triiodothyronine has been researched along with Shock, Septic in 17 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure." | 1.62 | Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association? ( Apostolaki, V; Kokkinos, L; Mourouzis, I; Pantos, C; Trikas, A, 2021) |
| "After sepsis was cured, there was no hormonal change, except in 3 NT." | 1.42 | Nonthyroidal illnesses syndrome in full-term newborns with sepsis. ( Araujo, MC; Carvalho, WB; Ceccon, ME; Diniz, EM; Silva, MH, 2015) |
| "Twenty-four children (13 boys) with septic shock and 25 children (14 boys) with sepsis were enrolled." | 1.34 | Thyroid function in children with sepsis and septic shock. ( Arun, S; Kabra, SK; Lodha, R; Sarthi, M; Vivekanandhan, S, 2007) |
| "Septic shock is the reason of human body organs dysfunctions including the hormonal system." | 1.33 | [Assessment of the release of thyroid hormones in septic shock--prognostic significance]. ( Borkowski, J; Czaban, SL; Jedynak, M; Siemiatkowski, A; Wołczyński, S, 2005) |
| "One hour of hemorrhagic shock in the dog produces alterations in thyroid hormone metabolism far exceeding those seen after elective surgery or thermal injury." | 1.27 | Thyroid hormone responses in hemorrhagic shock: study in dogs and preliminary findings in humans. ( Cowley, RA; Lang, DJ; Shatney, CH; Vitek, V, 1983) |
| "In acute septic shock circulating T3-concentrations are decreased." | 1.26 | Treatment of dopamine-dependent shock with triiodothyronine. ( Hesch, RD; Höffken, B; Hüsch, M; Ködding, R; Meyer, T, 1981) |
| "Triiodothyronine (T3) was administered to 11 patients in septic shock." | 1.26 | [Treatment of dopamine-dependent shock with triiodothyronine: prelimary results (author's transl)]. ( Hesch, RD; Höffken, B; Hüsch, M; Ködding, R; Meyer, T; van den Berg, E, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Vidart, J | 1 |
| Axelrud, L | 1 |
| Braun, AC | 1 |
| Marschner, RA | 1 |
| Wajner, SM | 1 |
| Pantos, C | 1 |
| Apostolaki, V | 1 |
| Kokkinos, L | 1 |
| Trikas, A | 1 |
| Mourouzis, I | 1 |
| Silva, MH | 1 |
| Araujo, MC | 1 |
| Diniz, EM | 1 |
| Ceccon, ME | 1 |
| Carvalho, WB | 1 |
| Maiden, MJ | 1 |
| Chapman, MJ | 1 |
| Torpy, DJ | 1 |
| Kuchel, TR | 1 |
| Clarke, IJ | 1 |
| Nash, CH | 1 |
| Fraser, JD | 1 |
| Ludbrook, GL | 1 |
| Meyer, S | 1 |
| Schuetz, P | 1 |
| Wieland, M | 1 |
| Nusbaumer, C | 1 |
| Mueller, B | 1 |
| Christ-Crain, M | 1 |
| Yildizdaş, D | 1 |
| Onenli-Mungan, N | 1 |
| Yapicioğlu, H | 1 |
| Topaloğlu, AK | 1 |
| Sertdemir, Y | 1 |
| Yüksel, B | 1 |
| Borkowski, J | 1 |
| Siemiatkowski, A | 1 |
| Wołczyński, S | 1 |
| Czaban, SL | 1 |
| Jedynak, M | 1 |
| Lodha, R | 1 |
| Vivekanandhan, S | 1 |
| Sarthi, M | 1 |
| Arun, S | 1 |
| Kabra, SK | 1 |
| Müller, MJ | 1 |
| Hesch, RD | 3 |
| Zouaghi, H | 1 |
| Savu, L | 1 |
| Delorme, J | 1 |
| Kleinknecht, D | 1 |
| Nunez, EA | 1 |
| Vitek, V | 1 |
| Shatney, CH | 1 |
| Lang, DJ | 1 |
| Cowley, RA | 1 |
| Goretzki, PE | 1 |
| Cavalieri, RR | 1 |
| Wahl, RA | 1 |
| Ellis, RJ | 1 |
| McMahon, FA | 1 |
| Goldfien, S | 1 |
| Gerend, P | 1 |
| Clark, OH | 1 |
| Hüsch, M | 2 |
| Ködding, R | 2 |
| Höffken, B | 2 |
| Meyer, T | 2 |
| Dulchavsky, SA | 1 |
| Lucas, CE | 1 |
| Ledgerwood, AM | 1 |
| Grabow, D | 1 |
| Brown, TR | 1 |
| Bagchi, N | 1 |
| van den Berg, E | 1 |
| Dennhardt, R | 1 |
| Gramm, HJ | 1 |
| Meinhold, K | 1 |
| Voigt, K | 1 |
| Hadjikostova, H | 1 |
| Nicolov, NA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection (Thy-Support)[NCT04348513] | Phase 2 | 5 participants (Actual) | Interventional | 2020-05-29 | Terminated (stopped due to Due to specific inclusion criteria no more subjects could be enrolled.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for triiodothyronine and Shock, Septic
| Article | Year |
|---|---|
Syndromes related to defective iodothyronine metabolism.
