Page last updated: 2024-11-08

triiodothyronine and Overweight

triiodothyronine has been researched along with Overweight in 27 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Overweight: A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.

Research Excerpts

ExcerptRelevanceReference
"In this randomized controlled intervention, iodine-deficient, overweight or obese Moroccan women (n = 163) received 200 μg oral iodine or a placebo daily for 6 mo."9.20Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial. ( Aboussad, A; Chabaa, L; Cherkaoui, M; El Ansari, N; Herter-Aeberli, I; Rohner, R; Stinca, S; von Eckardstein, A; Zimmermann, MB, 2015)
" Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group."7.81Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes. ( Hangai, M; Honma, H; Ishigaki, Y; Kajiwara, T; Matsui, M; Nagasawa, K; Nakagawa, R; Oda, T; Ono, M; Sasai, T; Satoh, J; Takahashi, K; Takahashi, Y; Takebe, N; Taneichi, H; Togashi, H, 2015)
"In this randomized controlled intervention, iodine-deficient, overweight or obese Moroccan women (n = 163) received 200 μg oral iodine or a placebo daily for 6 mo."5.20Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial. ( Aboussad, A; Chabaa, L; Cherkaoui, M; El Ansari, N; Herter-Aeberli, I; Rohner, R; Stinca, S; von Eckardstein, A; Zimmermann, MB, 2015)
"Overweight/obesity mediated the associations of MAFLD with triiodothyronine (T3), free triiodothyronine (FT3), free thyroxine (FT4), and the mediator accounted for 46."4.31The association between thyroid hormones and MAFLD is mediated by obesity and metabolic disorders and varies among MAFLD subtypes. ( Cao, L; Chen, X; Fan, H; Li, L; Liu, Z; Suo, C; Zhang, T, 2023)
" Autoimmune hypothyroidism is frequently associated with obesity, it is usually progressive and needs replacement treatment with L-thyroxine."4.12Possible added value of thyroglobulin antibody (TgAb) testing in the evaluation of thyroidal status of subjects with overweight or obesity. ( Basolo, A; Bechi Genzano, S; Ceccarini, G; Chiovato, L; Fierabracci, P; Rotondi, M; Salvetti, G; Santini, F; Scartabelli, G; Sotgia, G, 2022)
"The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance."4.02Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. ( Chen, Y; Huang, B; Li, Z; Lin, M; Liu, C; Ma, D; Xiao, F; Yan, F; Ye, J; Zeng, J; Zeng, X; Zheng, X, 2021)
" Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group."3.81Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes. ( Hangai, M; Honma, H; Ishigaki, Y; Kajiwara, T; Matsui, M; Nagasawa, K; Nakagawa, R; Oda, T; Ono, M; Sasai, T; Satoh, J; Takahashi, K; Takahashi, Y; Takebe, N; Taneichi, H; Togashi, H, 2015)
"Many patients treated for primary hypothyroidism have an unexplained reduced quality of life (QOL)."2.80Quality of life in patients with primary hypothyroidism related to BMI. ( Berghout, A; Kelderman-Bolk, N; Tijssen, JP; Visser, TJ, 2015)
"Weight loss was 9."2.74Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure. ( Bosy-Westphal, A; Glüer, CC; Goele, K; Heller, M; Heymsfield, SB; Hitze, B; Kossel, E; Later, W; Müller, MJ; Settler, U, 2009)
"Obesity is associated with alterations in thyroid hormone (TH) levels in obese, pregnant individuals."1.43Increasing maternal obesity is associated with alterations in both maternal and neonatal thyroid hormone levels. ( Aagaard, KM; Antony, KM; DelBeccaro, M; Hu, M; Kahr, MK; Suter, MA, 2016)
"Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide."1.42Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years. ( Boehm, BO; Denzer, C; Graeter, T; Greinert, A; Haenle, MM; Holzner, D; Koenig, W; Kratzer, W; Ludwig, U; Mason, RA; Oeztuerk, S, 2015)
"Weight loss was associated with decreases in fat mass (FM) and fat-free mass (FFM) by 72."1.40Impact of body composition during weight change on resting energy expenditure and homeostasis model assessment index in overweight nonsmoking adults. ( Bosy-Westphal, A; Braun, W; Glüer, CC; Müller, MJ; Pourhassan, M; Schautz, B, 2014)
"Obesity has been recognized as an independent risk factor for arterial hypertension."1.37Arterial hypertension in obesity: relationships with hormone and anthropometric parameters. ( De Pergola, G; Guida, P; Nardecchia, A; Silvestris, F, 2011)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (11.11)29.6817
2010's16 (59.26)24.3611
2020's8 (29.63)2.80

