Page last updated: 2024-11-08

triiodothyronine and Renal Insufficiency, Chronic

triiodothyronine has been researched along with Renal Insufficiency, Chronic in 21 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)

Research Excerpts

ExcerptRelevanceReference
"A direct association between low triiodothyronine (T3) syndrome and cardiovascular (CV) mortality has been reported in hemodialysis patients."7.81Low Triiodothyronine Syndrome and Long-Term Cardiovascular Outcome in Incident Peritoneal Dialysis Patients. ( Chang, TI; Kang, EW; Nam, JY; Shin, SK, 2015)
"Concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3) and thyroid peroxidase antibody (TPOAb) were quantified in 12 785 black and white participants of the ongoing community-based prospective Atherosclerosis Risk in Communities study."3.85Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. ( Coresh, J; Daya, N; Grams, ME; Köttgen, A; Schultheiss, UT; Selvin, E; Seufert, J; Steffes, M, 2017)
" Serum concentrations of creatinine, urea, electrolytes and total proteins and albumin were measured as well."3.81Evaluation of thyroid hormone levels in chronic kidney disease patients. ( Chickballapur Rayappa, WD; Kumar, S; Rajeev, G; Swathi, M; Vijayalakshmi, R, 2015)
"A direct association between low triiodothyronine (T3) syndrome and cardiovascular (CV) mortality has been reported in hemodialysis patients."3.81Low Triiodothyronine Syndrome and Long-Term Cardiovascular Outcome in Incident Peritoneal Dialysis Patients. ( Chang, TI; Kang, EW; Nam, JY; Shin, SK, 2015)
"Oral sodium bicarbonate has been shown to improve nutritional status and preserve renal function in CKD."2.75Oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease. ( Disthabanchong, S; Treeruttanawanich, A, 2010)
"triiodothyronine) have been associated with adverse cardiovascular sequelae in CKD and ESRD patients, but these metrics are confounded by malnutrition, inflammation and comorbid states, and hence may signify nonthyroidal illness (i."2.52Thyroid functional disease: an under-recognized cardiovascular risk factor in kidney disease patients. ( Brent, GA; Brunelli, SM; Budoff, MJ; Kalantar-Zadeh, K; Kovesdy, CP; Nguyen, D; Rhee, CM; Soldin, OP, 2015)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.76)29.6817
2010's14 (66.67)24.3611
2020's6 (28.57)2.80

Authors

AuthorsStudies
Zhang, L1
Wu, Y1
Nie, Y1
Lv, W1
Li, Y1
Zhu, B1
Jin, S1
Shen, Z1
Li, F1
Liu, H1
Fang, Y1
Ding, X1
Li, S1
Zeng, M1
Shreewastav, RK1
Ghosh, AK1
Yadav, R1
Katuwal, A1
Shrestha, S1
Li, J1
Wu, X1
Luo, M1
Yan, M1
Wang, Q1
Li, P1
Niu, W1
Yamazaki, Y1
Shoji, T1
Miyashima, M1
Nagata, Y1
Kakutani, Y1
Ochi, A1
Morioka, T1
Nakatani, S1
Mori, K1
Tsujimoto, Y1
Emoto, M1
Reinhardt, W2
Mülling, N1
Behrendt, S2
Benson, S2
Dolff, S2
Führer, D2
Tan, S1
Singh, S1
Verma, A1
Aryal, G1
Thapa, S1
Khakurel, S1
Shrestha, K1
Aryee, NA1
Tagoe, EA1
Anomah, V1
Arko-Boham, B1
Adjei, DN1
Pan, B1
Du, X1
Zhang, H1
Hua, X1
Wan, X1
Cao, C1
Rhee, CM2
Brent, GA1
Kovesdy, CP1
Soldin, OP1
Nguyen, D1
Budoff, MJ1
Brunelli, SM1
Kalantar-Zadeh, K1
Xu, G1
Yan, Y1
Liu, Y2
Rajeev, G1
Chickballapur Rayappa, WD1
Vijayalakshmi, R1
Swathi, M1
Kumar, S1
Chang, TI1
Nam, JY1
Shin, SK1
Kang, EW1
Broecker-Preuß, M1
Hög, A1
Schomburg, L1
Köhrle, J1
Fan, J1
Yan, P1
Wang, Y1
Shen, B1
Ding, F1
Al-Mendalawi, MD1
Schultheiss, UT1
Daya, N1
Grams, ME1
Seufert, J1
Steffes, M1
Coresh, J1
Selvin, E1
Köttgen, A1
Furuya, F1
Ishii, T1
Tamura, S1
Takahashi, K1
Kobayashi, H1
Ichijo, M1
Takizawa, S1
Kaneshige, M1
Suzuki-Inoue, K1
Kitamura, K1
Abozenah, H1
Shoeb, S1
Sabry, A1
Ismail, H1
Disthabanchong, S1
Treeruttanawanich, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evalution of Thyroid Functions in Hemodialysis Children in Sohag University Hospital[NCT05451472]39 participants (Anticipated)Interventional2022-07-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for triiodothyronine and Renal Insufficiency, Chronic

ArticleYear
Thyroid functional disease: an under-recognized cardiovascular risk factor in kidney disease patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015, Volume: 30, Issue:5

    Topics: Animals; Cardiovascular Diseases; Comorbidity; Hormone Replacement Therapy; Humans; Hypothyroidism;

2015

Trials

1 trial available for triiodothyronine and Renal Insufficiency, Chronic

ArticleYear
Oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease.
    American journal of nephrology, 2010, Volume: 32, Issue:6

    Topics: Acidosis; Adult; Aged; Aged, 80 and over; Bicarbonates; Female; Humans; Male; Middle Aged; Prospecti

