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triiodothyronine and Porphyrias

triiodothyronine has been researched along with Porphyrias in 7 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.

Research Excerpts

ExcerptRelevanceReference
"The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats."7.69Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994)
"The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined."7.68Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990)
"1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats."7.67Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986)
"The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats."3.69Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994)
"The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined."3.68Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990)
"1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats."3.67Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Matteis, F1
Harvey, C1
Sopena de Kracoff, YE1
Ferramola de Sancovich, AM1
Sancovich, HA1
Kleiman de Pisarev, DL2
Brodie, MJ2
Goldberg, A2
Beastall, GH2
Yeo, PP2
Ratcliffe, JG2
Graham, DJ1
Ratcliffe, WA1
Rios de Molina, MC1
San Martin de Viale, LC1
Rozman, K1
Gorski, JR1
Rozman, P1
Parkinson, A1
Kappas, A1
Bradlow, HL1
Gillette, PN1
Gallagher, TF1

Other Studies

7 other studies available for triiodothyronine and Porphyrias

ArticleYear
Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents.
    Archives of toxicology, 2005, Volume: 79, Issue:7

    Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Coproporphyrinogen Oxidase; Coproporphyrins; Cyclic A

2005
Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria.
    Journal of endocrinological investigation, 1994, Volume: 17, Issue:5

    Topics: Animals; Carboxy-Lyases; Female; Hexachlorobenzene; Porphyrias; Rats; Rats, Wistar; Thyroidectomy; T

1994
Abnormal thyroid function in symptomatic acute intermittent porphyria [proceedings].
    The Journal of endocrinology, 1977, Volume: 75, Issue:3

    Topics: Female; Humans; Hyperthyroidism; Porphyrias; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

1977
Thyroid function in acute intermittent porphyria: a neurogenic cause of hyperthyroidism?
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1978, Volume: 10, Issue:4

    Topics: Adult; Female; Humans; Hyperthyroidism; Male; Porphyrias; Pregnancy; Thyroid Gland; Thyroxine; Triio

1978
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria.
    Biochemical pharmacology, 1990, Mar-01, Volume: 39, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Animals; Body Weight; Chlorobenzenes; Dose-Response Relationship, Drug

1990
Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria.
    Toxicology letters, 1986, Volume: 30, Issue:1

    Topics: Administration, Oral; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes;

1986
Abnormal steroid hormone metabolism in the genetic liver disease acute intermittent porphyria.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Acyltransferases; Alcohols; Androstanes; Animals; Carbon Isotopes; Cell Line; Chick Embryo; Coenzyme

1971