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triiodothyronine and Seizures

triiodothyronine has been researched along with Seizures in 16 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)."7.68Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992)
" All women had a blood sample drawn in early pregnancy (median week 9), and the stored sample was used for measurement of free thyroxine and thyrotropin."3.88Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study. ( Andersen, S; Andersen, SL; Olsen, J; Vestergaard, P, 2018)
" We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU)."3.80Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. ( Gilbert, ME; Goodman, JH; McCloskey, DP; Ramos, RL, 2014)
" There were no alterations in body weight or plasma levels of triiodotHyronine (T3) and thyroxine (T4)."3.69Long-term antiepileptic effects of chronic intake of CNK-602A, a thyrotropin-releasing hormone analogue, on spontaneously epileptic rats. ( Fujita, Y; Ishihara, K; Kimura, K; Momiyama, T; Sasa, M; Serikawa, T; Todo, N, 1996)
"The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 micrograms/kg."3.69T3 deficiency prolongs convulsions induced by acute pentylenetetrazole. ( Chambert, G; Pacheco-Rosado, J; Quevedo-Corona, L; Zamudio-Hernández, SR, 1997)
"In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip)."3.68Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures. ( Bertolini, A; Marrama, D; Sandrini, M; Vergoni, AV, 1992)
"This is an overlooked scleromyxedema case of a 62-year-old female patient from 2-years ago."2.66Acute Encephalitic Syndrome Induced by Scleromyxedema. ( Anastasiadis, G; Karathanasi, V; Magira, EE; Malouchou, A; Mavropoulou, N; Siempos, II; Sykaras, A; Vourlakou, C, 2020)
"The seizures were controlled with phenobarbital, but the dog died 2 days after presentation."1.27Neurologic manifestations of cerebrovascular atherosclerosis associated with primary hypothyroidism in a dog. ( Patterson, JS; Rusley, MS; Zachary, JF, 1985)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's5 (31.25)18.2507
2000's1 (6.25)29.6817
2010's2 (12.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Magira, EE1
Malouchou, A1
Karathanasi, V1
Mavropoulou, N1
Siempos, II1
Vourlakou, C1
Sykaras, A1
Anastasiadis, G1
Andersen, SL1
Andersen, S1
Vestergaard, P1
Olsen, J1
Gilbert, ME1
Ramos, RL1
McCloskey, DP1
Goodman, JH1
Bolaris, S1
Constantinou, C1
Valcana, T1
Margarity, M1
Atterwill, CK1
Nutt, DJ1
Mellström, B1
Pipaón, C1
Naranjo, JR1
Perez-Castillo, A1
Santos, A1
Momiyama, T1
Ishihara, K1
Kimura, K1
Todo, N1
Fujita, Y1
Serikawa, T1
Sasa, M1
Surks, MI1
DeFesi, CR1
Pacheco-Rosado, J1
Quevedo-Corona, L1
Zamudio-Hernández, SR1
Chambert, G1
Alley, MC1
Killam, EK1
Stjernholm, MR1
Alsever, RN1
Rudolph, MC1
Sandrini, M1
Marrama, D1
Vergoni, AV1
Bertolini, A1
Patterson, JS1
Rusley, MS1
Zachary, JF1
Kulig, K1
Golightly, LK1
Rumack, BH1
Nelson, JH1
Fearnside, MR1
Grant, JM1

Reviews

1 review available for triiodothyronine and Seizures

ArticleYear
Acute Encephalitic Syndrome Induced by Scleromyxedema.
    The American journal of the medical sciences, 2020, Volume: 360, Issue:2

    Topics: Acute Febrile Encephalopathy; Biopsy; Blood Protein Electrophoresis; Brain; Coma; Diagnosis, Differe

2020

Other Studies

15 other studies available for triiodothyronine and Seizures

ArticleYear
Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study.
    Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:4

    Topics: Adult; Child; Child, Preschool; Denmark; Female; Fetal Development; Humans; Infant; Male; Neurodevel

2018
Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics.
    Journal of neuroendocrinology, 2014, Volume: 26, Issue:8

    Topics: Animals; Brain; Classical Lissencephalies and Subcortical Band Heterotopias; Dose-Response Relations

2014
Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain.
    Neuropharmacology, 2005, Volume: 48, Issue:6

    Topics: Animals; Blotting, Northern; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Female; Gen

2005
Thyroid hormones do not alter rat brain benzodiazepine receptor function in-vivo.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:11

    Topics: Animals; Brain; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Thyr

1983
Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.
    Endocrinology, 1994, Volume: 135, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Corpus Striatum; DNA-Binding Proteins; Early Grow

1994
Long-term antiepileptic effects of chronic intake of CNK-602A, a thyrotropin-releasing hormone analogue, on spontaneously epileptic rats.
    Epilepsia, 1996, Volume: 37, Issue:4

    Topics: Administration, Oral; Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Eating; Epilep

1996
Normal serum free thyroid hormone concentrations in patients treated with phenytoin or carbamazepine. A paradox resolved.
    JAMA, 1996, May-15, Volume: 275, Issue:19

    Topics: Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Carrier Proteins; Humans; Phenytoin; Seizur

1996
T3 deficiency prolongs convulsions induced by acute pentylenetetrazole.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1997, Volume: 29, Issue:11

    Topics: Animals; Antithyroid Agents; Colon; Convulsants; Drug Overdose; Male; Methimazole; Pentylenetetrazol

1997
Disparity of effects of thyroxine and triiodothyronine on photic seizures and behavior in the baboon.
    Proceedings of the Western Pharmacology Society, 1976, Volume: 19

    Topics: Animals; Behavior, Animal; Haplorhini; Heart Rate; Male; Papio; Photic Stimulation; Seizures; Thyrox

1976
Thyroid-function tests in diphenylhydantoin-treated patients.
    Clinical chemistry, 1975, Volume: 21, Issue:10

    Topics: Adult; Binding, Competitive; Female; Humans; Male; Phenytoin; Pregnancy; Protein Binding; Seizures;

1975
Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
    Life sciences, 1992, Volume: 51, Issue:10

    Topics: Animals; Binding Sites; Cerebral Cortex; Flunitrazepam; Hippocampus; Hyperthyroidism; Isoniazid; Mal

1992
Neurologic manifestations of cerebrovascular atherosclerosis associated with primary hypothyroidism in a dog.
    Journal of the American Veterinary Medical Association, 1985, Mar-01, Volume: 186, Issue:5

    Topics: Animals; Brain; Coma; Dog Diseases; Dogs; Female; Hypothyroidism; Intracranial Arteriosclerosis; Mus

1985
Levothyroxine overdose associated with seizures in a young child.
    JAMA, 1985, Oct-18, Volume: 254, Issue:15

    Topics: Child, Preschool; Humans; Male; Seizures; Thyroxine; Time Factors; Triiodothyronine

1985
Selecting the optimum oral contraceptive.
    The Journal of reproductive medicine, 1973, Volume: 11, Issue:4

    Topics: Acne Vulgaris; Blood Coagulation Disorders; Brain Edema; Breast; Candidiasis; Capillaries; Carbohydr

1973
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases.
    Journal of neurosurgery, 1972, Volume: 36, Issue:4

    Topics: Adenoma, Acidophil; Adult; Ampicillin; Anticonvulsants; Child; Craniotomy; Encephalitis; Herpes Simp

1972