triiodothyronine has been researched along with Schizophrenia in 45 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy." | 9.22 | Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia. ( Bunevicius, A; Bunevicius, R; Nemeroff, CB; Prange, AJ; Savickas, A; Steibliene, V, 2016) |
| "Thyroid function was assessed in 38 adult DSM-IV-diagnosed schizophrenia patients after 6 weeks of prospective, double-blind, randomized treatment with quetiapine (400 mg/day), risperidone (4 mg/day), or fluphenazine (12." | 9.11 | Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. ( Conley, RR; Kelly, DL, 2005) |
| "In this study, 93 chronic inpatients with schizophrenia were comprehensively investigated in order to examine the association of psychiatric and extrapyramidal symptoms with prolactin, thyroid hormones (free triiodothyronine (T₃), free thyroxine (T₄), thyroid stimulating hormone), cortisol and BDNF." | 7.78 | Triiodothyronine may be possibly associated with better cognitive function and less extrapyramidal symptoms in chronic schizophrenia. ( Hoaki, N; Hoaki, T; Ichioka, S; Matsushita, T; Terao, T, 2012) |
| "In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy." | 5.22 | Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia. ( Bunevicius, A; Bunevicius, R; Nemeroff, CB; Prange, AJ; Savickas, A; Steibliene, V, 2016) |
| "Thyroid function was assessed in 38 adult DSM-IV-diagnosed schizophrenia patients after 6 weeks of prospective, double-blind, randomized treatment with quetiapine (400 mg/day), risperidone (4 mg/day), or fluphenazine (12." | 5.11 | Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. ( Conley, RR; Kelly, DL, 2005) |
| "In this study, 93 chronic inpatients with schizophrenia were comprehensively investigated in order to examine the association of psychiatric and extrapyramidal symptoms with prolactin, thyroid hormones (free triiodothyronine (T₃), free thyroxine (T₄), thyroid stimulating hormone), cortisol and BDNF." | 3.78 | Triiodothyronine may be possibly associated with better cognitive function and less extrapyramidal symptoms in chronic schizophrenia. ( Hoaki, N; Hoaki, T; Ichioka, S; Matsushita, T; Terao, T, 2012) |
| "The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %." | 1.42 | Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. ( Degner, D; Haust, M; Meller, J; Reulbach, U; Rüther, E, 2015) |
| "Lithium carbonate was administered for 8 weeks at a dosage giving a mean serum level of 0." | 1.29 | Possible inhibitory effect of lithium on peripheral conversion of thyroxine to triiodothyronine: a prospective study. ( Nozaki, S; Oga, T; Ohta, A; Okada, M; Otsubo, Y; Terao, T; Yamamoto, S; Zamami, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (68.89) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 4 (8.89) | 24.3611 |
| 2020's | 3 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ouyang, H | 1 |
| Huang, M | 1 |
| Chen, S | 1 |
| Wu, X | 1 |
| Zhou, D | 1 |
| Tost, M | 1 |
| Monreal, JA | 1 |
| Armario, A | 1 |
| Barbero, JD | 1 |
| Cobo, J | 1 |
| García-Rizo, C | 1 |
| Bioque, M | 1 |
| Usall, J | 1 |
| Huerta-Ramos, E | 1 |
| Soria, V | 1 |
| Labad, J | 1 |
