Page last updated: 2024-11-08

triiodothyronine and Psoriasis

triiodothyronine has been researched along with Psoriasis in 15 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Research Excerpts

ExcerptRelevanceReference
"ADA activities were measured in plasma, erythrocyte and tissue samples of patients with psoriasis before and after 2 months of treatment with either PTU 100 mg three times daily or PTU plus thyroxine 25 microg once daily (to prevent possible hypothyroidism, which may be induced by PTU) as well as in healthy controls."9.09Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2001)
"ADA activities were measured in plasma, erythrocyte and tissue samples of patients with psoriasis before and after 2 months of treatment with either PTU 100 mg three times daily or PTU plus thyroxine 25 microg once daily (to prevent possible hypothyroidism, which may be induced by PTU) as well as in healthy controls."5.09Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2001)
"To determine the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions in middle-aged and older adults."4.31Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil). ( Bensenor, IM; de Almeida-Pititto, B; Goulart, AC; Lotufo, PA; Meneghini, V; Silva Janovsky, CCP; Souza Santos, I; Tebar, WR, 2023)
"TriAc in the dosage and formulation studied was safe but no more effective than placebo in treating plaque psoriasis."2.71Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial. ( Carlsson, B; Törmä, H; Vahlquist, A, 2004)
"The higher prevalence of autoimmune thyroiditis in the PsA group may be due to an immune dysfunction pathway in patients with psoriatic arthritis with a higher risk to develop other autoimmune diseases."1.62Is there any association between psoriasis, psoriatic arthritis and thyroid autoimmunity? ( Balato, A; Costa, L; Fabbrocini, G; Gallo, L; Lupoli, GA; Megna, M; Napolitano, M; Peluso, R; Tasso, M; Vastarella, M, 2021)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's2 (13.33)18.2507
2000's3 (20.00)29.6817
2010's2 (13.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Meneghini, V1
Tebar, WR1
Souza Santos, I1
Silva Janovsky, CCP1
de Almeida-Pititto, B1
Lotufo, PA1
Goulart, AC1
Bensenor, IM1
Namiki, K1
Kamata, M1
Shimizu, T1
Chijiwa, C1
Uchida, H1
Okinaga, S1
Harafuji, M1
Nagata, M1
Fukaya, S1
Hayashi, K1
Fukuyasu, A1
Tanaka, T1
Ishikawa, T1
Ohnishi, T1
Tada, Y1
Vastarella, M1
Megna, M1
Lupoli, GA1
Napolitano, M1
Gallo, L1
Balato, A1
Tasso, M1
Costa, L1
Fabbrocini, G1
Peluso, R1
Hansen, PR1
Isaksen, JL1
Jemec, GB1
Ellervik, C1
Kanters, JK1
Kiguradze, T1
Bruins, FM1
Guido, N1
Bhattacharya, T1
Rademaker, A1
Florek, AG1
Posligua, A1
Amin, S1
Laumann, AE1
West, DP1
Nardone, B1
Vahlquist, A1
Törmä, H1
Carlsson, B1
Angioni, AR1
Lania, A1
Cattaneo, A1
Beck-Peccoz, P1
Spada, A1
Weismann, K1
Verdich, J1
Howitz, J1
Hummer, L1
Giasuddin, AS1
El-Sherif, AI1
El-Ojali, SI1
Casado, M1
Martin, M1
Muñoz, A1
Bernal, J1
Köse, K1
Utaş, S1
Yazici, C1
Akdaş, A1
Keleştimur, F1
Baltabaev, TS1
Grice, K1
Blendis, LM1
Keir, MI1
Harvey, RF1
Lieberman, I1
Short, J1

Trials

2 trials available for triiodothyronine and Psoriasis

ArticleYear
Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial.
    The British journal of dermatology, 2004, Volume: 151, Issue:2

    Topics: Administration, Topical; Adult; Dermatologic Agents; Double-Blind Method; Female; Humans; Male; Midd

2004
Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis.
    The British journal of dermatology, 2001, Volume: 144, Issue:6

    Topics: Adenosine Deaminase; Adolescent; Adult; Aged; Biomarkers; Dermatologic Agents; Erythrocytes; Female;

2001

Other Studies

13 other studies available for triiodothyronine and Psoriasis

ArticleYear
Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil).
    Archives of endocrinology and metabolism, 2023, Jun-19, Volume: 67, Issue:6

    Topics: Aged; Brazil; Cross-Sectional Studies; Female; Humans; Hypothyroidism; Longitudinal Studies; Male; M

2023
Thyroid dysfunction in patients with psoriasis: Higher prevalence of thyroid dysfunction in patients with generalized pustular psoriasis.
    The Journal of dermatology, 2020, Volume: 47, Issue:2

    Topics: Adult; Aged; C-Reactive Protein; Female; Humans; Male; Middle Aged; Prevalence; Psoriasis; Retrospec

2020
Is there any association between psoriasis, psoriatic arthritis and thyroid autoimmunity?
    The Australasian journal of dermatology, 2021, Volume: 62, Issue:2

    Topics: Adult; Arthritis, Psoriatic; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Pro

2021
Thyroid function in psoriasis.
    The British journal of dermatology, 2019, Volume: 181, Issue:1

    Topics: Adult; Aged; Autoantibodies; Female; Humans; Iodide Peroxidase; Male; Middle Aged; Psoriasis; Severi

2019
Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross-sectional retrospective study.
    International journal of dermatology, 2017, Volume: 56, Issue:5

    Topics: Adult; Aged; Autoantibodies; Comorbidity; Cross-Sectional Studies; Female; Hashimoto Disease; Humans

2017
Effects of chronic retinoid administration on pituitary function.
    Journal of endocrinological investigation, 2005, Volume: 28, Issue:11

    Topics: Acitretin; Adult; Follicle Stimulating Hormone; Humans; Hydrocortisone; Insulin-Like Growth Factor I

2005
Normal function of the thyroid gland in PUVA-treated psoriatics.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Thera

1980
Prolactin: does it have a role in the pathogenesis of psoriasis?
    Dermatology (Basel, Switzerland), 1998, Volume: 197, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Child; Dermatitis, Atopic; Female; Humans; Male; Middle Age

1998
Vitamin D3 inhibits proliferation and increases c-myc expression in fibroblasts from psoriatic patients.
    Journal of endocrinological investigation, 1998, Volume: 21, Issue:8

    Topics: Adult; Blotting, Northern; Calcitriol; Cell Division; Culture Media; DNA; DNA Probes; Fibroblasts; G

1998
[Radioimmunologic study of the hormonal and immune status in eczema, psoriasis and neurodermatitis].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; C-Peptide; Eczema; Female; Humans; Hydrocortisone; Immun

1989
Accidental hypothermia in erythroderma from generalized psoriasis.
    Archives of dermatology, 1968, Volume: 98, Issue:3

    Topics: Aged; Arthritis; Dermatitis, Exfoliative; Electrocardiography; Female; Humans; Hypothermia; Pneumoni

1968
Hydroxyproline and collagen metabolism. Clinical implications.
    Annals of internal medicine, 1965, Volume: 63, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Child; Child, Preschool; Collagen; Female; Gelatin;

1965
Control of liver deoxyribonucleic acid synthesis.
    The Journal of investigative dermatology, 1972, Volume: 59, Issue:1

    Topics: Amino Acids; Animals; Cell Division; DNA; DNA Replication; Extracellular Space; Fatty Acids; Female;

1972