastman, CJ1
Studer, H1
Greer, MA1
Akiba, Y1
Itoh, H1
Matsumoto, T1

Reviews

1 review available for triiodothyronine and Substance Withdrawal Syndrome

ArticleYear
Dysregulation of the hypothalamic-pituitary-thyroid axis in alcoholism.
    Addiction (Abingdon, England), 2002, Volume: 97, Issue:11

    Topics: Alcoholism; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Substance Withdrawal Syndrome; T

2002

Trials

3 trials available for triiodothyronine and Substance Withdrawal Syndrome

ArticleYear
Quality of life and effectiveness comparisons of thyroxine withdrawal, triiodothyronine withdrawal, and recombinant thyroid-stimulating hormone administration for low-dose radioiodine remnant ablation of differentiated thyroid carcinoma.
    Thyroid : official journal of the American Thyroid Association, 2010, Volume: 20, Issue:2

    Topics: Adult; Carcinoma, Papillary; Combined Modality Therapy; Female; Humans; Hypothyroidism; Iodine Radio

2010
Prevention of propranolol withdrawal mechanism by prolonged small dose propranolol schedule.
    The American journal of cardiology, 1982, Volume: 49, Issue:4

    Topics: Adult; Aged; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Epineph

1982
Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts.
    Neuropeptides, 1999, Volume: 33, Issue:6

    Topics: Adult; Chronic Disease; Cocaine-Related Disorders; Human Growth Hormone; Humans; Male; Substance Wit

1999

Other Studies

28 other studies available for triiodothyronine and Substance Withdrawal Syndrome

ArticleYear
Stimulated thyroglobulin level at ablation in differentiated thyroid cancer: the impact of treatment preparation modalities and tumor burden.
    European journal of endocrinology, 2014, Volume: 171, Issue:2

    Topics: Adenocarcinoma, Follicular; Adult; Aged; Carcinoma; Carcinoma, Papillary; Female; Humans; Iodine Rad

2014
Biochemical Effects of Levothyroxine Withdrawal in Patients with Differentiated Thyroid Cancer.
    Anticancer research, 2015, Volume: 35, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypothyroidism; Iodine Radioisotopes; Male; Middle A

2015
Lithium toxicity precipitated by profound hypothyroidism.
    Thyroid : official journal of the American Thyroid Association, 2008, Volume: 18, Issue:6

    Topics: Bipolar Disorder; Female; Humans; Hypothyroidism; Lithium Compounds; Middle Aged; Renal Insufficienc

2008
An unusual cause of thyrotoxic periodic paralysis: triiodothyronine-containing weight reducing agents.
    The American journal of the medical sciences, 2009, Volume: 337, Issue:1

    Topics: Adult; Humans; Hypokalemic Periodic Paralysis; Male; Propranolol; Substance Withdrawal Syndrome; Thy

2009
Alterations in pituitary-thyroid axis function among opioid-dependent subjects after acute and protracted abstinence.
    Addiction biology, 2009, Volume: 14, Issue:3

    Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Male; Narcotics; Pituitary Glan

2009
Acute thyroid hormone withdrawal in athyreotic patients results in a state of insulin resistance.
    Thyroid : official journal of the American Thyroid Association, 2009, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Aged; Carcinoma, Medullary; Carcinoma, Papillary; Female; Glucose Tolerance Te

2009
Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:9

    Topics: Animals; Animals, Newborn; Female; Hypothyroidism; Lactation; Maternal Exposure; Milk; Nicotine; Rat

2011
ANTAGONISM BY CORTISONE OF THE LINEAR GROWTH INDUCED IN HYPOPITUITARY PATIENTS AND HYPOPHYSECTOMIZED RATS BY HUMAN GROWTH HORMONE.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: Adolescent; Cortisone; Drug Therapy; Growth; Growth Hormone; Human Growth Hormone; Humans; Hypophyse

1965
Chronic daily ethanol and withdrawal: 5. Diurnal effects on plasma thyroid hormone levels.
    Endocrine, 2003, Volume: 22, Issue:3

    Topics: Alcoholism; Animals; Circadian Rhythm; Ethanol; Male; Rats; Rats, Sprague-Dawley; Substance Withdraw

2003
Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated with undesirable cardiovascular effects in patients with differentiated thyroid carcinoma.
    Endocrine-related cancer, 2004, Volume: 11, Issue:2

    Topics: Adult; Blood Pressure; Carcinoma, Papillary, Follicular; Cardiovascular Diseases; Cell Differentiati

