triiodothyronine has been researched along with Injury, Myocardial Reperfusion in 31 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury." | 7.79 | Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013) |
| "Hyperthyroidism was induced by a daily injection of 2 mg T3/kg body weight for 5 days." | 5.35 | In hyperthyroid rats octylguanidine protects the heart from reperfusion damage. ( Aranda, A; Chávez, E; García, N; Hernández-Esquivel, L; Pavón, N, 2009) |
| " Type 2 Angiotensin II receptors (AT2R) are shown to be upregulated in cardiac hypertrophy observed in hyperthyroidism and this receptor has been reported to mediate cardioprotection against ischemic injury." | 3.79 | Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. ( Barreto-Chaves, ML; da Silva, IB; Gomes, DA; Tavares, FM, 2013) |
| "Ischemic heart disease is the major cause of mortality and morbidity worldwide." | 2.52 | Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine. ( Forini, F; Iervasi, G; Nicolini, G, 2015) |
| "Hyperthyroidism was established after a daily i." | 1.42 | Cardioprotective properties of citicoline against hyperthyroidism-induced reperfusion damage in rat hearts. ( Belmont, J; Buelna-Chontal, M; Chávez, E; González-Pacheco, H; Hernández-Esquivel, L; Pavón, N, 2015) |
| "Hyperthyroidism was induced by a daily injection of 2 mg T3/kg body weight for 5 days." | 1.35 | In hyperthyroid rats octylguanidine protects the heart from reperfusion damage. ( Aranda, A; Chávez, E; García, N; Hernández-Esquivel, L; Pavón, N, 2009) |
| "Hyperthyroidism was elicited by ten daily intraperitoneal injections of T3 (10 microg/100 g body weight)." | 1.31 | Effect of ischemia-reperfusion on heart mitochondria from hyperthyroid rats. ( Agnisola, C; Di Meo, S; Venditti, P, 2002) |
| "Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion." | 1.31 | Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. ( Beastall, GH; Furman, BL; Parratt, JR; Pyne, NJ; Zhang, L, 2002) |
| "Triiodothyronine or placebo was administered in a blinded, randomized fashion." | 1.29 | Effect of triiodothyronine on graft function in a model of heart transplantation. ( Canvasser, DA; Koga, M; Pennington, DG; Swartz, MT; Votapka, TV, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 14 (45.16) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Forini, F | 4 |
| Nicolini, G | 5 |
| Kusmic, C | 5 |
| D'Aurizio, R | 1 |
| Mercatanti, A | 1 |
| Iervasi, G | 6 |
| Pitto, L | 2 |
| Hermann, R | 1 |
| Mestre Cordero, VE | 1 |
| Fernández Pazos, MLM | 1 |
| Córdoba, MF | 1 |
| Reznik, FJ | 1 |
| Vélez, DE | 1 |
| Fellet, AL | 1 |
| Marina Prendes, MG | 1 |
| Zeng, B | 1 |
| Liu, L | 1 |
| Liao, X | 1 |
| Zhang, C | 1 |
| Lieder, HR | 1 |
| Braczko, F | 1 |
| Gedik, N | 1 |
| Stroetges, M | 1 |
| Heusch, G | 1 |
| Kleinbongard, P | 1 |
| Seara, FAC | 1 |
| Maciel, L | 1 |
| Barbosa, RAQ | 1 |
| Rodrigues, NC | 1 |
| Silveira, ALB | 1 |
| Marassi, MP | 1 |
| Carvalho, AB | 1 |
| Nascimento, JHM | 1 |
| Olivares, EL | 1 |
| Sabatino, L | 2 |
| Balzan, S | 2 |
| Tavares, FM | 1 |
| da Silva, IB | 1 |
| Gomes, DA | 1 |
| Barreto-Chaves, ML | 1 |
| Files, MD | 1 |
| Kajimoto, M | 2 |
| O'Kelly Priddy, CM | 1 |
| Ledee, DR | 2 |
| Xu, C | 2 |
| Des Rosiers, C | 1 |
| Isern, N | 1 |
| Portman, MA | 2 |
| Mariani, L | 1 |
| Zucchi, R | 1 |
| Matteucci, M | 1 |
| Matoba, S | 1 |
| Kajimoto, H | 1 |
| Isern, NG | 1 |
| Hernández-Esquivel, L | 2 |
| Pavón, N | 2 |
| Buelna-Chontal, M | 1 |
