triiodothyronine has been researched along with Hepatocellular Carcinoma in 83 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to determine the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and to evaluate possible mechanisms." | 7.85 | Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma. ( Beukhof, CM; Bins, S; Chaker, L; de Herder, WW; de Rijke, YB; Mathijssen, RH; Peeters, RP; van Doorn, L; van Heerebeek, R; van Kemenade, FJ; Visser, TJ; Visser, WE, 2017) |
| "The objective of this study was to determine the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and to evaluate possible mechanisms." | 3.85 | Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma. ( Beukhof, CM; Bins, S; Chaker, L; de Herder, WW; de Rijke, YB; Mathijssen, RH; Peeters, RP; van Doorn, L; van Heerebeek, R; van Kemenade, FJ; Visser, TJ; Visser, WE, 2017) |
| " We investigated the triiodothyronine (T3) modulation of gene expression, in human hepatocellular carcinoma cell lines, via a PCR-based cDNA subtraction method." | 3.72 | Regulation of fibronectin by thyroid hormone receptors. ( Chen, CY; Chen, SL; Huang, YH; Lin, KH; Shen, JJ; Shih, CH; Wang, CS; Yang, RC; Yen, CC, 2004) |
| " L-triiodothyronine and L-thyroxine stimulated hypoxia-induced Epo formation both in the kidney and in HepG2 cells in a dose-dependent fashion." | 3.69 | Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro. ( Fandrey, J; Frede, S; Jelkmann, W; Pagel, H; Wolff, M, 1994) |
| "We have studied the effects of triiodothyronine (T3) on the production of hepatic triacylglycerol lipase (HTGL) in the human hepatocellular carcinoma cell line, HepG2, by measuring its activity and mRNA levels." | 3.68 | Stimulation of the activity and mRNA level of hepatic triacylglycerol lipase by triiodothyronine in HepG2 cells. ( Funahashi, T; Kubo, M; Matsuzawa, Y; Menju, M; Nozaki, S; Shimomura, I, 1992) |
| "Different rat and mouse models of hepatocarcinogenesis were investigated." | 1.56 | Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming. ( Bellomo, SE; Cabras, L; Columbano, A; Follenzi, A; Fornari, F; Giordano, S; Gramantieri, L; Kowalik, MA; Ledda-Columbano, GM; Merlin, S; Morandi, A; Orrù, C; Parri, M; Perra, A; Petrelli, A; Puliga, E; Rasola, A; Sanchez-Martin, C; Sebastian, C; Sulas, P, 2020) |
| "THs are involved in a crosstalk between hepatoma and stromal cells, and disruption of TH signaling is associated with tumorigenesis." | 1.56 | Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression. ( Lin, KH; Wu, CH; Yeh, CT, 2020) |
| "The effects of miR-130b on hepatocellular carcinoma (HCC) invasion were further examined in vitro and in vivo." | 1.42 | Repression of microRNA-130b by thyroid hormone enhances cell motility. ( Chen, CY; Chen, WJ; Chi, HC; Chung, IH; Huang, YH; Liao, CJ; Lin, KH; Lin, TP; Lin, YH; Tsai, CY; Tsai, MM; Tseng, YH; Wu, MH; Wu, SM; Yeh, YH, 2015) |
