triiodothyronine has been researched along with Infant, Newborn, Diseases in 52 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new sensitive radioimmunoassay method for measuring reverse triiodothyronine (rT3) concentrations in dried blood samples, designed to screen newborn infants for congenital hypothyroidism, has been developed." | 7.66 | Measurement of reverse triiodothyronine in dried blood spot: methodology and clinical application as a screening procedure for detection of congenital hypothyroidism. ( Catanuso, A; Filetti, S; Lisi, E; Pezzino, V; Sangiorgio, L; Squatrito, S; Vigneri, R, 1980) |
| "Sodium-L-thyroxine (T4) was utilized in the treatment of 15 pediatric patients with hypothyroidism." | 7.65 | Evaluation of sodium L-thyroxine (T4) requirement in replacement therapy of hypothyroidism. ( Abbassi, V; Aldige, C, 1977) |
| " The male infant who was born by spontaneous delivery at 35 weeks of gestational age presented with fever, tachycardia and tachypnea at rest on day 11 after birth, and developed severe apnea on day 14." | 4.89 | [Neonatal hyperthyroidism: a case report and literature review]. ( Li, N; Li, XH; Yao, YM, 2013) |
| "The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring." | 3.66 | Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980) |
| "A new sensitive radioimmunoassay method for measuring reverse triiodothyronine (rT3) concentrations in dried blood samples, designed to screen newborn infants for congenital hypothyroidism, has been developed." | 3.66 | Measurement of reverse triiodothyronine in dried blood spot: methodology and clinical application as a screening procedure for detection of congenital hypothyroidism. ( Catanuso, A; Filetti, S; Lisi, E; Pezzino, V; Sangiorgio, L; Squatrito, S; Vigneri, R, 1980) |
| "Our regional cord blood screening programme for detecting neonatal hypothyroidism using initial cord blood thyroxine (T4) determinations, with supplemental thyrotropin (TSH), and triiodothyronine resin uptake (T3U) measurements, gave an incidence of thyroid abnormalities of 1/3000 births, with 1/5000 infants having severe primary hypothyroidism." | 3.66 | Results of a regional cord blood screening programme for detecting neonatal hypothyroidism. ( Ginsberg, J; Howard, NJ; Rosenberg, RA; Walfish, PG, 1979) |
| "Sodium-L-thyroxine (T4) was utilized in the treatment of 15 pediatric patients with hypothyroidism." | 3.65 | Evaluation of sodium L-thyroxine (T4) requirement in replacement therapy of hypothyroidism. ( Abbassi, V; Aldige, C, 1977) |
| " Whatever the mechanism, chronic use of excessive quantities of iodide should be avoided until the end of puberty." | 2.71 | Hyperthyrotropinemia during iodide administration in normal children and in children born with neonatal transient hypothyroidism. ( Georgopoulos, NA; Iconomou, G; Karaiskos, KS; Makri, M; Markou, KB; Mengreli, C; Paraskevopoulou, P; Vagenakis, AG, 2003) |