| González-Pacheco, H | 1 |
| Belmont, J | 1 |
| Chávez, E | 2 |
| Ragone, MI | 1 |
| Bonazzola, P | 1 |
| Colareda, GA | 1 |
| Consolini, AE | 1 |
| Ucciferri, N | 1 |
| Cecchettini, A | 1 |
| Rocchiccioli, S | 1 |
| Citti, L | 1 |
| Amato, R | 1 |
| Casini, G | 1 |
| Aranda, A | 1 |
| García, N | 1 |
| Yamagishi, T | 1 |
| Bessho, M | 1 |
| Yanagida, S | 1 |
| Nishizawa, K | 1 |
| Kusuhara, M | 1 |
| Ohsuzu, F | 1 |
| Tamai, S | 1 |
| Talukder, MA | 1 |
| Yang, F | 1 |
| Nishijima, Y | 1 |
| Chen, CA | 1 |
| Xie, L | 1 |
| Mahamud, SD | 1 |
| Kalyanasundaram, A | 1 |
| Bonagura, JD | 1 |
| Periasamy, M | 1 |
| Zweier, JL | 1 |
| Venditti, P | 3 |
| Agnisola, C | 3 |
| Di Meo, S | 3 |
| Ranasinghe, AM | 1 |
| Quinn, DW | 1 |
| Pagano, D | 1 |
| Edwards, N | 1 |
| Faroqui, M | 1 |
| Graham, TR | 1 |
| Keogh, BE | 1 |
| Mascaro, J | 1 |
| Riddington, DW | 1 |
| Rooney, SJ | 1 |
| Townend, JN | 1 |
| Wilson, IC | 1 |
| Bonser, RS | 1 |
| Bari, A | 1 |
| Di Stefano, L | 1 |
| Wechsler, AS | 1 |
| Kadletz, M | 1 |
| Ding, M | 1 |
| Abd-Elfattah, A | 1 |
| Dyke, C | 1 |
| Katz, MG | 1 |
| Cohen, AJ | 1 |
| Schwalb, H | 1 |
| Segal, J | 1 |
| Merin, G | 1 |
| Schachner, A | 1 |
| Votapka, TV | 1 |
| Canvasser, DA | 1 |
| Pennington, DG | 1 |
| Koga, M | 1 |
| Swartz, MT | 1 |
| Spinale, FG | 1 |
| Masullo, P | 1 |
| Oshiro, Y | 1 |
| Shimabukuro, M | 1 |
| Takasu, N | 1 |
| Asahi, T | 1 |
| Komiya, I | 1 |
| Yoshida, H | 1 |
| Zhang, L | 1 |
| Parratt, JR | 1 |
| Beastall, GH | 1 |
| Pyne, NJ | 1 |
| Furman, BL | 1 |
| Yokoyama, Y | 1 |
| Novitzky, D | 1 |
| Deal, MT | 1 |
| Snow, TR | 1 |
| White, FC | 1 |
| Boss, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery[NCT00845364] | Phase 2/Phase 3 | 290 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy[NCT00989508] | Phase 2/Phase 3 | 220 participants (Anticipated) | Interventional | 2009-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for triiodothyronine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.
Topics: Humans; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Triiodothyronine | 2015 |
Cellular and molecular therapeutic targets for treatment of contractile dysfunction after cardioplegic arrest.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cardioplegic Solutions; Cells, Cultured; Heart Arrest, I | 1999 |
1 trial available for triiodothyronine and Injury, Myocardial Reperfusion
28 other studies available for triiodothyronine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
Topics: Animals; Animals, Newborn; Chromatin Assembly and Disassembly; DNA; DNA Helicases; Epigenesis, Genet | 2020 |
Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Calcium; Cardiotonic Agents; Cell Su | 2021 |
Cardiomyocyte protective effects of thyroid hormone during hypoxia/reoxygenation injury through activating of IGF-1-mediated PI3K/Akt signalling.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Imidazoles; Male; Mice; Mice, Inbred C57BL; Morpholi | 2021 |
Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Isolated Heart Preparation; Male; Mitochondria, Heart | 2021 |
Cardiac ischemia/reperfusion injury is inversely affected by thyroid hormones excess or deficiency in male Wistar rats.
Topics: Animals; Male; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reverse Transcriptase Polymerase C | 2018 |
Modification of gene expression profiling related to renin-angiotensin system in an ischemia/reperfusion rat model after T3 infusion.