| "Overexpression of miR-21 promoted hepatoma cell migration and invasion, similar to that observed with T(3) stimulation in hepatoma cells." | 1.39 | Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma. ( Chen, CY; Chi, HC; Huang, YH; Hung, YT; Liao, CH; Liao, CJ; Lin, CD; Lin, KH; Lin, SY; Lin, YH; Tsai, CY; Tseng, YH; Wang, CJ; Wu, SM, 2013) |
| "Triiodothyronine (T3) is a potent form of thyroid hormone mediates several physiological processes including cellular growth, development, and differentiation via binding to the nuclear thyroid hormone receptor (TR)." | 1.39 | Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4. ( Chen, CY; Chen, WJ; Chi, HC; Chung, IH; Huang, YH; Liao, CH; Liao, CJ; Lin, KH; Lin, YH; Tsai, CY; Tseng, YH; Wu, SM; Wu, TI, 2013) |
| "We found that TR-overexpressing hepatoma cells treated with T(3) were apoptosis resistant, even when TRAIL was upregulated." | 1.38 | Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL. ( Chen, CY; Chen, SL; Chen, WJ; Chi, HC; Chung, IH; Huang, YH; Liao, CH; Liao, CJ; Lin, KH; Lin, YH; Tsai, CY; Tsai, MM; Tseng, YH; Wu, SM; Yeh, CT, 2012) |
| "In addition, C/EBP was upregulated in hepatoma cells after T(3) treatment and ectopic expression of MAT1A inhibited cell migration and invasion in J7 hepatoma cells." | 1.36 | Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines. ( Chen, WJ; Cheng, WL; Chien, LF; Huang, YH; Liao, CH; Liao, CJ; Lin, KH; Lu, YH; Tsai, MM; Wu, SM; Yeh, CT, 2010) |
| "To examine the influence of T3 on hepatoma cell growth, thyroid receptor (TR)alpha1 or TRbeta1 over-expressing HepG2 cell lines were used." | 1.33 | Mediation of the inhibitory effect of thyroid hormone on proliferation of hepatoma cells by transforming growth factor-beta. ( Chen, WJ; Cheng, WL; Huang, YH; Liao, CJ; Liao, CY; Lin, KH; Yen, CC, 2006) |
| "Mutant TRs have been detected in human hepatocellular carcinoma cell lines and tissue, but their contribution to carcinogenesis has remained unclear." | 1.31 | Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators. ( Chen, SL; Lin , KH; Wu , YH, 2001) |
| "Rats bearing the Zajdela hepatoma tumor and T3-treated hypothyroid rats were used to study the role of protein degradation in the process of mitochondrial biogenesis." | 1.30 | Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease. ( Chloupkova, M; Luciakova, K; Nelson, BD; Sokolikova, B, 1999) |
| "Treatment with cycloheximide together with any of the hormones resulted in an increase in SHBG mRNA levels." | 1.29 | Regulation of sex hormone-binding globulin secretion and gene expression by cycloheximide in vitro. ( Adlercreutz, H; Carson, M; Loukovaara, M, 1995) |
| "Amiodarone and EMD 21388 were without effect both in cytosol and nuclear extract." | 1.29 | Drug competition for intracellular triiodothyronine-binding sites. ( Barlow, JW; Curtis, AJ; Loidl, NM; Raggatt, LE; Stockigt, JR; Topliss, DJ, 1994) |
| "Phloretin is an inhibitor of the mammalian glucose transporter and the iodothyronine-5'-deiodinase." | 1.28 | Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human hep G2 hepatocarcinoma cells. ( Movius, EG; Phyillaier, MM; Robbins, J, 1989) |
