Page last updated: 2024-11-08

triiodothyronine and Graves Ophthalmopathy

triiodothyronine has been researched along with Graves Ophthalmopathy in 24 studies

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.

Graves Ophthalmopathy: An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.

Research Excerpts

ExcerptRelevanceReference
"Triiodothyronine (T3) levels were higher in GO patients than in those without GO."5.40Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves' ophthalmopathy. ( Koh, DG; Lee, JH; Park, SH; Suh, BK, 2014)
"0 mL, but we observed severe hyperthyroidism with elevated serum free triiodothyronine, free thyroxine, and thyrotropin receptor antibody levels."3.78Severe Graves' ophthalmopathy after percutaneous ethanol injection in a nontoxic thyroid nodule. ( Le Moli, R; Muscia, V; Pezzino, V; Regalbuto, C; Russo, M; Vigneri, R, 2012)
"Autoimmune reactions in Graves' disease (GD) occur not only in the thyroid gland, but also in the orbital connective tissue, eyelids, extraocular muscles."1.56Radioiodine therapy and Graves' disease - Myths and reality. ( Borowska, M; Czarnywojtek, A; Gut, P; Karlińska, M; Kobylecka, M; Krolicki, L; Plazinska, MT; Prasek, K; Ruchala, M; Sawicka-Gutaj, N; Wolinski, K; Zgorzalewicz-Stachowiak, M, 2020)
"Hyperthyroidism is a significant contributor to oxidative stress in patients with active TAO, which manifests as upregulated lipid peroxidation and antioxidant system activation."1.56The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves' disease and active thyroid-associated orbitopathy. ( Kos-Kudła, B; Londzin-Olesik, M; Nowak, A; Nowak, M; Wielkoszyński, T, 2020)
"Triiodothyronine (T3) levels were higher in GO patients than in those without GO."1.40Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves' ophthalmopathy. ( Koh, DG; Lee, JH; Park, SH; Suh, BK, 2014)
"Prednisone was started 1 d after RAI and withdrawn after 6 wk."1.36Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study. ( Bartalena, L; Compri, E; Lai, A; Marino, F; Piantanida, E; Sassi, L; Sivelli, P; Tanda, ML, 2010)
"Cataract surgery may lead to recrudescence of TAO in predisposed individuals."1.35Reactivation of thyroid-associated orbitopathy after cataract surgery. ( Douglas, RS; Goldberg, RA; Menghani, RM; Shadpour, JM; Tsirbas, A, 2009)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (16.67)29.6817
2010's14 (58.33)24.3611
2020's6 (25.00)2.80