| "Myxedema coma, neonatal hypothyroidism, primary hypothyroidism, and secondary and tertiary hypothyroidism are specific hypothyroid states for which drug therapy is discussed." | 2.36 | Drug therapy reviews: management of hypothyroidism. ( Cobb, WE; Jackson, IM, 1978) |
| "Hyperthyroidism is generally considered to be ameliorated during pregnancy, and there appears to be a high incidence of postpartum exacerbation." | 1.26 | The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. ( Petersen, S; Serup, J, 1977) |
| " When changing from the combined thyroid hormone therapy to treatment with L-thyroxine alone it is enough in most cases to replace the previous amount of L-thyroxine only; previous recommendations for the dosage of thyroid hormone were rather high." | 1.26 | [More recent aspects of treatment for hypothyroidism and goitre in children and adolescents (author's transl)]. ( Kuhn, N; Stahnke, N; Wiebel, J; Willig, RP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (82.69) | 18.7374 |
| 1990's | 1 (1.92) | 18.2507 |
| 2000's | 5 (9.62) | 29.6817 |
| 2010's | 3 (5.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaudhari, M | 1 |
| Slaughter, JL | 1 |
| Li, N | 1 |
| Li, XH | 1 |
| Yao, YM | 1 |
| Carrascosa, A | 2 |
| Ruiz-Cuevas, P | 2 |
| Clemente, M | 2 |
| Salcedo, S | 2 |
| Almar, J | 2 |
| Benvenga, S | 1 |
| Ordookhani, A | 1 |
| Pearce, EN | 1 |
| Tonacchera, M | 1 |
| Azizi, F | 1 |
| Braverman, LE | 1 |
| Kurt, A | 1 |
| Aygun, AD | 1 |
| Sengul, I | 1 |
| Sen, Y | 1 |
| Citak Kurt, AN | 1 |
| Ustundag, B | 1 |
| Markou, KB | 1 |
| Paraskevopoulou, P | 1 |
| Karaiskos, KS | 1 |
| Makri, M | 1 |
| Georgopoulos, NA | 1 |
| Iconomou, G | 1 |
| Mengreli, C | 1 |
| Vagenakis, AG | 1 |
| GAUTIER, A | 1 |
| JEANDET, J | 1 |
| LELONG, M | 1 |
| JOB, JC | 1 |
| DEBAUCHEZ, C | 1 |
| LEES, MH | 1 |
| RUTHVEN, CR | 1 |
| MARTIUS, G | 1 |
| BAEUMER, R | 1 |
| MOSER, X | 1 |
| Kruś, J | 1 |
| Szymański, W | 1 |
| Korbal, P | 1 |
| Potau, N | 1 |
| Yeste, D | 1 |
| Lauritzen, C | 2 |
| Lehmann, WD | 2 |
| Solomon, DH | 1 |
| Fisher, DA | 2 |
| Klein, AH | 1 |
| Viscardi, RM | 1 |
| Shea, M | 1 |
| Sriwantanakul, K | 1 |
| McCormick, K | 1 |
| De Filippis, V | 1 |
| Fabris, C | 1 |
| Bacolla, A | 1 |
| Bertino, E | 1 |
| Migliardi, M | 1 |
| Trapani, G | 1 |
| Chillemi, C | 1 |
| Mombrò, M | 1 |
| Mongardi, L | 1 |
| Montrucchio, F | 1 |
| Garzena, E | 1 |
| Costa, A | 1 |
| l'Allemand, D | 1 |
| Grüters, A | 1 |
| Heidemann, P | 1 |
| Schürnbrand, P | 1 |
| Chechkova, OB | 1 |
| Brashnina, NP | 1 |
| Samsygina, GA | 1 |
| Jhaveri, RC | 2 |
| Glass, L | 2 |
| Evans, HE | 2 |
| Dube, SK | 2 |
| Rosenfeld, W | 2 |
| Khan, F | 2 |
| Salazar, JD | 1 |
| Chandavasu, O | 1 |
| Zappulla, F | 1 |
| Bernardi, F | 1 |
| Cassio, A | 1 |
| Bergamaschi, R | 1 |
| Piazzi, S | 1 |
| Capelli, M | 1 |
| Pirazzoli, P | 1 |
| Cicognani, A | 1 |
| Cacciari, E | 1 |
| Jacobsen, BB | 2 |
| Schaeffer, HA | 1 |
| Filetti, S | 1 |
| Catanuso, A | 1 |
| Lisi, E | 1 |
| Pezzino, V | 1 |
| Sangiorgio, L | 1 |
| Squatrito, S | 1 |
| Vigneri, R | 1 |
| Montoro, M | 1 |