| "It was only found in hepatoma cells where it is regulated by estradiol, antiestrogen tamoxifen and triiodothyronine, in a similar way as secreted SBP." | 1.28 | Regulation of SBP synthesis in human cancer cell lines by steroid and thyroid hormones. ( Baulieu, EE; Baville, F; Bideux, G; Binart, N; Chambraud, B; Mercier-Bodard, C, 1989) |
| "It is postulated that this patient's hepatoma produced a substance stimulating thyroid-stimulating hormone synthesis and secretion with resultant inappropriate thyroid-stimulating hormone production and thyrotoxicosis." | 1.27 | Hepatocellular carcinoma: an unusual course with hyperthyroidism and inappropriate thyroid-stimulating hormone production. ( Helzberg, JH; Lukert, BP; McPhee, MS; Zarling, EJ, 1985) |
| "The human hepatoma-derived cell line, Hep G2, and a clone, H5A, isolated from Hep G2, were both found to secrete SBP-like protein." | 1.27 | Hormonal control of SBP in human hepatoma cells. ( Baulieu, EE; Mercier-Bodard, C, 1986) |
| "Similarly, the presence or absence of hepatic encephalopathy determined, and/or reflected, at least in part, the type of response observed." | 1.27 | Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease. ( Gavaler, JS; Sanghvi, A; Schade, RR; Tarter, R; Van Thiel, DH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (21.69) | 18.7374 |
| 1990's | 26 (31.33) | 18.2507 |
| 2000's | 14 (16.87) | 29.6817 |
| 2010's | 23 (27.71) | 24.3611 |
| 2020's | 2 (2.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kowalik, MA | 1 |
| Puliga, E | 1 |
| Cabras, L | 1 |
| Sulas, P | 1 |
| Petrelli, A | 1 |
| Perra, A | 1 |
| Ledda-Columbano, GM | 1 |
| Morandi, A | 1 |
| Merlin, S | 1 |
| Orrù, C | 1 |
| Sanchez-Martin, C | 1 |
| Fornari, F | 1 |
| Gramantieri, L | 1 |
| Parri, M | 1 |
| Rasola, A | 1 |
| Bellomo, SE | 1 |
| Sebastian, C | 1 |
| Follenzi, A | 1 |
| Giordano, S | 1 |
| Columbano, A | 1 |
| Wu, CH | 1 |
| Yeh, CT | 8 |
| Lin, KH | 22 |
| Chi, HC | 11 |
| Chen, SL | 6 |
| Lin, SL | 1 |
| Tsai, CY | 9 |
| Chuang, WY | 2 |
| Lin, YH | 9 |
| Huang, YH | 16 |
| Tsai, MM | 10 |
| Beukhof, CM | 1 |
| van Doorn, L | 1 |
| Visser, TJ | 1 |
| Bins, S | 1 |
| Visser, WE | 1 |
| van Heerebeek, R | 1 |
| van Kemenade, FJ | 1 |
| de Rijke, YB | 1 |
| de Herder, WW | 1 |
| Chaker, L | 1 |
| Mathijssen, RH | 1 |
| Peeters, RP | 1 |
| Pireddu, R | 1 |
| Pibiri, M | 1 |
| Valenti, D | 1 |
| Sinico, C | 1 |
| Fadda, AM | 1 |
| Simbula, G | 1 |
| Lai, F | 1 |
| Liao, CH | 7 |
| Liao, CJ | 8 |
| Wu, SM | 11 |
| Chen, CY | 8 |
| Tseng, YH | 7 |
| Lin, SY | 1 |
| Hung, YT | 1 |
| Wang, CJ | 1 |
| Lin, CD | 2 |
| Chung, IH | 4 |
| Wu, TI | 1 |
| Chen, WJ | 9 |
| Wu, MH | 2 |
| Lin, TP | 1 |
| Yeh, YH | 1 |
| Srivastava, J | 1 |
| Robertson, CL | 1 |
| Gredler, R | 1 |
| Siddiq, A | 1 |
| Rajasekaran, D | 1 |
| Akiel, MA | 1 |
| Emdad, L | 1 |
| Mas, V | 1 |
| Mukhopadhyay, ND | 1 |
| Fisher, PB | 1 |
| Sarkar, D | 1 |