Authors

AuthorsStudies
Ma, D1
Zeng, J1
Huang, B1
Yan, F1
Ye, J1
Chen, Y1
Zeng, X1
Zheng, X1
Xiao, F1
Lin, M1
Liu, C1
Li, Z1
Birck, MG1
Almeida-Pititto, B1
Janovsky, CCPS1
Goulart, AC1
Santos, IS1
Teixeira, PFDS1
Sgarbi, JA1
Barreto, SM1
Duncan, BB1
Schmidt, MI1
Lotufo, PA1
Bensenor, IM1
Fierabracci, P1
Basolo, A1
Scartabelli, G1
Bechi Genzano, S1
Salvetti, G1
Sotgia, G1
Rotondi, M1
Chiovato, L1
Ceccarini, G1
Santini, F1
Corica, D2
Licenziati, MR2
Calcaterra, V2
Currò, M2
Di Mento, C2
Curatola, S2
Zuccotti, G2
Alibrandi, A2
Ientile, R2
Aversa, T2
Wasniewska, M2
Fan, H1
Li, L1
Liu, Z1
Cao, L1
Chen, X1
Suo, C1
Zhang, T1
Zupo, R1
Castellana, F1
Sardone, R1
Lampignano, L1
Paradiso, S1
Giagulli, VA1
Triggiani, V1
Di Lorenzo, L1
Giannelli, G1
De Pergola, G3
Fu, J1
Zhang, L1
An, Y1
Duan, Y1
Liu, J1
Wang, G1
Surup, H1
Vogel, M1
Koerner, A1
Hiemisch, A1
Oelkers, L1
Willenberg, A1
Kiess, W1
Kratzsch, J1
Jun, JE1
Kim, TH1
Lee, SE1
Lee, YB1
Jee, JH1
Bae, JC1
Jin, SM1
Hur, KY1
Kim, JH1
Kim, SW1
Chung, JH1
Min, YK1
Lee, MK1
Ren, R1
Jiang, X1
Zhang, X1
Guan, Q1
Yu, C1
Li, Y1
Gao, L1
Zhang, H1
Zhao, J1
Pourhassan, M1
Bosy-Westphal, A2
Schautz, B1
Braun, W1
Glüer, CC2
Müller, MJ3
Oda, T1
Taneichi, H1
Takahashi, K1
Togashi, H1
Hangai, M1
Nakagawa, R1
Ono, M1
Matsui, M1
Sasai, T1
Nagasawa, K1
Honma, H1
Kajiwara, T1
Takahashi, Y1
Takebe, N1
Ishigaki, Y1
Satoh, J1
Kelderman-Bolk, N1
Visser, TJ1
Tijssen, JP1
Berghout, A1
Herter-Aeberli, I1
Cherkaoui, M1
El Ansari, N1
Rohner, R1
Stinca, S1
Chabaa, L1
von Eckardstein, A1
Aboussad, A1
Zimmermann, MB1
Ludwig, U1
Holzner, D1
Denzer, C1
Greinert, A1
Haenle, MM1
Oeztuerk, S1
Koenig, W1
Boehm, BO1
Mason, RA1
Kratzer, W1
Graeter, T1
Kahr, MK1
Antony, KM1
DelBeccaro, M1
Hu, M1
Aagaard, KM1
Suter, MA1
Florêncio, TM1
Bueno, NB1
Britto, RA1
Albuquerque, FC1
Lins, IL1
Sawaya, AL1
Dahl, M1
Ohrt, JD1
Fonvig, CE1
Kloppenborg, JT1
Pedersen, O1
Hansen, T1
Holm, JC1
Radetti, G2
Kleon, W1
Buzi, F2
Crivellaro, C1
Pappalardo, L1
di Iorgi, N1
Maghnie, M1
Kossel, E1
Goele, K1
Later, W1
Hitze, B1
Settler, U1
Heller, M1
Heymsfield, SB1
Haas, VK1
Gaskin, KJ1
Kohn, MR1
Clarke, SD1
Ciampolillo, A1
Alò, D1
Sciaraffia, M1
Guida, P2
Nardecchia, A1
Silvestris, F1
Longhi, S1
Baiocchi, M1
Cassar, W1
Radicioni, AF1
Tahani, N1
Spaziani, M1
Anzuini, A1
Piccheri, C1
Semeraro, A1
Tarani, L1
Lenzi, A1
Marwaha, RK1
Tandon, N1
Garg, MK1
Ganie, MA1
Narang, A1
Mehan, N1
Bhadra, K1
Bastemir, M1
Akin, F1
Emral, R1
Alkis, E1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Estudo Longitudinal de Saúde do Adulto[NCT02320461]15,105 participants (Actual)Observational2008-08-31Active, not recruiting
Effect of Body Composition on Thyroid Hormone Levels Among Overweight and Obese Subjects[NCT04327375]250 participants (Actual)Observational2019-01-01Completed
Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases[NCT02550236]7,000 participants (Anticipated)Observational2010-10-31Recruiting
Assessment of the Improvement of the Cardiovascular Risk Profile in Obese Women After Correction of Iodine Deficiency[NCT01985204]162 participants (Actual)Interventional2013-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for triiodothyronine and Overweight

