triiodothyronine has been researched along with Sepsis in 39 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Excerpt | Relevance | Reference |
---|---|---|
"The principal thyroxine (T4) binding proteins were measured in 8 septic patients and 8 controls to determine the extent to which a decrease in their concentration contributes to the decrease in serum T4 in sepsis." | 9.09 | Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis. ( Afandi, B; Schussler, GC; Vera, R; Yap, MG, 2000) |
"Despite major advances, the treatment of sepsis is still a challenging problem for surgeons." | 5.38 | Comparison of the therapeutic effects of tri-iodothyronine and methylprednisolone during early sepsis in laboratory animals. ( Coskun, F; Dolapci, I; Kulah, B; Ozer, MV; Saylam, B; Sungur, A, 2012) |
"The "sick euthyroid syndrome" is also seen in association with significant illnesses and consists of decreased levels of circulating triiodothyronine (T3)." | 5.31 | The effects of triiodothyronine augmentation on antithrombin III levels in sepsis. ( Chapital, AD; Hendrick, SR; Lloyd, L; Pieper, D, 2001) |
"To analyse the influence of selenium substitution on thyroid hormone metabolism in patients with severe sepsis." | 5.11 | Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients. ( Angstwurm, MW; Gaertner, R; Schopohl, J, 2004) |
"The principal thyroxine (T4) binding proteins were measured in 8 septic patients and 8 controls to determine the extent to which a decrease in their concentration contributes to the decrease in serum T4 in sepsis." | 5.09 | Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis. ( Afandi, B; Schussler, GC; Vera, R; Yap, MG, 2000) |
" The cord separation time, gender, mode of delivery, presence of sepsis, duration of antibiotic treatment, serum free thyroxine, free triiodothyronine (FT3), thyroid-stimulating hormone, lowest leukocyte, polymorphonuclear leukocytes (PMNLs), and platelet counts were recorded." | 4.12 | Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates. ( Arslan, Z; Bas, AY; Demirel, N; Tokgoz-Cuni, B; Ulubas-Isik, D; Unal, S, 2022) |
"Studies have documented a correlation between hypothyroxinemia and mortality in critically ill patients; however, there are limited data in sepsis." | 3.78 | The identification of thyroid dysfunction in surgical sepsis. ( Moore, FA; Moore, LJ; Sim, V; Sucher, JF; Todd, SR; Turner, KL, 2012) |
" Twenty patients suffering from severe non-endocrine diseases (septicaemia, fulminant hepatic and renal failure, acute pancreatitis, polytrauma, cerebral haemorrhage) were found to have serum thyroxine levels in the hypothyroid range (less than 4 micrograms/dl)." | 3.66 | Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome". ( Bratusch-Marrain, P; Grubeck-Loebenstein, B; Kleinberger, G; Vierhapper, H; Waldhäusl, W, 1982) |
"Depressed triiodothyronine and elevated reverse triiodothyronine levels are commonly seen in patients with acute and chronic illness and in patients receiving markedly hypocaloric diets." | 3.66 | Altered thyroid hormone levels in bacterial sepsis: the role of nutritional adequacy. ( Molitch, ME; O'Donnell, TF; Richmand, DA, 1980) |
"Tissue hypoxia is one of the main pathophysiologic mechanisms in sepsis and particularly in COVID-19." | 2.82 | The Potential of Thyroid Hormone Therapy in Severe COVID-19: Rationale and Preliminary Evidence. ( Alexandrou, N; Apostolaki, V; Avdikou, M; Giannoulopoulou, M; Kokkinos, L; Mourouzis, I; Pantos, C; Trikas, A; Tseti, I; Vassi, A, 2022) |