| McAninch, EA | 1 |
| Miller, BT | 1 |
| Ueta, CB | 1 |
| Jo, S | 1 |
| Kim, BW | 1 |
| Schmohl, KA | 1 |
| Müller, AM | 1 |
| Wechselberger, A | 1 |
| Rühland, S | 1 |
| Salb, N | 1 |
| Schwenk, N | 1 |
| Heuer, H | 1 |
| Carlsen, J | 1 |
| Göke, B | 1 |
| Nelson, PJ | 1 |
| Spitzweg, C | 1 |
| Liu, H | 1 |
| Yang, CC | 1 |
| Tan, BC | 1 |
| Sun, CP | 1 |
| Lin, TK | 1 |
| Chang, WC | 2 |
| Chang, YT | 1 |
| Stefos, GC | 1 |
| Becker, W | 1 |
| Lampidonis, AD | 1 |
| Rogdakis, E | 1 |
| Ritchie, JW | 1 |
| Taylor, PM | 1 |
| Yeh, SC | 1 |
| Chen, RN | 2 |
| Tai, PJ | 1 |
| Cheng, WL | 5 |
| Pai, LM | 1 |
| Attia, RR | 1 |
| Connnaughton, S | 1 |
| Boone, LR | 1 |
| Wang, F | 1 |
| Elam, MB | 1 |
| Ness, GC | 1 |
| Cook, GA | 1 |
| Park, EA | 2 |
| Lu, YH | 1 |
| Chien, LF | 1 |
| Rosen, MD | 1 |
| Chan, IH | 2 |
| Privalsky, ML | 2 |
| Gnoni, GV | 1 |
| Rochira, A | 1 |
| Leone, A | 1 |
| Damiano, F | 1 |
| Marsigliante, S | 1 |
| Siculella, L | 1 |
| Chi, LM | 1 |
| Timmer, DC | 1 |
| Bakker, O | 2 |
| Wiersinga, WM | 2 |
| Cassy, S | 1 |
| Derouet, M | 1 |
| Crochet, S | 1 |
| Dridi, S | 1 |
| Taouis, M | 1 |
| Kawai, K | 1 |
| Sasaki, S | 1 |
| Morita, H | 1 |
| Ito, T | 1 |
| Suzuki, S | 1 |
| Misawa, H | 1 |
| Nakamura, H | 1 |
| Yen, CC | 2 |
| Shih, CH | 1 |
| Shen, JJ | 1 |
| Yang, RC | 1 |
| Wang, CS | 1 |
| Liao, CY | 1 |
| Hashimoto, K | 1 |
| Yamada, M | 1 |
| Matsumoto, S | 1 |
| Monden, T | 1 |
| Satoh, T | 1 |
| Mori, M | 1 |
| Ventura-Holman, T | 1 |
| Mamoon, A | 1 |
| Maher, JF | 1 |
| Subauste, JS | 1 |
| Otto, T | 1 |
| Fandrey, J | 4 |
| Ordóñez-Llanos, J | 1 |
| Rodríguez-Espinosa, J | 1 |
| Gómez-Gerique, JA | 1 |
| Pagel, H | 1 |
| Frede, S | 1 |
| Wolff, M | 1 |
| Jelkmann, W | 3 |
| Kobayashi, M | 2 |
| Horiuchi, R | 2 |
| Loukovaara, M | 1 |
| Carson, M | 1 |
| Adlercreutz, H | 1 |
| Vandenbrouck, Y | 1 |
| Janvier, B | 1 |
| Loriette, C | 1 |
| Bereziat, G | 1 |
| Mangeney-Andreani, M | 1 |
| Lin, YW | 2 |
| Parkison, C | 1 |
| Cheng, SY | 4 |
| Kragie, L | 2 |
| Forrester, ML | 1 |
| Cody, V | 1 |
| McCourt, M | 1 |
| Brenner, B | 1 |
| Barlow, JW | 3 |
| Crowe, TC | 2 |
| Cowen, NL | 1 |
| Raggatt, LE | 2 |
| Topliss, DJ | 3 |
| Blok, RB | 1 |
| Stockigt, JR | 3 |
| Curtis, AJ | 1 |
| Loidl, NM | 2 |
| van Stralen, PG | 1 |
| van der Hoek, HJ | 1 |
| Docter, R | 1 |
| de Jong, M | 1 |
| Krenning, EP | 1 |
| Lim, CF | 1 |
| Hennemann, G | 1 |
| Lee, HF | 1 |
| Liu, WL | 1 |
| Chen, ST | 3 |
| Chang, KS | 1 |
| Nakamura, N | 1 |
| Shidoji, Y | 1 |
| Moriwaki, H | 1 |
| Muto, Y | 1 |
| Payne, KL | 1 |
| Zhu, XG | 2 |
| Shieh, HY | 2 |
| Hsu, HC | 2 |
| McPhie, P | 2 |
| Stephan, ZF | 1 |
| Yurachek, EC | 1 |
| Sharif, R | 1 |
| Wasvary, JM | 1 |
| Leonards, KS | 1 |
| Hu, CW | 1 |
| Hintze, TH | 1 |
| Steele, RE | 1 |
| Li, X | 1 |
| Sumi, T | 1 |
| Matsukawa, T | 1 |
| Nakanishi, Y | 1 |
| Ohba, Y | 1 |
| Hudig, F | 1 |
| Meijssen, S | 1 |
| Luciakova, K | 1 |
| Sokolikova, B | 1 |
| Chloupkova, M | 1 |