| Misiak, B | 1 |
| Stańczykiewicz, B | 1 |
| Wiśniewski, M | 1 |
| Bartoli, F | 1 |
| Carra, G | 1 |
| Cavaleri, D | 1 |
| Samochowiec, J | 1 |
| Jarosz, K | 1 |
| Rosińczuk, J | 1 |
| Frydecka, D | 1 |
| Radhakrishnan, R | 1 |
| Calvin, S | 1 |
| Singh, JK | 1 |
| Thomas, B | 1 |
| Srinivasan, K | 1 |
| Degner, D | 1 |
| Haust, M | 1 |
| Meller, J | 1 |
| Rüther, E | 1 |
| Reulbach, U | 1 |
| Steibliene, V | 1 |
| Bunevicius, A | 1 |
| Savickas, A | 1 |
| Prange, AJ | 4 |
| Nemeroff, CB | 1 |
| Bunevicius, R | 1 |
| Ichioka, S | 1 |
| Terao, T | 2 |
| Hoaki, N | 1 |
| Matsushita, T | 1 |
| Hoaki, T | 1 |
| FLACH, FF | 3 |
| CELIAN, CI | 1 |
| STOKES, PE | 1 |
| RAWSON, RW | 1 |
| GALLAGHER, WJ | 1 |
| SCHROEPPEL, AB | 1 |
| PFEIFFER, CC | 1 |
| TOLAN, EJ | 1 |
| KOVITZ, B | 1 |
| DILLON, L | 1 |
| SIMPSON, GM | 3 |
| HARRIS, AH | 1 |
| Lochner, KH | 1 |
| Scheuing, MR | 2 |
| CRANSWICK, EH | 1 |
| BLAIR, JH | 1 |
| Kelly, DL | 1 |
| Conley, RR | 1 |
| Rinieris, P | 2 |
| Christodoulou, GN | 1 |
| Souvatzoglou, A | 2 |
| Koutras, DA | 2 |
| Stefanis, C | 2 |
| Naber, D | 1 |
| Steinböck, H | 1 |
| Greil, W | 1 |
| DeMilio, L | 1 |
| Kobayashi, K | 1 |
| Nakaoka, K | 1 |
| Tsuji, H | 1 |
| Shohmori, T | 1 |
| Loosen, PT | 2 |
| Extein, I | 2 |
| Pottash, AL | 1 |
| Gold, MS | 2 |
| Cowdry, RW | 1 |
| Oga, T | 1 |
| Nozaki, S | 1 |
| Ohta, A | 1 |
| Otsubo, Y | 1 |
| Yamamoto, S | 1 |
| Zamami, M | 1 |
| Okada, M | 1 |
| Yazici, K | 1 |
| Yazici, AE | 1 |
| Taneli, B | 1 |
| Wilson, IC | 1 |
| Meltzer, HY | 1 |
| Fang, VS | 1 |
| Murphy, DL | 1 |
| Belmaker, R | 1 |
| Carpenter, WT | 1 |
| Wyatt, RJ | 1 |
| Eggers, C | 1 |
| Turianitsa, IM | 1 |
| Lavkaĭ, IIu | 1 |
| Mishanich, II | 1 |
| Margitich, VM | 1 |
| Razhov, KF | 1 |
| Wang, X | 1 |
| Roca, RP | 1 |
| Blackman, MR | 1 |
| Ackerley, MB | 1 |
| Harman, SM | 1 |
| Gregerman, RI | 1 |
| Chopra, IJ | 1 |
| Solomon, DH | 1 |
| Huang, TS | 1 |
| Nakanishi, T | 2 |
| Kunitake, JM | 1 |
| Hartman, N | 1 |
| Henson, LC | 1 |
| Lieberman, J | 1 |
| Williams, DE | 1 |
| Wong, M | 1 |
| Hershman, JM | 1 |
| Baumgartner, A | 2 |
| Martinos, A | 1 |
| Papachristou, DN | 1 |
| Gräf, KJ | 1 |
| Kürten, I | 1 |
| Meinhold, H | 1 |
| Lavretskaia, EF | 1 |
| Tenidieva, VD | 1 |
| Lavretskaia, GI | 1 |
| Drucker, D | 1 |
| Josse, R | 1 |
| Stabenau, JR | 1 |
| Pollin, W | 1 |
| Stainbrook, E | 1 |
| West, ED | 1 |
| Walter, CJ | 1 |
| Wolpert, A | 1 |
| Yaryura-Tobias, JA | 1 |
| White, L | 1 |
| Merlis, S | 1 |
| Amuso, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for triiodothyronine and Schizophrenia
| Article | Year |
|---|---|
Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin.
Topics: Bipolar Disorder; Cognition Disorders; Depressive Disorder, Major; Humans; Hypothyroidism; Mood Diso | 2020 |
Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis.
Topics: Datasets as Topic; Humans; Psychotic Disorders; Schizophrenia; Thyroid Hormones; Thyrotropin; Thyrox | 2021 |
[Psychotropic drug therapy in children].
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
The hypothalamic-pituitary-thyroid axis in psychiatric patients and healthy subjects: Parts 1-4.