"Sepsis is a systemic inflammatory response syndrome with high mortality, which results from severe infection and can lead to secondary organ dysfunction." | 2.55 | Thyroid hormone disorders and sepsis. ( Li, Y; Luo, B; Yu, Z, 2017) |
"Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure." | 1.62 | Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association? ( Apostolaki, V; Kokkinos, L; Mourouzis, I; Pantos, C; Trikas, A, 2021) |
"Triiodothyronine (T3) was markedly raised with normal TSH receptor antibodies, and the patient later confessed to supplementary testosterone and T3 use as part of bodybuilding activities." | 1.56 | Delayed diagnosis of T3 supplementation in a bodybuilder presenting with tachycardia and features of sepsis. ( Pal, A; Warner, BE; Woodrow, CJ, 2020) |
"Sepsis is a life-threatening organ dysfunction caused by a dysregulated host reaction to infection." | 1.51 | Thyroid hormones as potential prognostic factors in sepsis. ( Dudek, A; Foks, M; Fronczek, J; Nowak-Kózka, I; Polok, K; Szczeklik, W, 2019) |
"Sepsis was a systemic response to a local infection." | 1.43 | Sepsis leads to thyroid impairment and dysfunction in rat model. ( Lin, X; Shi, S, 2016) |
"After sepsis was cured, there was no hormonal change, except in 3 NT." | 1.42 | Nonthyroidal illnesses syndrome in full-term newborns with sepsis. ( Araujo, MC; Carvalho, WB; Ceccon, ME; Diniz, EM; Silva, MH, 2015) |
"Despite major advances, the treatment of sepsis is still a challenging problem for surgeons." | 1.38 | Comparison of the therapeutic effects of tri-iodothyronine and methylprednisolone during early sepsis in laboratory animals. ( Coskun, F; Dolapci, I; Kulah, B; Ozer, MV; Saylam, B; Sungur, A, 2012) |
"Compared with the control group and non-severe sepsis cases, the levels of free T3 (FT3), free T4 (FT4), T3, T4 and monocyte HLA-DR expression were significantly lower in severe sepsis cases (P<0." | 1.36 | [Changes of thyroxin and monocyte human leukocyte antigen-DR expression in senior patients with sepsis]. ( Feng, DG; Guo, ZH; Su, L; Wu, J; Xiong, RC; Xu, C; Yu, Z; Zhang, YY, 2010) |
"Twenty-four children (13 boys) with septic shock and 25 children (14 boys) with sepsis were enrolled." | 1.34 | Thyroid function in children with sepsis and septic shock. ( Arun, S; Kabra, SK; Lodha, R; Sarthi, M; Vivekanandhan, S, 2007) |
"The "sick euthyroid syndrome" is also seen in association with significant illnesses and consists of decreased levels of circulating triiodothyronine (T3)." | 1.31 | The effects of triiodothyronine augmentation on antithrombin III levels in sepsis. ( Chapital, AD; Hendrick, SR; Lloyd, L; Pieper, D, 2001) |
"Triiodothyronine (T3) was measured in serum and muscle tissue." | 1.27 | Studies on the possible role of thyroid hormone in altered muscle protein turnover during sepsis. ( Chen, IW; Fischer, JE; Hasselgren, PO; James, JH; Sperling, M; Warner, BW, 1987) |
"Iodine metabolism was studied by organ radioassay and by imaging with a multiwire proportional chamber (MWPC) at various time intervals after intravenous injection of 125I." | 1.26 | Marked suppression of thyroid function in rats with gram-negative septicemia. ( Chang, LT; Garcia, JF; Kan, MK; Linfoot, JA; McCrae, J; Perez-Mendez, V, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (23.08) | 18.7374 |
1990's | 5 (12.82) | 18.2507 |