2004
Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer.
    Journal of endocrinological investigation, 2006, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Attention; Blood Pressure; Cardiovascular System; Female; Heart Rate; Humans; Hyp

2006
Effects of oral thyrotropin-releasing hormone, exogenous thyroid-stimulating hormone, and withdrawal of triiodothyronine on 131I uptake after subtotal thyroidectomy.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Receptors, Cell Surface;

1980
TSH and prolactin secretions in Hashimoto's thyroiditis following withdrawal of thyroid hormone therapy.
    Endocrinologia japonica, 1981, Volume: 28, Issue:3

    Topics: Adenoma; Female; Humans; Prolactin; Substance Withdrawal Syndrome; Thyroid Neoplasms; Thyroiditis, A

1981
Alteration of thyroid hormone economy during alcohol withdrawal in alcoholics.
    Drug-nutrient interactions, 1982, Volume: 1, Issue:2

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Humans; Substance Withdrawal Syndrome; Thyroid Hormones; Th

1982
Metoprolol withdrawal phenomena: mechanism and prevention.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:1

    Topics: Adult; Aged; Blood Pressure; Drug Administration Schedule; Epinephrine; Heart Rate; Humans; Isoprote

1982
Effects of methadone on thyroid function in mother, fetus, and newborn.
    Pediatrics, 1980, Volume: 65, Issue:3

    Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea

1980
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:4

    Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective

1981
The effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects.
    Clinical endocrinology, 1980, Volume: 13, Issue:1

    Topics: Adult; Female; Humans; Hyperthyroidism; Male; Middle Aged; Propranolol; Substance Withdrawal Syndrom

1980
Hormone-specific alterations of T4, T3, and reverse T3 metabolism with recent ethanol abstinence in humans.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 1

    Topics: Adult; Alcoholism; Ethanol; Female; Humans; Male; Middle Aged; Models, Biological; Reference Values;

1997
[Risks in sudden withdrawal of beta-blocking drugs--beta-blockade withdrawal syndrome].
    Ugeskrift for laeger, 1978, Sep-25, Volume: 140, Issue:39

    Topics: Adrenergic beta-Antagonists; Humans; Risk; Substance Withdrawal Syndrome; Syndrome; Triiodothyronine

1978
The pathogenesis of propranolol-withdrawal syndrome in essential hypertension.
    Clinical science (London, England : 1979), 1979, Volume: 57 Suppl 5

    Topics: Adult; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Propranolol; Substance Withdrawa

1979
Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy.
    The New England journal of medicine, 1975, Oct-02, Volume: 293, Issue:14

    Topics: Adult; Aged; Female; Goiter; Humans; Middle Aged; Substance Withdrawal Syndrome; Thyroid (USP); Thyr

1975
Neuropsychiatric manifestations of altered thyroid state.
    The American journal of psychiatry, 1990, Volume: 147, Issue:1

    Topics: Adult; Affect; Attitude to Health; Cognition; Depressive Disorder; Female; Humans; Male; Mental Diso

1990
Primary hypothyroidism and human spermatogenesis.
    Archives of andrology, 1990, Volume: 25, Issue:1

    Topics: Humans; Hypothyroidism; Male; Spermatogenesis; Substance Withdrawal Syndrome; Thyrotropin; Thyroxine

1990
The binding of 3H-(3-MeHis2) thyrotropin releasing hormone to brain and pituitary membranes of morphine tolerant-dependent and abstinent rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:1

    Topics: Animals; Brain; Cell Membrane; Drug Tolerance; Male; Morphine; Morphine Dependence; Naloxone; Pituit

1989
Abnormalities in thyroid function associated with chronic therapy with methadone.
    Clinical chemistry, 1988, Volume: 34, Issue:11

    Topics: Adolescent; Adult; Female; Humans; Male; Methadone; Substance Withdrawal Syndrome; Thyroid Gland; Th

1988
Thyroid function during the rebound phase following the discontinuation of antithyroid drugs.
    Endocrinology, 1967, Volume: 80, Issue:1

    Topics: Animals; Deficiency Diseases; Diiodotyrosine; Humans; Iodine; Perchlorates; Propylthiouracil; Rats;

1967
Rebound phenomena in thyroid function after withdrawal of propylthiouracil in growing chicks.
    General and comparative endocrinology, 1971, Volume: 17, Issue:3

    Topics: Animals; Body Weight; Chickens; Diiodotyrosine; Humans; Iodides; Iodine Isotopes; Male; Monoiodotyro

1971