triiodothyronine has been researched along with Medulloblastoma in 3 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Excerpt | Relevance | Reference |
---|---|---|
"From Jan 1998 to Feb 2001, a total of 37 euthyroid children scheduled for CSI for medulloblastoma/primitive neuroectodermal tumor underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of CSI." | 3.74 | Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor. ( Biassoni, V; Bombardieri, E; Collini, P; Fossati-Bellani, F; Gandola, L; Marchianò, A; Massimino, M; Pallotti, F; Pignoli, E; Seregni, E; Serra, A; Spreafico, F; Terenziani, M, 2007) |
"The uptake of 3,5,3'-triiodothyronine (T3) and thyroxine (T4) was studied in human glioma cells (Hs 683) and compared with that in several other neural cell lines." | 3.68 | Thyroid hormone transport in a human glioma cell line. ( Goncalves, E; Lakshmanan, M; Pontecorvi, A; Robbins, J, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (33.33) | 18.2507 |
2000's | 2 (66.67) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Monden, T | 1 |
Nakajima, Y | 1 |
Hashida, T | 1 |
Ishii, S | 1 |
Tomaru, T | 1 |
Shibusawa, N | 1 |
Hashimoto, K | 1 |
Satoh, T | 1 |
Yamada, M | 1 |
Mori, M | 1 |
Kasai, K | 1 |
Massimino, M | 1 |
Gandola, L | 1 |
Collini, P | 1 |
Seregni, E | 1 |
Marchianò, A | 1 |
Serra, A | 1 |
Pignoli, E | 1 |
Spreafico, F | 1 |
Pallotti, F | 1 |
Terenziani, M | 1 |
Biassoni, V | 1 |
Bombardieri, E | 1 |
Fossati-Bellani, F | 1 |
Goncalves, E | 1 |
Lakshmanan, M | 1 |
Pontecorvi, A | 1 |
Robbins, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Protection From Iatrogenic Hypothyroidism Patients With MBL and Pediatric Patients With HL and Non-HL Needing Radiotherapy on Thyroid Site[NCT05316922] | Phase 3 | 68 participants (Anticipated) | Interventional | 2021-12-13 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 other studies available for triiodothyronine and Medulloblastoma
Article | Year |
---|---|
Expression of thyroid hormone receptor isoforms down-regulated by thyroid hormone in human medulloblastoma cells.
Topics: Brain Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Profiling; Gene | 2006 |
Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor.
Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Diseas | 2007 |
Thyroid hormone transport in a human glioma cell line.
Topics: Aminoisobutyric Acids; Antimycin A; Binding, Competitive; Biological Transport; Cadaverine; Cell Mem | 1990 |