triiodothyronine has been researched along with Osteosarcoma in 14 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the dose-response studies, a biphasic increase in medium IGF-I was observed in both cells and limb bones, with peak stimulatory concentrations of 10(-8) M for T3 and 10(-7) M for T4 in both systems." | 1.29 | Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue. ( Caplice, MD; Khanna, V; Lakatos, P; Stern, PH, 1993) |
| "Tri-iodothyronine (T3) increases bone resorption in vivo and in vitro." | 1.28 | Tri-iodothyronine stimulates rat osteoclastic bone resorption by an indirect effect. ( Allain, TJ; Chambers, TJ; Flanagan, AM; McGregor, AM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gouveia, CH | 2 |
| Schultz, JJ | 2 |
| Jackson, DJ | 1 |
| Williams, GR | 4 |
| Brent, GA | 2 |
| Arnold, LA | 1 |
| Estébanez-Perpiñá, E | 1 |
| Togashi, M | 1 |
| Jouravel, N | 1 |
| Shelat, A | 1 |
| McReynolds, AC | 1 |
| Mar, E | 1 |
| Nguyen, P | 1 |
| Baxter, JD | 1 |
| Fletterick, RJ | 1 |
| Webb, P | 1 |
| Guy, RK | 1 |
| Scarlett, A | 1 |
| Parsons, MP | 1 |
| Hanson, PL | 1 |
| Sidhu, KK | 1 |
| Milligan, TP | 1 |
| Burrin, JM | 1 |
| Bland, R | 3 |
| Sheppard, MC | 3 |
| Lakatos, P | 1 |
| Caplice, MD | 1 |
| Khanna, V | 1 |
| Stern, PH | 2 |
| Sammons, RL | 1 |
| Gu, WX | 1 |
| Madison, LD | 1 |
| Du, GG | 1 |
| Banovac, K | 1 |
| Koren, E | 1 |
| Bianco, AC | 1 |
| Allain, TJ | 1 |
| Chambers, TJ | 1 |
| Flanagan, AM | 1 |
| McGregor, AM | 1 |
| Pirskanen, A | 1 |
| Mahonen, A | 1 |
| Mäenpää, PH | 1 |
| LeBron, BA | 1 |
| Pekary, AE | 1 |
| Mirell, C | 1 |
| Hahn, TJ | 1 |
| Hershman, JM | 1 |
| Rizzoli, R | 1 |
| Poser, J | 1 |
| Bürgi, U | 1 |
14 other studies available for triiodothyronine and Osteosarcoma
| Article | Year |
|---|---|
Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis.
Topics: Adenosine Triphosphatases; Animals; Gene Expression; Gene Expression Profiling; Mitochondria; Myosin | 2002 |
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
Topics: Binding, Competitive; Dose-Response Relationship, Drug; Genetic Vectors; Glutathione Transferase; Hu | 2005 |
Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin alphaVbeta3.
Topics: Cell Division; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expre | 2008 |
Retinoids modify regulation of endogenous gene expression by vitamin D3 and thyroid hormone in three osteosarcoma cell lines.
Topics: Animals; Calcitriol; Gene Expression Regulation; Osteoblasts; Osteocalcin; Osteopontin; Osteosarcoma | 1995 |
Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling.
Topics: Animals; Base Sequence; Bone Neoplasms; Cholecalciferol; Molecular Probes; Molecular Sequence Data; | 1994 |
Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue.
Topics: Animals; Bone and Bones; Bone Resorption; Culture Media; Culture Techniques; Dose-Response Relations | 1993 |
Thyroid hormone, vitamin D and retinoid receptor expression and signalling in primary cultures of rat osteoblastic and immortalised osteosarcoma cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Cholecalciferol; Osteoblasts; Osteosarcoma; Rats; Rats, | 1997 |
Mutual up-regulation of thyroid hormone and parathyroid hormone receptors in rat osteoblastic osteosarcoma 17/2.8 cells.
Topics: Animals; Dose-Response Relationship, Drug; Kinetics; Osteosarcoma; Parathyroid Hormone; Rats; Recept | 2001 |
Triiodothyronine stimulates the release of membrane-bound alkaline phosphatase in osteoblastic cells.
Topics: Actins; Alkaline Phosphatase; Animals; Cell Count; Cell Fractionation; Cell Membrane; Cytochalasin B | 2000 |
Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
Topics: Animals; Bone Neoplasms; Gene Expression Regulation; Osteoblasts; Osteocalcin; Osteosarcoma; Rats; R | 2001 |
Tri-iodothyronine stimulates rat osteoclastic bone resorption by an indirect effect.
Topics: Animals; Bone Resorption; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Osteoclasts; | 1992 |
Modulation of 1,25(OH)2D3-induced osteocalcin synthesis in human osteosarcoma cells by other steroidal hormones.
Topics: Alkaline Phosphatase; Calcifediol; Cell Division; Dexamethasone; Estradiol; Humans; Osteocalcin; Ost | 1991 |
Thyroid hormone 5'-deiodinase activity, nuclear binding, and effects on mitogenesis in UMR-106 osteoblastic osteosarcoma cells.
Topics: Alkaline Phosphatase; Cell Division; Cell Nucleus; Humans; Iodide Peroxidase; Osteoblasts; Osteosarc | 1989 |
Nuclear thyroid hormone receptors in cultured bone cells.
Topics: Animals; Binding, Competitive; Bone and Bones; Calcium-Binding Proteins; Cell Line; Cell Nucleus; Co | 1986 |