| Nelson, BD | 1 |
| Lin , KH | 1 |
| Wu , YH | 1 |
| Benvenga, S | 1 |
| Lakshmanan, M | 1 |
| Trimarchi, F | 1 |
| Drover, VA | 1 |
| Wong, NC | 1 |
| Agellon, LB | 1 |
| Sorimachi, K | 1 |
| Robbins, J | 2 |
| Theriault, A | 1 |
| Ogbonna, G | 1 |
| Adeli, K | 1 |
| Nozaki, S | 1 |
| Shimomura, I | 1 |
| Funahashi, T | 1 |
| Menju, M | 1 |
| Kubo, M | 1 |
| Matsuzawa, Y | 1 |
| Giralt, M | 1 |
| Gurney, AL | 1 |
| Liu, JS | 1 |
| Hakimi, P | 1 |
| Hanson, RW | 1 |
| Mercier-Bodard, C | 3 |
| Nivet, V | 1 |
| Baulieu, EE | 3 |
| Darby, IA | 1 |
| Bouhnik, J | 1 |
| Coezy, ED | 1 |
| Corvol, P | 1 |
| Seydel, FP | 1 |
| Siegers, CP | 1 |
| Matsuda, M | 1 |
| Nagai, K | 1 |
| Okano, Y | 1 |
| Tanabashi, S | 1 |
| Kametani, M | 1 |
| Tokimitsu, N | 1 |
| Sakata, S | 1 |
| Miura, K | 1 |
| Conti, R | 1 |
| Ceccarini, C | 1 |
| Tecce, MF | 1 |
| Movius, EG | 1 |
| Phyillaier, MM | 1 |
| Ober, KP | 1 |
| Lowder, SC | 1 |
| Baville, F | 1 |
| Bideux, G | 1 |
| Binart, N | 1 |
| Chambraud, B | 1 |
| Hachisu, T | 1 |
| Takikawa, H | 1 |
| Chou, CK | 1 |
| Ho, LT | 1 |
| Ting, LP | 1 |
| Hu, CP | 1 |
| Su, TS | 1 |
| Suen, CS | 1 |
| Huang, MY | 1 |
| Chang, CM | 1 |
| Helzberg, JH | 1 |
| McPhee, MS | 1 |
| Zarling, EJ | 1 |
| Lukert, BP | 1 |
| Murata, Y | 1 |
| Sarne, DH | 1 |
| Horwitz, AL | 1 |
| Lecocq, R | 1 |
| Aden, DP | 1 |
| Knowles, BB | 1 |
| Refetoff, S | 1 |
| Van Thiel, DH | 1 |
| Tarter, R | 1 |
| Gavaler, JS | 1 |
| Schade, RR | 1 |
| Sanghvi, A | 1 |
| Ichikawa, K | 1 |
| DeGroot, LJ | 1 |
| Jemec, B | 1 |
| Hamada, S | 1 |
| Nakagawa, T | 1 |
| Mori, T | 1 |
| Torizuka, K | 1 |
| Hunt, SM | 1 |
| Osnos, M | 1 |
| Rivlin, RS | 1 |
| Karsten, U | 1 |
| Sydow, G | 1 |
| Wollenberger, A | 1 |
| Graffi, A | 1 |
1 review available for triiodothyronine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Thyroid hormone actions in liver cancer.
Topics: Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Models, | 2013 |
82 other studies available for triiodothyronine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming.
Topics: Aged; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Cell Differentiat | 2020 |
Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression.
Topics: Carcinoma, Hepatocellular; Cell Proliferation; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Disea | 2020 |
Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Hepatocytes; Humans; L | 2017 |
Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma.
Topics: Aged; Amino Acid Transport Systems, Neutral; Animals; Antineoplastic Agents; Carcinoma, Hepatocellul | 2017 |
A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine.
Topics: Animals; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cell Line, Tumor; Delayed-Action Pr | 2018 |
Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Gene Ex | 2013 |
Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Humans; Intercellular Signal | 2013 |
Repression of microRNA-130b by thyroid hormone enhances cell motility.