| Collea, JV | 1 |
| Frasier, SD | 1 |
| Mestman, JH | 1 |
| Homoki, J | 1 |
| Birk, J | 1 |
| Loos, U | 1 |
| Rothenbuchner, G | 1 |
| Fazekas, AT | 1 |
| Teller, WM | 1 |
| Burger, A | 1 |
| Buerer, Th | 1 |
| Lacourt, G | 1 |
| Dussault, JH | 2 |
| Letarte, J | 2 |
| Guyda, H | 2 |
| Laberge, C | 2 |
| LaFranchi, SH | 1 |
| Murphey, WH | 1 |
| Foley, TP | 1 |
| Larsen, PR | 1 |
| Buist, NR | 1 |
| Diamond, FB | 1 |
| Parks, JS | 1 |
| Tenore, A | 1 |
| Marino, JM | 1 |
| Bongiovanni, AM | 2 |
| Carta Sorcini, M | 1 |
| Tomarchio, S | 1 |
| Fiore, L | 1 |
| Carta, S | 1 |
| Cobb, WE | 1 |
| Jackson, IM | 1 |
| Walfish, PG | 1 |
| Ginsberg, J | 1 |
| Rosenberg, RA | 1 |
| Howard, NJ | 1 |
| Abbassi, V | 1 |
| Aldige, C | 1 |
| Serup, J | 1 |
| Petersen, S | 1 |
| Dissanayake, S | 1 |
| Tortorolo, G | 1 |
| Marietti, G | 1 |
| Martino, F | 1 |
| Troncone, L | 1 |
| Luchino, F | 1 |
| Smallridge, RC | 1 |
| Wartofsky, L | 1 |
| Chopra, IJ | 1 |
| Marinelli, PV | 1 |
| Broughton, RE | 1 |
| Dimond, RC | 1 |
| Burman, KD | 1 |
| Klett, M | 1 |
| Mayer, P | 1 |
| Schönberg, D | 1 |
| Andersen, H | 1 |
| Dige-Petersen, H | 1 |
| Hummer, L | 1 |
| Wilkin, TJ | 1 |
| Kenyon, E | 1 |
| Isles, TE | 1 |
| Wiebel, J | 1 |
| Kuhn, N | 1 |
| Stahnke, N | 1 |
| Willig, RP | 1 |
| Harkavy, KL | 1 |
| Enecio, CE | 1 |
| Franklin, R | 1 |
| O'Grady, C | 1 |
| Kalra, A | 1 |
| Jain, AK | 1 |
| Hazra, DK | 1 |
| Shukla, AK | 1 |
| Mathur, DD | 1 |
| Dayal, RS | 1 |
| Schenken, JR | 1 |
| Brabec, P | 1 |
| Goluboff, LG | 1 |
| Sisson, JC | 1 |
| Hamburger, JI | 1 |
| Holt, WA | 1 |
| Talbert, LM | 1 |
| Thomas, CG | 1 |
| Rankin, P | 1 |
| Morrow, G | 1 |
| Bomberger, JH | 1 |
| Boggs, TR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound and Functional Thyroid Evaluation in Preterm Infants Born Between 24 and 32 Weeks of Gestation[NCT04208503] | 200 participants (Anticipated) | Observational [Patient Registry] | 2019-12-19 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for triiodothyronine and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Thyroid Function in the Neonatal Intensive Care Unit.
Topics: Gestational Age; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Infant, Extremely Premature | 2018 |
[Neonatal hyperthyroidism: a case report and literature review].
Topics: Antithyroid Agents; Apnea; Female; Graves Disease; Humans; Hyperthyroidism; Infant, Newborn; Infant, | 2013 |
Thyroid development and disorders of thyroid function in the newborn.
Topics: Animals; Feedback; Homeostasis; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Infant, Newb | 1981 |
[Congenital hypothyroidism: metabolic aspects and neonatal screening].
Topics: Canada; Congenital Hypothyroidism; Fetal Blood; Humans; Hypothyroidism; Infant, Newborn; Infant, New | 1979 |
Drug therapy reviews: management of hypothyroidism.
Topics: Autoimmune Diseases; Coma; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; Infant, Newborn | 1978 |
Thyroid function in the fetus and newborn.
