triiodothyronine has been researched along with Myocardial Ischemia in 27 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to explore the use of triiodothyronine (T(3)) concentrations as an adjunct to clinical and functional parameters when estimating prognosis in patients with chronic heart failure." | 7.73 | Triiodothyronine levels for risk stratification of patients with chronic heart failure. ( Iervasi, G; L'Abbate, A; Landi, P; Pingitore, A; Ripoli, A; Taddei, MC, 2005) |
| "Triiodothyronine was well tolerated without episodes of ischemia or clinical arrhythmia." | 6.69 | Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. ( Child, JS; Chopra, IJ; Fonarow, GC; Goldhaber, JI; Hage, A; Hamilton, MA; Moriguchi, JD; Steimle, A; Stevenson, LW, 1998) |
| "We sought to explore the use of triiodothyronine (T(3)) concentrations as an adjunct to clinical and functional parameters when estimating prognosis in patients with chronic heart failure." | 3.73 | Triiodothyronine levels for risk stratification of patients with chronic heart failure. ( Iervasi, G; L'Abbate, A; Landi, P; Pingitore, A; Ripoli, A; Taddei, MC, 2005) |
| "Triiodothyronine was well tolerated without episodes of ischemia or clinical arrhythmia." | 2.69 | Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. ( Child, JS; Chopra, IJ; Fonarow, GC; Goldhaber, JI; Hage, A; Hamilton, MA; Moriguchi, JD; Steimle, A; Stevenson, LW, 1998) |
| "Ischemic heart disease is the major cause of mortality and morbidity worldwide." | 2.52 | Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine. ( Forini, F; Iervasi, G; Nicolini, G, 2015) |
| "Because myocardial ischemia is still associated with apparently well-managed anesthesia and operation, investigators are now looking for new avenues to prevent morbid perioperative ischemic events." | 2.38 | Implications of triiodothyronine administration before cardiac and noncardiac operations. ( Lowenstein, E, 1993) |
| "Hyperthyroidism was induced by daily intraperitoneal injection of thyroxine (T4) (600 microg/kg) with or without cilazapril (10 mg/kg per day, orally), and control rats were given by vehicle." | 1.31 | Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats. ( Asahi, T; Oshiro, Y; Shimabukuro, M; Takasu, N; Yoshida, H, 2001) |
| "Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion." | 1.31 | Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. ( Beastall, GH; Furman, BL; Parratt, JR; Pyne, NJ; Zhang, L, 2002) |
| "Myocardial ischemia was revealed in 1 patient but was seen in both hypothyroid and euthyroid examinations." | 1.30 | Severe short-term hypothyroidism is not associated with an increased incidence of myocardial ischemia as assessed by thallium-201 stress/rest myocardial scintigraphy. ( Dudczak, R; Holm, C; Hurtl, I; Najemnik, C; Prasch, F; Wogritsch, S, 1999) |
| "It is stated that CHD patients with arrhythmia develop latent hypothyrosis of T3-low-syndrome type." | 1.29 | [The effect of kordaron on thyroid function in patients with ischemic heart disease]. ( Tereshchenko, IV; Tsepelev, VV, 1995) |
| "Triiodothyronine treatment was associated with significantly decreased coronary resistance and increased coronary flow through a range of diastolic loading conditions in the postischemic hearts." | 1.29 | Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia. ( Berman, K; Helm, RE; Isom, OW; Klein, I; Klemperer, JD; Krieger, K; Ojamaa, K; Zelano, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (44.44) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Che, W | 1 |
