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triiodothyronine and Iron Overload

triiodothyronine has been researched along with Iron Overload in 6 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Iron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)

Research Excerpts

ExcerptRelevanceReference
"Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences."1.38Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia. ( Kurtoglu, AU; Kurtoglu, E; Temizkan, AK, 2012)
"L-Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function."1.35Hormonal and nutritional control of L-carnitine uptake in myoblastic C2C12 cells. ( Demarquoy, J; Georges, B; Le Borgne, F; Rigault, C, 2008)
" It is concluded that hyperthyroidism increases the susceptibility of the liver to the toxic effects of iron, which seems to be related to the development of a severe oxidative stress status in the tissue, thus contributing to the concomitant liver injury and impairment of Kupffer cell phagocytosis and particle-induced respiratory burst activity."1.30Derangement of Kupffer cell functioning and hepatotoxicity in hyperthyroid rats subjected to acute iron overload. ( Basualdo, A; Boisier, X; Bosco, C; Carrión, Y; Cornejo, P; Fernández, V; Galleano, M; Puntarulo, S; Schön, M; Sepúlveda, A; Tapia, G; Videla, LA, 1999)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Le Borgne, F1
Rigault, C1
Georges, B1
Demarquoy, J1
De Sanctis, V2
Tanas, R1
Gamberini, MR2
Sprocati, M1
Govoni, MR1
Marsella, M1
De Sanctis, E1
Ricchieri, P1
Gubellini, E1
Gilli, G1
Kurtoglu, AU1
Kurtoglu, E1
Temizkan, AK1
Boisier, X1
Schön, M1
Sepúlveda, A1
Basualdo, A1
Cornejo, P1
Bosco, C1
Carrión, Y1
Galleano, M1
Tapia, G1
Puntarulo, S1
Fernández, V1
Videla, LA1
Del Monte, U1

Other Studies

6 other studies available for triiodothyronine and Iron Overload

ArticleYear
Hormonal and nutritional control of L-carnitine uptake in myoblastic C2C12 cells.
    Muscle & nerve, 2008, Volume: 38, Issue:1

    Topics: Blotting, Northern; Carnitine; Cell Line; Hormones; Humans; Insulin; Iron Compounds; Iron Overload;

2008
Exaggerated TSH response to TRH ("sub-biochemical" hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history.
    Pediatric endocrinology reviews : PER, 2008, Volume: 6 Suppl 1

    Topics: Adolescent; beta-Thalassemia; Child; Humans; Hypothyroidism; Iron Overload; Retrospective Studies; S

2008
Mild subclinical hypothyroidism in thalassaemia major: prevalence, multigated radionuclide test, clinical and laboratory long-term follow-up study.
    Pediatric endocrinology reviews : PER, 2008, Volume: 6 Suppl 1

    Topics: Adolescent; Adult; beta-Thalassemia; Child; Female; Humans; Hypothyroidism; Iron Overload; Longitudi

2008
Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia.
    Endokrynologia Polska, 2012, Volume: 63, Issue:4

    Topics: Adolescent; Adult; beta-Thalassemia; Child; Endocrine System Diseases; Female; Ferritins; Glucose In

2012
Derangement of Kupffer cell functioning and hepatotoxicity in hyperthyroid rats subjected to acute iron overload.
    Redox report : communications in free radical research, 1999, Volume: 4, Issue:5

    Topics: Animals; Hyperthyroidism; Iron Overload; Kupffer Cells; Male; Oxidative Stress; Oxygen Consumption;

1999
Thyroid hormones, acute iron overload and the pathogenesis of cloudy swelling.
    Redox report : communications in free radical research, 2001, Volume: 6, Issue:2

    Topics: 2,4-Dinitrophenol; Acute Disease; Animals; Bacterial Toxins; Cell Nucleus; Cell Size; Edema; Guinea

2001