Authors

AuthorsStudies
Nakano, M1
Konishi, H1
Koshiba, M1
Zhou, J1
Yu, X1
Lou, Y1
Bao, J1
Xia, Y1
Zhu, L1
Liu, R1
Ye, Z1
Liu, Q1
Xuan, M1
Li, R1
Zhang, L1
Zhang, K1
Fang, P1
Xue, Y1
Plazinska, MT1
Sawicka-Gutaj, N2
Czarnywojtek, A1
Wolinski, K1
Kobylecka, M1
Karlińska, M1
Prasek, K1
Zgorzalewicz-Stachowiak, M1
Borowska, M1
Gut, P1
Ruchala, M1
Krolicki, L1
Londzin-Olesik, M1
Kos-Kudła, B1
Nowak, A1
Wielkoszyński, T1
Nowak, M2
Van Regemorter, E1
Joris, V1
Van Regemorter, V1
Marique, L1
Behets, C1
Lengelé, B1
Boschi, A1
Baldeschi, L1
Daumerie, C1
Many, MC1
Craps, J1
Machen, L1
MacIntosh, P1
Bruscolini, A1
Abbouda, A1
Locuratolo, N1
Restivo, L1
Trimboli, P1
Romanelli, F1
Lee, JH1
Park, SH1
Koh, DG1
Suh, BK1
Erdei, A1
Paragh, G1
Kovacs, P1
Karanyi, Z1
Berenyi, E1
Galuska, L1
Lenkey, A1
Szabados, L1
Gyory, F1
Ujhelyi, B1
Berta, A1
Boda, J1
Berta, E1
Bodor, M1
Gazdag, A1
Nagy, EV1
Sendhil Kumaran, M1
Dutta, P1
Sakia, U1
Dogra, S1
Budny, B1
Zybek-Kocik, A1
Sowiński, J1
Ziemnicka, K1
Waligórska-Stachura, J1
Ruchała, M1
Tu, Y1
Wang, Y1
Ding, L1
Zhang, J1
Wu, W1
Fernando, R1
Placzek, E1
Reese, EA1
Placzek, AT1
Schwartz, S1
Trierweiler, A1
Niziol, LM1
Raychaudhuri, N1
Atkins, S1
Scanlan, TS1
Smith, TJ1
Sieminska, L1
Niedziolka, D1
Pillich, A1
Kos-Kudla, B1
Marek, B1
Borgiel-Marek, H1
Shadpour, JM1
Menghani, RM1
Douglas, RS1
Goldberg, RA1
Tsirbas, A1
Daroszewski, J1
Pawlak, E1
Karabon, L1
Frydecka, I1
Jonkisz, A1
Slowik, M1
Bolanowski, M1
Lai, A1
Sassi, L1
Compri, E1
Marino, F1
Sivelli, P1
Piantanida, E1
Tanda, ML1
Bartalena, L1
Akarsu, E1
Buyukhatipoglu, H1
Aktaran, S1
Kurtul, N1
Regalbuto, C1
Le Moli, R1
Muscia, V1
Russo, M1
Vigneri, R1
Pezzino, V1
Jang, SY1
Lee, SY1
Lee, EJ1
Yoon, JS1
Subekti, I1
Boedisantoso, A1
Moeloek, ND1
Waspadji, S1
Mansyur, M1
Profilo, MA1
Sisti, E1
Marcocci, C1
Vitti, P1
Pinchera, A1
Nardi, M1
Rocchi, R1
Latrofa, F1
Menconi, F1
Altea, MA1
Leo, M1
Rago, T1
Marinò, M1
Xia, N1
Zhou, S1
Liang, Y1
Xiao, C1
Shen, H1
Pan, H1
Deng, H1
Wang, N1
Li, QQ1

Other Studies

24 other studies available for triiodothyronine and Graves Ophthalmopathy

ArticleYear
Thyroid-Stimulating Antibody/Thyroid-Stimulating Hormone Receptor Antibody Ratio as a Sensitive Screening Test for Active Graves' Orbitopathy.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2022, Volume: 28, Issue:10

    Topics: Autoantibodies; Graves Disease; Graves Ophthalmopathy; Humans; Immunoglobulins, Thyroid-Stimulating;

2022
Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Glycated Hemoglobin; Graves Ophthalmopathy; Humans; Thyroid Hormones; Thyrotropin; Thyroxine; Triiod

2022
MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2.
    Endocrine, 2023, Volume: 82, Issue:1

    Topics: Graves Ophthalmopathy; Humans; Hyaluronan Synthases; Leukocytes, Mononuclear; MicroRNAs; Triiodothyr

2023
Radioiodine therapy and Graves' disease - Myths and reality.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Cigarette Smoking; Female; Graves Disease; Graves Ophthalmopa

2020
The effect of thyroid hormone status on selected antioxidant parameters in patients with Graves' disease and active thyroid-associated orbitopathy.
    Endokrynologia Polska, 2020, Volume: 71, Issue:5

    Topics: Adult; Female; Graves Ophthalmopathy; Humans; Hyperthyroidism; Male; Middle Aged; Oxidative Stress;

2020
Downregulation of Caveolin-1 and Upregulation of Deiodinase 3, Associated with Hypoxia-Inducible Factor-1α Increase, Are Involved in the Oxidative Stress of Graves' Orbital Adipocytes.
    Thyroid : official journal of the American Thyroid Association, 2021, Volume: 31, Issue:4

    Topics: Adipocytes; Adult; Case-Control Studies; Caveolin 1; Cells, Cultured; Female; Gene Expression Regula

2021
Considerations in Pediatric Proptosis.
    JAMA ophthalmology, 2018, 10-01, Volume: 136, Issue:10

    Topics: Adolescent; Antithyroid Agents; Blepharoptosis; Cholinesterase Inhibitors; Drug Therapy, Combination