ArticleYear
Higher Muscle Mass Implies Increased Free-Thyroxine to Free-Triiodothyronine Ratio in Subjects With Overweight and Obesity.
    Frontiers in endocrinology, 2020, Volume: 11

    Topics: Adult; Anthropometry; Biomarkers; Body Mass Index; Electric Impedance; Female; Humans; Male; Middle

2020
Quality of life in patients with primary hypothyroidism related to BMI.
    European journal of endocrinology, 2015, Volume: 173, Issue:4

    Topics: Adult; Anxiety; Autoantibodies; Autoantigens; Body Mass Index; Depression; Female; Hormone Replaceme

2015
Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    The Journal of nutrition, 2015, Volume: 145, Issue:9

    Topics: Administration, Oral; Adult; Blood Glucose; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Die

2015
Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure.
    The American journal of clinical nutrition, 2009, Volume: 90, Issue:4

    Topics: Adipose Tissue; Adult; Body Fluid Compartments; Diet, Reducing; Energy Metabolism; Female; Humans; M

2009
Changes in lifestyle improve body composition, thyroid function, and structure in obese children.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:3

    Topics: Adolescent; Autoantibodies; Body Composition; Child; Female; Humans; Life Style; Male; Obesity; Over

2012

Other Studies

22 other studies available for triiodothyronine and Overweight

ArticleYear
Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults.
    BMC gastroenterology, 2021, Nov-18, Volume: 21, Issue:1

    Topics: Adult; China; Cross-Sectional Studies; Fatty Liver; Humans; Insulin Resistance; Obesity; Overweight;

2021
Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL).
    Thyroid : official journal of the American Thyroid Association, 2022, Volume: 32, Issue:6

    Topics: Adult; Aged; Brazil; Cohort Studies; Diabetes Mellitus; Female; Humans; Incidence; Longitudinal Stud

2022
Possible added value of thyroglobulin antibody (TgAb) testing in the evaluation of thyroidal status of subjects with overweight or obesity.
    Journal of endocrinological investigation, 2022, Volume: 45, Issue:11

    Topics: Adult; Autoantibodies; Humans; Hyperthyroidism; Hypothyroidism; Iodide Peroxidase; Iodine Radioisoto

2022
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome

2023
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome

2023
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome

2023
Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Child; Glucose; Humans; Insulin Resistance; Obesity; Overweight; Thyroid Hormone Resistance Syndrome

2023
The association between thyroid hormones and MAFLD is mediated by obesity and metabolic disorders and varies among MAFLD subtypes.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2023, Volume: 55, Issue:6

    Topics: Humans; Metabolic Diseases; Non-alcoholic Fatty Liver Disease; Obesity; Overweight; Thyroid Hormones

2023
Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults.
    Medical science monitor : international medical journal of experimental and clinical research, 2021, Mar-19, Volume: 27

    Topics: Adult; Asian People; Body Mass Index; Body Weight; China; Female; Humans; Male; Middle Aged; Obesity

2021
Pediatric Reference Intervals for Thyrotropin, Free Triiodothyronine, and Free Thyroxine and the Relevance of Body Mass Index and Puberty in Measurement Interpretation.
    Thyroid : official journal of the American Thyroid Association, 2021, Volume: 31, Issue:8