Topics: Congenital Hypothyroidism; Female; Fetus; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; | 1975 |
Hyperthyroidism during pregnancy.
Topics: Abortion, Spontaneous; Congenital Hypothyroidism; Female; Fetal Death; Humans; Hyperthyroidism; Infa | 1970 |
3 trials available for triiodothyronine and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Hyperthyrotropinemia during iodide administration in normal children and in children born with neonatal transient hypothyroidism.
Topics: Adolescent; Age Factors; Child; Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant, N | 2003 |
[The importance of steroid hormones in the pathogenesis of hyperbilirubinemia and neonatal jaundice].
Topics: Bilirubin; Breast Feeding; Clinical Trials as Topic; Cortisone; Dexamethasone; Estriol; Female; Gluc | 1966 |
The effect of triiodothyronine on neonatal hyperbilirubinemia.
Topics: Anemia, Hemolytic; Clinical Trials as Topic; Exchange Transfusion, Whole Blood; Humans; Hyperbilirub | 1966 |
42 other studies available for triiodothyronine and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Thyroid function in 76 sick preterm infants 30-36 weeks: results from a longitudinal study.
Topics: Case-Control Studies; Female; Gestational Age; Humans; Hypothyroidism; Infant, Newborn; Infant, Newb | 2008 |
Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hy
Topics: Autoantibodies; Autoantigens; Body Height; Body Weight; Child, Preschool; Congenital Hypothyroidism; | 2008 |
Serum thyroid hormones levels are significantly decreased in septic neonates with poor outcome.
Topics: Anti-Bacterial Agents; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newbo | 2011 |
[Congenital goiter resistant to hormone therapy].
Topics: Child; Congenital Hypothyroidism; Goiter; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases | 1957 |
[GOITERS IN THE NEWBORN].
Topics: Female; Goiter; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; | 1964 |
The effect of triiodothyronine in neonatal hyperbilirubianaemia.
Topics: Child; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Jaundice; Triiodothyronine | 1959 |
[Prevention of iodine deficiency goiter in newborn infants by the use of iodine salt and triiodothyronine (Thybon)].
Topics: Child; Goiter; Goiter, Endemic; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Iodine; | 1961 |
[Thyroid dysfunction in pregnant women and correlation with clinical and metabolical status of their newborns].
Topics: Adult; Female; Graves Disease; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; P | 2003 |
Thyroid function in preterm infants 27-29 weeks of gestational age during the first four months of life: results from a prospective study comprising 80 preterm infants.
Topics: Birth Weight; Databases, Factual; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Disease | 2007 |
The significance of steroid hormones for the development of hyperbilirubinaemia and icterus in the newborn infant.
Topics: Bilirubin; Birth Weight; Cortisone; Dexamethasone; Estriol; Female; Glucosyltransferases; Glucuronat | 1967 |
Pregnancy and PTU.
Topics: Female; Fetus; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Immunoglobulin G; Immunoglob | 1981 |
Hyperthyroxinemia in newborns due to excess thyroxine-binding globulin.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Thyrotropin; Thyroxine; Thyroxine-Binding | 1983 |
[Screening for congenital hypothyroidism. Results of screening of 20,000 newborn infants].
Topics: Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant; Infant, Newborn; Infant, Newborn, | 1981 |
Iodine-induced alterations of thyroid function in newborn infants after prenatal and perinatal exposure to povidone iodine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Iodides; Povidone; Povidone-Iodine; Preg | 1983 |
[State of the hypophyseal-thyroid system in suppurative inflammatory diseases in newborn infants (radioimmunological study)].
Topics: Conjunctivitis; Dermatitis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pituitary Gland, Ant | 1983 |
Effects of methadone on thyroid function in mother, fetus, and newborn.
Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea | 1980 |
[Behavior of TSH, T4, free T4, T3, free T3 and reverse T3 in the first 15 days of life].