Topics: Adolescent; Adult; Aged; Arousal; Depressive Disorder; Female; Humans; Male; Middle Aged; Prognosis; | 1988 |
Psychotropic drugs and the thyroid axis: a review of interactions.
Topics: Animals; Body Temperature; Brain; Chlorpromazine; Depressive Disorder; Desipramine; Drug Interaction | 1985 |
6 trials available for triiodothyronine and Schizophrenia
| Article | Year |
|---|---|
Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Drug Synergism; Female; Humans; Male; Middle Aged | 2016 |
Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine.
Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Double-Blind Method; Drug Resistance; Female; Fluph | 2005 |
Effects of thyrotropin-releasing hormone in chronic schizophrenic patients.
Topics: Adult; Behavior; Blood Platelets; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Middl | 1980 |
Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients.
Topics: Adult; Chi-Square Distribution; Dexamethasone; Female; Follow-Up Studies; Growth Hormone; Humans; Ma | 2002 |
Behavioral and endocrine responses of schizophrenic patients to TRH (protirelin).
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Growth Hormone; Humans; Male; Prolacti | 1979 |
Monoamine oxidase in chronic schizophrenia: Studies of hormonal and other factors affecting enzyme activity.
Topics: Benzylamines; Blood Platelets; Chronic Disease; Clinical Trials as Topic; Female; Humans; Iron; Male | 1977 |
34 other studies available for triiodothyronine and Schizophrenia
| Article | Year |
|---|---|
Peripheral lower triiodothyronine levels related to interleukin-6 in patients with first-episode schizophrenia.
Topics: Humans; Interleukin-6; Psychiatric Status Rating Scales; Schizophrenia; Thyroid Function Tests; Trii | 2022 |
Thyroid dysfunction in major psychiatric disorders in a hospital based sample.
Topics: Adult; Bipolar Disorder; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Mood Di | 2013 |
Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients.
Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Bipolar Disorder; Depressive Disorder; Female; Human | 2015 |
Triiodothyronine may be possibly associated with better cognitive function and less extrapyramidal symptoms in chronic schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Basal Ganglia Diseases; Brain-Derived Neurotro | 2012 |
The influence of thyroid hormones on metabolism in psychiatric disorders. I. The effect of 3:5:3'-triiodothyronine on calcium and phosphorus metabolism in psychiatric patients.
Topics: Calcium; Calcium, Dietary; Humans; Mental Disorders; Phosphorus; Schizophrenia; Thyroid Hormones; Tr | 1959 |
Effects of reserpine, iproniazid (marsilid), and triiodothyronine (trionine), and of reserpine alone.
Topics: Iproniazid; Psychosurgery; Psychotic Disorders; Reserpine; Schizophrenia; Triiodothyronine | 1959 |
Treatment of chronic schizophrenics with liothyronine (L-triiodothyronine).
Topics: Humans; Schizophrenia; Triiodothyronine | 1960 |
The effect of tri-iodothyronine on abnormalities in the cerebrospinal fluid of chronic schizophrenic patients.
Topics: Cerebrospinal Fluid; Schizophrenia; Triiodothyronine | 1962 |
THE EFFECT OF L-TRIIODOTHYRONINE ON CHRONIC SCHIZOPHRENIC PATIENTS.
Topics: Biomedical Research; Humans; Placebos; Schizophrenia; Triiodothyronine | 1963 |
THYROID INDICES IN CHRONIC SCHIZOPHRENIA. II.
Topics: Behavior; Cardiomegaly; Cerebrospinal Fluid Proteins; Cholesterol; Hemoglobins; Humans; Iodine Isoto | 1964 |
THE EFFECT OF L-TRIIODOTHYRONINE ON CHRONIC SCHIZOPHRENIC PATIENTS.
Topics: Drug Therapy; Humans; Placebos; Schizophrenia; Triiodothyronine | 1964 |
Free-thyroxine index in schizophrenic patients before and after neuroleptic treatment.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Humans; Male; Middle Age | 1980 |
Effects of short- and long-term neuroleptic treatment on thyroid function.
Topics: Adult; Antipsychotic Agents; Female; Humans; Male; Schizophrenia; Thyroid Hormones; Thyrotropin; Thy | 1980 |
TRH response pattern in adolescent schizophrenic males.