2000's | 6 (15.38) | 29.6817 |
2010's | 12 (30.77) | 24.3611 |
2020's | 7 (17.95) | 2.80 |
Authors | Studies |
---|---|
Lin, X | 3 |
Chen, X | 1 |
Yang, CY | 1 |
Mourouzis, I | 2 |
Apostolaki, V | 2 |
Trikas, A | 2 |
Kokkinos, L | 2 |
Alexandrou, N | 1 |
Avdikou, M | 1 |
Giannoulopoulou, M | 1 |
Vassi, A | 1 |
Tseti, I | 1 |
Pantos, C | 2 |
Tu, F | 1 |
Yu, G | 1 |
Wu, W | 1 |
Xiang, J | 1 |
Wei, Z | 1 |
Liu, Q | 1 |
Fu, L | 3 |
Long, W | 3 |
Liu, T | 3 |
Chen, Y | 3 |
Wu, S | 3 |
Li, D | 3 |
Liu, K | 3 |
Gao, Y | 3 |
Luo, X | 3 |
Foks, M | 1 |
Dudek, A | 1 |
Polok, K | 1 |
Nowak-Kózka, I | 1 |
Fronczek, J | 1 |
Szczeklik, W | 1 |
Özozan, ÖV | 1 |
Ertorul, D | 1 |
Warner, BE | 1 |
Woodrow, CJ | 1 |
Pal, A | 1 |
Unal, S | 1 |
Demirel, N | 1 |
Arslan, Z | 1 |
Tokgoz-Cuni, B | 1 |
Ulubas-Isik, D | 1 |
Bas, AY | 1 |
Luo, B | 1 |
Yu, Z | 2 |
Li, Y | 1 |
Silva, MH | 1 |
Araujo, MC | 1 |
Diniz, EM | 1 |
Ceccon, ME | 1 |
Carvalho, WB | 1 |
Shi, S | 2 |
Wu, J | 1 |
Zhang, YY | 1 |
Feng, DG | 1 |
Xu, C | 1 |
Xiong, RC | 1 |
Guo, ZH | 1 |
Su, L | 1 |
Kurt, A | 1 |
Aygun, AD | 1 |
Sengul, I | 1 |
Sen, Y | 1 |
Citak Kurt, AN | 1 |
Ustundag, B | 1 |
Meyer, S | 1 |
Schuetz, P | 1 |
Wieland, M | 1 |
Nusbaumer, C | 1 |
Mueller, B | 2 |
Christ-Crain, M | 2 |
Dilli, D | 1 |
Dilmen, U | 1 |
Koenig, KF | 1 |
Potlukova, E | 1 |
Trendelenburg, M | 1 |
Coskun, F | 1 |
Saylam, B | 1 |
Kulah, B | 1 |
Dolapci, I | 1 |
Sungur, A | 1 |
Ozer, MV | 1 |
Todd, SR | 1 |
Sim, V | 1 |
Moore, LJ | 1 |
Turner, KL | 1 |
Sucher, JF | 1 |
Moore, FA | 1 |
Das, BK | 1 |
Agarwal, P | 1 |
Agarwal, JK | 1 |
Mishra, OP | 1 |
Angstwurm, MW | 1 |
Schopohl, J | 1 |
Gaertner, R | 1 |
Toyoda, N | 1 |
Nomura, E | 1 |
Nishikawa, M | 1 |
Lodha, R | 1 |
Vivekanandhan, S | 1 |
Sarthi, M | 1 |
Arun, S | 1 |
Kabra, SK | 1 |
Sokolov, IaA | 1 |
Chlok, TA | 1 |
Serova, TA | 1 |
Vierhapper, H | 2 |
Laggner, A | 1 |
Waldhäusl, W | 2 |
Grubeck-Loebenstein, B | 2 |
Kleinberger, G | 2 |
Bratusch-Marrain, P | 1 |
Schönberger, W | 1 |
Grimm, W | 1 |
Emmrich, P | 1 |
Gempp, W | 1 |
Richmand, DA | 1 |
Molitch, ME | 1 |
O'Donnell, TF | 1 |
Dulchavsky, SA | 3 |
Ksenzenko, SM | 1 |
Saba, AA | 1 |
Diebel, LN | 3 |
Davidson, SB | 1 |
Dutta, S | 1 |
Cullen, WJ | 1 |
Pinna, G | 1 |
Meinhold, H | 1 |
Hiedra, L | 1 |
Thoma, R | 1 |
Hoell, T | 1 |
Gräf, KJ | 1 |
Stoltenburg-Didinger, G | 1 |
Eravci, M | 1 |
Prengel, H | 1 |
Brödel, O | 1 |
Finke, R | 1 |
Baumgartner, A | 1 |
Raafat, AM | 1 |
Franko, AP | 1 |
Zafar, R | 1 |
Ksenzenko, S | 1 |
Afandi, B | 1 |
Vera, R | 1 |
Schussler, GC | 1 |
Yap, MG | 1 |
Chapital, AD | 1 |
Hendrick, SR | 1 |
Lloyd, L | 1 |
Pieper, D | 1 |
Kan, MK | 1 |
Garcia, JF | 1 |
McCrae, J | 1 |
Chang, LT | 1 |
Linfoot, JA | 1 |
Perez-Mendez, V | 1 |
Jia, XM | 1 |
Dennhardt, R | 1 |
Gramm, HJ | 1 |
Meinhold, K | 1 |
Voigt, K | 1 |
Hasselgren, PO | 1 |
Chen, IW | 1 |
James, JH | 1 |
Sperling, M | 1 |
Warner, BW | 1 |
Fischer, JE | 1 |
Shambaugh, GE | 1 |
Beisel, WR | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection (Thy-Support)[NCT04348513] | Phase 2 | 5 participants (Actual) | Interventional | 2020-05-29 | Terminated (stopped due to Due to specific inclusion criteria no more subjects could be enrolled.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for triiodothyronine and Sepsis
Article | Year |
---|---|
The Potential of Thyroid Hormone Therapy in Severe COVID-19: Rationale and Preliminary Evidence.