Topics: Aged; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Disease Progression; Down-Regulati | 2015 |
Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Line, Tumor; Down-Regulation; Euth | 2015 |
Thyroid Hormone at Near Physiologic Concentrations Acutely Increases Oxygen Consumption and Extracellular Acidification in LH86 Hepatoma Cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Homeostasis; Humans; Hypothyroidism; Liver; Liver Neopl | 2015 |
Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentia | 2015 |
ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance.
Topics: Carcinoma, Hepatocellular; Chromatin Immunoprecipitation; Gene Expression Regulation, Neoplastic; He | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Division; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neo | 2016 |
Cloning and functional characterization of the ovine malic enzyme promoter.
Topics: Adipose Tissue; Animals; Base Sequence; Carcinoma, Hepatocellular; Cells, Cultured; Cloning, Molecul | 2009 |
Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells.
Topics: Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Primers; Humans; Liver Neoplasms; Tr | 2010 |
Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cells, Cultured; Extracellular | 2010 |
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha).
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Hepatocytes; Humans; Hyperthyro | 2010 |
Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines.
Topics: Base Sequence; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cell Mo | 2010 |
Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cathepsin H; Cell Movement; Gene Expression Regul | 2011 |
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.
Topics: Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Gene Expression Profiling; Gene Expression Regulat | 2011 |
3,5,3'triiodo-L-thyronine induces SREBP-1 expression by non-genomic actions in human HEP G2 cells.
Topics: Carcinoma, Hepatocellular; Feedback, Physiological; Hep G2 Cells; Humans; Integrin alphaVbeta3; Live | 2012 |
Stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics study of a thyroid hormone-regulated secretome in human hepatoma cells.
Topics: Amino Acids; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; | 2012 |
Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Hep G2 Cells; Humans | 2012 |
Thyroid hormone suppresses cell proliferation through endoglin-mediated promotion of p21 stability.
Topics: Antigens, CD; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatin Immunopreci | 2013 |
Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.
Topics: Alternative Splicing; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hypoth | 2003 |
Leptin and insulin downregulate leptin receptor gene expression in chicken-derived leghorn male hepatoma cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Dexamethasone; Gene Expression Regulation; In | 2003 |
Unliganded thyroid hormone receptor-beta1 represses liver X receptor alpha/oxysterol-dependent transactivation.
Topics: Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Dimerization; | 2004 |
Regulation of fibronectin by thyroid hormone receptors.
Topics: Carcinoma, Hepatocellular; Cycloheximide; DNA-Binding Proteins; Enzyme Inhibitors; Fibronectins; Gen | 2004 |
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cloning, Molecular; DNA-Binding Proteins; Electrophoret | 2006 |
Mediation of the inhibitory effect of thyroid hormone on proliferation of hepatoma cells by transforming growth factor-beta.
Topics: Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferati | 2006 |
Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone.
Topics: Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chlorocebus aethiops | 2006 |
Thyroid hormone responsive genes in the murine hepatocyte cell line AML 12.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cholesterol; DNA, Complementary; Ge | 2007 |
Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor.
Topics: Active Transport, Cell Nucleus; Basic-Leucine Zipper Transcription Factors; Binding Sites; Carcinoma | 2008 |
Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; Gene E | 2008 |
Antibody binding serum T3 in a patient with hepatocarcinoma.
Topics: Aged; Carcinoma, Hepatocellular; Humans; Immunoglobulins; Liver Neoplasms; Male; Protein Binding; Ra | 1984 |
Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA; Dose-Response Relation | 1994 |
Actions of 3,5,3'-tri-iodothyronine on the synthesis and secretion of major plasma proteins by a human hepatoblastoma cell line (Hep G2).
Topics: Acute-Phase Proteins; Carcinoma, Hepatocellular; Culture Media, Serum-Free; Electrophoresis, Gel, Tw | 1995 |
Regulation of sex hormone-binding globulin secretion and gene expression by cycloheximide in vitro.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cycloheximide; Drug Interactions; Estradiol; Gene Exp | 1995 |
The modulation of apolipoprotein E gene expression by 3,3'-5-triiodothyronine in HepG2 cells occurs at transcriptional and post-transcriptional levels.
Topics: Apolipoproteins E; Blotting, Northern; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Cyclohexi | 1994 |
Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor.