Topics: Adolescent; Female; Growth Hormone; Humans; Male; Schizophrenia; Stimulation, Chemical; Thyrotropin; | 1984 |
Thyrotropin releasing hormone (TRH): a useful tool for psychoneuroendocrine investigation.
Topics: Adult; Alcoholism; Depression; Endocrine Glands; Female; Growth Hormone; Humans; Male; Middle Aged; | 1980 |
Using the protirelin test to distinguish mania from schizophrenia.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Female; Humans; Male; Schizophrenia; Thyrot | 1982 |
Possible inhibitory effect of lithium on peripheral conversion of thyroxine to triiodothyronine: a prospective study.
Topics: Adult; Aged; Chronic Disease; Hospitalization; Humans; Lithium Carbonate; Male; Middle Aged; Prospec | 1995 |
[Status of the thyroid gland in patients with schizophrenia].
Topics: Humans; Pituitary Function Tests; Pituitary Gland, Anterior; Schizophrenia; Thyroid Function Tests; | 1991 |
[Developments observation of serum thyrohormone level in schizophrenics].
Topics: Adult; Female; Humans; Male; Psychiatric Status Rating Scales; Psychotropic Drugs; Schizophrenia; Th | 1991 |
Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism.
Topics: Adult; Bipolar Disorder; Blood Pressure; Depressive Disorder; Down-Regulation; Feedback; Female; Hal | 1990 |
Serum thyrotropin in hospitalized psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Dementia; Depression; Female; Humans; Male; Mental | 1990 |
T3-toxicosis and T4-toxicosis in a schizophrenic patient: report on a rare case.
Topics: Adult; Humans; Male; Schizophrenia; Thyrotoxicosis; Thyroxine; Triiodothyronine | 1989 |
3,5,3'-triiodothyroacetic acid therapy for thyroid hormone resistance.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Hyperthyroidism; Lipids; Male; Pituitary Gl | 1989 |
Psychiatric applications of thyroid tests.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Diagnosis, Differential; Dr | 1986 |
Central thyroid stimulation in severely ill depressed, manic and schizophrenic patients.
Topics: Bipolar Disorder; Depressive Disorder; Dexamethasone; Humans; Pituitary Gland, Anterior; Schizophren | 1986 |
Effects of six weeks' neuroleptic treatment on the pituitary-thyroid axis in schizophrenic patients.
Topics: Adolescent; Adult; Chlorpromazine; Circadian Rhythm; Fluspirilene; Humans; Male; Pituitary Gland; Pr | 1986 |
T3-thyrotoxicosis in a schizophrenic patient--comment on triiodothyronine to mental function.
Topics: Adult; Humans; Male; Schizophrenia; Thyrotoxicosis; Triiodothyronine | 1988 |
[Hormonal profile of depressed patients].
Topics: Adult; Aged; Bipolar Disorder; Depression; Female; Growth Hormone; Hormones; Humans; Hydrocortisone; | 1987 |
Inappropriate TSH secretion with abnormal thyrotroph sensitivity to dopamine.
Topics: Dopamine; Humans; Hydrocortisone; Infusions, Parenteral; Male; Middle Aged; Pituitary Gland, Anterio | 1985 |
Adult protein-bound iodine and maturity at birth in monozygotic twins.
Topics: Adolescent; Adult; Analysis of Variance; Birth Weight; Blood Proteins; Female; Genetics, Medical; Hu | 1968 |
Clinical psychiatry.
Topics: Abortion, Spontaneous; Bipolar Disorder; Brain; Carbonates; Drug Therapy, Combination; Electric Stim | 1971 |
Effect of L-triiodothyronine and chlorpromazine on ankle reflex time and a clinical thyroid scale in schizophrenics and controls.
Topics: Adult; Ankle; Chlorpromazine; Humans; Reflex; Schizophrenia; Statistics as Topic; Triiodothyronine | 1968 |
Triiodothyronine and phenothiazines in schizophrenia.
Topics: Adult; Chlorpromazine; Female; Fluphenazine; Humans; Male; Middle Aged; Phenothiazines; Prochlorpera | 1969 |
Treatment of chronic schizophrenia with tri-iodothyronine.
Topics: Chlorpromazine; Humans; Pigmentation Disorders; Schizophrenia; Triiodothyronine | 1966 |