Topics: COVID-19 Drug Treatment; Humans; Hypoxia; Sepsis; Thyroid Hormones; Triiodothyronine | 2022 |
Thyroid hormone disorders and sepsis.
Topics: Animals; Blood Coagulation; Heart; Humans; Lung; Myocardium; Prognosis; Sepsis; Thyroid Hormones; Tr | 2017 |
[Low T3 syndrome, low T4 syndrome (euthyroid sick syndrome)].
Topics: Animals; Diabetes Complications; Diagnosis, Differential; Euthyroid Sick Syndromes; Humans; Liver Ci | 2006 |
2 trials available for triiodothyronine and Sepsis
Article | Year |
---|---|
Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients.
Topics: Antioxidants; APACHE; Critical Illness; Female; Glutathione; Humans; Iodide Peroxidase; Male; Middle | 2004 |
Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis.
Topics: Adult; Female; Humans; Immunodiffusion; Male; Middle Aged; Prealbumin; Protein Binding; Radioimmunoa | 2000 |
34 other studies available for triiodothyronine and Sepsis
Article | Year |
---|---|
An analysis of perinatal factors of low T3 syndrome in preterm neonates with a gestational age of 28-35 weeks.
Topics: Birth Weight; Dopamine; Euthyroid Sick Syndromes; Female; Gestational Age; Humans; Infant; Infant, N | 2021 |
Triiodothyronine enhances cardiac contractility in septic rats and probably through Akt-Caspase9 pathway to reduce septic-induced cardiomyocyte apoptosis.
Topics: Animals; Apoptosis; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Rats; Sepsis; Triiodothyronine | 2022 |
Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Topics: Case-Control Studies; Child; Humans; Leukocyte Count; Sepsis; Thyroid Function Tests; Triiodothyroni | 2022 |
Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Topics: Case-Control Studies; Child; Humans; Leukocyte Count; Sepsis; Thyroid Function Tests; Triiodothyroni | 2022 |
Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Topics: Case-Control Studies; Child; Humans; Leukocyte Count; Sepsis; Thyroid Function Tests; Triiodothyroni | 2022 |
Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.
Topics: Case-Control Studies; Child; Humans; Leukocyte Count; Sepsis; Thyroid Function Tests; Triiodothyroni | 2022 |
Thyroid hormones as potential prognostic factors in sepsis.
Topics: Aged; Female; Humans; Intensive Care Units; Male; Middle Aged; Poland; Prevalence; Prognosis; Prospe | 2019 |
Is tri-iodothyronine a better choice than activated protein C in sepsis treatment?
Topics: Animals; Disease Models, Animal; Hemoglobins; Intestines; Liver; Lung; Protein C; Rats; Recombinant | 2019 |
Delayed diagnosis of T3 supplementation in a bodybuilder presenting with tachycardia and features of sepsis.
Topics: Adult; Athletes; Delayed Diagnosis; Diagnosis, Differential; Humans; Male; Sepsis; Tachycardia; Test | 2020 |
Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates.
Topics: Anti-Bacterial Agents; Birth Weight; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Prema | 2022 |
Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association?
Topics: Blood Sedimentation; COVID-19; Critical Illness; Erythrocytes; Humans; SARS-CoV-2; Sepsis; Shock, Se | 2021 |
Nonthyroidal illnesses syndrome in full-term newborns with sepsis.
Topics: Disease Progression; Euthyroid Sick Syndromes; Humans; Infant; Infant, Newborn; Sepsis; Shock, Septi | 2015 |
Sepsis leads to thyroid impairment and dysfunction in rat model.
Topics: Animals; Apoptosis; Disease Models, Animal; Gene Expression Regulation; Humans; Rats; Sepsis; Thyroi | 2016 |
[Changes of thyroxin and monocyte human leukocyte antigen-DR expression in senior patients with sepsis].
Topics: Aged; Aged, 80 and over; Case-Control Studies; Female; HLA-DR Antigens; Humans; Male; Monocytes; Pne | 2010 |
Serum thyroid hormones levels are significantly decreased in septic neonates with poor outcome.