Topics: Biomarkers; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Gene Expression; Humans; | 1994 |
Computer-assisted molecular modeling of benzodiazepine and thyromimetic inhibitors of the HepG2 iodothyronine membrane transporter.
Topics: Benzodiazepines; Biological Transport; Carcinoma, Hepatocellular; Cell Membrane; Humans; Image Proce | 1994 |
Serum immunoreactive erythropoietin in hyper- and hypothyroidism: clinical observations related to cell culture studies.
Topics: Carcinoma, Hepatocellular; Erythropoietin; Hemoglobins; Humans; Hyperthyroidism; Hypothyroidism; Liv | 1994 |
Stimulation of sex hormone-binding globulin mRNA and attenuation of corticosteroid-binding globulin mRNA by triiodothyronine in human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Culture Media, Conditioned; Culture Media, Serum-Free; Cycloheximide; Dos | 1994 |
Drug competition for intracellular triiodothyronine-binding sites.
Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; C | 1994 |
Reduced T3 deiodination by the human hepatoblastoma cell line HepG2 caused by deficient T3 sulfation.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Humans; Iodides; Liver; Oxidation-Reduction; Ra | 1993 |
Increased invasive activity of human hepatocellular carcinoma cells is associated with an overexpression of thyroid hormone beta 1 nuclear receptor and low expression of the anti-metastatic nm23 gene.
Topics: Carcinoma, Hepatocellular; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Ne | 1995 |
Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cells, Cultured; Epidermal | 1996 |
Differential modulation of thyroid hormone responsiveness by retinoids in a human cell line.
Topics: Carcinoma, Hepatocellular; Clofibrate; Dose-Response Relationship, Drug; Humans; Sex Hormone-Binding | 1996 |
Identification of naturally occurring dominant negative mutants of thyroid hormone alpha 1 and beta 1 receptors in a human hepatocellular carcinoma cell line.
Topics: Carcinoma, Hepatocellular; DNA; Genes, Dominant; Humans; Liver Neoplasms; Point Mutation; Promoter R | 1996 |
Demonstration of potent lipid-lowering activity by a thyromimetic agent devoid of cardiovascular and thermogenic effects.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Binding, Competitive; Body Temperature; Carcino | 1996 |
Dominant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma.
Topics: Base Sequence; Carcinoma, Hepatocellular; Cloning, Molecular; DNA-Binding Proteins; Genes, Dominant; | 1997 |
Thyroid hormone, all-trans retinoic acid, and 9-cis retinoic acid functioned as negative modulators of the effect of glucocorticoid on induction of alpha 1-acid glycoprotein mRNA in RLN-10 cells.
Topics: Alitretinoin; Animals; Carcinoma, Hepatocellular; Cell Line; Dexamethasone; Down-Regulation; Gene Ex | 1998 |
Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene.
Topics: Amiodarone; Anti-Arrhythmia Agents; Carcinoma, Hepatocellular; Gene Expression; Humans; Liver Neopla | 1998 |
Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease.
Topics: Adenosine Triphosphate; Animals; ATP-Dependent Proteases; Carcinoma, Hepatocellular; Caseins; Gene E | 1999 |
Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators.
Topics: Animals; Carcinoma, Hepatocellular; COS Cells; DNA; DNA-Binding Proteins; Gene Silencing; Genes, Dom | 2001 |
Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepatocellular; Carnitine; Cell Line | 2000 |
A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter.
Topics: Binding Sites; Carcinoma, Hepatocellular; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Humans; | 2002 |
Metabolism of thyroid hormones by cultured monkey hepatocarcinoma cells. Nonphenolic ring dieodination and sulfation.
Topics: Carcinoma, Hepatocellular; Cell Line; Chromatography, Ion Exchange; Chromatography, Thin Layer; Hydr | 1977 |
Thyroid hormone modulates apolipoprotein B gene expression in HepG2 cells.
Topics: Apolipoproteins B; Blotting, Northern; Carcinoma, Hepatocellular; Cell Line; DNA Probes; Gene Expres | 1992 |
Stimulation of the activity and mRNA level of hepatic triacylglycerol lipase by triiodothyronine in HepG2 cells.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Heparin; | 1992 |
Requisite structural characteristics for benzodiazepine inhibition of triiodothyronine uptake into a human liver cell line.