2018
Dry Eye Syndrome in Non-Exophthalmic Graves' Disease.
    Seminars in ophthalmology, 2015, Volume: 30, Issue:5-6

    Topics: Adult; Dry Eye Syndromes; Female; Graves Ophthalmopathy; Humans; Immunoglobulins, Thyroid-Stimulatin

2015
Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves' ophthalmopathy.
    World journal of pediatrics : WJP, 2014, Volume: 10, Issue:2

    Topics: Adolescent; Autoantibodies; Child; Female; Graves Ophthalmopathy; Humans; Iodide Peroxidase; Male; P

2014
Rapid response to and long-term effectiveness of anti-CD20 antibody in conventional therapy resistant Graves' orbitopathy: A five-year follow-up study.
    Autoimmunity, 2014, Volume: 47, Issue:8

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Female; Follow-Up Studies; Graves Ophthalmopathy; Hum

2014
Long-term follow-up and epidemiological trends in patients with pretibial myxedema: an 11-year study from a tertiary care center in northern India.
    International journal of dermatology, 2015, Volume: 54, Issue:8

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Clobetasol; Drug Therapy, Combination;

2015
Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves' opthalmopathy.
    Endocrine, 2016, Volume: 53, Issue:2

    Topics: Adult; Autoantibodies; Body Mass Index; Cross-Sectional Studies; Female; Graves Ophthalmopathy; Huma

2016
Development of a Novel Thyroid Function Fluctuated Animal Model for Thyroid-Associated Ophthalmopathy.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Animals; Body Weight; Disease Models, Animal; Drug Administration Schedule; Endoplasmic Reticulum; G

2016
Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy.
    The Journal of clinical endocrinology and metabolism, 2017, 03-01, Volume: 102, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Case-Control Studies; Cells, Cultured; Chromatograp

2017
Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients.
    Journal of endocrinological investigation, 2008, Volume: 31, Issue:9

    Topics: Adiponectin; Autoantibodies; Female; Graves Ophthalmopathy; Humans; Male; Middle Aged; Regression An

2008
Reactivation of thyroid-associated orbitopathy after cataract surgery.
    Japanese journal of ophthalmology, 2009, Volume: 53, Issue:1

    Topics: Aged, 80 and over; Cataract Extraction; Female; Graves Ophthalmopathy; Humans; Orbital Diseases; Rec

2009
Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms.
    European journal of endocrinology, 2009, Volume: 161, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD; Cohort Studies; CTLA-4 Antigen; DNA; Femal

2009
Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent graves' orbitopathy: a retrospective cohort study.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:3

    Topics: Adult; Aged; Chi-Square Distribution; Female; Glucocorticoids; Graves Disease; Graves Ophthalmopathy

2010
Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves' ophthalmopathy.
    Clinical endocrinology, 2011, Volume: 74, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Female; Glutathione; Graves Ophthalmopathy; Humans; Iodide Peroxida

2011
Severe Graves' ophthalmopathy after percutaneous ethanol injection in a nontoxic thyroid nodule.
    Thyroid : official journal of the American Thyroid Association, 2012, Volume: 22, Issue:2

    Topics: Administration, Cutaneous; Ethanol; Graves Ophthalmopathy; Humans; Hyperthyroidism; Immunoglobulins,

2012
Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients.
    Eye (London, England), 2012, Volume: 26, Issue:9

    Topics: Adult; Euthyroid Sick Syndromes; Eyelid Diseases; Female; Graves Ophthalmopathy; Humans; Hyperthyroi

2012
Association of TSH receptor antibody, thyroid stimulating antibody, and thyroid blocking antibody with clinical activity score and degree of severity of Graves ophthalmopathy.
    Acta medica Indonesiana, 2012, Volume: 44, Issue:2

    Topics: Adipose Tissue; Adult; Cross-Sectional Studies; Female; Graves Ophthalmopathy; Humans; Immunoglobuli

2012
Thyroid volume and severity of Graves' orbitopathy.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Female; Graves Ophthalmopathy; Humans; M

2013
CD4+ T cells and the Th1/Th2 imbalance are implicated in the pathogenesis of Graves' ophthalmopathy.
    International journal of molecular medicine, 2006, Volume: 17, Issue:5

    Topics: Adolescent; Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Female;

2006