Topics: Anti-Bacterial Agents; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newbo | 2011 |
Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
Topics: Aged; Biomarkers; Critical Care; Euthyroid Sick Syndromes; Female; Health Status Indicators; Humans; | 2011 |
The role of interleukin-6 and C-reactive protein in non-thyroidal illness in premature infants followed in neonatal intensive care unit.
Topics: C-Reactive Protein; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Intensive Care Unit | 2012 |
MBL serum levels in patients with sepsis correlate with thyroid function but not with outcome.
Topics: Humans; Mannose-Binding Lectin; Sepsis; Thyroid Gland; Triiodothyronine | 2012 |
Comparison of the therapeutic effects of tri-iodothyronine and methylprednisolone during early sepsis in laboratory animals.
Topics: Animals; Glucocorticoids; Hormone Replacement Therapy; Hydrocortisone; Male; Methylprednisolone; Per | 2012 |
The identification of thyroid dysfunction in surgical sepsis.
Topics: Euthyroid Sick Syndromes; Female; Humans; Male; Middle Aged; Retrospective Studies; Sepsis; Thyrotro | 2012 |
Serum cortisol and thyroid hormone levels in neonates with sepsis.
Topics: Humans; Hydrocortisone; Infant, Newborn; Sepsis; Thyroid Hormones; Thyroxine; Triiodothyronine | 2002 |
Thyroid function in children with sepsis and septic shock.
Topics: Child; Female; Humans; Male; Prospective Studies; Sepsis; Shock, Septic; Thyroid Hormones; Thyrotrop | 2007 |
[Immunohormonal homeostasis in meningococcal meningitis].
Topics: Animals; Diabetes Mellitus, Experimental; Factor Analysis, Statistical; Guinea Pigs; Homeostasis; Hu | 1984 |
Impaired secretion of TSH in critically ill patients with 'low T4-syndrome'.
Topics: Adult; Aged; Bacterial Infections; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone | 1982 |
Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome".
Topics: Acute Disease; Acute Kidney Injury; Adolescent; Adult; Aged; Critical Care; Female; Hepatic Encephal | 1982 |
Reduction of mortality rate in premature infants by substitution of thyroid hormones.
Topics: Female; Germany, West; Humans; Hypothyroidism; Infant Mortality; Infant, Newborn; Infant, Premature; | 1981 |
Altered thyroid hormone levels in bacterial sepsis: the role of nutritional adequacy.
Topics: Acute Disease; Adult; Aged; Bacteria; Chronic Disease; Female; Humans; Male; Middle Aged; Nutritiona | 1980 |
Triiodothyronine (T3) supplementation maintains surfactant biochemical integrity during sepsis.
Topics: Animals; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Lung; Lung Compliance | 1995 |
Effect of sepsis and 3,5,3'-triiodothyronine replacement on myocardial integrity during oxidant challenge.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glutathione; L-Lactate Dehydrogenase; | 1996 |
Elevated 3,5-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors.
Topics: Astrocytoma; Brain Injuries; Brain Neoplasms; Craniocerebral Trauma; Diiodothyronines; Glioblastoma; | 1997 |
Effect of thyroid hormone (T3)-responsive changes in surfactant apoproteins on surfactant function during sepsis.
Topics: Animals; Blotting, Northern; Disease Models, Animal; Drug Evaluation, Preclinical; Lung Compliance; | 1997 |
The effects of triiodothyronine augmentation on antithrombin III levels in sepsis.
Topics: Analysis of Variance; Animals; Antithrombin III; Disease Models, Animal; Disseminated Intravascular | 2001 |
Marked suppression of thyroid function in rats with gram-negative septicemia.
Topics: Animals; Escherichia coli Infections; Iodine; Iodine Radioisotopes; Male; Proteus Infections; Proteu | 1976 |
[Dynamic changes in serum levels of T3 and T4 in burn patients and its clinical significance].
Topics: Adolescent; Adult; Aged; Burns; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; | 1990 |
Patterns of endocrine secretion during sepsis.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Diiodothyronines; Hormones; Humans; Hyd | 1989 |
Studies on the possible role of thyroid hormone in altered muscle protein turnover during sepsis.
Topics: Animals; Carbon Radioisotopes; Male; Muscle Proteins; Muscles; Phenylalanine; Rats; Rats, Inbred Str | 1987 |
Alterations in thyroid physiology during pneumococcal septicemia in the rat.
Topics: Animals; Iodine Isotopes; Mice; Pneumococcal Infections; Rats; Sepsis; Thyroid Function Tests; Thyro | 1966 |