Topics: Anti-Anxiety Agents; Benzodiazepines; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Hu | 1992 |
Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements.
Topics: Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Chromosome Deletion; Cyclic AMP; | 1991 |
Effects of hormones on SBP mRNA levels in human cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Cycloheximide; Endometri | 1991 |
Thyroid hormone receptors and stimulation of angiotensinogen production in HepG2 cells.
Topics: Angiotensinogen; Binding, Competitive; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Humans; K | 1991 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoi | 1990 |
[A case of primary hepatocellular carcinoma associated with hyperthyroxine-binding-globulinemia].
Topics: alpha-Fetoproteins; Alpha-Globulins; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Mid | 1986 |
Thyroid hormone effect on alpha-fetoprotein and albumin coordinate expression by a human hepatoma cell line.
Topics: Albumins; alpha-Fetoproteins; Blotting, Northern; Carcinoma, Hepatocellular; Electrophoresis, Polyac | 1989 |
Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human hep G2 hepatocarcinoma cells.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Gluco | 1989 |
Massive hyperthyroxinemia in a euthyroid patient with hepatocellular carcinoma.
Topics: Aged; Carcinoma, Hepatocellular; Female; Humans; Hyperthyroxinemia; Liver Neoplasms; Triiodothyronin | 1989 |
Regulation of SBP synthesis in human cancer cell lines by steroid and thyroid hormones.
Topics: Blotting, Northern; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line; Estradiol; Female; Gene | 1989 |
Dualistic effects of thyroid hormone on a human hepatoma cell line: inhibition of thyroxine-binding globulin synthesis and stimulation of alpha 1-acid glycoprotein synthesis.
Topics: Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Humans; Kinetics; Liver Neoplasms; Orosomucoid; | 1988 |
Selective suppression of insulin-induced proliferation of cultured human hepatoma cells by somatostatin.
Topics: Carcinoma, Hepatocellular; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Insul | 1987 |
Hepatocellular carcinoma: an unusual course with hyperthyroidism and inappropriate thyroid-stimulating hormone production.
Topics: Carcinoma, Hepatocellular; Female; Humans; Hyperthyroidism; Liver Neoplasms; Middle Aged; Paraneopla | 1985 |
Characterization of thyroxine-binding globulin secreted by a human hepatoma cell line.
Topics: Carcinoma, Hepatocellular; Cell Line; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; | 1985 |
Hormonal control of SBP in human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line; Dexamethasone; Dihydrotestosterone; Dose-Response Relationship | 1986 |
Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease.
Topics: Carcinoma, Hepatocellular; Growth Hormone; Hepatic Encephalopathy; Humans; Liver Diseases; Liver Neo | 1986 |
Thyroid hormone receptors in a human hepatoma cell line: multiple receptor forms on isoelectric focusing.
Topics: Binding, Competitive; Carcinoma, Hepatocellular; Cell Line; Cell Nucleus; Hot Temperature; Humans; H | 1987 |
Studies of the goitrogenic and oncogenic effect of methylthiouracil in C3H mice.
Topics: Adenoma; Animals; Antithyroid Agents; Carcinogens; Carcinoma, Hepatocellular; Cysts; Female; Glucose | 1971 |
Re-evaluation of thyroxine binding and free thyroxine in human serum by paper electrophoresis and equilibrium dialysis, and a new free thyroxine index.
Topics: Anorexia Nervosa; Carcinoma, Hepatocellular; Diabetes Mellitus; Dialysis; Electrophoresis; Female; G | 1970 |
Thyroid hormone regulation of mitochondrial alpha-glycerophosphate dehydrogenase in liver and hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Enzyme Induction; Glycerolphosphate Dehydrogenase; Liver Neoplas | 1970 |
Rat liver glycerolphosphate dehydrogenases: activity changes and induction by thyroid hormone of the mitochondrial enzyme in hepatomas and in precancerous and growing liver.
Topics: Animals; Carcinoma, Hepatocellular; Cytoplasm; Enzyme Induction; Female; Glycerolphosphate Dehydroge | 1971 |