Topics: Adult; Age Factors; Female; Fetal Blood; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; I | 1980 |
T3 uptake tests in newborn infants.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Thyroxine; Triiodothyronine | 1981 |
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective | 1981 |
Measurement of reverse triiodothyronine in dried blood spot: methodology and clinical application as a screening procedure for detection of congenital hypothyroidism.
Topics: Congenital Hypothyroidism; Fetal Blood; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Di | 1980 |
Successful outcome of pregnancy in women with hypothyroidism.
Topics: Adult; Female; Fertility; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Matern | 1981 |
Thyroid function in term newborn infants with congenital goiter.
Topics: Bone Development; Goiter; Humans; Infant, Newborn; Infant, Newborn, Diseases; Thyroid Function Tests | 1975 |
Letter: Reverse T3 in screening for neonatal hypothyroidism.
Topics: Fetal Blood; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Triiodothyronine | 1976 |
Serum thyroid hormone and TSH concentrations in newborn infants with congenital absence of thyroxine-binding globulin.
Topics: Alpha-Globulins; Diagnosis, Differential; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, N | 1977 |
Neonatal hypothyroidism detected by the Northwest Regional Screening Program.
Topics: Congenital Hypothyroidism; Cost-Benefit Analysis; Diagnosis, Differential; False Positive Reactions; | 1979 |
Hypothyroxinemia in sick and well preterm infants.
Topics: Creatine Kinase; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Infant, Prematu | 1979 |
Results of a regional cord blood screening programme for detecting neonatal hypothyroidism.
Topics: Female; Fetal Blood; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Male; Mass | 1979 |
Evaluation of sodium L-thyroxine (T4) requirement in replacement therapy of hypothyroidism.
Topics: Adolescent; Body Weight; Child; Child, Preschool; Congenital Hypothyroidism; Female; Humans; Hypothy | 1977 |
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis.
Topics: Female; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange | 1977 |
Levels of immunoglobulins G and M and tri-iodothyronine in cord blood and the diagnosis of neonatal thyroid disease.
Topics: Female; Fetal Blood; Humans; Immunoglobulin G; Immunoglobulin M; Infant, Newborn; Infant, Newborn, D | 1978 |
[Study of thyroid function in the neonatal period].
Topics: Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Thyroid Function Tests; Thyroxi | 1978 |
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2.
Topics: Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Long-Acting Thyroid Stimulator; | 1978 |
[Neonatal screening for hypothyroidism. Preliminary results from different methods (author's transl)].
Topics: Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Disease | 1978 |
Thyrotropin response to thyrotropin-releasing hormone in fullterm, euthyroid and hypothyroid newborns.
Topics: Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Disease | 1976 |
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis.
Topics: Adult; Female; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Male; Pregnancy; | 1977 |
Thyroid function in neonatal hypothyroidism.
Topics: Female; Humans; Hypothalamus; Hypothyroidism; Infant, Newborn; Infant, Newborn, Diseases; Male; Pitu | 1976 |
[More recent aspects of treatment for hypothyroidism and goitre in children and adolescents (author's transl)].
Topics: Adolescent; Adult; Age Factors; Child; Child Care; Child Development; Child Guidance; Child, Prescho | 1976 |
Free thyroxine levels in hospitalized newborns: depressed levels in critical, nonthyroidal illness.
Topics: Female; Gestational Age; Hospitalization; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant | 1991 |
Neonatal thyroid function: effects of nonthyroidal illness.
Topics: Asphyxia Neonatorum; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Infections; M | 1985 |
Thyroid screening in newborns.
Topics: Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Postmature; Male; M | 1985 |
Free thyroxine index in maternal and cord sera: coefficients of variation evaluated by the method of differences of duplicates.
Topics: Congenital Hypothyroidism; Female; Humans; Hypothyroidism; Infant, Newborn; Infant, Newborn, Disease | 1973 |
Hyperthyroidism associated with pregnancy.
Topics: Adolescent; Adult; Antithyroid Agents; Drug Therapy, Combination; Female; Fetal Diseases; Goiter; Hu | 1974 |