Topics: Body Temperature Regulation; Catecholamines; Glucose; Humans; Infant, Newborn; Iodide Peroxidase; Ke | 1984 |
1 trial available for triiodothyronine and Shock, Septic
| Article | Year |
|---|---|
Thyroid hormone levels and their relationship to survival in children with bacterial sepsis and septic shock.
Topics: Bacteremia; Child; Child, Preschool; Female; Humans; Male; Matched-Pair Analysis; Predictive Value o | 2004 |
15 other studies available for triiodothyronine and Shock, Septic
| Article | Year |
|---|---|
Relationship among Low T3 Levels, Type 3 Deiodinase, Oxidative Stress, and Mortality in Sepsis and Septic Shock: Defining Patient Outcomes.
Topics: Humans; Iodide Peroxidase; Oxidative Stress; Prospective Studies; ROC Curve; Shock, Septic; Triiodot | 2023 |
Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association?
Topics: Blood Sedimentation; COVID-19; Critical Illness; Erythrocytes; Humans; SARS-CoV-2; Sepsis; Shock, Se | 2021 |
Nonthyroidal illnesses syndrome in full-term newborns with sepsis.
Topics: Disease Progression; Euthyroid Sick Syndromes; Humans; Infant; Infant, Newborn; Sepsis; Shock, Septi | 2015 |
Triiodothyronine Administration in a Model of Septic Shock: A Randomized Blinded Placebo-Controlled Trial.
Topics: Animals; Anti-Inflammatory Agents; Arterial Pressure; Disease Models, Animal; Drug Therapy, Combinat | 2016 |
Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
Topics: Aged; Biomarkers; Critical Care; Euthyroid Sick Syndromes; Female; Health Status Indicators; Humans; | 2011 |
[Assessment of the release of thyroid hormones in septic shock--prognostic significance].
Topics: Adult; Aged; Case-Control Studies; Euthyroid Sick Syndromes; Humans; Male; Middle Aged; Predictive V | 2005 |
Thyroid function in children with sepsis and septic shock.
Topics: Child; Female; Humans; Male; Prospective Studies; Sepsis; Shock, Septic; Thyroid Hormones; Thyrotrop | 2007 |
Loss of serum transcortin in human shock associated with severe infection by candida albicans.
Topics: Adult; Candidiasis; Female; Haptoglobins; Humans; Hydrocortisone; Male; Prealbumin; Progesterone; Se | 1983 |
Thyroid hormone responses in hemorrhagic shock: study in dogs and preliminary findings in humans.
Topics: Adult; Animals; Dogs; Female; Humans; Male; Pilot Projects; Shock, Hemorrhagic; Shock, Septic; Thyro | 1983 |
Serum and tissue T3 levels in endotoxin shock in the rat.
Topics: Animals; Endotoxins; Female; Injections, Intraperitoneal; Kidney; Liver; Methylprednisolone; Propran | 1983 |
Treatment of dopamine-dependent shock with triiodothyronine.
Topics: Dopamine; Humans; Pilot Projects; Shock, Septic; Triiodothyronine | 1981 |
Triiodothyronine (T3) improves cardiovascular function during hemorrhagic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Male; Shock, Septic; Thyrot | 1993 |
[Treatment of dopamine-dependent shock with triiodothyronine: prelimary results (author's transl)].
Topics: Blood Pressure; Dopamine; Humans; Shock, Septic; Time Factors; Triiodothyronine | 1979 |
Patterns of endocrine secretion during sepsis.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Diiodothyronines; Hormones; Humans; Hyd | 1989 |
Changes in thyrotropic hormone, triiodothyronine and thyroxine level in endotoxin shock in rats.
Topics: Animals; Male; Rats; Rats, Inbred Strains; Shock, Septic; Thyrotropin; Thyroxine; Triiodothyronine | 1985 |