2010

Other Studies

19 other studies available for triiodothyronine and Renal Insufficiency, Chronic

ArticleYear
The serum free triiodothyronine to free thyroxine ratio as a potential prognostic biomarker of chronic kidney disease in patients with glomerular crescents: A retrospective study.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Albumins; Biomarkers; Creatinine; Humans; Immunosuppressive Agents; Natriuretic Peptide, Brain; Prog

2022
J-shaped association of free triiodothyronine to free thyroxine ratio with 5-year mortality among patients with chronic kidney disease: a prospective cohort study.
    International urology and nephrology, 2023, Volume: 55, Issue:10

    Topics: Cardiovascular Diseases; Humans; Nutrition Surveys; Prospective Studies; Renal Insufficiency, Chroni

2023
Subclinical Hypothyroidism among Chronic Kidney Disease Patients Admitted to Nephrology Department of a Tertiary Care Centre: A Descriptive Cross-sectional Study.
    JNMA; journal of the Nepal Medical Association, 2023, Apr-01, Volume: 61, Issue:260

    Topics: Cross-Sectional Studies; Humans; Hypothyroidism; Nephrology; Quality of Life; Renal Insufficiency, C

2023
Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Jun-22, Volume: 26

    Topics: Adult; Asian People; Biomarkers; China; Creatinine; Female; Humans; Male; Middle Aged; Renal Insuffi

2020
Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort.
    Journal of atherosclerosis and thrombosis, 2021, Oct-01, Volume: 28, Issue:10

    Topics: Aged; Cardiovascular Diseases; Cross-Sectional Studies; Female; Heart Disease Risk Factors; Humans;

2021
Association between albuminuria and thyroid function in patients with chronic kidney disease.
    Endocrine, 2021, Volume: 73, Issue:2

    Topics: Aged; Aged, 80 and over; Albuminuria; Humans; Middle Aged; Renal Insufficiency, Chronic; Thyroid Gla

2021
Thyroid hormone profile in patients with chronic kidney disease: a single centre study.
    Journal of Nepal Health Research Council, 2016, Volume: 14, Issue:34

    Topics: Adult; Age Factors; Creatinine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nepal; R

2016
Thyroid hormone status in Ghanaian patients with chronic kidney disease.
    The Pan African medical journal, 2018, Volume: 29

    Topics: Adult; Aged; Case-Control Studies; Creatinine; Female; Ghana; Glomerular Filtration Rate; Humans; In

2018
Relationships of Chronic Kidney Disease and Thyroid Dysfunction in Non-Dialysis Patients: A Pilot Study.
    Kidney & blood pressure research, 2019, Volume: 44, Issue:2

    Topics: Adult; Aged; Biomarkers; Euthyroid Sick Syndromes; Female; Glomerular Filtration Rate; Humans; Male;

2019
The cardiovascular disease risks of nonthyroidal illness syndrome and inflammatory responses on patients with chronic kidney disease: from the association to clinical prognosis.
    Cardiovascular therapeutics, 2014, Volume: 32, Issue:6

    Topics: Adult; Aged; Cardiovascular Diseases; Echocardiography; Female; Humans; Hypertrophy, Left Ventricula

2014
Evaluation of thyroid hormone levels in chronic kidney disease patients.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:1

    Topics: Case-Control Studies; Creatinine; Cross-Sectional Studies; Electrolytes; Female; Humans; Male; Middl

2015
Low Triiodothyronine Syndrome and Long-Term Cardiovascular Outcome in Incident Peritoneal Dialysis Patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2015, Jun-05, Volume: 10, Issue:6

    Topics: Adult; Aged; Cardiovascular Diseases; Female; Humans; Hypothyroidism; Incidence; Kaplan-Meier Estima

2015
Low-T3 Syndrome in Peritoneal Dialysis: Metabolic Adaptation, Marker of Illness, or Mortality Mediator?
    Clinical journal of the American Society of Nephrology : CJASN, 2015, Jun-05, Volume: 10, Issue:6

    Topics: Cardiovascular Diseases; Female; Humans; Hypothyroidism; Male; Peritoneal Dialysis; Renal Insufficie

2015
Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters.
    Thyroid : official journal of the American Thyroid Association, 2015, Volume: 25, Issue:10

    Topics: Aged; Aged, 80 and over; Female; Humans; Kidney Function Tests; Male; Middle Aged; Renal Dialysis; R

2015
Prevalence and Clinical Significance of Low T3 Syndrome in Non-Dialysis Patients with Chronic Kidney Disease.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Apr-08, Volume: 22

    Topics: Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Disease Progression; Female; Glomerula

2016
Remarks about the study on evaluation of thyroid hormone levels in chronic kidney disease patients.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2016, Volume: 27, Issue:3

    Topics: Female; Humans; Male; Renal Insufficiency, Chronic; Thyrotropin; Thyroxine; Triiodothyronine

2016
Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017, Nov-01, Volume: 32, Issue:11

    Topics: Atherosclerosis; Biomarkers; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hy

2017
The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities.
    Scientific reports, 2017, 03-08, Volume: 7

    Topics: Animals; Disease Models, Animal; Interleukin-1beta; Kidney Tubules; Ligands; Macrophages; Male; Mice

2017
Relation between thyroid hormone concentration and serum levels of interleukin-6 and interleukin-10 in patients with nonthyroidal illness including chronic kidney disease.
    Iranian journal of kidney diseases, 2008, Volume: 2, Issue:1

    Topics: Adult; Case-Control Studies; Euthyroid Sick Syndromes; Female; Humans; Interleukin-10; Interleukin-6

2008