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triiodothyronine and Scleroderma, Systemic

triiodothyronine has been researched along with Scleroderma, Systemic in 6 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

Research Excerpts

ExcerptRelevanceReference
" The aim of this study was therefore to evaluate the effect of propylthiouracil (PTU), and of the hypothyroidism induced by it, on the development of cutaneous and pulmonary fibrosis in the oxidant stress murine model of SSc."7.79Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis. ( Altavilla, D; Atteritano, M; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Pizzino, G; Roberts, W; Saitta, A; Sangari, D; Squadrito, F, 2013)
" The aim of this study was therefore to evaluate the effect of propylthiouracil (PTU), and of the hypothyroidism induced by it, on the development of cutaneous and pulmonary fibrosis in the oxidant stress murine model of SSc."3.79Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis. ( Altavilla, D; Atteritano, M; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Pizzino, G; Roberts, W; Saitta, A; Sangari, D; Squadrito, F, 2013)
"The underlying diseases were systemic lupus erythematosus (n = 5), systemic sclerosis (n = 3) and rheumatoid arthritis (n = 1)."1.28Treatment of Raynaud's phenomenon with triiodothyronine corrects co-existent autonomic dysfunction: preliminary findings. ( Dessein, PH; Gledhill, RF; Van der Merwe, CA, 1992)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bagnato, G2
Bitto, A1
Irrera, N1
Pizzino, G1
Sangari, D1
Cinquegrani, M1
Roberts, W1
Atteritano, M1
Altavilla, D1
Squadrito, F1
Saitta, A1
Marasini, B1
Ferrari, PA1
Solaro, N1
Selmi, C1
Molnár, I1
Balázs, C1
Szabó, E1
Czirják, L1
Gledhill, RF1
Dessein, PH1
Van der Merwe, CA1
Serup, J1
Hangdrup, H1

Other Studies

6 other studies available for triiodothyronine and Scleroderma, Systemic

ArticleYear
Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis.
    Arthritis research & therapy, 2013, Sep-16, Volume: 15, Issue:5

    Topics: Actins; Animals; Antithyroid Agents; Blotting, Western; Disease Models, Animal; Extracellular Signal

2013
Thyroid dysfunction in women with systemic sclerosis.
    Annals of the New York Academy of Sciences, 2007, Volume: 1108

    Topics: Autoantibodies; Biomarkers; Female; Humans; Iodide Peroxidase; Mass Screening; Middle Aged; Risk Fac

2007
Evaluation of thyroid function and anti-thyroid autoantibodies in systemic sclerosis.
    Acta dermato-venereologica, 1992, Volume: 72, Issue:2

    Topics: Adult; Autoantibodies; Female; Humans; Iodide Peroxidase; Male; Microsomes; Middle Aged; Scleroderma

1992
Treatment of Raynaud's phenomenon with triiodothyronine corrects co-existent autonomic dysfunction: preliminary findings.
    Postgraduate medical journal, 1992, Volume: 68, Issue:798

    Topics: Adult; Arousal; Arthritis, Rheumatoid; Autonomic Nervous System Diseases; Blood Pressure; Dose-Respo

1992
Thyroid hormones in generalized scleroderma. A controlled study.
    Acta dermato-venereologica, 1986, Volume: 66, Issue:1

    Topics: Adolescent; Adult; Aged; Female; Humans; Immunoglobulin G; Immunoglobulins, Thyroid-Stimulating; Mal

1986
Hydroxyproline and collagen metabolism. Clinical implications.
    Annals of internal medicine, 1965, Volume: 63, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Child; Child, Preschool; Collagen; Female; Gelatin;

1965