Topics: Animals; Gene Expression Profiling; Gene Expression Regulation; Male; Muscle Proteins; Myocardial Re | 2018 |
Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion.
Topics: AMP-Activated Protein Kinases; Angiotensin I; Angiotensin II; Angiotensin II Type 2 Receptor Blocker | 2013 |
Triiodothyronine facilitates weaning from extracorporeal membrane oxygenation by improved mitochondrial substrate utilization.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Disease Models, Animal; Energy Metabolism; Extracorpo | 2014 |
Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis.
Topics: Animals; Animals, Newborn; Cells, Cultured; Male; MicroRNAs; Mitochondria, Heart; Myocardial Reperfu | 2014 |
Triiodothyronine as a therapeutic candidate for cardiac metabolism in the failing heart.
Topics: Animals; Citric Acid Cycle; Extracorporeal Membrane Oxygenation; Fatty Acids; Lactates; Male; Myocar | 2014 |
Triiodothyronine activates lactate oxidation without impairing fatty acid oxidation and improves weaning from extracorporeal membrane oxygenation.
Topics: Adenosine Triphosphate; Animals; Citric Acid Cycle; Drug Evaluation; Extracorporeal Membrane Oxygena | 2014 |
Cardioprotective properties of citicoline against hyperthyroidism-induced reperfusion damage in rat hearts.
Topics: Aconitate Hydratase; Animals; Calcium; Cardiotonic Agents; Cytidine Diphosphate Choline; DNA, Mitoch | 2015 |
Cardioprotective effect of hyperthyroidism on the stunned rat heart during ischaemia-reperfusion: energetics and role of mitochondria.
Topics: Animals; Calcium Channels; Calcium Signaling; Disease Models, Animal; Energy Metabolism; Female; Hyp | 2015 |
Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach.
Topics: Animals; Cell Death; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation; Male; | 2015 |
T3 enhances Ang2 in rat aorta in myocardial I/R: comparison with left ventricle.
Topics: Angiopoietin-2; Animals; Aorta; Disease Models, Animal; Echocardiography; Endothelial Cells; Gene Ex | 2016 |
In hyperthyroid rats octylguanidine protects the heart from reperfusion damage.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Guanidines; Hyperthyroidism; Interferon-gamm | 2009 |
Severe, short-term food restriction improves cardiac function following ischemia/reperfusion in perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Caloric Restriction; Creatine Kinase; D | 2010 |
Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Blotting, Western; Cardiotonic Agents; Data Interpret | 2011 |
Effect of ischemia-reperfusion on heart mitochondria from hyperthyroid rats.
Topics: Animals; Antioxidants; Calcium; Coenzymes; Disease Susceptibility; Heart Rate; Hydrogen Peroxide; Hy | 2002 |
Effect of T3 treatment on the response to ischemia-reperfusion of heart preparations from sedentary and trained rats.
Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Disease Models, Animal; Hydrogen Peroxide; Hyperthyroid | 2008 |
Effects of triiodothyronine on stunned myocardium.
Topics: Animals; Dose-Response Relationship, Drug; Myocardial Contraction; Myocardial Reperfusion Injury; Ra | 1993 |
Interaction of thyroid hormone and heparin in postischemic myocardial recovery.
Topics: Animals; Anticoagulants; Binding, Competitive; Cardioplegic Solutions; Drug Evaluation, Preclinical; | 1995 |
Effect of triiodothyronine on graft function in a model of heart transplantation.
Topics: Abdomen; Animals; Brain Death; Cardiac Output; Heart Transplantation; Hemodynamics; Male; Myocardial | 1996 |
Role of nitric oxide in the reperfusion induced injury in hyperthyroid rat hearts.
Topics: Animals; Antioxidants; Enzyme Inhibitors; Hyperthyroidism; Injections, Intraperitoneal; Lipid Peroxi | 2000 |
Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Heart; Hemodyna | 2001 |
Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Body Temperature; Body Weight; Diabetes Mellitus, Expe | 2002 |
Facilitated recovery of cardiac performance by triiodothyronine following a transient ischemic insult.
Topics: Animals; Dogs; Energy Metabolism; Female; Male; Myocardial Contraction; Myocardial Reperfusion Injur | 1992 |
Inotropic interventions during myocardial "stunning" in the pig.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Calcium; Female; Iso | 1990 |