| Shi, K | 1 |
| Huang, Y | 1 |
| Xu, C | 1 |
| Fei, M | 1 |
| Fan, X | 1 |
| Zhang, J | 1 |
| Hu, X | 1 |
| Hu, F | 1 |
| Qin, S | 1 |
| Zhang, X | 1 |
| Huang, Q | 1 |
| Yu, F | 1 |
| Forini, F | 1 |
| Nicolini, G | 1 |
| Iervasi, G | 3 |
| Kozdağ, G | 1 |
| Ertaş, G | 1 |
| Aygün, F | 1 |
| Emre, E | 1 |
| Kirbaş, A | 1 |
| Ural, D | 1 |
| Soran, O | 1 |
| Telkova, IL | 1 |
| Tepliakov, AT | 1 |
| Kazmierczak, P | 1 |
| Polak, A | 1 |
| Mussur, M | 1 |
| Pingitore, A | 1 |
| Landi, P | 1 |
| Taddei, MC | 1 |
| Ripoli, A | 1 |
| L'Abbate, A | 1 |
| Pantos, C | 1 |
| Malliopoulou, V | 1 |
| Mourouzis, I | 1 |
| Thempeyioti, A | 1 |
| Paizis, I | 1 |
| Dimopoulos, A | 1 |
| Saranteas, T | 1 |
| Xinaris, C | 1 |
| Cokkinos, DV | 2 |
| Chen, YF | 1 |
| Kobayashi, S | 1 |
| Chen, J | 1 |
| Redetzke, RA | 1 |
| Said, S | 1 |
| Liang, Q | 1 |
| Gerdes, AM | 1 |
| Tereshchenko, IV | 1 |
| Tsepelev, VV | 1 |
| Klemperer, JD | 1 |
| Zelano, J | 1 |
| Helm, RE | 1 |
| Berman, K | 1 |
| Ojamaa, K | 2 |
| Klein, I | 2 |
| Isom, OW | 1 |
| Krieger, K | 1 |
| Sinci, V | 1 |
| Soncul, H | 1 |
| Gunaydin, S | 1 |
| Halit, V | 1 |
| Gokgoz, L | 1 |
| Tatlican, O | 1 |
| Yener, A | 1 |
| Bilgehan, A | 1 |
| Ersoz, A | 1 |
| Kadletz, M | 1 |
| Mullen, PG | 1 |
| Ding, M | 3 |
| Wolfe, LG | 1 |
| Wechsler, AS | 3 |
| Lowenstein, E | 1 |
| Dyke, CM | 2 |
| Abd-Elfattah, AS | 1 |
| Loesser, K | 1 |
| Dignan, RJ | 1 |
| Salter, DR | 2 |
| Hamilton, MA | 1 |
| Stevenson, LW | 1 |
| Fonarow, GC | 1 |
| Steimle, A | 1 |
| Goldhaber, JI | 1 |
| Child, JS | 1 |
| Chopra, IJ | 2 |
| Moriguchi, JD | 1 |
| Hage, A | 1 |
| Bak, MI | 1 |
| Ingwall, JS | 1 |
| Liu, Q | 1 |
| Clanachan, AS | 1 |
| Lopaschuk, GD | 1 |
| Yeh, T | 1 |
| Lehman, JD | 1 |
| Abd-Elfattah, A | 1 |
| Prasch, F | 1 |
| Wogritsch, S | 1 |
| Hurtl, I | 1 |
| Holm, C | 1 |
| Najemnik, C | 1 |
| Dudczak, R | 1 |
| Masullo, P | 1 |
| Venditti, P | 1 |
| Agnisola, C | 1 |
| Di Meo, S | 1 |
| Kenessey, A | 1 |
| Shenoy, R | 1 |
| Sabatino, L | 1 |
| Ferrazzi, P | 1 |
| Francesconi, D | 1 |
| Lifshits, GI | 1 |
| Nikolaev, KIu | 1 |
| Oteva, EA | 1 |
| Nikolaeva, AA | 1 |
| Pantos, CI | 1 |
| Malliopoulou, VA | 1 |
| Mourouzis, IS | 1 |
| Karamanoli, EP | 1 |
| Tzeis, SM | 1 |
| Carageorgiou, HC | 1 |
| Varonos, DD | 1 |
| Asahi, T | 1 |
| Shimabukuro, M | 1 |
| Oshiro, Y | 1 |
| Yoshida, H | 1 |
| Takasu, N | 1 |
| Zhang, L | 1 |
| Parratt, JR | 1 |
| Beastall, GH | 1 |
| Pyne, NJ | 1 |
| Furman, BL | 1 |
| Babin, VP | 1 |
| Stepanova, EG | 1 |
| Malyutina, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction[NCT02512978] | Phase 4 | 160 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for triiodothyronine and Myocardial Ischemia
| Article | Year |
|---|---|
Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.
Topics: Humans; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Triiodothyronine | 2015 |
Implications of triiodothyronine administration before cardiac and noncardiac operations.
Topics: Cardiac Surgical Procedures; Humans; Intraoperative Complications; Myocardial Ischemia; Myocardium; | 1993 |
2 trials available for triiodothyronine and Myocardial Ischemia
| Article | Year |
|---|---|
Clinical effects of enhanced external counterpulsation treatment in patients with ischemic heart failure.
Topics: Aged; Blood Pressure; Cohort Studies; Counterpulsation; Electrocardiography; Female; Heart Failure; | 2012 |
Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure.