    Topics: Adolescent; Age Factors; Body Mass Index; Child; Cohort Studies; Female; Germany; Humans; Longitudin

2021
Hormetic effect of triiodothyronine in metabolically healthy obese persons.
    Endocrine, 2017, Volume: 57, Issue:3

    Topics: Academic Medical Centers; Adiposity; Adult; Body Mass Index; Female; Hormesis; Humans; Incidence; In

2017
Association between thyroid hormones and body fat in euthyroid subjects.
    Clinical endocrinology, 2014, Volume: 80, Issue:4

    Topics: Adipose Tissue; Adult; Blood Glucose; Body Composition; Cross-Sectional Studies; Female; Humans; Ins

2014
Impact of body composition during weight change on resting energy expenditure and homeostasis model assessment index in overweight nonsmoking adults.
    The American journal of clinical nutrition, 2014, Volume: 99, Issue:4

    Topics: Adiposity; Adult; Basal Metabolism; Body Mass Index; Diet, Reducing; Energy Metabolism; Female; Foll

2014
Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:2

    Topics: Adult; Aged; Body Mass Index; Cholesterol, HDL; Female; Glucose Tolerance Test; Humans; Insulin; Ins

2015
Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years.
    BMC endocrine disorders, 2015, Aug-15, Volume: 15

    Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Cross-Secti

2015
Increasing maternal obesity is associated with alterations in both maternal and neonatal thyroid hormone levels.
    Clinical endocrinology, 2016, Volume: 84, Issue:4

    Topics: Adult; Birth Weight; Body Mass Index; Female; Fetal Blood; Humans; Infant, Newborn; Linear Models; M

2016
Waist-to-Height Gain and Triiodothyronine Concentrations in a Cohort of Socially Vulnerable Short-Stature Women: A Four-Year Follow-Up Study.
    Annals of nutrition & metabolism, 2016, Volume: 68, Issue:4

    Topics: Adult; Body Mass Index; Brazil; Cohort Studies; Comorbidity; Female; Growth Disorders; Humans; Hypot

2016
Subclinical Hypothyroidism in Danish Lean and Obese Children and Adolescents.
    Journal of clinical research in pediatric endocrinology, 2017, Mar-01, Volume: 9, Issue:1

    Topics: Adolescent; Body Mass Index; Body Weight; Child; Cross-Sectional Studies; Denmark; Female; Humans; H

2017
Thyroid function and structure are affected in childhood obesity.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:12

    Topics: Autoantibodies; Biopsy, Fine-Needle; Body Mass Index; Child; Cohort Studies; Cross-Sectional Studies

2008
Different thermic effects of leptin in adolescent females with varying body fat content.
    Clinical nutrition (Edinburgh, Scotland), 2010, Volume: 29, Issue:5

    Topics: Absorptiometry, Photon; Adipose Tissue; Adiposity; Adolescent; Anorexia Nervosa; Body Composition; B

2010
Free triiodothyronine is associated with smoking habit, independently of obesity, body fat distribution, insulin, and metabolic parameters.
    Journal of endocrinological investigation, 2010, Volume: 33, Issue:11

    Topics: Adolescent; Adult; Aged; Body Composition; Body Fat Distribution; Body Mass Index; Cholesterol, HDL;

2010
Arterial hypertension in obesity: relationships with hormone and anthropometric parameters.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2011, Volume: 18, Issue:2

    Topics: Adult; Aldosterone; Biomarkers; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory

2011
Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents.
    Journal of endocrinological investigation, 2013, Volume: 36, Issue:5

    Topics: Adolescent; Adolescent Development; Adult; Body Mass Index; Child; Child Development; Female; Humans

2013
Impact of body mass index on thyroid functions in Indian children.
    Clinical endocrinology, 2013, Volume: 79, Issue:3

    Topics: Adolescent; Body Mass Index; Child; Child, Preschool; Female; Humans; Hypothyroidism; India; Male; O

2013
Impact of insulin sensitivity in relationship with prolactin and thyroid stimulating hormone.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2007, Volume: 115, Issue:4

    Topics: Adult; Blood Glucose; Body Mass Index; Body Size; Cross-Sectional Studies; Fasting; Female; Humans;

2007