Topics: Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Injections, Intravenous; Male; | 1998 |
23 other studies available for triiodothyronine and Myocardial Ischemia
| Article | Year |
|---|---|
FT4/FT3 ratio: A novel biomarker predicts coronary microvascular dysfunction (CMD) in euthyroid INOCA patients.
Topics: Biomarkers; Coronary Artery Disease; Humans; Myocardial Ischemia; Prospective Studies; Thyroxine; Tr | 2022 |
[Changes of thyroid hormone levels in the progression of coronary arteriosclerosis].
Topics: Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Disease Progression; Heart Fail | 2004 |
Influence of preischemic short-term triiodothyronine administration on hemodynamic function and metabolism of reperfused isolated rat heart.
Topics: Animals; Coronary Circulation; Coronary Vessels; Heart; Hemodynamics; In Vitro Techniques; Male; Myo | 2004 |
Triiodothyronine levels for risk stratification of patients with chronic heart failure.
Topics: Aged; Aged, 80 and over; Biomarkers; Chronic Disease; Female; Heart Failure; Humans; Male; Middle Ag | 2005 |
Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70.
Topics: Animals; Cardiomegaly; Cell Survival; Heart; HSP70 Heat-Shock Proteins; Hyperthyroidism; Male; Malon | 2006 |
Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats.
Topics: Animals; Apoptosis; Body Weight; Diiodothyronines; Enzyme Activation; Female; Hemodynamics; Myocardi | 2008 |
[The effect of kordaron on thyroid function in patients with ischemic heart disease].
Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Female; Humans; Hypothyroidism; Male; Middle Aged; Myocardia | 1995 |
Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia.
Topics: Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Hemodynamics; Hypothermia, Induced; I | 1995 |
The effects of thyroid hormones on the heart following global ischemia. A clinical and experimental study.
Topics: Aged; Animals; Cardiac Output, Low; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease | 1994 |
Effect of triiodothyronine on postischemic myocardial function in the isolated heart.
Topics: Animals; Coronary Circulation; Dose-Response Relationship, Drug; Edema, Cardiac; Heart; In Vitro Tec | 1994 |
Effects of triiodothyronine supplementation after myocardial ischemia.
Topics: Adenine Nucleotides; Animals; Cardiopulmonary Bypass; Hemodynamics; Myocardial Ischemia; Myocardial | 1993 |
Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Hydrogen; Hydrogen-Ion Concentration; In Vitro Tec | 1998 |
Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Glucose; Glycol | 1998 |
As originally published in 1991: Triiodothyronine-enhanced left ventricular function after ischemic injury. Updated in 1998.
Topics: Animals; Cardiopulmonary Bypass; Heart; Humans; Hypothyroidism; Myocardial Ischemia; Perfusion; Rabb | 1998 |
Severe short-term hypothyroidism is not associated with an increased incidence of myocardial ischemia as assessed by thallium-201 stress/rest myocardial scintigraphy.
Topics: Adult; Aged; Exercise Test; Female; Humans; Hypothyroidism; Iodine Radioisotopes; Male; Middle Aged; | 1999 |
Role of nitric oxide in the reperfusion induced injury in hyperthyroid rat hearts.
Topics: Animals; Antioxidants; Enzyme Inhibitors; Hyperthyroidism; Injections, Intraperitoneal; Lipid Peroxi | 2000 |
Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat.
Topics: Animals; Calcium-Transporting ATPases; Gene Expression; Hypertrophy, Left Ventricular; Kv1.5 Potassi | 2000 |
A study of iodothyronine 5'-monodeiodinase activities in normal and pathological tissues in man and their comparison with activities in rat tissues.
Topics: Aged; Animals; Humans; Hydrocortisone; Intestines; Iodide Peroxidase; Iodothyronine Deiodinase Type | 2000 |
[Ischemic heart disease and metabolic syndrome X (family study)].
Topics: Adolescent; Adult; Apolipoproteins B; Arteriosclerosis; Autonomic Nervous System Diseases; Body Weig | 2000 |
Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia.
Topics: Animals; Cardiomegaly; Chronic Disease; Electrophoresis, Polyacrylamide Gel; HSP70 Heat-Shock Protei | 2001 |
Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Cell S | 2001 |
Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Body Temperature; Body Weight; Diabetes Mellitus, Expe | 2002 |
IHD in Chukotka residents: concentration of thyrotropin, thyroxin, triiodothyronine in blood serum.
Topics: Adult; Humans; Male; Middle Aged; Myocardial Ischemia; Native Hawaiian or Other Pacific Islander; Ra | 1991 |